{"id":10841,"date":"2017-01-10T13:32:33","date_gmt":"2017-01-10T10:32:33","guid":{"rendered":"https:\/\/www.synevo.ro\/informatii-medicale\/testare-genetica-tehnici\/"},"modified":"2021-01-20T15:00:21","modified_gmt":"2021-01-20T13:00:21","slug":"testare-genetica-tehnici","status":"publish","type":"synevo_medical","link":"https:\/\/old.synevo.md\/ru\/informatii-medicale\/testare-genetica-tehnici\/","title":{"rendered":"Testare genetic\u0103 (tehnici)"},"content":{"rendered":"<h2 class=\"has-luminous-vivid-amber-color has-text-color wp-block-heading\"><strong>Citogenetic\u0103<\/strong><\/h2><ul class=\"wp-block-list\"><li><strong><a href=\"https:\/\/www.synevo.md\/shop\/analiza-cromozomiala-cariotip-in-lichid-amniotic\/\" class=\"rank-math-link\" rel=\"nofollow noopener\" target=\"_blank\">Cariotipul constitu\u021bional pentru diagnostic prenatal din lichid amniotic<\/a><\/strong><\/li><\/ul><p class=\"has-text-color\" style=\"color:#00539f\"><strong>Principiul metodei<\/strong><\/p><p>Principiul analizei cromozomilor din lichid amniotic const\u0103 \u00een <strong>cultivarea amniocitelor fetale<\/strong> pentru ob\u021binerea de cromozomi \u0219i blocarea diviziunii celulelor \u00een etapa de metafaz\u0103 a mitozei. Cromozomii ob\u021binu\u021bi sunt banda\u021bi \u0219i colora\u021bi \u00een scopul introducerii unui pattern specific pentru fiecare cromozom \u00een parte \u0219i sunt cariotipa\u021bi cu softul Gen ASIs.<\/p><div class=\"synevo-shop-products\">\r\n    <div class=\"sysprod\">\r\n        \r\n        <div class=\"sysprod-products\">\r\n                            <div class=\"sysprod-product\">\r\n                    <a class=\"sysprod-product-title\" href=\"https:\/\/old.synevo.md\/ru\/shop\/analiza-cromozomiala-cariotip-in-lichid-amniotic\/\">Analiza cromozomial\u0103 (cariotip) \u00een lichid amniotic<\/a>\r\n                    <div class=\"sysprod-product-price\">\r\n                        <span>Pre\u021b:<\/span>\r\n                        <span>4100.00 lei<\/span>\r\n                    <\/div>\r\n                                            <div class=\"sysprod-product-addcart\">\r\n                            <a\r\n                                href=\"?add-to-cart=10259\"\r\n                                data-quantity=\"1\"\r\n                                class=\"addToCart button product_type_simple add_to_cart_button ajax_add_to_cart \"\r\n                                data-product_id=\"10259\"\r\n                                data-product_sku=\"CITOGEN2\"\r\n                                rel=\"nofollow\"\r\n                            ><div><\/div><\/a>\r\n                        <\/div>\r\n                                    <\/div>\r\n                    <\/div>\r\n        \r\n    <\/div>\r\n<\/div>\r\n\r\n<style>\r\n.synevo-shop-products {\r\n    padding: 24px 0;\r\n    margin: 24px 0;\r\n    border-radius: 10px;\r\n    background: #F6F7F9;\r\n}\r\n.synevo-shop-products .sysprod-product {\r\n    position: relative;\r\n    margin: 0 24px;\r\n    margin-bottom: 24px;\r\n    border-radius: 10px;\r\n    background: #fff;\r\n    display: flex;\r\n    flex-direction: row;\r\n    align-items: center;\r\n}\r\n.synevo-shop-products .sysprod-product:last-child {\r\n    margin-bottom: 0;\r\n}\r\n.synevo-shop-products .sysprod-product-title {\r\n    flex-grow: 1;\r\n    padding: 15px;\r\n    margin-left: 14px;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 16px;\r\n    color: #29263F;\r\n}\r\n.synevo-shop-products .sysprod-product-price {\r\n    flex-shrink: 0;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 18px;\r\n    color: #FDB813;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart {\r\n    flex-shrink: 0;\r\n    position: relative;\r\n    width: 38px;\r\n    height: 38px;\r\n    margin-left: 24px;\r\n    margin-right: 24px;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart .button {\r\n    top: unset;\r\n    right: unset;\r\n}\r\n<\/style><ul class=\"wp-block-list\"><li><strong><a href=\"https:\/\/www.synevo.md\/shop\/analiza-cromozomiala-in-sange-cariotip-constitutional\/\" class=\"rank-math-link\" rel=\"nofollow noopener\" target=\"_blank\">Cariotipul constitu\u021bional pentru diagnostic postnatal din s\u00e2nge periferic<\/a><\/strong><\/li><\/ul><p class=\"has-text-color\" style=\"color:#00539f\"><strong> Principiul metodei<\/strong><\/p><p>Principiul analizei cromozomilor din s\u00e2nge periferic const\u0103 \u00een <strong>stimularea prolifer\u0103rii limfocitelor T cu phitohemaglutinin\u0103<\/strong> pentru ob\u021binerea de cromozomi \u0219i blocarea diviziunii celulelor \u00een etapa de metafaz\u0103 a mitozei. Cromozomii ob\u021binu\u021bi sunt banda\u021bi \u0219i colora\u021bi pentru inducerea unui pattern specific pentru fiecare cromozom \u00een parte \u0219i sunt cariotipa\u021bi.<\/p><div class=\"synevo-shop-products\">\r\n    <div class=\"sysprod\">\r\n        \r\n        <div class=\"sysprod-products\">\r\n                            <div class=\"sysprod-product\">\r\n                    <a class=\"sysprod-product-title\" href=\"https:\/\/old.synevo.md\/ru\/shop\/analiza-cromozomiala-in-sange-cariotip-constitutional\/\">Analiza cromozomial\u0103 \u00een s\u00e2nge (cariotip constitu\u021bional)<\/a>\r\n                    <div class=\"sysprod-product-price\">\r\n                        <span>Pre\u021b:<\/span>\r\n                        <span>2330 lei<\/span>\r\n                    <\/div>\r\n                                            <div class=\"sysprod-product-addcart\">\r\n                            <a\r\n                                href=\"?add-to-cart=47904\"\r\n                                data-quantity=\"1\"\r\n                                class=\"addToCart button product_type_simple add_to_cart_button ajax_add_to_cart \"\r\n                                data-product_id=\"47904\"\r\n                                data-product_sku=\"CITOGEN1\"\r\n                                rel=\"nofollow\"\r\n                            ><div><\/div><\/a>\r\n                        <\/div>\r\n                                    <\/div>\r\n                    <\/div>\r\n        \r\n    <\/div>\r\n<\/div>\r\n\r\n<style>\r\n.synevo-shop-products {\r\n    padding: 24px 0;\r\n    margin: 24px 0;\r\n    border-radius: 10px;\r\n    background: #F6F7F9;\r\n}\r\n.synevo-shop-products .sysprod-product {\r\n    position: relative;\r\n    margin: 0 24px;\r\n    margin-bottom: 24px;\r\n    border-radius: 10px;\r\n    background: #fff;\r\n    display: flex;\r\n    flex-direction: row;\r\n    align-items: center;\r\n}\r\n.synevo-shop-products .sysprod-product:last-child {\r\n    margin-bottom: 0;\r\n}\r\n.synevo-shop-products .sysprod-product-title {\r\n    flex-grow: 1;\r\n    padding: 15px;\r\n    margin-left: 14px;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 16px;\r\n    color: #29263F;\r\n}\r\n.synevo-shop-products .sysprod-product-price {\r\n    flex-shrink: 0;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 18px;\r\n    color: #FDB813;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart {\r\n    flex-shrink: 0;\r\n    position: relative;\r\n    width: 38px;\r\n    height: 38px;\r\n    margin-left: 24px;\r\n    margin-right: 24px;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart .button {\r\n    top: unset;\r\n    right: unset;\r\n}\r\n<\/style><p class=\"has-text-color\" style=\"color:#00539f\"><strong>Cariotip spectral<\/strong><\/p><ul class=\"wp-block-list\"><li><strong><a href=\"https:\/\/www.synevo.md\/shop\/microdeletii-brat-scurt-cromozom-y-sry-cariotip-si-testare-fish\/\" class=\"rank-math-link\" rel=\"nofollow noopener\" target=\"_blank\">detec\u021bie microdele\u021bii pe bra\u021bul scurt al cromozomuluI Y<\/a><\/strong><\/li><li><strong>detec\u021bie duplica\u021bii cromozom 22q11,2<\/strong><\/li><\/ul><p class=\"has-text-color\" style=\"color:#00539f\"><strong> Principiul metodei<\/strong><\/p><p><strong>Hibridizarea fluorescent \u00een situ (FISH)<\/strong> este o tehnic\u0103 de citogenetic\u0103 molecular\u0103 utilizat\u0103 \u00een scopul identific\u0103rii anomaliilor cromozomiale, numerice \u0219i structurale (care nu pot fi determinate prin cariotipare).<\/p><p>Principiul acestei metode const\u0103 \u00een ata\u0219area la secven\u021ba-\u021bint\u0103 a unei sonde de ADN monocatenar (de circa 40kb), marcat\u0103 fluorescent, pe baza complementarit\u0103\u021bii, de o secven\u021b\u0103-\u021bint\u0103 a unui cromozom. Hibridizarea sondei cu ADN-ul celular este vizualizat\u0103 la microscopul cu fluorescent echipat cu filtre de excita\u021bie \u0219i emisie, ceea ce permite citirea semnalelor zonei \u021bint\u0103.<\/p><p>Sonda pentru gena SRY, marcat\u0103 cu ro\u0219u, este format\u0103 din dou\u0103 secven\u021be care nu se suprapun, 30Kb \u0219i 50kb. Secven\u021bele acoper\u0103 \u00eentreaga gen\u0103 SRY \u0219i AND-ul care o flancheaz\u0103, inclusiv gena RPS4Y1. Sondele con\u021bin, de asemenea, o sond\u0103 de control pentru centromerul cromozomului X(DXZ1) marcat \u00een bleu \u0219i pentru cromozomul Y (DYZ1, regiunea heterocromatic\u0103Yq12) marcat \u00een verde.<\/p><div class=\"synevo-shop-products\">\r\n    <div class=\"sysprod\">\r\n        \r\n        <div class=\"sysprod-products\">\r\n                            <div class=\"sysprod-product\">\r\n                    <a class=\"sysprod-product-title\" href=\"https:\/\/old.synevo.md\/ru\/shop\/microdeletii-brat-scurt-cromozom-y-sry\/\">Microdeletii brat scurt cromozom Y (SRY)<\/a>\r\n                    <div class=\"sysprod-product-price\">\r\n                        <span>Pre\u021b:<\/span>\r\n                        <span>3850.00 lei<\/span>\r\n                    <\/div>\r\n                                    <\/div>\r\n                    <\/div>\r\n        \r\n    <\/div>\r\n<\/div>\r\n\r\n<style>\r\n.synevo-shop-products {\r\n    padding: 24px 0;\r\n    margin: 24px 0;\r\n    border-radius: 10px;\r\n    background: #F6F7F9;\r\n}\r\n.synevo-shop-products .sysprod-product {\r\n    position: relative;\r\n    margin: 0 24px;\r\n    margin-bottom: 24px;\r\n    border-radius: 10px;\r\n    background: #fff;\r\n    display: flex;\r\n    flex-direction: row;\r\n    align-items: center;\r\n}\r\n.synevo-shop-products .sysprod-product:last-child {\r\n    margin-bottom: 0;\r\n}\r\n.synevo-shop-products .sysprod-product-title {\r\n    flex-grow: 1;\r\n    padding: 15px;\r\n    margin-left: 14px;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 16px;\r\n    color: #29263F;\r\n}\r\n.synevo-shop-products .sysprod-product-price {\r\n    flex-shrink: 0;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 18px;\r\n    color: #FDB813;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart {\r\n    flex-shrink: 0;\r\n    position: relative;\r\n    width: 38px;\r\n    height: 38px;\r\n    margin-left: 24px;\r\n    margin-right: 24px;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart .button {\r\n    top: unset;\r\n    right: unset;\r\n}\r\n<\/style><div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/2017\/01\/2.png\" alt=\"-\" class=\"wp-image-24349\" width=\"413\" height=\"216\"><\/figure><\/div><div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/2017\/01\/1.jpg\" alt=\"-\" class=\"wp-image-24348\" width=\"479\" height=\"360\"><\/figure><\/div><p>Examinarea preparatelor pe lam\u0103 se face cu ajutorul microscopului Zeiss.<\/p><hr class=\"wp-block-separator\"\/><h2 class=\"has-luminous-vivid-amber-color has-text-color wp-block-heading\"><strong>Genetica molecular\u0103 <\/strong><\/h2><p><a href=\"https:\/\/www.synevo.md\/shop\/cariotip-molecular-hibridizarea-genomica-comparativa\/\" class=\"rank-math-link\" rel=\"nofollow noopener\" target=\"_blank\"><strong>Cariotip molecular<\/strong><\/a> pentru diagnostic postnatal-array cgh (<em>array-based Comparative Genomic Hybridization<\/em>)<\/p><p class=\"has-text-color\" style=\"color:#00539f\"><strong>Principiul metodei<\/strong><\/p><p>Principiul aCGH se bazeaz\u0103 pe compararea cantitativ\u0103 a ADN-ului testat cu ADN-ul de referin\u021b\u0103 (de obicei apar\u021bin\u00e2nd unui individ s\u0103n\u0103tos). ADN-ul (testat \u0219i de refetin\u021b\u0103) este marcat cu 2 substan\u021be fluorescente diferite:<\/p><ul class=\"wp-block-list\"><li>ADN testat \u2013 fluorocrom <strong>ro\u0219u<\/strong><\/li><li>ADN referin\u021b\u0103 \u2013 fluorocrom <strong>verde<\/strong><\/li><\/ul><p>Array CGH se lucreaz\u0103 pe scanner Agilent.<\/p><p>Rezultatul cariotipului molecular array CGH descrie, conform ISCN (International System of Human Cytogenetic Nomenclature), modific\u0103rile numerice \u0219i structurale neechilibrate identificate (pierdere sau c\u00e2\u0219tig de material genetic), punctele de ruptur\u0103, dimensiunile exacte ale modific\u0103rilor.<\/p><div class=\"synevo-shop-products\">\r\n    <div class=\"sysprod\">\r\n        \r\n        <div class=\"sysprod-products\">\r\n                            <div class=\"sysprod-product\">\r\n                    <a class=\"sysprod-product-title\" href=\"https:\/\/old.synevo.md\/ru\/shop\/cariotip-molecular-hibridizarea-genomica-comparativa\/\">Cariotip molecular (Hibridizarea genomic\u0103 comparativ\u0103)<\/a>\r\n                    <div class=\"sysprod-product-price\">\r\n                        <span>Pre\u021b:<\/span>\r\n                        <span>12000.00 lei<\/span>\r\n                    <\/div>\r\n                                            <div class=\"sysprod-product-addcart\">\r\n                            <a\r\n                                href=\"?add-to-cart=11868\"\r\n                                data-quantity=\"1\"\r\n                                class=\"addToCart button product_type_simple add_to_cart_button ajax_add_to_cart \"\r\n                                data-product_id=\"11868\"\r\n                                data-product_sku=\"CITOGEN10\"\r\n                                rel=\"nofollow\"\r\n                            ><div><\/div><\/a>\r\n                        <\/div>\r\n                                    <\/div>\r\n                    <\/div>\r\n        \r\n    <\/div>\r\n<\/div>\r\n\r\n<style>\r\n.synevo-shop-products {\r\n    padding: 24px 0;\r\n    margin: 24px 0;\r\n    border-radius: 10px;\r\n    background: #F6F7F9;\r\n}\r\n.synevo-shop-products .sysprod-product {\r\n    position: relative;\r\n    margin: 0 24px;\r\n    margin-bottom: 24px;\r\n    border-radius: 10px;\r\n    background: #fff;\r\n    display: flex;\r\n    flex-direction: row;\r\n    align-items: center;\r\n}\r\n.synevo-shop-products .sysprod-product:last-child {\r\n    margin-bottom: 0;\r\n}\r\n.synevo-shop-products .sysprod-product-title {\r\n    flex-grow: 1;\r\n    padding: 15px;\r\n    margin-left: 14px;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 16px;\r\n    color: #29263F;\r\n}\r\n.synevo-shop-products .sysprod-product-price {\r\n    flex-shrink: 0;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 18px;\r\n    color: #FDB813;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart {\r\n    flex-shrink: 0;\r\n    position: relative;\r\n    width: 38px;\r\n    height: 38px;\r\n    margin-left: 24px;\r\n    margin-right: 24px;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart .button {\r\n    top: unset;\r\n    right: unset;\r\n}\r\n<\/style><h2 class=\"has-luminous-vivid-amber-color has-text-color wp-block-heading\"><strong>Real Time PCR<\/strong><\/h2><ul class=\"wp-block-list\"><li><strong><a href=\"https:\/\/www.synevo.md\/shop\/fibroza-chistica-38-mutatii-cftr\/\" class=\"rank-math-link\" rel=\"nofollow noopener\" target=\"_blank\">Diagnostic fibroz\u0103 chistic\u0103<\/a><\/strong><\/li><\/ul><p class=\"has-text-color\" style=\"color:#00539f\"><strong>Principiul Metodei<\/strong><\/p><p>Metoda se bazeaz\u0103 pe amplificarea prin PCR multiplex a moleculelor de ADN cu primeri specifici biotinila\u021bi, apoi revershibridizarea pe stripuri a acestor produ\u0219i PCR; aceste stripuri (strips) constau \u00een membrane pe care sunt fixate sonde oligonucleotidice specifice pentru detec\u021bia celor 38 de muta\u021bii din gena <em>CFTR<\/em>. Recunoa\u0219terea \u0219i legarea exact\u0103, pe baz\u0103 de complementaritate, a produ\u0219ilor PCR biotinila\u021bi la sondele specifice acestora sunt apoi vizualizate colorimetric, cu ajutorul sistemului de colorare biotin\u0103-streptavidin\u0103 conjugat\u0103 cu fosfataza alcalin\u0103 \u0219i a unui substrat (\u201cdeveloper\u201d) colorat.<\/p><p><a href=\"https:\/\/www.synevo.md\/shop\/fibroza-chistica-38-mutatii-cftr\/\" class=\"rank-math-link\" rel=\"nofollow noopener\" target=\"_blank\">Metoda detecteaz\u0103 simultan 38 de muta\u021bii\/variante \u00een gena CFTR<\/a>, \u0219i anume<strong>: <\/strong>F508del, I507del, F508C, I502T, 1706del17, 1677del TA, G542X, 1717-1G&gt;A, R553X, Q552X, G551D, S549R A&gt;C, N1303K, 4016insT, R1162X, R1158X, W1282X, G1244E, 2789+5G&gt;A, 2183AA&gt;G, 711+5G&gt;A, 711+1G&gt;T, G85E, 3849+10kbC&gt;T, 621+1G&gt;T, R117H, D1152H, L1065P, R1066H, L1077P, 4382delA, 1259insA, 852del 22, R347P, T338I, S912X, I148T, 3199del6, Allele 5T-7T-9T.<\/p><div class=\"synevo-shop-products\">\r\n    <div class=\"sysprod\">\r\n        \r\n        <div class=\"sysprod-products\">\r\n                    <\/div>\r\n        \r\n    <\/div>\r\n<\/div>\r\n\r\n<style>\r\n.synevo-shop-products {\r\n    padding: 24px 0;\r\n    margin: 24px 0;\r\n    border-radius: 10px;\r\n    background: #F6F7F9;\r\n}\r\n.synevo-shop-products .sysprod-product {\r\n    position: relative;\r\n    margin: 0 24px;\r\n    margin-bottom: 24px;\r\n    border-radius: 10px;\r\n    background: #fff;\r\n    display: flex;\r\n    flex-direction: row;\r\n    align-items: center;\r\n}\r\n.synevo-shop-products .sysprod-product:last-child {\r\n    margin-bottom: 0;\r\n}\r\n.synevo-shop-products .sysprod-product-title {\r\n    flex-grow: 1;\r\n    padding: 15px;\r\n    margin-left: 14px;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 16px;\r\n    color: #29263F;\r\n}\r\n.synevo-shop-products .sysprod-product-price {\r\n    flex-shrink: 0;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 18px;\r\n    color: #FDB813;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart {\r\n    flex-shrink: 0;\r\n    position: relative;\r\n    width: 38px;\r\n    height: 38px;\r\n    margin-left: 24px;\r\n    margin-right: 24px;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart .button {\r\n    top: unset;\r\n    right: unset;\r\n}\r\n<\/style><ul class=\"wp-block-list\"><li><strong><a href=\"https:\/\/www.synevo.md\/shop\/microdeletii-brat-lung-cromozom-y-azfa-azfb-azfc\/\" class=\"rank-math-link\" rel=\"nofollow noopener\" target=\"_blank\">Eviden\u021biere microdele\u021bii AZF<\/a><\/strong><\/li><\/ul><p class=\"has-text-color\" style=\"color:#00539f\"><strong>Principiul metodei<\/strong><\/p><p>ADN genomic izolat din s\u00e2nge venos este amplificat cu primeri specifici regiunilor de interes AZF prin tehnica PCR multiplex. Analiza fragmentelor fluorescente rezultate este realizat\u0103 prin electroforeza capilar\u0103 utiliz\u00e2nd analizorul ABI3500.<\/p><div class=\"synevo-shop-products\">\r\n    <div class=\"sysprod\">\r\n        \r\n        <div class=\"sysprod-products\">\r\n                            <div class=\"sysprod-product\">\r\n                    <a class=\"sysprod-product-title\" href=\"https:\/\/old.synevo.md\/ru\/shop\/microdeletii-brat-lung-cromozom-y-azfa-azfb-azfc\/\">Microdele\u021bii bra\u021b lung cromozom Y (AZFa, AZFb, AZFc)<\/a>\r\n                    <div class=\"sysprod-product-price\">\r\n                        <span>Pre\u021b:<\/span>\r\n                        <span>2500 lei<\/span>\r\n                    <\/div>\r\n                                            <div class=\"sysprod-product-addcart\">\r\n                            <a\r\n                                href=\"?add-to-cart=10257\"\r\n                                data-quantity=\"1\"\r\n                                class=\"addToCart button product_type_simple add_to_cart_button ajax_add_to_cart \"\r\n                                data-product_id=\"10257\"\r\n                                data-product_sku=\"BM133\"\r\n                                rel=\"nofollow\"\r\n                            ><div><\/div><\/a>\r\n                        <\/div>\r\n                                    <\/div>\r\n                    <\/div>\r\n        \r\n    <\/div>\r\n<\/div>\r\n\r\n<style>\r\n.synevo-shop-products {\r\n    padding: 24px 0;\r\n    margin: 24px 0;\r\n    border-radius: 10px;\r\n    background: #F6F7F9;\r\n}\r\n.synevo-shop-products .sysprod-product {\r\n    position: relative;\r\n    margin: 0 24px;\r\n    margin-bottom: 24px;\r\n    border-radius: 10px;\r\n    background: #fff;\r\n    display: flex;\r\n    flex-direction: row;\r\n    align-items: center;\r\n}\r\n.synevo-shop-products .sysprod-product:last-child {\r\n    margin-bottom: 0;\r\n}\r\n.synevo-shop-products .sysprod-product-title {\r\n    flex-grow: 1;\r\n    padding: 15px;\r\n    margin-left: 14px;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 16px;\r\n    color: #29263F;\r\n}\r\n.synevo-shop-products .sysprod-product-price {\r\n    flex-shrink: 0;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 18px;\r\n    color: #FDB813;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart {\r\n    flex-shrink: 0;\r\n    position: relative;\r\n    width: 38px;\r\n    height: 38px;\r\n    margin-left: 24px;\r\n    margin-right: 24px;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart .button {\r\n    top: unset;\r\n    right: unset;\r\n}\r\n<\/style><ul class=\"wp-block-list\"><li><strong>Determinare EGFR \u021besut \u0219i plasm\u0103<\/strong><\/li><\/ul><p class=\"has-text-color\" style=\"color:#00539f\"><strong>Principiul Metodei<\/strong><\/p><p>Test Cobas EGFR are la baz\u0103 2 procese majore: prepararea probei \u0219i ob\u021binerea AND-ului din FFPET (formalin fixed paraffin embedded \u2013 \u021besut fixat \u00een formol \u0219i inclus \u00een parafin\u0103) \u0219i amplificarea prin PCR multiplex a moleculelor de AND cu primeri specifici \u0219i sonde oligonucleotidice specific marcate cu fluorochrome (Real-Time PCR).<\/p><p>Aceast\u0103 metod\u0103 Real-Time PCR detecteaz\u0103 simultan 42 de muta\u021bii \u00een gena EGFR la nivelul exonilor:<\/p><ul class=\"wp-block-list\"><li>Exon 18: grupul de muta\u021bii (G719X, G719A, GG719C, G719S)<\/li><li>Exon 19: grupul de dele\u021bii<\/li><li>Exon 20: grupul de muta\u021bii (S768I, T790M) \u0219i inser\u021bii<\/li><li>Exon 21: grupul de muta\u021bii (L858R, L861Q)<\/li><\/ul>","protected":false},"featured_media":22635,"template":"","synevo_medical_category":[889],"class_list":["post-10841","synevo_medical","type-synevo_medical","status-publish","has-post-thumbnail","hentry","synevo_medical_category-articole"],"synevo_medical_metadata_title":["Testare genetic\u0103 (tehnici)"],"synevo_medical_metadata_author":[",11289"],"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/synevo_medical\/10841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/synevo_medical"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/synevo_medical"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media\/22635"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10841"}],"wp:term":[{"taxonomy":"synevo_medical_category","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/synevo_medical_category?post=10841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}