{"id":10463,"date":"2012-10-17T16:14:07","date_gmt":"2012-10-17T13:14:07","guid":{"rendered":"https:\/\/www.synevo.ro\/afectiuni\/investigatii-de-anatomie-patologica-pentru-gastroenterologie\/"},"modified":"2020-07-10T11:44:08","modified_gmt":"2020-07-10T08:44:08","slug":"investigatii-de-anatomie-patologica-pentru-gastroenterologie","status":"publish","type":"synevo_diseases","link":"https:\/\/old.synevo.md\/ru\/afectiuni\/investigatii-de-anatomie-patologica-pentru-gastroenterologie\/","title":{"rendered":"Investiga\u0163ii de anatomie patologic\u0103 pentru gastroenterologie"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n\n
\n

Tip examen<\/strong><\/span><\/p>\n

\n<\/td>\n		\n
\n

Proba tisular\u0103 \/ pies\u0103 chirurgical\u0103<\/strong><\/span><\/p>\n

\n<\/td>\n<\/tr>\n
1<\/strong><\/td>\nExamen histopatologic conven\u0163ional<\/em><\/strong><\/p>\n

Platform\u0103 semiautomatizat\u0103<\/em><\/td>\n

Biopsii endoscopice digestive<\/td>\n<\/tr>\n
Biopsii\/punc\u0163ii biopsii hepatice<\/td>\n<\/tr>\n
Biopsii\/punc\u0163ii biopsii leziuni solide perete abdominal \/ ombilic<\/td>\n<\/tr>\n
Biopsie omental\u0103 \/ peritoneal\u0103<\/td>\n<\/tr>\n
Biopsii excizionale margini anale \/ tegument perineal<\/td>\n<\/tr>\n
Colecistectomii<\/td>\n<\/tr>\n
Apendicectomii<\/td>\n<\/tr>\n
Necrozectomie pancreatic\u0103<\/td>\n<\/tr>\n
Esofagectomii (par\u0163iale, totale, cu gastrectomie limitat\u0103)<\/td>\n<\/tr>\n
Gastrectomii (par\u0163ial\u0103 \u2013proximale\/distal\u0103, total\u0103, cu splenectomie)<\/td>\n<\/tr>\n
Enterectomii<\/td>\n<\/tr>\n
Colectomii<\/td>\n<\/tr>\n
Recto-colectomii<\/td>\n<\/tr>\n
Amputa\u0163ii ano-rectale<\/td>\n<\/tr>\n
Pancreatectomii (proximal\u0103, distal\u0103+\/-splenectomie, duodenopancreatectomie Kausch-Whipple)<\/td>\n<\/tr>\n
Piese de enucleorezec\u0163ie tumoral\u0103<\/td>\n<\/tr>\n
Piese de rezec\u0163ie ducte biliare extrahepatice proximale<\/td>\n<\/tr>\n
Hepatectomii (segmentar\u0103, par\u0163ial\u0103, lobectomie)<\/td>\n<\/tr>\n
Omentectomie<\/td>\n<\/tr>\n
Limfodisec\u0163ii\/limfoganglioni loco-regionale\/i<\/td>\n<\/tr>\n
\u00a0<\/strong><\/td>\n\n
\n

Tipuri colora\u0163ii speciale<\/strong><\/span><\/p>\n

\n<\/td>\n<\/tr>\n
2<\/strong><\/td>\nColora\u0163ii speciale<\/em><\/strong><\/td>\nAlcian Blue pH 0,5; Alcian Blue pH 2,5; Alcian Blue pH 2,5 \u2013 PAS; Congo Red (Highman); Giemsa; Masson Trichrome; Mucicarmine; PAS; PAS-A; Pearls; Silver Impregnation; Wilson\u2019s Disease Stain<\/td>\n<\/tr>\n
\u00a0<\/em><\/strong><\/td>\n\n
\n

Panel IHC<\/strong><\/span><\/p>\n

\n<\/td>\n<\/tr>\n
3<\/strong><\/td>\nTeste imunohistochimice (IHC)<\/em><\/strong><\/p>\n

Platform\u0103 automatizat\u0103<\/em><\/td>\n

Panel IHC pentru diagnostic morfologic de certitudine<\/td>\n<\/tr>\n
Panel IHC pentru precizare tip\/subtip histologic tumoral<\/td>\n<\/tr>\n
Panel IHC pentru precizarea histogenezei tumorale<\/td>\n<\/tr>\n
Panel IHC pentru precizarea invaziei tumorale vasculare\/angiolimfatice<\/td>\n<\/tr>\n
Panel IHC pentru identificarea micrometastazelor tumorale limfoganglionare<\/td>\n<\/tr>\n
Panel IHC pentru tumori GIST\/extraGIST<\/strong> (c-KIT\/CD117, CD34, SMA, Desmin, S100, Ki67<\/em>)<\/td>\n<\/tr>\n
Panel IHC pentru tumori endocrine\/neuroendocrine<\/strong> (Chromogranin-A, Synaptophysin, NSE, Ki67<\/em>)<\/td>\n<\/tr>\n
Panel IHC pentru evaluare factori de prognostic\/predic\u0163ie:<\/p>\n
    \n
  • carcinoame gastrice (Her2\/neu, IGF-1R, caderina-E, CDX2, CD34, p53, Ki67)<\/em><\/li>\n
  • carcinoame colo-rectale (beta-catenina, EGFR, p53, EGFR)<\/em><\/li>\n
  • tumori endocrine pancreatice (CK19, c-KIT\/CD117, Ki67, TOP-2A, CD99)<\/em><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Panel IHC pentru evaluarea instabilit\u0103\u0163ii microsatelitare (MLH1, MSH2, MSH6)<\/em><\/td>\n<\/tr>\n
\u00a0<\/strong><\/td>\n\n
\n

ISH (Hibridizare In Situ)<\/strong><\/span><\/p>\n

\n<\/td>\n<\/tr>\n
4<\/strong><\/td>\nTeste de biologie molecular\u0103<\/em><\/strong><\/p>\n

Platform\u0103 automatizat\u0103<\/em><\/p>\n

\u00a0<\/em><\/strong><\/td>\n

\n

Test BDISH (Brightfield Double In Situ Hybridization) <\/em><\/strong>pentru evaluare status gena HER2\/neu<\/em><\/strong><\/p>\n

Examinare in microscopie optic\u0103 obi\u015fnuit\u0103 cu\u00a0 determinarea cantitativ\u0103 a statusului genei HER2\/neu prin hibridizare in situ (ISH) cu dubl\u0103 colorare cromogenic\u0103 pe aceeasi sec\u0163iune tisular\u0103 din fragmente de carcinoame gastrice<\/em><\/strong> fixate in formol \u015fi incluse la parafin\u0103: num\u0103r copii gena HER2, via SISH \u015fi num\u0103r copii cromozom 17 (Chr17), via CISH.<\/p>\n

    \n
  • Kit: INFORM HER2 Dual ISH DNA Probe Cocktail<\/em><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n
\n<\/td>\n		\n
\n<\/td>\n<\/tr>\n
5<\/strong><\/td>\nConsult extern<\/em><\/strong><\/p>\n

(,,second opinion\u201d)<\/em><\/strong><\/td>\n

Consult bloc extern (sec\u0163ionare+colorare H&E+examinare microscopic\u0103+\/-investiga\u0163ii complementare+elaborare rezultat)<\/em><\/td>\n<\/tr>\n
Consult lam\u0103\/preparat histopatologic permanent colorat (examinare microscopic\u0103+elaborare rezultat)<\/em><\/td>\n<\/tr>\n
Consult preparat citologic colorat (examinare microscopic\u0103+elaborare rezultat) (produs biologic:<\/em> lichid\/lavaj peritoneal; lichid\/lavaj pleural; punc\u0163ie aspirativ\u0103 cu ac fin\/PAAF leziuni chistice \u015fi solide abdomino-pelvine )<\/p>\n
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