{"id":10476,"date":"2007-11-15T13:55:54","date_gmt":"2007-11-15T10:55:54","guid":{"rendered":"https:\/\/www.synevo.ro\/afectiuni\/profil-hepatita-autoimuna\/"},"modified":"2020-07-10T14:21:36","modified_gmt":"2020-07-10T11:21:36","slug":"profil-hepatita-autoimuna","status":"publish","type":"synevo_diseases","link":"https:\/\/old.synevo.md\/ru\/afectiuni\/profil-hepatita-autoimuna\/","title":{"rendered":"Profil hepatit\u0103 autoimun\u0103"},"content":{"rendered":"

Hepatita autoimun\u0103<\/strong><\/span> este o afec\u0163iune necroinflamatorie a ficatului, cu predilec\u0163ie pentru sexul feminin (4:1), caracterizat\u0103 prin: hipergamaglobulinemie, autoanticorpi caracteristici, asocierea cu HLA DR3 sau DR4 \u015fi un r\u0103spuns favorabil la terapia imunosupresoare. Etiologia sa este necunoscut\u0103.1<\/sup>
De obicei, se prezint\u0103 ca o hepatit\u0103 cronic\u0103, dar un num\u0103r important de pacien\u0163i pot prezenta o form\u0103 acut\u0103 de boal\u0103, cu icter, mim\u00e2nd prezentarea hepatitei acute virale. Ocazional se poate prezenta ca insuficien\u0163\u0103 hepatic\u0103 acut\u0103.<\/p>\n

Important\u0103 \u00een diagnosticarea hepatitei autoimune<\/strong> este asocierea frecvent\u0103 cu alte boli autoimune (tiroidita, colita ulcerativ\u0103, poliartrita reumatoid\u0103, diabetul zaharat, sindromul Sjogren, etc.).2<\/sup><\/p>\n

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Clasificarea<\/strong> actual\u0103 a hepatitelor autoimune include 2 tipuri majore, \u00een func\u0163ie de caracteristicile serologice.<\/p>\n

Tipul 1<\/strong><\/span> este caracterizat \u00een mod tipic prin prezen\u0163a autoanticorpilor antinucleari(ANA) \u015fi\/sau anti-fibra muscular\u0103 neted\u0103 (ASMA). Determinarea suplimentar\u0103 a anticorpilor p-ANCA, a anticorpilor \u00eendrepta\u0163i \u00eempotriva receptorului pentru asialoglicoproteine (anti-ASGP-R) precum \u015fi a anticorpilor \u00eempotriva antigenelor solubile hepatice \u015fi pancreatice (anti-SLA\/LP) este util\u0103 pentru identificarea pacien\u0163ilor care sunt seronegativi pentru ANA \u015fi ASMA.<\/p>\n

Tipul 2 <\/strong><\/span>este asociat cu prezen\u0163a autoanticorpilor \u00eendrepta\u0163i \u00eempotriva antigenelor microzomiale hepatice \u015fi renale (anti-LKM tipul 1 \u015fi mai rar tipul 3) \u015fi\/sau a anticorpilor \u00eempotriva antigenului de tip 1 din citosolul hepatic (anti-LC1). Din punct de vedere clinic, hepatita autoimun\u0103 de tip 2 debuteaz\u0103 \u00een copil\u0103rie, fiind caracteristic\u0103 grupei de v\u00e2rsta 2-14 ani \u015fi are o evolu\u0163ie mai sever\u0103 dec\u00e2t hepatita autoimun\u0103 de tip 1.1 <\/sup>Tipul 1 de hepatit\u0103 autoimun\u0103 este cel mai frecvent \u00eent\u00e2lnit.2<\/sup><\/p>\n

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Clasificarea hepatitelor autoimune\u00b9<\/strong><\/span><\/p>\n

\u00a0<\/div>\n
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Tipul hepatitei autoimune\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Autoanticorpi prezen\u0163i<\/strong><\/div>\n
\u00a0<\/div>\n
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Tipul\u00a01\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 ANA, ASMA, p-ANCA \u015fi\/sau anti-SLA\/LP<\/p>\n<\/div>\n

\u00a0<\/div>\n
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Tipul\u00a02\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 anti-LKM-1, anti-LKM-3 \u015fi\/sau anti-LC1<\/p>\n<\/div>\n

\u00a0<\/div>\n

Teste disponibile \u00een laboratoarele Synevo:<\/p><\/div>\n\n

\r\n
\r\n \r\n
\r\n
\r\n Anticorpi anti-SLA\/LP<\/a>\r\n
\r\n Pre\u021b:<\/span>\r\n 540 lei<\/span>\r\n <\/div>\r\n
\r\n
<\/div><\/a>\r\n <\/div>\r\n <\/div>\r\n
\r\n Anticorpi anti-mu\u0219chi neted (ASMA)<\/a>\r\n
\r\n Pre\u021b:<\/span>\r\n 410.00 lei<\/span>\r\n <\/div>\r\n
\r\n
<\/div><\/a>\r\n <\/div>\r\n <\/div>\r\n
\r\n Anticorpi anti-citoplasma neutrofile (ANCA) – imunofluorescenta<\/a>\r\n
\r\n Pre\u021b:<\/span>\r\n 1120 lei<\/span>\r\n <\/div>\r\n
\r\n
<\/div><\/a>\r\n <\/div>\r\n <\/div>\r\n
\r\n Anticorpi anti-LKM1<\/a>\r\n
\r\n Pre\u021b:<\/span>\r\n 410.00 lei<\/span>\r\n <\/div>\r\n
\r\n
<\/div><\/a>\r\n <\/div>\r\n <\/div>\r\n
\r\n Anticorpi-mitocondrii ( AMA )<\/a>\r\n
\r\n Pre\u021b:<\/span>\r\n 380.00 lei<\/span>\r\n <\/div>\r\n
\r\n
<\/div><\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n \r\n <\/div>\r\n<\/div>\r\n\r\n