{"id":9961,"date":"2020-04-23T03:52:28","date_gmt":"2020-04-23T00:52:28","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/virusul-rubeolei-arn-in-sange-lichid-amniotic-urina-lcr\/"},"modified":"2025-01-31T11:39:16","modified_gmt":"2025-01-31T09:39:16","slug":"virusul-rubeolei-arn","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/virusul-rubeolei-arn\/","title":{"rendered":"\u0420\u041d\u041a \u0432\u0438\u0440\u0443\u0441\u0430 \u043a\u0440\u0430\u0441\u043d\u0443\u0445\u0438"},"content":{"rendered":"<p><strong><em>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f <\/em><\/strong><\/p>\n<p>Rubeola, una din bolile exantematoase ale copilariei, este produsa de un togavirus cu ARN monocatenar. In mod obisnuit copiii prezinta febra si o eruptie maculo-papulara tranzitorie, in timp ce la adulti manifestarile cutanate, adesea discrete, sunt precedate de o faza prodromala de 1-5 zile asociata cu limfadenopatie (cel mai frecvent in regiunea cervicala) si semne constitutionale. Totusi multe cazuri raman subclinice<sup>2<\/sup>.<\/p>\n<p>Infectia cu virusul rubeolei are o evolutie autolimitanta si, spre deosebire de rujeola, complicatiile sunt rare. Aproximativ o treime din femeile cu rubeola pot prezenta artrita sau artralgii; aceste complicatii sunt neobisnuite la copii si barbati. Cel mai adesea sunt afectate articulatiile pumnului si genunchiului; manifestarile se remit lent (pot dura pana la o luna) si rareori se poate dezvolta o artrita cronica. Complicatiile hemoragice au o incidenta redusa (~1 la 3000 cazuri), afecteaza in special copiii si sunt consecinta atat a trombocitopeniei, cat si a leziunilor vasculare, care sunt probabil mediate imunologic. Encefalita este o complicatie extrem de rara a rubeolei, se manifesta in principal la adulti si este insotita de o mortalitate ridicata (20-50%); pacientii care supravietuiesc encefalitei nu prezinta de obicei sechele neurologice<sup>1<\/sup>.<\/p>\n<p>ARN-ul viral poate fi detectat prin RT-PCR in secretii nazofaringiene, sange integral, ser si urina <span style=\"text-decoration: underline;\">in cursul primelor 7 zile de la debutul eruptiei<\/span><sup>5<\/sup>.<\/p>\n<p>Rubeola poate avea consecinte dezastruoase daca infectia primara a mamei se produce in primul trimestru de sarcina; virusul infecteaza placenta, este transmis fatului si poate conduce la moartea acestuia, nastere prematura sau la un spectru larg de anomalii congenitale. Incidenta rubeolei congenitale intr-o populatie data este extrem de variabila, fiind influentata de numarul persoanelor susceptibile, circulatia virusului in comunitate si de modul de implementare a vaccinarii fata de virusul rubeolei.<\/p>\n<p>Efectele virusului rubeolei asupra fatului depind in mare masura de momentul in care s-a produs infectia; in general, cu cat virsta gestationala la care s-a contractat infectia este mai mica, cu atat afectarea fetala este mai severa. Astfel, in primele 2 luni de sarcina riscul de afectare fetala este de 65-85%, avand drept rezultat defecte congenitale multiple, avort spontan sau ambele. Rubeola dobandita in cursul celei de a treia luni de viata intrauterina a fost asociata cu un risc de 30-35% de dezvolta un defect unic, cum ar fi surditatea sau cardiopatia congenitala. In cea de-a patra luna exista un risc de 10% ca fatul sa dezvolte un defect congenital unic<sup>1<\/sup>. Detectia prin RT-PCR a ARN-ului viral in lichidul amniotic are o sensibiliate si o specificitate de aproape 100% pentru diagnosticul infectiei congenitale<sup>4<\/sup>. Defectele sunt rareori intalnite in cazul in care infectia mamei s-a produs dupa saptamana 20 de sarcina<sup>1<\/sup>.<\/p>\n<p>Sindromul rubeolei congenitale asociaza manifestari oftalmice (cataracta, microftalmie, glaucom, retinopatie pigmentara, corioretinopatie), auditive (surditate), cardiace (persistenta canalului arterial, defecte septale ventriculare, stenoza arterei pulmonare periferice) si craniofaciale (microcefalie)<sup>5<\/sup>.<\/p>\n<p>Expunerea secundara la virus sau reinfectia se asociaza extrem de rar cu transmiterea intrauterina a virusului, indicand faptul ca imunitatea mamei (dobandita natural sau indusa prin vaccinare) confera protectie impotriva infectiei in <em>utero<\/em><sup>2<\/sup>.<\/p>\n<p>Nou-nascutul cu infectie congenitala excreta virusul in urina o perioada de timp indelungata (luni sau chiar ani) fiind astfel contagios pentru persoanele din jur<sup>4;5<\/sup>. Printre manifestarile neonatale ale sindromului rubeolei congenitale se numara meningoencefalita, hepatita, hepatosplenomegalia, pneumonita interstitiala, trombocitopenia (care poate fi fatala), modificarile radiologice caracteristice ale oaselor lungi (radiotransparenta)<sup>5<\/sup>. RT-PCR efectuat in diverse produse patologice recoltate la nou-nascut (sange, urina, lichid cefalo-rahidian) reprezinta un instrument util pentru confirmarea diagnosticului de infectie congenitala cu virusul rubeolei<sup>1;2;4;5<\/sup>.<\/p>\n<p><strong><em>Recomandari pentru determinarea virusului rubeolei \u2013 ARN <\/em><\/strong>\u2013 diagnosticul pre- si postnatal al infectiilor congenitale cu virusul rubeolei; \u00a0utilitate in diagnosticul rubeolei postnatale (impreuna cu testele serologice)<sup>5<\/sup>.<\/p>\n<p><strong><em>Pregatire pacient<\/em><\/strong> \u2013 nu este necesara<sup>3<\/sup>.<\/p>\n<p><strong><em>Specimen recoltat<\/em><\/strong> \u2013 a) exsudat faringian si nazal; b) sange venos; c) o proba spontana de urina; d) lichid cefalorahidian recoltat prin punctie lombara; e) lichid amniotic<sup>3<\/sup>.<\/p>\n<p><strong><em>Recipient de recoltare<\/em><\/strong>\u00a0\u2013 a) doua tampoane fara mediu de transport; b) vacutainer ce contine EDTA ca anticoagulant; c) eprubeta pentru urina; d) si e) recipient steril<sup>3<\/sup>.<\/p>\n<p><strong><em>Cantitate recoltata <\/em><\/strong>\u2013 b) cat permite vacuumul; c) si d) \u00a0si e) minimum 2 mL<sup>3<\/sup>.<\/p>\n<p><strong><em>Prelucrare necesara dupa recoltare <\/em><\/strong>\u2013 b), c), d), e) probele <strong>nu<\/strong> vor fi centrifugate<sup>3<\/sup>.<\/p>\n<p><strong><em>Cauze de respingere a probei<\/em><\/strong> \u2013 b) probe vechi, coagulate, hemolizate; folosirea heparinei ca anticoagulant<sup>3<\/sup>.<\/p>\n<p><strong><em>Stabilitate proba <\/em><\/strong>\u2013 probele de sange, secretii nazofaringiene, urina, LCR sau lichid amniotic sunt stabile <em>1 saptamana <\/em>la 2-4\u00b0C<sup>3<\/sup>.<\/p>\n<p><strong><em>Metoda<\/em><\/strong> - <span style=\"text-decoration: underline;\">RT- PCR<\/span>: intr-o prima etapa are loc transcrierea inversa a ARN-ului tinta pentru a genera ADN-ul complementar (ADNc); urmeaza etapa de amplificare a ADN-ului folosindu-se primeri corespunzatori unei regiuni variabile a genei E1; detectia ampliconului se efectueaza in timp real<sup>3<\/sup>.<\/p>\n<p><strong><em>Valori de referinta <\/em><\/strong>\u2013 Virusul rubeolei \u2013 ARN nedetectabil<sup>3<\/sup>.<\/p>\n<p><strong><em>Interpretarea rezultatelor<\/em><\/strong><\/p>\n<p>Detectia ARN-ului pentru virusul rubeolei in diverse produse patologice sustine diagnosticul clinic de infectie datorata acestui virus<sup>3;5<\/sup>.<\/p>\n<p><strong><em>Limite si interferente<\/em><\/strong><\/p>\n<p>Un rezultat negativ nu elimina posibilitatea unei infectii cu virusul rubeolei<sup>3;5<\/sup>.<\/p>\n<p><span style=\"font-size: small;\">\u00a0<\/span><\/p>\n<p><span style=\"font-size: small;\">\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/p>\n<p><span style=\"font-size: small;\">1. Anne A. Gershan. Rubella Virus (German Measles). In Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases, 7th edition, Churchill Livingstone, Elsevier, 2010, 2127-2130.<\/span><\/p>\n<p><span style=\"font-size: small;\">2. Ann M.Gronowski. Prenatal Screening and Diagnosis of Congenital Infections. In Handbook of Clinical Laboratory Testing During Pregnancy. Totowa, NJ: Humana Press ed. 2004; 264-266.<\/span><\/p>\n<p><span style=\"font-size: small;\">3. Laborator Synevo. Referintele specifice tehnologiei de lucru utilizate 2015. Ref Type: Catalog.<\/span><\/p>\n<p><span style=\"font-size: small;\">4. Michael Costello, Margaret Yungbluth. Viral Infections. In Henry\u2019s Clinical Diagnosis and Management by Laboratory Methods, Saunders-Elsevier, 21st Edition, 987-988.<\/span><\/p>\n<p><span style=\"font-size: small;\">5. Surveillance Guidelines for Measles, Rubella and Congenital Rubella Syndrome in the WHO European Region, WHO, 2009.<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>\u041a\u0440\u0430\u0441\u043d\u0443\u0445\u0430 &#8211; \u0448\u0438\u0440\u043e\u043a\u043e \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u043d\u043e\u0435 \u043e\u0441\u0442\u0440\u043e\u0435 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u043e\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435, \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u0443\u044e\u0449\u0435\u0435\u0441\u044f \u043a\u043e\u0436\u043d\u043e\u0439 \u0441\u044b\u043f\u044c\u044e \u0438 \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u0435\u043c \u043b\u0438\u043c\u0444\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0443\u0437\u043b\u043e\u0432. \u0412\u0438\u0440\u0443\u0441 \u043a\u0440\u0430\u0441\u043d\u0443\u0445\u0438 \u043f\u0435\u0440\u0435\u0434\u0430\u0435\u0442\u0441\u044f \u0432\u043e\u0437\u0434\u0443\u0448\u043d\u043e-\u043a\u0430\u043f\u0435\u043b\u044c\u043d\u044b\u043c \u043f\u0443\u0442\u0435\u043c \u043f\u0440\u0438 \u0447\u0438\u0445\u0430\u043d\u0438\u0438 \u0438\u043b\u0438 \u043a\u0430\u0448\u043b\u0435 \u0438\u043d\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0433\u043e \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430. \u0427\u0435\u043b\u043e\u0432\u0435\u043a \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0435\u0434\u0438\u043d\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c \u0438\u0437\u0432\u0435\u0441\u0442\u043d\u044b\u043c \u043d\u043e\u0441\u0438\u0442\u0435\u043b\u0435\u043c \u0432\u0438\u0440\u0443\u0441\u0430 \u043a\u0440\u0430\u0441\u043d\u0443\u0445\u0438.<br \/>\n\u0423 \u0434\u0435\u0442\u0435\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u0440\u043e\u0442\u0435\u043a\u0430\u0435\u0442 \u0432 \u0431\u043e\u043b\u044c\u0448\u0438\u043d\u0441\u0442\u0432\u0435 \u0441\u043b\u0443\u0447\u0430\u0435\u0432 \u043b\u0435\u0433\u043a\u043e, \u0441 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0430\u043c\u0438, \u0432\u043a\u043b\u044e\u0447\u0430\u044e\u0449\u0438\u043c\u0438 \u0441\u044b\u043f\u044c, \u043d\u0435\u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u0442\u0435\u043c\u043f\u0435\u0440\u0430\u0442\u0443\u0440\u044b \u0442\u0435\u043b\u0430 (&lt;39\u00b0C), \u043b\u0435\u0433\u043a\u0438\u0439 \u043a\u043e\u043d\u044a\u044e\u043d\u043a\u0442\u0438\u0432\u0438\u0442.<br \/>\n\u041f\u043e\u0441\u043b\u0435 \u0438\u043d\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0432\u0438\u0440\u0443\u0441 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u044f\u0435\u0442\u0441\u044f \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0435 \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 5-7 \u0434\u043d\u0435\u0439. \u0421\u0438\u043c\u043f\u0442\u043e\u043c\u044b \u043e\u0431\u044b\u0447\u043d\u043e \u043f\u043e\u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0447\u0435\u0440\u0435\u0437 2-3 \u043d\u0435\u0434\u0435\u043b\u0438 \u043f\u043e\u0441\u043b\u0435 \u044d\u043a\u0441\u043f\u043e\u0437\u0438\u0446\u0438\u0438. \u041d\u0430\u0438\u0431\u043e\u043b\u0435\u0435 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0439 \u043f\u0435\u0440\u0438\u043e\u0434 \u043d\u0430\u0441\u0442\u0443\u043f\u0430\u0435\u0442 \u043e\u0431\u044b\u0447\u043d\u043e \u0447\u0435\u0440\u0435\u0437 1-5 \u0434\u043d\u0435\u0439 \u043f\u043e\u0441\u043b\u0435 \u043f\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0441\u044b\u043f\u0438. \u0421\u044b\u043f\u044c, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u0435\u0442\u0441\u044f \u0443 50-80% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432, \u0441\u043d\u0430\u0447\u0430\u043b\u0430 \u0432\u044b\u0441\u0442\u0443\u043f\u0430\u0435\u0442 \u043d\u0430 \u043b\u0438\u0446\u0435 \u0438 \u0448\u0435\u0435, \u0437\u0430\u0442\u0435\u043c \u043e\u043f\u0443\u0441\u043a\u0430\u0435\u0442\u0441\u044f \u043d\u0438\u0436\u0435 \u043f\u043e \u0442\u0435\u043b\u0443 \u0438 \u0434\u043b\u0438\u0442\u0441\u044f 1-3 \u0434\u043d\u044f. \u041e\u043f\u0443\u0445\u0448\u0438\u0435 \u043b\u0438\u043c\u0444\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0443\u0437\u043b\u044b \u0437\u0430 \u0443\u0448\u0430\u043c\u0438 \u0438 \u043d\u0430 \u0448\u0435\u0435 \u0441\u043b\u0443\u0436\u0430\u0442 \u043d\u0430\u0438\u0431\u043e\u043b\u0435\u0435 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u044b\u043c \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u043f\u0440\u0438\u0437\u043d\u0430\u043a\u043e\u043c.<\/p>\n<p>\u041e\u0441\u043e\u0431\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u043a\u0440\u0430\u0441\u043d\u0443\u0445\u0438 \u043a\u0430\u043a \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u043e\u0433\u043e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u0441\u0432\u044f\u0437\u0430\u043d\u043e \u0441 \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u044c\u044e \u0442\u044f\u0436\u0435\u043b\u044b\u0445 \u043e\u0441\u043b\u043e\u0436\u043d\u0435\u043d\u0438\u0439 \u0434\u043b\u044f \u043f\u043b\u043e\u0434\u0430, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043c\u043e\u0433\u0443\u0442 \u0440\u0430\u0437\u0432\u0438\u0442\u044c\u0441\u044f \u0432 \u0441\u043b\u0443\u0447\u0430\u0435 \u0437\u0430\u0440\u0430\u0436\u0435\u043d\u0438\u044f \u0436\u0435\u043d\u0449\u0438\u043d\u044b \u0432 \u043f\u0435\u0440\u0432\u043e\u043c \u0442\u0440\u0438\u043c\u0435\u0441\u0442\u0440\u0435 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438.<\/p>\n<p><em><strong>\u041f\u0440\u0430\u0432\u0438\u043b\u0430 \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438 \u043a \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044e \u0420\u041d\u041a \u0432\u0438\u0440\u0443\u0441\u0430 \u043a\u0440\u0430\u0441\u043d\u0443\u0445\u0438 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438 &#8211; <\/strong><\/em>\u0421\u043f\u0435\u0446\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438 \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e \u043d\u0435 \u0442\u0440\u0435\u0431\u0443\u0435\u0442\u0441\u044f.<\/p>\n<p><em><strong>\u0412 \u043a\u0430\u043a\u0438\u0445 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u043f\u0440\u043e\u0432\u043e\u0434\u044f\u0442 \u0430\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0420\u041d\u041a \u0432\u0438\u0440\u0443\u0441\u0430 \u043a\u0440\u0430\u0441\u043d\u0443\u0445\u0438 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438:<\/strong><\/em><\/p>\n<ul>\n<li>\u043d\u0430\u043b\u0438\u0447\u0438\u0435 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u044b\u0445 \u0432\u044b\u0441\u044b\u043f\u0430\u043d\u0438\u0439 \u043d\u0430 \u043a\u043e\u0436\u0435 \u0438 \u0441\u043b\u0438\u0437\u0438\u0441\u0442\u044b\u0445 \u043d\u0430 \u0444\u043e\u043d\u0435 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u043e\u0439 \u0442\u0435\u043c\u043f\u0435\u0440\u0430\u0442\u0443\u0440\u044b \u0442\u0435\u043b\u0430;<\/li>\n<li>\u043a\u043e\u043d\u0442\u0430\u043a\u0442 \u0441 \u043b\u0438\u0446\u0430\u043c\u0438, \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0448\u0438\u043c\u0438 \u043a\u0440\u0430\u0441\u043d\u0443\u0445\u043e\u0439;<\/li>\n<li>\u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u0440\u0430\u043d\u043d\u0438\u0445 \u0441\u0440\u043e\u043a\u043e\u0432;<\/li>\n<li>\u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433\u043e\u0432\u043e\u0435 \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0445.<\/li>\n<\/ul>\n<p><em><strong>\u0415\u0434\u0438\u043d\u0438\u0446\u044b \u0438\u0437\u043c\u0435\u0440\u0435\u043d\u0438\u044f &#8211; <\/strong><\/em>\u0422\u0435\u0441\u0442 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439. \u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442 \u0432\u044b\u0434\u0430\u0451\u0442\u0441\u044f \u0432 \u0442\u0435\u0440\u043c\u0438\u043d\u0430\u0445 \u00ab\u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u043e\u00bb \u0438\u043b\u0438 \u00ab\u043d\u0435 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u043e\u00bb.<\/p>\n<p>\u0422\u0440\u0430\u043a\u0442\u043e\u0432\u043a\u0430 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u0420\u041d\u041a \u0432\u0438\u0440\u0443\u0441\u0430 \u043a\u0440\u0430\u0441\u043d\u0443\u0445\u0438 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438<br \/>\n\u041e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u043e<br \/>\n\u0412 \u0430\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u0443\u0435\u043c\u043e\u043c \u043e\u0431\u0440\u0430\u0437\u0446\u0435 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430 \u043d\u0430\u0439\u0434\u0435\u043d \u0444\u0440\u0430\u0433\u043c\u0435\u043d\u0442 \u0420\u041d\u041a, \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u044b\u0439 \u0434\u043b\u044f Rubella virus, \u0438\u043d\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 Rubella virus.<\/p>\n<p>\u041d\u0435 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u043e<br \/>\n\u0412 \u0430\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u0443\u0435\u043c\u043e\u043c \u043e\u0431\u0440\u0430\u0437\u0446\u0435 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430 \u043d\u0435 \u043d\u0430\u0439\u0434\u0435\u043d\u043e \u0444\u0440\u0430\u0433\u043c\u0435\u043d\u0442\u043e\u0432 \u0420\u041d\u041a, \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u044b\u0445 \u0434\u043b\u044f Rubella virus, \u0438\u043b\u0438 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f \u0432\u043e\u0437\u0431\u0443\u0434\u0438\u0442\u0435\u043b\u044f \u0432 \u043e\u0431\u0440\u0430\u0437\u0446\u0435 \u043d\u0438\u0436\u0435 \u0433\u0440\u0430\u043d\u0438\u0446\u044b \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u0438 \u043c\u0435\u0442\u043e\u0434\u0430.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[968,971],"product_tag":[],"class_list":{"0":"post-9961","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-de-biologie-moleculara","6":"product_cat-teste-moleculare-pentru-diagnosticul-infectiilor","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9961"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9961"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9961"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9961"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}