{"id":10424,"date":"2007-12-12T13:08:57","date_gmt":"2007-12-12T10:08:57","guid":{"rendered":"https:\/\/www.synevo.ro\/afectiuni\/profil-mononucleoza-infectioasa\/"},"modified":"2020-07-10T13:30:51","modified_gmt":"2020-07-10T10:30:51","slug":"profil-mononucleoza-infectioasa","status":"publish","type":"synevo_diseases","link":"https:\/\/old.synevo.md\/ru\/afectiuni\/profil-mononucleoza-infectioasa\/","title":{"rendered":"Profil mononucleoz\u0103 infec\u0163ioas\u0103"},"content":{"rendered":"<p><strong>Virusul Epstein-Barr (EBV)<\/strong> este un virus herpetic limfotrop cu r\u0103sp\u00e2ndire ubicuitar\u0103, care <strong>infecteaz\u0103 aproximativ 95% din popula\u0163ie<\/strong>, p\u00e2n\u0103 la v\u00e2rsta adult\u0103. Reprezint\u0103 agentul etiologic al mononucleozei infec\u0163ioase \u015fi este implicat, de asemenea, \u00een limfomul Burkitt, carcinomul nazofaringian, sindromul limfoproliferativ X-linkat \u015fi sindromul de oboseal\u0103 cronic\u0103.<br><strong>Transmiterea virusului<\/strong> se realizeaz\u0103 \u00een principal prin contactul cu secre\u0163ii orofaringiene infectate.<\/p><!--more--><p><strong>Replicarea EBV<\/strong> are loc \u00een epiteliul orofaringian av\u00e2nd drept rezultat eliberarea virionilor din limfocitele infectate \u015fi excretarea acestora \u00een saliv\u0103.<\/p><p>La copii, <strong>infec\u0163ia este adesea asimptomatic\u0103<\/strong>. Mononucleoza infec\u0163ioas\u0103 apare cel mai adesea la adul\u0163ii tineri, care nu au prezentat o expunere anterioar\u0103 la virus. Dup\u0103 infec\u0163ia primar\u0103, EBV r\u0103m\u00e2ne \u00een organism toat\u0103 via\u0163a, \u00eentr-o stare latent\u0103.<sup>1<\/sup><\/p><p>La pacien\u0163ii imunocompeten\u0163i limfocitele B infectate latent \u015fi imortalizate se afl\u0103 sub controlul limfocitelor T, de aceea <strong>majoritatea infec\u0163iilor reactivate r\u0103m\u00e2n subclinice<\/strong>. La pacien\u0163ii cu SIDA clona de celule B imortalizate se poate dezvolta \u00eentr-un limfom.<sup>2,4<\/sup><\/p><p><strong>Diagnosticul de mononucleoz\u0103 infec\u0163ioas\u0103<\/strong> se stabile\u015fte pe date clinice (febr\u0103, faringit\u0103, adenopatii, hepatosplenomegalie), aspectul frotiului de s\u00e2nge periferic (limfomonocite atipice) \u015fi teste serologice (anticorpi heterofili \u015fi\/sau anticorpi fa\u0163\u0103 de proteinele specifice EBV).<\/p><p>\u015ei al\u0163i agen\u0163i patogeni cum ar fi Citomegalovirusul (CMV), Toxoplasma gondii, virusurile hepatitice, HIV pot induce manifest\u0103ri clinice \u015fi hematologice similare mononucleozei infec\u0163ioase (sindrom mononucleozic).<\/p><p><strong>Confirmarea diagnosticului de infec\u0163ie acut\u0103 EBV<\/strong> se face de obicei prin demonstrarea prezen\u0163ei \u00een ser a anticorpilor heterofili. Totu\u015fi, pot s\u0103 apar\u0103 dificult\u0103\u0163i de diagnostic \u00een situa\u0163iile \u00een care anticorpii heterofili sunt absen\u0163i, iar manifest\u0103rile clinice sunt atipice.1,3 Anticorpii heterofili sunt absen\u0163i \u00een 10-20% din cazurile de mononucleoz\u0103 infec\u0163ioas\u0103 la adult, procentul fiind mai mare la copiii cu infec\u0163ie manifest\u0103. \u00cen aceste situa\u0163ii, confirmarea diagnosticului se face pe baza depist\u0103rii anticorpilor fa\u0163\u0103 de proteinele specifice EBV: antigenul capsidei virale (VCA) \u015fi antigenul precoce-difuz [EA(D)].<sup>1,3<\/sup><\/p><div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\"><div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\"><p><strong>Teste disponibile \u00een laboratorul Synevo:<\/strong><\/p><\/div>\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"synevo-shop-products\">\r\n    <div class=\"sysprod\">\r\n        \r\n        <div class=\"sysprod-products\">\r\n                            <div class=\"sysprod-product\">\r\n                    <a class=\"sysprod-product-title\" href=\"https:\/\/old.synevo.md\/ru\/shop\/hemograma-cu-formula-leucocitara-cu-hb-ht-si-indici\/\">Hemogram\u0103 cu formul\u0103 leucocitar\u0103 cu Hb, Ht \u0219i indici (analiza general\u0103 a s\u00e2ngelui)<\/a>\r\n                    <div class=\"sysprod-product-price\">\r\n                        <span>Pre\u021b:<\/span>\r\n                        <span>135.00 lei<\/span>\r\n                    <\/div>\r\n                                            <div class=\"sysprod-product-addcart\">\r\n                            <a\r\n                                href=\"?add-to-cart=9407\"\r\n                                data-quantity=\"1\"\r\n                                class=\"addToCart button product_type_simple add_to_cart_button ajax_add_to_cart \"\r\n                                data-product_id=\"9407\"\r\n                                data-product_sku=\"HE07\"\r\n                                rel=\"nofollow\"\r\n                            ><div><\/div><\/a>\r\n                        <\/div>\r\n                                    <\/div>\r\n                            <div class=\"sysprod-product\">\r\n                    <a class=\"sysprod-product-title\" href=\"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-heterofili-mononucleoza-infectioasa\/\">Anticorpi heterofili (mononucleoza infectioasa)<\/a>\r\n                    <div class=\"sysprod-product-price\">\r\n                        <span>Pre\u021b:<\/span>\r\n                        <span>140 lei<\/span>\r\n                    <\/div>\r\n                                            <div class=\"sysprod-product-addcart\">\r\n                            <a\r\n                                href=\"?add-to-cart=9161\"\r\n                                data-quantity=\"1\"\r\n                                class=\"addToCart button product_type_simple add_to_cart_button ajax_add_to_cart \"\r\n                                data-product_id=\"9161\"\r\n                                data-product_sku=\"IM09\"\r\n                                rel=\"nofollow\"\r\n                            ><div><\/div><\/a>\r\n                        <\/div>\r\n                                    <\/div>\r\n                            <div class=\"sysprod-product\">\r\n                    <a class=\"sysprod-product-title\" href=\"https:\/\/old.synevo.md\/ru\/shop\/virus-epstein-barr-ebv-anticorpi-vca-igg\/\">Virus Epstein-Barr (EBV)-Anticorpi VCA IgG<\/a>\r\n                    <div class=\"sysprod-product-price\">\r\n                        <span>Pre\u021b:<\/span>\r\n                        <span>260 lei<\/span>\r\n                    <\/div>\r\n                                            <div class=\"sysprod-product-addcart\">\r\n                            <a\r\n                                href=\"?add-to-cart=9332\"\r\n                                data-quantity=\"1\"\r\n                                class=\"addToCart button product_type_simple add_to_cart_button ajax_add_to_cart \"\r\n                                data-product_id=\"9332\"\r\n                                data-product_sku=\"IM41\"\r\n                                rel=\"nofollow\"\r\n                            ><div><\/div><\/a>\r\n                        <\/div>\r\n                                    <\/div>\r\n                            <div class=\"sysprod-product\">\r\n                    <a class=\"sysprod-product-title\" href=\"https:\/\/old.synevo.md\/ru\/shop\/virus-epstein-barr-ebv-anticorpi-vca-igm\/\">Virus Epstein-Barr (EBV)-Anticorpi VCA IgM<\/a>\r\n                    <div class=\"sysprod-product-price\">\r\n                        <span>Pre\u021b:<\/span>\r\n                        <span>270 lei<\/span>\r\n                    <\/div>\r\n                                            <div class=\"sysprod-product-addcart\">\r\n                            <a\r\n                                href=\"?add-to-cart=9333\"\r\n                                data-quantity=\"1\"\r\n                                class=\"addToCart button product_type_simple add_to_cart_button ajax_add_to_cart \"\r\n                                data-product_id=\"9333\"\r\n                                data-product_sku=\"IM42\"\r\n                                rel=\"nofollow\"\r\n                            ><div><\/div><\/a>\r\n                        <\/div>\r\n                                    <\/div>\r\n                    <\/div>\r\n        \r\n    <\/div>\r\n<\/div>\r\n\r\n<style>\r\n.synevo-shop-products {\r\n    padding: 24px 0;\r\n    margin: 24px 0;\r\n    border-radius: 10px;\r\n    background: #F6F7F9;\r\n}\r\n.synevo-shop-products .sysprod-product {\r\n    position: relative;\r\n    margin: 0 24px;\r\n    margin-bottom: 24px;\r\n    border-radius: 10px;\r\n    background: #fff;\r\n    display: flex;\r\n    flex-direction: row;\r\n    align-items: center;\r\n}\r\n.synevo-shop-products .sysprod-product:last-child {\r\n    margin-bottom: 0;\r\n}\r\n.synevo-shop-products .sysprod-product-title {\r\n    flex-grow: 1;\r\n    padding: 15px;\r\n    margin-left: 14px;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 16px;\r\n    color: #29263F;\r\n}\r\n.synevo-shop-products .sysprod-product-price {\r\n    flex-shrink: 0;\r\n    font-family: Poppins,sans-serif;\r\n    font-weight: 600;\r\n    font-size: 18px;\r\n    color: #FDB813;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart {\r\n    flex-shrink: 0;\r\n    position: relative;\r\n    width: 38px;\r\n    height: 38px;\r\n    margin-left: 24px;\r\n    margin-right: 24px;\r\n}\r\n.synevo-shop-products .sysprod-product-addcart .button {\r\n    top: unset;\r\n    right: unset;\r\n}\r\n<\/style><\/div><\/div><p><small><br><strong>Bibliografie:<\/strong><\/small><\/p><p><small>1. Frances Fischbach. Immunodiagnostics Studies. In A Manual of Laboratory and Diagnostics Tests. Lippincott Williams &amp; Wilkins, USA, 7 ed. 2004, 544-545<br>2. Hans W.Doerr. Viral Diseases. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. Lothar Thomas. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany,1 ed. 1998, 1234-1236.<br>3. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2006. Ref Type: Catalog<br>4. Lothar Thomas. Prenatal monitoring. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany,1 ed. 1998, 1117<\/small><\/p><hr class=\"wp-block-separator\"\/><p>Mai multe informa\u021bii despre teste:<\/p><ul class=\"wp-block-list\"><li><a href=\"\/shop\/hemograma-cu-formula-leucocitara-cu-hb-ht-si-indici\/\" class=\"rank-math-link\">Hemograma<\/a><\/li><li><a href=\"\/shop\/frotiu-de-sange-periferic\/\" class=\"rank-math-link\">Frotiu s\u00e2nge perferic<\/a><\/li><li><a href=\"\/shop\/anticorpi-heterofili-mononucleoza-infectioasa\/\" class=\"rank-math-link\">Anticorpi heterofili mononucleoz\u0103 infec\u0163ioas\u0103<\/a><\/li><li><a href=\"\/shop\/virus-epstein-barr-ebv-anticorpi-vca-igg\/\" class=\"rank-math-link\">Virus Epstein Barr: Anticorpi IgG<\/a><\/li><li><a href=\"\/shop\/virus-epstein-barr-ebv-anticorpi-vca-igm\/\" class=\"rank-math-link\">Virus Epstein Barr: Anticorpi IgM<\/a><\/li><\/ul>","protected":false},"featured_media":0,"template":"","synevo_diseases_category":[890],"class_list":["post-10424","synevo_diseases","type-synevo_diseases","status-publish","hentry","synevo_diseases_category-boli-infectioase"],"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/synevo_diseases\/10424","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/synevo_diseases"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/synevo_diseases"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10424"}],"wp:term":[{"taxonomy":"synevo_diseases_category","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/synevo_diseases_category?post=10424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}