{"id":9416,"date":"2020-04-23T03:37:23","date_gmt":"2020-04-23T00:37:23","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/coxiella-burnetii-serologie\/"},"modified":"2025-02-05T13:28:44","modified_gmt":"2025-02-05T11:28:44","slug":"coxiella-burnetii-serologie","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/coxiella-burnetii-serologie\/","title":{"rendered":"Coxiella burnetii - \u0441\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><b><i><span style=\"color: #000000;\">\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/span><\/i><\/b><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000; font-size: 12pt;\">Febra Q este o zoonoz\u0103 determinat\u0103 de Coxiella burnetii, o bacterie Gram negativ\u0103 obligatoriu intracelular\u0103. Infec\u0163ia este contractat\u0103 de om prin inhalarea de aerosoli sau\u00a0praf contaminat, de la animale domestice infectate (vite, oi \u015fi capre). Mai rar, transmiterea se poate face prin mu\u015fcatura de c\u0103pu\u015f\u0103, ingestia de lapte nepasteurizat \u015fi derivate ale acestuia sau de la om la om<sup>1;2<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000; font-size: 12pt;\">Clasificat\u0103 ini\u0163ial ca o specie a genului Rickettsia, Coxiella burnetii este recunoscut\u0103 ast\u0103zi ca un microorganism din grupul gamma al Proteobacteriilor. Tehnicile moleculare au eviden\u0163iat o omologie cu Legionella pneumophilae, de asemenea membr\u0103 a aceluia\u015fi grup taxonomic<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000; font-size: 12pt;\">Rezisten\u0163a la c\u0103ldur\u0103, agen\u0163ii chimici \u015fi deshidratarea permit supravie\u0163uirea \u00eendelungat\u0103 a bacteriei \u00een afara organismului gazd\u0103<sup>3<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000; font-size: 12pt;\">Infec\u0163ia devine simptomatic\u0103 doar la jum\u0103tate din pacien\u0163ii infecta\u0163i. Forma acut\u0103 de boal\u0103 Q debuteaz\u0103 cu febr\u0103, frisoane, transpira\u0163ii, mialgii, tuse neproductiv\u0103, stare de r\u0103u general. Febra persist\u0103 de obicei 1-2 s\u0103pt\u0103m\u00e2ni. Aproximativ 30-50% din pacien\u0163ii cu infec\u0163ie simptomatic\u0103 dezvolt\u0103 pneumonie. Rareori, boala poate s\u0103 \u00eembrace o form\u0103 cronic\u0103 sever\u0103, caracterizat\u0103 prin endocardit\u0103, hepatit\u0103 cronic\u0103 \u015fi sindromul de oboseal\u0103 cronic\u0103.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000; font-size: 12pt;\">Deoarece simptomele clinice sunt nespecifice, diagnosticul se stabile\u015fte numai pe investiga\u0163ii de laborator<sup>1;2<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000; font-size: 12pt;\">Ca orice bacterie Gram negativ\u0103, Coxiella burnetii prezint\u0103 ca factor de virulen\u0163\u0103 un lipopolizaharid ce este responsabil de asemenea \u015fi de varia\u0163ia de faz\u0103 antigenic\u0103 ce survine \u00een cursul evolu\u0163iei infec\u0163iei<sup>1;3<\/sup>. Aceast\u0103 diferen\u0163\u0103 antigenic\u0103 este important\u0103 pentru diagnostic, fiind util\u0103 \u00een diferen\u0163ierea infec\u0163iei acute de cea cronic\u0103:<\/span><\/p>\n<ul>\n<li style=\"text-align: justify; padding-left: 30px;\"><span style=\"color: #000000; font-size: 12pt;\">\u00een formele acute de boal\u0103, predomin\u0103 anticorpii \u00eendrepta\u0163i \u00eempotriva antigenelor de faz\u0103 II, put\u00e2nd fi depista\u0163i \u00eencep\u00e2nd cu cea de a 2-a s\u0103pt\u0103m\u00e2n\u0103 de boal\u0103; de\u015fi \u00een probele recoltate mai t\u00e2rziu se poate \u00eenregistra \u015fi o cre\u015ftere a anticorpilor fa\u0163\u0103 de antigenele de faz\u0103 I, titrul anticorpilor fa\u0163\u0103 de antigenele de faz\u0103 II este mai mare;<\/span><\/li>\n<li style=\"text-align: justify; padding-left: 30px;\"><span style=\"color: #000000; font-size: 12pt;\">\u00een infec\u0163ia cronic\u0103 situa\u0163ia este invers\u0103, demonstr\u00e2ndu-se \u00een serul pacien\u0163ilor o cre\u015ftere marcat\u0103 a anticorpilor fa\u0163\u0103 de antigenele de faz\u0103 I;<\/span><\/li>\n<li style=\"text-align: justify; padding-left: 30px;\"><span style=\"color: #000000; font-size: 12pt;\">\u00een cazurile de hepatit\u0103 cronic\u0103 granulomatoas\u0103 titrurile anticorpilor IgG \u015fi IgM at\u00e2t fa\u0163\u0103 de antigenele faz\u0103 I c\u00e2t \u015fi fa\u0163\u0103 de antigenele de faz\u0103 II sunt crescute semnificativ, \u00eens\u0103 titrul anticorpilor fa\u0163\u0103 de antigenele de faz\u0103 II este mai mare\u00a0sau cel pu\u0163in egal cu cel al anticorpilor fa\u0163\u0103 de antigenele de faz\u0103 I;<\/span><\/li>\n<li style=\"text-align: justify; padding-left: 30px;\"><span style=\"color: #000000; font-size: 12pt;\">\u00een endocardit\u0103 se \u00eenregistreaz\u0103 de asemenea titruri mari de anticorpi, titrul anticorpilor fa\u0163\u0103 de antigenele de faz\u0103 I fiind de obicei mai mare dec\u00e2t cel al anticorpilor fa\u0163\u0103 de antigenele de faz\u0103 II<sup>3<\/sup>.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"color: #000000; font-size: 12pt;\"><b><i>Preg\u0103tire pacient<\/i><\/b><i> <\/i>\u2013 nu este necesar\u0103<sup>4<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\"><b><i>Specimen recoltat <\/i><\/b><i>-<b> <\/b><\/i>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>4<\/sup>.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\"><b><i>Recipient de recoltare <\/i><\/b><i>-<b> <\/b><\/i>vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator<sup>4<\/sup>. <b><i><\/i><\/b><\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\"><b><i>Prelucrare necesar\u0103 dup\u0103 recoltare <\/i><\/b>\u2013 se separ\u0103 serul prin centrifugare<sup>4<\/sup>.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\"><b><i>Volum prob\u0103 <\/i><\/b>\u2013 minim 2 mL ser<sup>4<\/sup>.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\"><b><i>Cauze de respingere a probei<\/i><\/b> \u2013 specimen hemolizat, lipemic sau contaminat bacterian<sup>4<\/sup>.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\"><b><i>Stabilitate prob\u0103<\/i><\/b> \u2013 serul separat este stabil <i>14 zile<\/i> la 2-8\u00baC; <i>timp \u00eendelungat<\/i> la -20 \u00baC<sup>4<\/sup>.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\"><b><i>Metod\u0103 <\/i><\/b>- <span style=\"text-decoration: underline;\">imunofluorescen\u0163\u0103 indirect\u0103<\/span>; sunt detecta\u0163i anticorpi de tip IgG \u015fi IgM at\u00e2t fa\u0163\u0103 de antigenele de faz\u0103 I c\u00e2t \u015fi fa\u0163\u0103 de antigenele de faz\u0103 II<sup>4<\/sup>.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\"><b><i>Valori de referin\u0163\u0103<\/i><\/b><sup>4<\/sup><\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\">Rezultatele sunt exprimate sunt form\u0103 de titruri\u00a0:<\/span><\/span><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\">Coxiella burnetii IgG\u00a0fa\u0163\u0103 de antigenele de faz\u0103 I:\u00a0&lt;1\/16<\/span><\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\">Coxiella burnetii IgM\u00a0fa\u0163\u0103 de antigenele de faz\u0103 I:\u00a0&lt;1\/16<\/span><\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\">Coxiella burnetii IgG fa\u0163\u0103 de antigenele de faz\u0103 II:\u00a0&lt;1\/16<\/span><\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\">Coxiella burnetii IgM fa\u0163\u0103 de antigenele de faz\u0103 II:\u00a0&lt;1\/16<\/span><\/span><\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><b><i><span style=\"color: #000000;\">Interpretarea rezultatelor<\/span><\/i><\/b><\/span><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\">Ob\u0163inerea unor titruri de anticorpi de faz\u0103 I mai mari \u00a0sau egale cu cele ale anticorpilor de faz\u0103 II este sugestiv\u0103 pentru infec\u0163ia cronic\u0103 sau pentru faza de convalescen\u0163\u0103 a febrei Q.<\/span><\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\">Ob\u0163inerea unor titruri de anticorpi fa\u0163\u0103 de antigenele de faza II mai mari sau egale cu cele ale anticorpilor fa\u0163\u0103 de antigenele de faz\u0103 I indic\u0103 o infec\u0163ie acut\u0103\/activ\u0103.<\/span><\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\">Un rezultat negativ face improbabil\u0103 infec\u0163ia cu Coxiella burnetii. Totu\u015fi dac\u0103 este suspectat\u0103 o febr\u0103 Q \u00een stadiu precoce se recomand\u0103 retestarea peste 2-3 s\u0103pt\u0103m\u00e2ni.<\/span><\/span><\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\">\u00cen febra Q se \u00eent\u00e2lnesc \u00een mod obi\u015fnuit titruri de anticorpi IgG \u2265 1\/128 fa\u0163\u0103 de antigenele de ambele faze. Anticorpii IgG apar precoce \u00een cursul infec\u0163iei; anticorpii IgG de faz\u0103 II ating un maximum \u00een s\u0103pt\u0103m\u00e2na 8 dup\u0103 care persist\u0103 \u00een titruri ridicate mai mult de 1 an. Anticorpii IgG de faz\u0103 I urmeaz\u0103 o dinamic\u0103 similar\u0103, \u00eens\u0103 titrurile acestora sunt\u00a0mult mai sc\u0103zute, astfel c\u0103 uneori pot fi detecta\u0163i numai \u00een perioada de convalescen\u0163\u0103.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\">\u00cen febra Q se \u00eent\u00e2lnesc de obicei titruri de anticorpi IgM \u2265 1\/64. Anticorpii IgM apar precoce\u00a0\u00een cursul infec\u0163iei; anticorpii IgM de faz\u0103 II ating un maximum \u00een s\u0103pt\u0103m\u00e2na 3 dup\u0103 care scad progresiv p\u00e2n\u0103 \u00een s\u0103pt\u0103m\u00e2na 14 c\u00e2nd se ob\u0163in titruri foarte mici. Anticorpii IgM de faz\u0103 I urmeaz\u0103 o dinamic\u0103 similar\u0103, \u00eens\u0103 titrurile acestora sunt\u00a0mult mai sc\u0103zute, astfel c\u0103 uneori pot fi detecta\u0163i numai \u00een perioada de convalescen\u0163\u0103<sup>3<\/sup>.<\/span><\/span><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><b><i><span style=\"color: #000000;\">Limite \u015fi interferen\u0163e<\/span><\/i><\/b><\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"color: #000000;\">R\u0103spunsul serologic variaz\u0103 \u00een func\u0163ie de stadiul infec\u0163iei. Probele recoltate foarte devreme \u00een cursul infec\u0163iei pot s\u0103 nu deceleze anticorpi astfel c\u0103 este necesar\u0103 repetarea recolt\u0103rii peste 2-4 s\u0103pt\u0103m\u00e2ni<sup>3<\/sup>.<\/span><\/span><\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: 10pt;\"><strong>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/span><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">1. <span style=\"font-size: 10pt;\">Cleveland KO, Lacasse A, Cunha AB. Q Fever. www. emedicine.medscape.com. August 2013. Ref Type: Internet Communication.<\/span><\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">2. Woldehiwet Z. Q Fever (Coxiellosis): Epidemiology and Pathogenesis. Res.Vet.Sci. 77(2), 93-100. 2004. Ref Type: Journal (Full)<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">3. Mayo Clinic, Mayo Medical Laboratories. Reference Laboratory Services for Health Care Organizations. Q Fever Antibody, IgG and IgM, serum. www.mayomedicallaboratories.com. 2014. Ref Type: Internet Communication.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">4. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2014. Ref Type: Catalog<\/span><\/div>","protected":false},"excerpt":{"rendered":"<p><strong>\u041b\u0438\u0445\u043e\u0440\u0430\u0434\u043a\u0430 Q<\/strong> \u2013 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435, \u0432\u044b\u0437\u044b\u0432\u0430\u0435\u043c\u043e\u0435 Coxiella burnetii, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u043c\u043e\u0436\u0435\u0442 \u0441\u043b\u0443\u0436\u0438\u0442\u044c \u043f\u0440\u0438\u0447\u0438\u043d\u043e\u0439 \u043b\u0438\u0445\u043e\u0440\u0430\u0434\u043a\u0438, \u0430\u0442\u0438\u043f\u0438\u0447\u043d\u043e\u0439 \u043f\u043d\u0435\u0432\u043c\u043e\u043d\u0438\u0438, \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0438\u043b\u0438 \u044d\u043d\u0434\u043e\u043a\u0430\u0440\u0434\u0438\u0442\u0430. \u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u043e\u0441\u043d\u043e\u0432\u044b\u0432\u0430\u0435\u0442\u0441\u044f \u043d\u0430 \u0441\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043c\u0435\u0442\u043e\u0434\u0430\u0445, \u0442\u0430\u043a \u043a\u0430\u043a \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0437\u0430\u0442\u0440\u0443\u0434\u043d\u0435\u043d\u0430 \u043f\u043e\u043b\u0438\u043c\u043e\u0440\u0444\u0438\u0437\u043c\u043e\u043c \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0430\u0442\u0438\u043a\u0438. Coxiella burnetii, \u0438\u0437\u043e\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u0430\u044f \u043e\u0442 \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430 \u0438\u043b\u0438 \u0436\u0438\u0432\u043e\u0442\u043d\u044b\u0445, \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0442 \u0430\u043d\u0442\u0438\u0433\u0435\u043d \u0444\u0430\u0437\u044b I, \u0430 \u0438\u0437\u043e\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u0438\u0437 \u043a\u0443\u043b\u044c\u0442\u0443\u0440\u044b \u043a\u043b\u0435\u0442\u043e\u043a \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0442 \u0430\u043d\u0442\u0438\u0433\u0435\u043d \u0444\u0430\u0437\u044b II.<\/p>\n<p>\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043f\u0440\u043e\u0442\u0438\u0432 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 \u0444\u0430\u0437\u044b II \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u043f\u0440\u0435\u0434\u043e\u043c\u0438\u043d\u0430\u043d\u0442\u043d\u044b\u043c\u0438 \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u043e\u0441\u0442\u0440\u043e\u0439 \u0444\u0430\u0437\u044b \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f. \u041e\u0431\u044b\u0447\u043d\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u044e\u0442 \u0440\u0435\u0430\u043a\u0446\u0438\u044e \u0444\u0438\u043a\u0441\u0430\u0446\u0438\u0438 \u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442\u0430, \u043d\u0435\u043f\u0440\u044f\u043c\u0443\u044e \u0438\u043c\u043c\u0443\u043d\u043e\u0444\u043b\u0443\u043e\u0440\u0435\u0441\u0446\u0435\u043d\u0446\u0438\u044e \u0438 ELISA. \u041f\u043e \u043f\u0440\u043e\u0448\u0435\u0441\u0442\u0432\u0438\u0438 4-8 \u043d\u0435\u0434\u0435\u043b\u044c \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u0435\u0442\u0441\u044f \u043c\u0430\u043a\u0441\u0438\u043c\u0430\u043b\u044c\u043d\u044b\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c IgG-\u0430\u043d\u0442\u0438\u0442\u0435\u043b. IgM-\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043f\u043e\u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u043d\u0430\u0447\u0438\u043d\u0430\u044f \u0441\u043e \u0432\u0442\u043e\u0440\u043e\u0439 \u043d\u0435\u0434\u0435\u043b\u0438 \u0438 \u0434\u043e \u0447\u0435\u0442\u0432\u0435\u0440\u0442\u043e\u0433\u043e \u043c\u0435\u0441\u044f\u0446\u0430 \u043e\u0441\u0442\u0440\u043e\u0439 \u0444\u0430\u0437\u044b \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f. \u0412 \u044d\u0442\u0438\u0445 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u043e\u0441\u0442\u0440\u043e\u0439 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 \u043a\u043e\u0433\u0434\u0430 IgG-\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u0434\u0435\u0442\u0435\u043a\u0442\u0438\u0440\u0443\u044e\u0442\u0441\u044f \u0432 \u043c\u0430\u043a\u0441\u0438\u043c\u0430\u043b\u044c\u043d\u044b\u0445 \u0442\u0438\u0442\u0440\u0430\u0445, \u0432\u0435\u0441\u044c\u043c\u0430 \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0442\u044c \u0442\u0430\u043a\u0436\u0435 IgM-\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430. \u0412\u043e \u0432\u0440\u0435\u043c\u044f \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0444\u0430\u0437\u044b (\u044d\u043d\u0434\u043e\u043a\u0430\u0440\u0434\u0438\u0442\u044b), IgM \u043d\u0435 \u0432\u044b\u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f. \u0411\u043b\u0430\u0433\u043e\u0434\u0430\u0440\u044f \u0432\u044b\u0441\u043e\u043a\u043e\u0439 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u0438 \u0438 \u0445\u043e\u0440\u043e\u0448\u0435\u0439 \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u0438, \u0442\u0435\u0441\u0442\u044b ELISA \u0432\u0435\u0441\u044c\u043c\u0430 \u043f\u043e\u043b\u0435\u0437\u043d\u044b \u043a\u0430\u043a \u0434\u043b\u044f \u044d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433\u0430, \u0442\u0430\u043a \u0438 \u0434\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 Q-\u043b\u0438\u0445\u043e\u0440\u0430\u0434\u043a\u0438 \u0443 \u043b\u044e\u0434\u0435\u0439.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[961],"product_tag":[],"class_list":{"0":"post-9416","1":"product","2":"type-product","3":"status-publish","5":"product_cat-serologie-boli-infectioase","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9416","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9416"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9416"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9416"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9416"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9416"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}