{"id":9425,"date":"2020-04-23T03:37:38","date_gmt":"2020-04-23T00:37:38","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/anticorpi-anti-proteinaza-3-c-anca\/"},"modified":"2025-02-06T14:41:31","modified_gmt":"2025-02-06T12:41:31","slug":"anticorpi-anti-proteinaza-3-c-anca","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-proteinaza-3-c-anca\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437\u0435 3 (cANCA)"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong><em>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Antigenul proteinaza 3 (PR3) este o serin-proteaz\u0103 de 29 kDa care se g\u0103se\u015fte \u00een neutrofilele umane sub forma unui triplet proteic. Prezen\u0163a anticorpilor anti-PR3 este asociat\u0103 \u00een mod specific cu <em>granulomatoza Wegener<\/em> \u2013 o vasculit\u0103 autoimun\u0103 care afecteaz\u0103 \u00een principal rinichii \u015fi pl\u0103m\u00e2nii. Nivelul anticorpilor se coreleaz\u0103 cu activitatea bolii, fiind crescut \u00een puseele de activitate \u015fi sc\u0103zut \u00een perioadele de remisiune<sup>3<\/sup>.<\/p>\n<p style=\"text-align: justify;\">\u00cen imunofluorescen\u0163a indirect\u0103, ce folose\u015fte ca substrat neutrofile umane fixate cu etanol, ace\u015fti anticorpi dau o fluorescen\u0163\u0103 citoplasmatic\u0103 difuz\u0103 (aspect c-ANCA)<sup>4<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Recomand\u0103ri pentru determinarea anti-PR3<\/em><\/strong><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2022 evaluarea pacien\u0163ilor suspecta\u0163i de vasculit\u0103 sistemic\u0103;<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2022 monitorizarea evolu\u0163iei bolii \u015fi a r\u0103spunsului terapeutic \u00een granulomatoza Wegener;<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">\u2022 confirmarea rezultatelor ANCA pozitive ob\u0163inute la imunofluorescen\u0163a indirect\u0103 (\u00een special aspect c-ANCA)<sup>2;3<\/sup>.<\/div>\n<p style=\"text-align: justify;\"><strong><em>Preg\u0103tire pacient <\/em><\/strong><em>- <\/em>\u00e0 jeun (pe nem\u00e2ncate) sau postprandial (dup\u0103 mese)<sup>1<\/sup>.<strong><em>\u00a0<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\"><strong><em>Specimen recoltat <\/em><\/strong><em>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>1<\/sup>.<strong><em>\u00a0<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\"><strong><em>Recipient de recoltare <\/em><\/strong><em>- <\/em>vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong><em>- <\/em>se separ\u0103 serul prin centrifugare<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Cauze de respingere<\/em><\/strong> <strong><em>a probei <\/em><\/strong><em>- <\/em>ser intens hemolizat, lipemic sau puternic contaminat bacterian<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Stabilitate prob\u0103 <\/em><\/strong><em>- <\/em>serul separat este stabil <em>7 zile <\/em>\u00a0la 4\u00b0C; <em>timp mai \u00eendelungat<\/em> la -20\u00b0C<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Metod\u0103 <\/em><\/strong>- <span style=\"text-decoration: underline;\">imunoenzimatic\u0103 cu detec\u0163ie prin fluorescen\u0163\u0103 (FEIA)<\/span>. Antigenul folosit este reprezentat de enzima PR3 purificat\u0103 ob\u0163inut\u0103 din neutrofile umane<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Valori de referin\u0163\u0103<\/em><\/strong><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\">&lt;7\u00a0\u00a0\u00a0 U\/mL\u00a0: negativ<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">7-10 U\/mL\u00a0: echivoc<\/div>\n<div style=\"text-align: justify; padding-left: 30px;\">&gt;10\u00a0 U\/mL: pozitiv<sup>1<\/sup><\/div>\n<p style=\"text-align: justify;\"><strong><em>Interpretarea rezultatelor<\/em><\/strong><\/p>\n<div style=\"text-align: justify;\">Anti-PR3 sunt detecta\u0163i \u00een aproape toate cazurile de boal\u0103 Wegener activ\u0103, prezen\u0163a lor fiind un indicator specific pentru aceast\u0103 afec\u0163iune (specificitate &gt;98%)<sup>2;3<\/sup>.<\/div>\n<div style=\"text-align: justify;\">\u00cen cazul unei boli active cu vasculit\u0103 sistemic\u0103, glomerulonefrita necrotizant\u0103 \u015fi inflama\u0163ie de tip granulomatos a tractului respirator, sensibilitatea clinic\u0103 a anti-PR3 este de 85-90%. In lipsa afect\u0103rii renale sensibilitatea clinic\u0103 este de numai 75%<sup>4<\/sup>. Dup\u0103 terapia imunosupresoare nivelul anticorpilor scade foarte mult sau se ob\u0163ine un rezultat negativ<sup>2;3;4<\/sup>.<\/div>\n<p style=\"text-align: justify;\"><strong><em>Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n<div style=\"text-align: justify;\">Un rezultat negativ nu exclude boala, deoarece aproximativ 20% dintre pacien\u0163ii cu boala Wegener limitat\u0103 nu prezint\u0103 anti-PR3<sup>3<\/sup>.<\/div>\n<div style=\"text-align: justify;\">Anti-PR3 mai pot ap\u0103rea \u00een poliangeita microscopic\u0103 \u015fi \u00een sindromul Churg-Strauss, \u00eens\u0103 cu o prevalen\u0163\u0103 redus\u0103 (45% si respectiv, 10%)<sup>4<\/sup>.<\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: small;\">\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 10pt;\">\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-size: small;\">1. <span style=\"font-size: 10pt;\">Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog<\/span><\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">2. Laboratory Corporation of America.Directory of Services and Interpretive Guide. Antiproteinase 3 (PR3) Antibodies. www.labcorp.com 2010. Ref Type: Internet Communication.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">3. Mayo Clinic. Mayo Medical Laboratories. Test Catalog: Proteinase 3 Antibodies, IgG, Serum. www.mayomedicallaboratories.com. Ref Type: Internet Communication.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">4. Werner J.Mayet.Autoantibodies in Systemic Vasculitis. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. Lothar Thomas. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany,1 ed. 1998, 842-845.<\/span><\/div>","protected":false},"excerpt":{"rendered":"<p>\u041f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437\u0430 3 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f\u00a0\u0446\u0435\u043b\u0435\u0432\u044b\u043c\u00a0\u0430\u043d\u0442\u0438\u0433\u0435\u043d\u043e\u043c\u00a0\u0432\u00a090%\u00a0\u0441\u043b\u0443\u0447\u0430\u0435\u0432\u00a0\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439\u00a0\u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0438\u00a0\u043a\u0440\u043e\u0432\u0438,\u00a0\u0441\u043e\u0434\u0435\u0440\u0436\u0430\u0449\u0435\u0439\u00a0c-ANCA.<\/p>\n<p>\u041f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437\u0430 3 \u0431\u044b\u043b\u0430 \u043e\u043f\u0438\u0441\u0430\u043d\u0430 \u043a\u0430\u043a \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u0439 \u0430\u043d\u0442\u0438\u0433\u0435\u043d \u043f\u0440\u0438 \u0433\u0435\u043c\u043e\u0440\u0440\u0430\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0432\u0430\u0441\u043a\u0443\u043b\u0438\u0442\u0435. \u0412 \u043e\u0442\u043b\u0438\u0447\u0438\u0435 \u043e\u0442 \u043c\u0438\u043a\u0440\u043e\u0441\u043a\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u043e\u043b\u0438\u0430\u0440\u0442\u0435\u0440\u0438\u0438\u0442\u0430, \u043f\u0440\u0438 \u043a\u043e\u0442\u043e\u0440\u043e\u043c \u0441 \u043e\u0434\u0438\u043d\u0430\u043a\u043e\u0432\u043e\u0439 \u0447\u0430\u0441\u0442\u043e\u0442\u043e\u0439 \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u044e\u0442\u0441\u044f \u043a\u0430\u043a \u0430\u043d\u0442\u0438-PR3, \u0442\u0430\u043a \u0438 \u0430\u043d\u0442\u0438-MPO, \u0434\u043b\u044f \u0433\u0435\u043c\u043e\u0440\u0440\u0430\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0432\u0430\u0441\u043a\u0443\u043b\u0438\u0442\u0430 \u0441\u0432\u043e\u0439\u0441\u0442\u0432\u0435\u043d\u043d\u044b \u043f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437\u0435-3 (\u0431\u043e\u043b\u0435\u0435 90%).<\/p>\n<p>\u041f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437\u0430 3 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043d\u0435\u0431\u043e\u043b\u044c\u0448\u0438\u043c \u0431\u0435\u043b\u043a\u043e\u043c (29 \u043a\u0414\u0430), \u043b\u043e\u043a\u0430\u043b\u0438\u0437\u0443\u044e\u0449\u0438\u043c\u0441\u044f \u0432 \u0430\u0437\u0443\u0440\u043e\u0444\u0438\u043b\u044c\u043d\u044b\u0445 \u0433\u0440\u0430\u043d\u0443\u043b\u0430\u0445 \u043d\u0435\u0439\u0442\u0440\u043e\u0444\u0438\u043b\u043e\u0432, \u0433\u0440\u0430\u043d\u0443\u043b\u0430\u0445 \u043c\u043e\u043d\u043e\u0446\u0438\u0442\u043e\u0432 \u0438 \u0446\u0438\u0442\u043e\u043f\u043b\u0430\u0437\u043c\u0435 \u044d\u043d\u0434\u043e\u0442\u0435\u043b\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a. \u042d\u0442\u043e \u043e\u0434\u0438\u043d \u0438\u0437 \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u0445 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u043e\u0432 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u0446\u0438\u0442\u043e\u043f\u043b\u0430\u0437\u043c\u0435 \u043d\u0435\u0439\u0442\u0440\u043e\u0444\u0438\u043b\u043e\u0432, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0432 \u0438\u043c\u043c\u0443\u043d\u043e\u0444\u043b\u044e\u043e\u0440\u0435\u0441\u0446\u0435\u043d\u0442\u043d\u043e\u043c \u0442\u0435\u0441\u0442\u0435 \u0438\u043d\u0434\u0443\u0446\u0438\u0440\u0443\u0435\u0442 \u0446\u0438\u0442\u043e\u043f\u043b\u0430\u0437\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0442\u0438\u043f \u0441\u0432\u0435\u0447\u0435\u043d\u0438\u044f (\u0446\u0410\u041d\u0426\u0410, cANCA).<\/p>\n<p>\u041e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437\u0435 3 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0432\u044b\u0441\u043e\u043a\u043e\u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u044b\u043c \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u043c \u0442\u0435\u0441\u0442\u043e\u043c \u0432 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u0433\u0440\u0430\u043d\u0443\u043b\u0435\u043c\u0430\u0442\u043e\u0437\u0430 \u0441 \u043f\u043e\u043b\u0438\u0430\u043d\u0433\u0438\u0438\u0442\u043e\u043c (\u0440\u0430\u043d\u0435\u0435 \u043d\u0430\u0437\u044b\u0432\u0430\u0435\u043c\u043e\u0433\u043e \u00ab\u0433\u0440\u0430\u043d\u0443\u043b\u0435\u043c\u0430\u0442\u043e\u0437 \u0412\u0435\u0433\u0435\u043d\u0435\u0440\u0430\u00bb), \u0442\u044f\u0436\u0435\u043b\u043e\u0433\u043e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u043f\u0440\u043e\u044f\u0432\u043b\u044f\u044e\u0449\u0435\u0433\u043e\u0441\u044f \u0442\u0440\u0438\u0430\u0434\u043e\u0439 &#8212; \u0433\u0440\u0430\u043d\u0443\u043b\u0435\u043c\u0430\u0442\u043e\u0437\u043d\u044b\u043c \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u0435\u043c \u0432\u0435\u0440\u0445\u043d\u0438\u0445 \u0434\u044b\u0445\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043f\u0443\u0442\u0435\u0439, \u043b\u0435\u0433\u043a\u0438\u0445 \u0438 \u043f\u043e\u0447\u0435\u043a. \u0427\u0430\u0441\u0442\u043e \u044d\u0442\u043e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435 \u0441\u043e\u043f\u0440\u043e\u0432\u043e\u0436\u0434\u0430\u0435\u0442\u0441\u044f \u043f\u043e\u043b\u0438\u043d\u0435\u0432\u0440\u0438\u0442\u043e\u043c.<\/p>\n<p>\u0412\u044b\u0441\u043e\u043a\u0438\u0435 \u0442\u0438\u0442\u0440\u044b \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437\u0435 3 \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u044e\u0442\u0441\u044f \u0443 90-95% \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u0440\u0430\u0437\u0432\u0435\u0440\u043d\u0443\u0442\u043e\u0439 \u043a\u0430\u0440\u0442\u0438\u043d\u043e\u0439 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0433\u043e \u0433\u0440\u0430\u043d\u0443\u043b\u0435\u043c\u0430\u0442\u043e\u0437\u043d\u043e\u0433\u043e \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0430. \u041b\u043e\u043a\u0430\u043b\u0438\u0437\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u0444\u043e\u0440\u043c\u044b \u0433\u0440\u0430\u043d\u0443\u043b\u0435\u043c\u0430\u0442\u043e\u0437\u0430 \u0412\u0435\u0433\u0435\u043d\u0435\u0440\u0430, \u043f\u043e\u0440\u0430\u0436\u0430\u044e\u0449\u0438\u0435 \u0432\u0435\u0440\u0445\u043d\u0438\u0435 \u0434\u044b\u0445\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u043f\u0443\u0442\u0438, \u0440\u0435\u0436\u0435 \u0441\u043e\u043f\u0440\u043e\u0432\u043e\u0436\u0434\u0430\u044e\u0442\u0441\u044f \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b (50-60%). \u0420\u0435\u0434\u043a\u043e \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437\u0435 3 \u043c\u043e\u0433\u0443\u0442 \u0431\u044b\u0442\u044c \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u044b \u043f\u0440\u0438 \u0434\u0440\u0443\u0433\u0438\u0445 \u0410\u041d\u0426\u0410-\u0430\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u0432\u0430\u0441\u0443\u043b\u0438\u0442\u0430\u0445 &#8212; \u043c\u0438\u043a\u0440\u043e\u0441\u043a\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u043f\u043e\u043b\u0438\u0430\u043d\u0433\u0438\u0438\u0442\u0435, \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0435 \u0427\u0430\u0440\u0433\u0430-\u0421\u0442\u0440\u043e\u0441\u0441\u0430 \u0438 \u0443\u0437\u0435\u043b\u043a\u043e\u0432\u043e\u043c \u043f\u043e\u043b\u0438\u0430\u0440\u0442\u0435\u0440\u0438\u0438\u0442\u0435. \u0421\u043e\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u0435 \u0430\u043d\u0442\u0438\u043d\u0435\u0439\u0442\u0440\u043e\u0444\u0438\u043b\u044c\u043d\u044b\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043f\u0440\u0438 \u0433\u0440\u0430\u043d\u0443\u043b\u0435\u043c\u0430\u0442\u043e\u0437\u0435 \u0412\u0435\u0433\u0435\u043d\u0435\u0440\u0430 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438 \u0437\u043d\u0430\u0447\u0438\u043c\u044b\u043c \u0438 \u043a\u043e\u0440\u0440\u0435\u043b\u0438\u0440\u0443\u0435\u0442 \u0441 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c\u044e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f. \u0412\u044b\u0441\u043e\u043a\u0438\u0439 \u0438\u0445 \u0442\u0438\u0442\u0440 \u0441\u043b\u0443\u0436\u0438\u0442 \u043e\u0441\u043d\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u0434\u043b\u044f \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0438\u043c\u043c\u0443\u043d\u043e\u0441\u0443\u043f\u0440\u0435\u0441\u0441\u0438\u0432\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438.<\/p>\n<p>\u0414\u043b\u044f \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u044f \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u0438 \u0441\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u044b\u043c\u0438 \u0432\u0430\u0441\u043a\u0443\u043b\u0438\u0442\u0430\u043c\u0438 \u0434\u0435\u0439\u0441\u0442\u0432\u0443\u044e\u0449\u0438\u0435 \u043c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u0442\u0440\u0435\u0431\u0443\u044e\u0442 \u043e\u0434\u043d\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0433\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u0438\u043c\u043c\u0443\u043d\u043e\u0444\u043b\u044e\u043e\u0440\u0435\u0441\u0446\u0435\u043d\u0442\u043d\u043e\u0433\u043e \u0442\u0435\u0441\u0442\u0430 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u044f \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u0446\u0438\u0442\u043e\u043f\u043b\u0430\u0437\u043c\u0435 \u043d\u0435\u0439\u0442\u0440\u043e\u0444\u0438\u043b\u043e\u0432 \u0438 \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u043c \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430\u043c \u0410\u041d\u0426\u0410 &#8212; \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437\u0435 3 \u0438 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u043c\u0438\u0435\u043b\u043e\u043f\u0435\u0440\u043e\u043a\u0441\u0438\u0434\u0430\u0437\u0435.<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"262\"><b>\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c<\/b><\/td>\n<td width=\"361\"><b>\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n<td width=\"361\">\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/b><\/td>\n<td width=\"361\">\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n<td width=\"361\">\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0433\u0435\u043b\u0435\u0432\u043e\u0439\u00a0\u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n<td width=\"361\">\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><\/td>\n<td width=\"361\"><\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><\/td>\n<td width=\"361\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" width=\"624\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table>\n<tbody>\n<tr>\n<td width=\"624\"><b>\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"624\"><b>\u041c\u0430\u0440\u043a\u0435\u0440\u00a0<\/b><b>\u0433\u0440\u0430\u043d\u0443\u043b\u0435\u043c\u0430\u0442\u043e\u0437\u0430\u00a0\u0441\u00a0\u043f\u043e\u043b\u0438\u0430\u043d\u0433\u0438\u0438\u0442\u043e\u043c\u00a0(\u00ab\u0433\u0440\u0430\u043d\u0443\u043b\u0435\u043c\u0430\u0442\u043e\u0437\u00a0\u0412\u0435\u0433\u0435\u043d\u0435\u0440\u0430\u00bb)<\/b><\/p>\n<ul>\n<li>\u0420\u0430\u043d\u043d\u044f\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0438 \u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u0430\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u044b\u0445 \u0432\u0430\u0441\u043a\u0443\u043b\u0438\u0442\u043e\u0432;<\/li>\n<li>\u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u043b\u0438\u043c\u0438\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0439 (\u043d\u043e\u0441\u043e\u0433\u043b\u043e\u0442\u043e\u0447\u043d\u043e\u0439) \u0438 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0439 \u0444\u043e\u0440\u043c\u044b \u0433\u0440\u0430\u043d\u0443\u043b\u0435\u043c\u0430\u0442\u043e\u0437\u0430 \u0412\u0435\u0433\u0435\u043d\u0435\u0440\u0430;<\/li>\n<li>\u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0433\u0440\u0430\u043d\u0443\u043b\u0435\u043c\u0430\u0442\u043e\u0437\u0430 \u0412\u0435\u0433\u0435\u043d\u0435\u0440\u0430;<\/li>\n<li>\u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0431\u044b\u0441\u0442\u0440\u043e\u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0449\u0435\u0433\u043e \u0433\u043b\u043e\u043c\u0435\u0440\u0443\u043b\u043e\u043d\u0435\u0444\u0440\u0438\u0442\u0430 \u0438 \u043e\u0441\u0442\u0440\u043e\u0439 \u043f\u043e\u0447\u0435\u0447\u043d\u043e\u0439 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u0438;<\/li>\n<li>\u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u0430\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u043f\u043e\u043b\u0438\u043d\u0435\u0439\u0440\u043e\u043f\u0430\u0442\u0438\u0438<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"624\"><b>\u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f\u00a0\u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"624\"><b>\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"624\">\u00b7\u00a0\u0413\u0440\u0430\u043d\u0443\u043b\u0435\u043c\u0430\u0442\u043e\u0437\u00a0\u0412\u0435\u0433\u0435\u043d\u0435\u0440\u0430<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[928,929],"product_tag":[],"class_list":{"0":"post-9425","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-boli-autoimune","6":"product_cat-markeri-pentru-afectiuni-reumatismale-si-vasculite","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9425","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9425"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9425"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9425"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9425"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}