{"id":9981,"date":"2020-04-23T03:53:01","date_gmt":"2020-04-23T01:53:01","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/vitamina-b1\/"},"modified":"2025-01-31T12:54:10","modified_gmt":"2025-01-31T10:54:10","slug":"vitamina-b1-tiamin-pirosfosfat","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/vitamina-b1-tiamin-pirosfosfat\/","title":{"rendered":"\u0412\u0438\u0442\u0430\u043c\u0438\u043d B1 (\u0442\u0438\u0430\u043c\u0438\u043d-\u043f\u0438\u0440\u043e\u0444\u043e\u0441\u0444\u0430\u0442)"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Vitamina B1, numit\u0103 \u015fi tiamin\u0103,\u00a0 este o vitamin\u0103 hidrosolubil\u0103 care sub form\u0103 de pirofosfat are rol de coenzim\u0103 \u00een reac\u0163iile de decarboxilare, esen\u0163iale pentru metabolismul protidic \u015fi glucidic4<\/sup>. Este indispensabil\u0103 pentru activitatea cerebral\u0103 \u015fi mielinizarea nervilor periferici1<\/sup>. In ser circul\u0103 \u00een parte legat\u0103 de albumin\u0103; p\u00e2n\u0103 la 85% din cantitatea de tiamin\u0103 este preluat\u0103 de eritrocite; excesul se elimin\u0103 prin urin\u01034<\/sup>.<\/p>\n

Tiamin\u0103 se g\u0103se\u015fte \u00een cantit\u0103\u0163i apreciabile\u00a0\u00een drojdia de bere, legume, semin\u0163e \u015fi nuci, cereale germinate, carne de porc (\u00een special organe). Vitamina B1 se distruge prin fierbere deoarece este instabil\u0103 la temperaturi \u00eenalte. Ceaiul \u015fi unele alimente con\u0163in factori antitiaminici. In \u0163\u0103rile dezvoltate cerealele sunt \u00eembog\u0103\u0163ite cu tiamin\u01031;3<\/sup>.<\/p>\n

Rezerva organismului la adultul s\u0103n\u0103tos este de 30 mg de tiamin\u0103, fiind necesar un aport de 0,5mg\/1000kcal\/zi pentru a asigura aceast\u0103 rezerv\u0103. Dac\u0103 se \u00eentrerupe aportul alimentar deficitul de vitamina B1 se instaleaz\u0103 \u00een 10 p\u00e2n\u0103 la 21 de zile1<\/sup>.<\/p>\n

Semnele precoce ale deficitului de tiamin\u0103 includ anorexie, sc\u0103dere \u00een greutate, hipotonie muscular\u0103, apatie, confuzie \u015fi iritabilitate. Manifest\u0103rile tardive ale deficitului sunt insuficien\u0163a cardiac\u0103 congestiv\u0103 (\u201cberi-beri umed\u201d), polineuropatie cu reflexe diminuate, parestezii, atrofie muscular\u0103 (\u201cberi-beri uscat\u201d) \u015fi sindromul Wernicke-Korsakoff, caracterizat prin demen\u0163\u0103, ataxie \u015fi oftalmoplegie3<\/sup>.<\/p>\n

Exist\u0103 \u015fi un deficit infantil la copiii al\u0103pta\u0163i timp \u00eendelungat f\u0103r\u0103 diversificarea alimenta\u0163iei. La gravide se poate instala un deficit u\u015for datorit\u0103 nevoilor crescute de tiamin\u01034<\/sup>. Majoritatea alcoolicilor cronici prezint\u0103 deficit de tiamin\u0103, datorat at\u00e2t interferen\u0163elor alcoolului cu metabolismul tiaminei, c\u00e2t \u015fi nutri\u0163iei precare3;4<\/sup>.<\/p>\n

Nu s-au raportat cazuri de intoxica\u0163ii cu doze orale de tiamin\u0103. In cadrul administr\u0103rii parenterale a unor doze mari, poate surveni decesul prin inhibarea centrului respirator1;3<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea vitaminei<\/em><\/strong> B1<\/strong> - <\/em>persoane cu tulbur\u0103ri comportamentale, modific\u0103ri oftalmologice, tulbur\u0103ri de mers, delir, encefalopatie, nutri\u0163ie necorespunz\u0103toare, alcoolici (pentru diagnosticarea unui deficit) 1;3<\/sup>.\u00a0<\/em><\/p>\n

Preg\u0103tire pacient<\/em><\/strong> - <\/em>\u00e0 jeun (pe nem\u00e2ncate) minimum 8 ore; se va evita consumul de alimente ce con\u0163in vitamina B1 cu 48 ore \u00eenaintea recolt\u0103rii pentru pacien\u0163ii peste 6 luni \u015fi cu 24 ore \u00eenaintea recolt\u0103rii pentru cei <6 luni2<\/sup>.<\/p>\n

Specimen recoltat<\/em><\/strong> - <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c2<\/sup>.<\/p>\n

Recipient de recoltare<\/em><\/strong>\u00a0\u2013 vacutainer ce con\u0163ine EDTA ca anticoagulant2<\/sup>.<\/p>\n

Cantitate recoltat\u0103 <\/em><\/strong>\u2013 c\u00e2t permite vacuumul2<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong> \u2013 proba nu<\/strong> se centrifugheaz\u0103 \u015fi se congeleaz\u0103 imediat2<\/sup>.<\/p>\n

Volum minim prob\u0103<\/em><\/strong> - <\/em>2 mL2<\/sup>.\u00a0<\/em><\/p>\n

Cauze\u00a0 de respingere a probei<\/em><\/strong> \u2013 s<\/em>pecimen intens hemolizat, lipemic sau decongelat2<\/sup>.<\/p>\n

Stabilitate prob\u0103<\/em><\/strong> \u2013 s\u00e2ngele este stabil 1 lun\u0103 <\/em>la -20\u00b0C2<\/sup>.<\/p>\n

Metod\u0103 <\/em><\/strong>- <\/em>cromatografie de lichide sub \u00eenalt\u0103 presiune<\/span> (HPLC)<\/span>2<\/sup>.<\/p>\n

Valori de referin\u0163\u0103<\/em><\/strong>\u00a0\u2013 <49 \u03bcg\/L2<\/sup>.<\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/p>\n

Sc\u0103deri<\/strong><\/span>: boala beri-beri; sindromul Wernicke-Korsakoff; nutri\u0163ie deficitar\u0103; alcoolism; insuficien\u0163\u0103 cardiac\u01031;4<\/sup>.<\/div>\n
Cre\u015fteri<\/strong><\/span>:<\/em> intoxica\u0163ia cu tiamina (numai \u00een cazul administr\u0103rii parenterale)1<\/sup>.<\/div>\n
<\/div>\n
Limite \u015fi interferen\u0163e<\/em><\/strong><\/div>\n
Substan\u0163e care scad nivelul de tiamin\u0103: diuretice, antiacide, fenitoin, nicotin\u0103, antibiotice, contraceptive orale, 5-fluorouracil, indometacin1<\/sup>.<\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Ball GFM: Vitamins: their role in the human body. Oxford, Blackwel Publishing, 2004, 133-187<\/span><\/div>\n
2. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n
3. Martin J. Salwen.Vitamins and Trace Elements. In Henry\u2019s Clinical Diagnosis and Management by Laboratory <\/span>Methods.Sauders Elsevier 21-Ed 2007, 381-382.<\/span><\/div>\n
4. Naidoo DP, Bramdev A, Cooper K: Wernicke\u2019s encephalopathy and alcohol-related disease. Postgrad Med J 1991;67;978-981<\/span><\/div>","protected":false},"excerpt":{"rendered":"

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\u0412\u0437\u044f\u0442\u0438\u0435 \u043a\u0440\u043e\u0432\u0438 \u0441\u043b\u0435\u0434\u0443\u0435\u0442 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u0443\u0442\u0440\u043e\u043c \u043d\u0430\u0442\u043e\u0449\u0430\u043a (\u043f\u043e\u0441\u043b\u0435 8-12-\u0447\u0430\u0441\u043e\u0432\u043e\u0433\u043e \u043f\u0435\u0440\u0438\u043e\u0434\u0430 \u043d\u043e\u0447\u043d\u043e\u0433\u043e \u0433\u043e\u043b\u043e\u0434\u0430\u043d\u0438\u044f, \u0432\u043e\u0434\u0443 \u043f\u0438\u0442\u044c \u043c\u043e\u0436\u043d\u043e).<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[953,959],"product_tag":[],"class_list":{"0":"post-9981","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-de-biochimie","6":"product_cat-vitamine-oligoelemente-stres-oxidativ","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9981","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9981"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9981"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9981"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9981"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}