{"id":9421,"date":"2020-04-23T04:37:32","date_gmt":"2020-04-23T01:37:32","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/imunoglobulina-ige\/"},"modified":"2026-02-18T23:53:37","modified_gmt":"2026-02-18T21:53:37","slug":"imunoglobulina-ige","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/imunoglobulina-ige\/","title":{"rendered":"\u0418\u043c\u043c\u0443\u043d\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d E (Ig E)"},"content":{"rendered":"
IgE sunt imunoglobuline fixate prin fragmentul Fc pe suprafa\u0163a mastocitelor cuplarea lor cu antigenul produce degranularea mastocitului cu declan\u015farea reac\u0163iei alergice (tip I, imediat, anafilactic)6<\/sup>. \u00cen serul persoanelor normale concentra\u0163ia IgE reprezint\u0103 mai pu\u0163in de 0.001% din totalul imunoglobulinelor. IgE de\u0163in un rol important \u00een medierea reac\u0163iilor alergice care se produc \u00een urma expunerii la alergeni a indivizilor susceptibili (atopici). IgE au o structur\u0103 similar\u0103 cu a celorlalte imunoglobuline, fiind alc\u0103tuite din 2 lan\u0163uri u\u015foare \u015fi 2 lan\u0163uri grele. Lan\u0163urile grele ale fiec\u0103rei molecule de IgE con\u0163in o regiune variabil\u0103 responsabil\u0103 de specificitatea antigenic\u0103.<\/div>\n
<\/div>\n
Deoarece mielomul IgE este extrem de rar, utilitatea clinic\u0103 a determin\u0103rii IgE se rezum\u0103 \u00een general la rolul s\u0103u de mediator al r\u0103spunsului alergic. Majoritatea moleculelor de IgE din ser sunt fixate pe suprafa\u0163a mastocitelor \u015fi a granulocitelor bazofile. Interac\u0163iunea alergenilor cu IgE specifice de pe suprafa\u0163a acestor celule determin\u0103 eliberararea de histamin\u0103 \u015fi a altor substan\u0163e vasoactive, ini\u0163iind astfel reac\u0163ia alergic\u0103. Aproximativ jum\u0103tate din indivizii cu rinit\u0103 alergic\u0103 sau astm prezint\u0103 niveluri crescute de IgE; restul, de\u015fi au concentra\u0163ii crescute de IgE alergen specifice, prezint\u0103 niveluri normale de IgE totale. Studiile au indicat c\u0103 nivelul IgE totale este adesea crescut la pacien\u0163ii cu dermatit\u0103 atopic\u0103, iar nivelul IgE tinde s\u0103 se coreleze cu severitatea eczemei.<\/div>\n
<\/div>\n
Concentra\u0163ia IgE este de asemenea crescut\u0103 la pacien\u0163ii cu infest\u0103ri parazitare, aspergiloza bronhopulmonar\u0103 alergic\u0103 \u015fi \u00eentr-un anumit tip de imunodeficien\u0163\u0103 (sindromul Job)5<\/sup>.<\/div>\n
<\/div>\n
Preg\u0103tire pacient <\/em><\/strong>-<\/em> \u00e0 jeun (pe nem\u00e2ncate)4<\/sup>.<\/div>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c4<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>-<\/em> vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator4<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>-<\/em> probele suspectate a avea crioglobuline se men\u0163in la 37\u00baC; dup\u0103 ce se produce coagularea, se separ\u0103 serul prin centrifugare; serul separat se lucreaz\u0103 imediat ori se stocheaz\u0103 la 4\u00baC sau la -20\u00baC. Probele suspectate a avea aglutinine la rece se trateaz\u0103 la fel4<\/sup>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser4<\/sup>.<\/p>\n

Cauze\u00a0 de respingere a probei <\/em><\/strong>-<\/em> specimen intens hemolizat sau lipemic4<\/sup>.<\/p>\n

\u0422tabilitate prob\u0103 <\/em><\/strong>-<\/em> serul separat este stabil: 7 zile<\/em> la 2-8\u00b0C; 6 luni<\/em> la \u2013 20\u00b0C4<\/sup>.<\/p>\n

Metoda <\/em><\/strong>- <\/em>imunochimic\u0103 cu detec\u0163ie prin electrochemiluminiscen\u0163\u0103 (ECLIA)<\/span>4<\/sup><\/p>\n

Valori de referin\u0163\u0103<\/em><\/strong>4<\/sup><\/p>\n\n\n\n\n\n\n\n\n
\n

Varsta<\/em><\/strong><\/p>\n<\/td>\n

\n

Valori (UI\/mL)<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

<1 an<\/p>\n<\/td>\n

\n

<15<\/p>\n<\/td>\n<\/tr>\n

\n

1-5 ani<\/p>\n<\/td>\n

\n

<60<\/p>\n<\/td>\n<\/tr>\n

\n

6-9 ani<\/p>\n<\/td>\n

\n

<90<\/p>\n<\/td>\n<\/tr>\n

\n

10-15 ani<\/p>\n<\/td>\n

\n

< 200<\/p>\n<\/td>\n<\/tr>\n

\n

Adult<\/p>\n<\/td>\n

\n

< 100<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Factori de conversie: <\/em>UI\/mL x 2.4 = ng\/mL<\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 ng\/mL x 0.42 = UI\/mL.<\/p>\n

Limita de detec\u0163ie <\/em><\/strong>\u2013 0.10 UI\/mL (0.24 ng\/mL)4<\/sup>.\u00a0<\/em><\/strong><\/p>\n

Interpretarea rezultatelor <\/em><\/strong><\/p>\n\n\n\n\n
\n

Cre\u015fterea IgE este asociat\u0103 cu :<\/em><\/strong><\/p>\n<\/td>\n

\n

Sc\u0103derea IgE este asociat\u0103 cu:<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n
\u2022 astm bronsic extrinsec<\/div>\n
\u2022 febra f\u00e2nului<\/div>\n
\u2022 eczema atopic\u0103<\/div>\n
\u2022 parazitoze<\/div>\n
\u2022 sindromul Job<\/div>\n
\u2022 mielomul IgE1;3<\/sup><\/div>\n<\/td>\n
\n
\u2022 deficien\u0163e ereditare<\/div>\n
\u2022 imunodeficien\u0163a dob\u00e2ndit\u0103<\/div>\n
\u2022 sindromul ataxie-telengiectazie<\/div>\n
\u2022 mielom non-IgE1;3<\/sup><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

Un nivel normal de IgE nu excude existen\u0163a fenomenelor alergice5<\/sup>. Pentru depistarea statusului atopic se recomand\u0103, \u00een func\u0163ie de v\u00e2rst\u0103, efecturea testelor Phadiatop Infant \u015fi Phadiatop4<\/sup>.<\/p>\n

\u2022 Medicamente<\/p>\n

Cre\u015fteri<\/strong><\/span>: aztreonam, penicilina G2<\/sup>.<\/div>\n
Sc\u0103deri<\/strong><\/span>: fenitoin2<\/sup>.<\/div>\n

\u2022 Interferen\u0163e analitice<\/p>\n

Pot produce interferen\u0163e cu unele componente ale kit-ului \u015fi conduce la rezultate neconcludente urm\u0103toarele:<\/p>\n

\u2013 tratamentul cu biotin\u0103 \u00een doze mari (>5 mg\/zi); de aceea se recomand\u0103 ca recoltarea de s\u00e2nge s\u0103 se fac\u0103 dup\u0103 minimum 8 ore de la ultima administrare;<\/div>\n
\u2013 titrurile foarte crescute de anticorpi anti-streptavidina \u015fi anti-ruteniu;<\/div>\n
\u2013 anticorpii monoclonali proveni\u0163i de la \u015foarece administra\u0163i la unii pacien\u0163i \u00een scop diagnostic sau terapeutic4<\/sup>.<\/div>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Frances Fischbach. Immunodiagnostic studies. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 7 Ed., 2004, 530-651.<\/span><\/div>\n
2. Frances Fischbach. Effects of the Most Commonly Used Drugs on Frequently Ordered Laboratory Tests. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 7 Ed., 2004, 1188-1238.<\/span><\/div>\n
3. Jacques Wallach. Analize de sange. In Interpretarea testelor de diagnostic. Editura Stiin\u0163elor Medicale, Romania, 7 Ed., 2001, 49-121.<\/span><\/div>\n
4. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n
5. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Immunoglobulin E, Total. www.labcorp.com .2010. Ref Type: Internet Communication.<\/span><\/div>\n
6. Minodora Dobreanu. Metabolismul proteinelor. In Biochimie clinica. Implicatii practice. University Press, Romania, Ed. 2006, 133-150.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0418\u043c\u043c\u0443\u043d\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d E (IgE) \u2013 \u044d\u0442\u043e \u043a\u043b\u0430\u0441\u0441 \u0431\u0435\u043b\u043a\u043e\u0432, \u043e\u0442\u0432\u0435\u0447\u0430\u044e\u0449\u0438\u0445 \u0437\u0430 \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u0447\u0435\u0441\u043a\u0443\u044e \u0440\u0435\u0430\u043a\u0446\u0438\u044e \u043d\u0435\u043c\u0435\u0434\u043b\u0435\u043d\u043d\u043e\u0433\u043e \u0442\u0438\u043f\u0430. \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u0438\u0445 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438 \u043c\u043e\u0436\u0435\u0442 \u0433\u043e\u0432\u043e\u0440\u0438\u0442\u044c \u043d\u0435 \u0442\u043e\u043b\u044c\u043a\u043e \u043e\u0431 \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u0438, \u043d\u043e \u0438 \u043e \u0433\u043b\u0438\u0441\u0442\u043d\u044b\u0445 \u0438\u043d\u0432\u0430\u0437\u0438\u044f\u0445. \u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0438\u043c\u0435\u0435\u0442 \u0432\u0430\u0436\u043d\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u043a\u0430\u043a \u0434\u043b\u044f \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u043e\u0439 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0439, \u0442\u0430\u043a \u0438 \u0434\u043b\u044f \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044f \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f.<\/p>\n

\u0417\u0430\u0431\u043e\u0440 \u043a\u0440\u043e\u0432\u0438 \u0434\u043e\u043b\u0436\u0435\u043d \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u044c\u0441\u044f \u0443\u0442\u0440\u043e\u043c, \u0441\u0442\u0440\u043e\u0433\u043e \u043d\u0430\u0442\u043e\u0449\u0430\u043a. \u0427\u0442\u043e\u0431\u044b \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442 \u0431\u044b\u043b \u0434\u043e\u0441\u0442\u043e\u0432\u0435\u0440\u043d\u044b\u043c, \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0441\u0442\u044b \u043d\u0430\u0441\u0442\u043e\u044f\u0442\u0435\u043b\u044c\u043d\u043e \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0443\u044e\u0442:<\/p>\n

    \n
  • \u0438\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u043f\u0440\u0438\u0435\u043c \u043f\u0438\u0449\u0438 \u0438 \u043f\u0438\u0442\u044c\u044f \u043c\u0435\u043d\u0435\u0435 \u0447\u0435\u043c \u0437\u0430 8 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0432\u0437\u044f\u0442\u0438\u044f \u043a\u0440\u043e\u0432\u0438;<\/li>\n
  • \u043d\u0435 \u043f\u0438\u0442\u044c \u044d\u043d\u0435\u0440\u0433\u0435\u0442\u0438\u043a\u0438, \u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u044b\u0435 \u043d\u0430\u043f\u0438\u0442\u043a\u0438 \u0437\u0430 \u0441\u0443\u0442\u043a\u0438 \u0434\u043e \u0430\u043d\u0430\u043b\u0438\u0437\u0430;<\/li>\n
  • \u0437\u0430 2\u20133 \u0434\u043d\u044f \u0441\u043d\u0438\u0437\u0438\u0442\u044c \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043d\u0430\u0433\u0440\u0443\u0437\u043a\u0438, \u043e\u0442\u043a\u0430\u0437\u0430\u0442\u044c\u0441\u044f \u043e\u0442 \u0441\u043f\u043e\u0440\u0442\u0430 \u0438 \u0444\u0438\u0442\u043d\u0435\u0441\u0430.<\/li>\n<\/ul>\n

    \u0423\u0442\u0440\u043e\u043c \u0434\u043e \u0437\u0430\u0431\u043e\u0440\u0430 \u043a\u0440\u043e\u0432\u0438 \u043d\u0435\u0436\u0435\u043b\u0430\u0442\u0435\u043b\u044c\u043d\u043e \u043a\u0443\u0440\u0438\u0442\u044c, \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c \u0436\u0435\u0432\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u0440\u0435\u0437\u0438\u043d\u043a\u0438, \u043f\u0430\u0441\u0442\u0438\u043b\u043a\u0438, \u043f\u0438\u0442\u044c \u043c\u043e\u0436\u043d\u043e \u0442\u043e\u043b\u044c\u043a\u043e \u0447\u0438\u0441\u0442\u0443\u044e \u0432\u043e\u0434\u0443 \u0431\u0435\u0437 \u0433\u0430\u0437\u0430 \u0438 \u0434\u043e\u0431\u0430\u0432\u043e\u043a.<\/p>\n

    \u041e\u0431\u044b\u0447\u043d\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u043d\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0443\u0435\u0442\u0441\u044f \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u0438\u043b\u0438 \u0441\u0440\u0430\u0437\u0443 \u043f\u043e\u0441\u043b\u0435 \u0444\u0438\u0437\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043f\u0440\u043e\u0446\u0435\u0434\u0443\u0440, \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0438\u043d\u0441\u0442\u0440\u0443\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u044b\u0445 \u043c\u0435\u0442\u043e\u0434\u043e\u0432 \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f (\u041c\u0420\u0422, \u041a\u0422, \u0440\u0435\u043d\u0442\u0433\u0435\u043d\u043e\u0433\u0440\u0430\u0444\u0438\u0438).<\/p>\n

    \u041a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f \u043e\u0431\u0449\u0435\u0433\u043e \u0438\u043c\u043c\u0443\u043d\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u0430 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438 \u0440\u0430\u0441\u0441\u0447\u0438\u0442\u044b\u0432\u0430\u0435\u0442\u0441\u044f \u0432 \u043a\u0415\/\u043b (\u043a\u0438\u043b\u043e\u0435\u0434\u0438\u043d\u0438\u0446\u0430 \u043d\u0430 \u043b\u0438\u0442\u0440) \u0438\u043b\u0438 \u0432 \u041c\u0415\/\u043c\u043b (\u043c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0435 \u0435\u0434\u0438\u043d\u0438\u0446\u044b \u043d\u0430 \u043c\u0438\u043b\u043b\u0438\u043b\u0438\u0442\u0440).<\/p>\n

    \u0420\u0435\u0444\u0435\u0440\u0435\u043d\u0441\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
    \u0412\u043e\u0437\u0440\u0430\u0441\u0442 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/strong><\/th>\n\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0438 IgE (ME\/\u043c\u043b)<\/strong><\/th>\n<\/tr>\n<\/thead>\n
    \u0414\u0435\u0442\u0438 \u0434\u043e \u0433\u043e\u0434\u0430<\/td>\n<15<\/td>\n<\/tr>\n
    \u0414\u0435\u0442\u0438 \u043e\u0442 1 \u0434\u043e 6 \u043b\u0435\u0442<\/td>\n<60<\/td>\n<\/tr>\n
    \u0414\u0435\u0442\u0438 \u043e\u0442 6 \u0434\u043e 10 \u043b\u0435\u0442<\/td>\n<90<\/td>\n<\/tr>\n
    \u041f\u043e\u0434\u0440\u043e\u0441\u0442\u043a\u0438 \u043e\u0442 10 \u0434\u043e 16 \u043b\u0435\u0442<\/td>\n<200<\/td>\n<\/tr>\n
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