{"id":10445,"date":"2009-08-12T14:58:27","date_gmt":"2009-08-12T11:58:27","guid":{"rendered":"https:\/\/www.synevo.ro\/afectiuni\/despre-profilul-lipidic\/"},"modified":"2020-07-10T11:59:35","modified_gmt":"2020-07-10T08:59:35","slug":"despre-profilul-lipidic","status":"publish","type":"synevo_diseases","link":"https:\/\/old.synevo.md\/ru\/afectiuni\/despre-profilul-lipidic\/","title":{"rendered":"Despre profilul lipidic"},"content":{"rendered":"

Profilul lipidic<\/a><\/strong> reprezint\u0103 un grup de teste indicate pentru determinarea riscului de boal\u0103 coronarian\u0103 (CHD). National Cholesterol Education Program (NCEP) a utilizat datele Framingham Heart Study \u00een dezvoltarea strategiei de prevenire a bolii coronariene prin controlul nivelului crescut al colesterolului \u2013 Expert Panel on Detection, Evaluation, and Treatment of Hight Blood Cholesterol in Adults (Adults Treatment Panel III sau ATP III). ATP III recomand\u0103 tratamentul intensiv al pacien\u0163ilor cu CHD \u015fi preven\u0163ia primar\u0103 la pacien\u0163ii cu multipli factori de risc. Studiile efectuate indic\u0103 nivelul seric crescut de LDL-colesterol <\/strong>drept cauz\u0103 major\u0103 de boal\u0103 coronarian\u0103 (CHD). Din acest motiv, AT III continu\u0103 s\u0103 considere nivelul crescut de LDL-colesterol ca \u0163int\u0103 primar\u0103 a terapiei de reducere a colesterolului. Primul pas \u00een alegerea terapiei de sc\u0103dere a LDL este evaluarea statusului de risc al pacientului. Evaluarea riscului necesit\u0103 m\u0103surarea LDL-colesterol \u015fi identificarea determinan\u0163ilor de risc asocia\u0163i. La to\u0163i adul\u0163ii cu v\u00e2rst\u0103 \u2265 20 ani, s\u0103n\u0103to\u015fi, f\u0103r\u0103 factori de risc, un profil lipidic (colesterol total, LDL-colesterol, HDL-colesterol \u015fi trigliceride) trebuie s\u0103 fie ob\u0163inut o dat\u0103 la 5 ani. La adul\u0163ii cu factori de risc sau colesterol crescut \u00een antecedente, profilul lipidic complet se va face mai frecvent. \u00cen prezent, interpretarea valorilor lipidelor serice se face conform clasific\u0103rii revizuite din cadrul ATP III.<\/p>

Clasificarea ATP III a colesterolului LDL, total, HDL, trigliceride (mg\/dl)<\/strong> (tabelul 1)<\/em><\/p>

LDL colesterol<\/em><\/strong><\/p>

<100<\/td>Optim<\/td><\/tr>
100-129<\/td>Optim la limit\u0103<\/td><\/tr>
130-159<\/td>Borderline crescut<\/td><\/tr>
160-189<\/td>Crescut<\/td><\/tr>
\u2265190<\/td>Foarte crescut<\/td><\/tr><\/tbody><\/table><\/figure>
Colesterol total<\/em><\/strong><\/div>
<200<\/td>Optim<\/td><\/tr>
200-239<\/td>Borderline crescut<\/td><\/tr><\/tbody><\/table><\/figure>
HDL colesterol<\/strong><\/em><\/div>
<40<\/td>Sc\u0103zut<\/td><\/tr>
\u226560<\/td>Crescut<\/td><\/tr><\/tbody><\/table><\/figure>
Trigliceride<\/em><\/strong><\/div>
<150<\/td>Optim<\/td><\/tr>
150-199<\/td>Borderline crescut<\/td><\/tr>
200-499<\/td>Crescut<\/td><\/tr>
\u2265500<\/td>Foarte crescut<\/td><\/tr><\/tbody><\/table><\/figure>

Determinan\u0163ii de risc asocia\u0163i LDL colesterol includ: prezen\u0163a\/absen\u0163a CHD, alte forme clinice de boal\u0103 aterosclerotic\u0103 \u015fi factorii de risc major al\u0163ii dec\u00e2t LDL (tabelul 2). Pe baza acestor determinan\u0163i de risc, ATPIII identific\u0103 3 categorii de risc, care modific\u0103 nivelul \u201c\u0163int\u0103\u201d pentru LDL colesterol \u015fi modalit\u0103\u0163ile de sc\u0103dere a LDL \u201c\u0163int\u0103\u201d (tabelul 3).<\/p>

Factori majori de risc (\u00een afar\u0103 de LDL colesterol)<\/strong> (tabelul <\/em>2)<\/div>
<\/div>