{"id":9397,"date":"2020-04-23T03:36:49","date_gmt":"2020-04-23T01:36:49","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/homocisteina\/"},"modified":"2026-02-18T23:46:24","modified_gmt":"2026-02-18T21:46:24","slug":"homocisteina","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/homocisteina\/","title":{"rendered":"\u0413\u043e\u043c\u043e\u0446\u0438\u0441\u0442\u0435\u0438\u043d"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Homocisteina, un aminoacid care con\u0163ine o grupare thiol, se formeaz\u0103 prin demetilarea intracelular\u0103 a metioninei. \u00cen plasm\u0103, homocisteina se g\u0103se\u015fte \u00een principal legat\u0103 de proteine, dar sunt prezente, de asemenea, \u015fi forme libere, oxidate \u015fi disulfidice<sup>4<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Nivelul homocisteinei plasmatice variaz\u0103 \u00een func\u0163ie de cele 2 c\u0103i de metabolizare ale acesteia. Prima ar fi trans-sulfurarea la cistein\u0103, prin intermediul enzimei cistationin beta-sintetaza (CBS), enzima care necesit\u0103 vitamina B6 drept cofactor. A doua cale ar fi remetilarea la metionin\u0103 necesit\u00e2nd prezen\u0163a unor enzime (metilentetrahidrofolat reductaza MTHFR \u015fi metionin-sintetaza), care au co-substrat acidul folic \u015fi co-enzima vitamina B12. Astfel, nivelul homocisteinei\u00a0\u00een s\u00e2nge este invers propor\u0163ional cu nivelul plasmatic al fola\u0163ilor, vitaminei B12 \u015fi piridoxal 5-fosfatului (vitamina B6) \u015fi implicit cu aportul exogen al acestor vitamine<sup>3<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Hiperhomocisteinemia (un nivel plasmatic &gt;12-15 \u03bcmol\/L) apare \u00een situa\u0163iile\u00a0\u00een care este blocat\u0103 una din cele 2 c\u0103i de metabolizare. Hiperhomocisteinemia sever\u0103 care conduce la homocisteinurie este produs\u0103 de defecte genetice, cel mai frecvent fiind deficitul homozigot de CBS cu o inciden\u0163\u0103 de 1 la 300.000 na\u015fteri. Ace\u015fti pacien\u0163i prezint\u0103 retard mental, tromboembolism arterial \u015fi dezvolt\u0103 ateroscleroz\u0103 precoce. Acela\u015fi tip de manifest\u0103ri este \u00eent\u00e2lnit \u015fi\u00a0\u00een cazul deficitului homozigot de MTHFR. Deficitul heterozigot de CBS \u00eent\u00e2lnit la aproximativ 1% din popula\u0163ie este asociat cu o hiperhomocisteinemie moderat\u0103 la fel ca \u015fi deficitul heterozigot de MTHFR. La nivelul enzimei MTHFR mai este descris\u0103 o muta\u0163ie care genereaz\u0103 o variant\u0103 enzimatic\u0103 termolabil\u0103. Pacien\u0163ii care sunt heterozigo\u0163i pentru aceast\u0103 muta\u0163ie nu prezint\u0103 hiperhomocisteinemie sau un risc crescut de evenimente trombotice\u00a0\u00een timp ce homozigo\u0163ii pot dezvolta hiperhomocisteinemie<sup>7<\/sup>. Alte cauze de hiperhomocisteinemie sunt: deficitul de fola\u0163i \u015fi de vitamina B6, v\u00e2rsta \u00eenaintat\u0103, hipotiroidism, lupus eritematos sistemic, afec\u0163iuni renale cronice, medicamente: acid nicotinic, methotrexat, teofilina, L-dopa<sup>5;7<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Numeroasele studii efectuate au ar\u0103tat c\u0103 hiperhomocisteinemia se asociaz\u0103 cu urm\u0103toarele:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span style=\"font-size: 12pt;\">risc crescut de afec\u0163iuni cardiovasculare \u2013 <span style=\"text-decoration: underline;\">hiperhomocisteinemia constituie un factor de risc independent at\u00e2t pentru femei (chiar \u015fi \u00eenainte de menopauz\u0103) c\u00e2t \u015fi pentru b\u0103rba\u0163i<\/span>;<\/span><\/li>\n<li><span style=\"font-size: 12pt;\">risc crescut de tromboze venoase;<\/span><\/li>\n<li><span style=\"font-size: 12pt;\">risc crescut de complica\u0163ii ale sarcinii \u015fi defecte de tub neural<sup>2<\/sup>.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">O metaanaliz\u0103 a 27 studii epidemiologice a indicat c\u0103 o cre\u015ftere cu 5 \u03bcmol\/L a homocisteinemiei se asociaz\u0103 cu un risc de boal\u0103 coronarian\u0103 similar cu cel indus de o cre\u015ftere cu 0.5 mmol\/L \u00a0a nivelului de colesterol (un \u201codds ratio\u201d de 1.6 la b\u0103rba\u0163i \u015fi de 1.8 la femei)<sup>4<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Sunt multe teorii cu privire la mecanismul prin care hiperhomocisteinemia favorizeaz\u0103 apari\u0163ia \u015fi dezvoltarea aterosclerozei. Unii sugereaz\u0103 c\u0103 este implicat\u0103 gruparea sulfidril din molecula homocisteinei deoarece aceasta este u\u015for oxidabil\u0103. Au fost elaborate teorii, care s\u0103 justifice rolul patogenic al homocisteinei, precum favorizarea agreg\u0103rii plachetare, dezvoltarea leziunilor endoteliale, alterarea afinit\u0103\u0163ii pentru fibrin\u0103 a lipidelor \u015fi lipoproteinelor, alter\u0103ri ale prolifer\u0103rii celulelor musculare netede \u015fi cre\u015fterea produc\u0163iei de specii reactive de oxigen, conduc\u00e2nd la cre\u015fterea stresului oxidativ.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">A fost demonstrat c\u0103 acidul folic \u00eembun\u0103t\u0103\u0163e\u015fte func\u0163ia endotelial\u0103 la adul\u0163ii s\u0103n\u0103to\u015fi cu hiperhomocisteinemie. La pacien\u0163ii cu boal\u0103 coronarian\u0103 documentat\u0103, sc\u0103derea nivelului plasmatic al homocisteinei, prin suplimentarea aportului de acid folic (5 mg\/zi) \u00eembun\u0103t\u0103\u0163e\u015fte func\u0163ia vaselor de rezisten\u0163\u0103. Se pare c\u0103 sc\u0103derea nivelului homocisteinei este responsabil\u0103 de acest efect \u015fi nu cre\u015fterea nivelului seric al folatului. O doz\u0103 de acid folic mai mare sau egal\u0103 cu 0,8 mg este necesar\u0103 pentru o sc\u0103dere optim\u0103 a nivelului de homocistein\u0103.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Pacien\u0163ii cu insuficien\u0163\u0103 renal\u0103 preterminal\u0103, \u00een dializ\u0103, sau primitorii unui transplant renal au un risc cardiovascular crescut, mediat\u00a0\u00een parte de cre\u015fterea nivelului homocisteinei. Strategiile de reducere a nivelului homocisteinei nu sunt \u00eens\u0103 foarte eficace, mai ales la pacien\u0163ii afla\u0163i sub dializ\u0103<sup>3<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Riscul de boal\u0103 tromboembolic\u0103 la pacien\u0163ii cu hiperhomocisteinemie a fost eviden\u0163iat pentru prima oar\u0103 \u00een 1991. Multe studii au ar\u0103tat c\u0103 ace\u015ftia prezint\u0103 un risc de 2-4 ori mai mare de tromboz\u0103 venoas\u0103 \u00een compara\u0163ie cu persoanele s\u0103n\u0103toase. Riscul\u00a0 este de 20 ori mai mare dac\u0103 la hiperhomocisteinemie se asociaz\u0103 statusul heterozigot pentru factorul V Leiden<sup>7<\/sup>. Administrarea de contraceptive orale la pacientele cu hiperhomocisteinemie se asociaz\u0103 cu un risc crescut de tromboz\u0103 a venelor cerebrale<sup>1<\/sup><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Recent, nivelurile crescute de homocistein\u0103 \u015fi\u00a0 statusul homozigot pentru muta\u0163ia C677T de la nivelul genei MTHFR (care genereaz\u0103 o variant\u0103 enzimatic\u0103 termolabil\u0103 ce este cu 20% mai pu\u0163in eficient\u0103 \u00een metabolizarea homocisteinei) au fost asociate cu anumite complica\u0163ii ale sarcinii ce includ anomalii cromozomiale, malforma\u0163ii congenitale, pierderi recurente de sarcin\u0103, afec\u0163iuni ale placentei \u015fi preeclampsie. Mai mult, pe l\u00e2ng\u0103 consecin\u0163ele asupra embrionului sau f\u0103tului\u00a0\u00een prima parte a sarcinii cei doi factori sunt implica\u0163i \u015fi\u00a0\u00een fenomenele tromboembolice survenite tardiv\u00a0\u00een sarcin\u0103 \u015fi chiar\u00a0\u00een perioada post-partum<sup>6<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Recomand\u0103ri pentru determinarea homocisteinei <\/em><\/strong>\u2013 screening-ul pacien\u0163ilor cu risc crescut de afec\u0163iuni cardiovasculare (la fiecare 3-5 ani); pacien\u0163i &lt; 40 ani cu afec\u0163iuni cardiovasculare (pentru a exclude homocistinuria); avorturi recurente spontane<sup>5;2<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Preg\u0103tire pacient <\/em><\/strong><em>- <\/em>\u00e0 jeun (pe nem\u00e2ncate<sup>4<\/sup>).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Specimen recoltat <\/em><\/strong><em>- <\/em>s\u00e2nge venos.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Recipient de recoltare <\/em><\/strong><em>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu gel separator<sup>4<\/sup><sup>;5<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Specimen recoltat <\/em><\/strong><em>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>4<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>\u2013 centrifugarea va fi efectuat\u0103 \u00eentr-o ora.<br \/>\n<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Cauze de respingere a probei<\/em><\/strong> \u2013 specimen intens hemolizat sau care nu a fost centrifugat \u00een intervalul men\u0163ionat<sup>2<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Stabilitate prob\u0103 <\/em><\/strong><em>-\u00a0<\/em>Dup\u0103 centrifugare proba poate fi pastrata in frigider la temperatura +2 &#8211; +8\u00b0C timp de 4 zile. <\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Metod\u0103 <\/em><\/strong>- <span style=\"text-decoration: underline;\">enzimatic\u0103<\/span><sup>4<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Valori de referin\u0163\u0103\u00a0 <\/em><\/strong>-\u00a0<b>&lt;<\/b>12 \u03bcmol\/L<sup>4<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Limita de detec\u0163ie <\/em><\/strong>\u2013 2.8 \u03bcmol\/L<sup>4<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">\u00a0\u2022 Medicamente<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Valori fals crescute ale homocisteinei se pot \u00eent\u00e2lni la pacien\u0163ii afla\u0163i sub tratament cu preparate care con\u0163in S-adenozil-metionin\u0103, methotrexat (prin deple\u0163ia de 5-metiltetrahidrofolat), oxid nitric (prin inactivarea metionin-sintetazei), carbamazepin, fenitoin (prin interferarea cu metabolismul fola\u0163ilor), 6-azauridin triacetat (prin antagonizarea vitaminei B6), contraceptive orale (prin deficitul de vitamina B6 indus de estrogeni)<sup>4<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 10pt;\">\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f:<\/span><\/strong><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">1. <span style=\"font-size: 10pt;\">Francesco Dentali, Mark Crowther, and Walter Ageno. Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis. In Blood, April 2006, vol.107, 2766-2773.<\/span><\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">2. Frances Fischbach. Chemistry Studies. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams &amp; Wilkins, USA, 8 Ed., 2009, 436-438.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">3. H. Paunescu, Isabel Ghi\u0163a, Oana Andreia Coman, I. Fulga. Vitaminele ca factori protectori cardiovasculari. \u00cen Medicina modern\u0103, nr.4, 2006.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">4. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">5. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Homocysteine, Plasma. www.labcorp.com 2010. Ref Type: Internet Communication.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">6. Willianne L.D.M. Nelen and Henk J. Blom. Pregnancy Complications. In MTHFR Polymorphisms and Disease. Edited by: Per Magne Ueland, 2005.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">7. www. med. uiuc.edu. University of Illinois. Hematology Resource Page. Hyperhomocysteinemia. Ref Type: Internet Communication.<\/span><\/div>","protected":false},"excerpt":{"rendered":"<p><em><strong>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/strong><\/em><\/p>\n<p>\u0413\u043e\u043c\u043e\u0446\u0438\u0441\u0442\u0435\u0438\u043d &#8211; \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442\u0430, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u043e\u0431\u0440\u0430\u0437\u0443\u0435\u0442\u0441\u044f \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0435 (\u0432 \u043f\u0438\u0449\u0435 \u043d\u0435 \u0441\u043e\u0434\u0435\u0440\u0436\u0438\u0442\u0441\u044f) \u0432 \u0445\u043e\u0434\u0435 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u043c\u0430 \u043c\u0435\u0442\u0438\u043e\u043d\u0438\u043d\u0430 (\u043a\u043e\u0442\u043e\u0440\u044b\u043c \u0431\u043e\u0433\u0430\u0442\u044b \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u044b \u0436\u0438\u0432\u043e\u0442\u043d\u043e\u0433\u043e \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u044f, \u043f\u0440\u0435\u0436\u0434\u0435 \u0432\u0441\u0435\u0433\u043e, \u043c\u044f\u0441\u043e, \u043c\u043e\u043b\u043e\u0447\u043d\u044b\u0435 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u044b, \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e \u0442\u0432\u043e\u0440\u043e\u0433, \u044f\u0439\u0446\u0430).<\/p>\n<p>\u0412 \u043f\u043b\u0430\u0437\u043c\u0435 \u043d\u0430\u0445\u043e\u0434\u0438\u0442\u0441\u044f \u043f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u0432 \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u043e\u0439 \u0441 \u0431\u0435\u043b\u043a\u0430\u043c\u0438 \u0444\u043e\u0440\u043c\u0435. \u0411\u043e\u043b\u044c\u0448\u0430\u044f \u0447\u0430\u0441\u0442\u044c \u043f\u043e\u0434\u0432\u0435\u0440\u0433\u0430\u0435\u0442\u0441\u044f \u043e\u0431\u0440\u0430\u0442\u043d\u043e\u043c\u0443 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\u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c\u00a0\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0435\u00a0\u0442\u0435\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435\u00a0\u0434\u043b\u044f\u00a0\u0443\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u044f\u00a0\u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0439\u00a0\u043f\u0440\u0438\u0447\u0438\u043d\u044b\u00a0\u0413\u0413\u0426\u00a0\u0438\u00a0\u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u0438\u044f\u00a0\u0430\u0434\u0435\u043a\u0432\u0430\u0442\u043d\u043e\u0433\u043e\u00a0\u043b\u0435\u0447\u0435\u043d\u0438\u044f.<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"262\"><b>\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c<\/b><\/td>\n<td colspan=\"2\" width=\"361\"><b>\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n<td colspan=\"2\" width=\"361\">\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/b><\/td>\n<td colspan=\"2\" width=\"361\">\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n<td colspan=\"2\" width=\"361\">\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0433\u0435\u043b\u0435\u0432\u043e\u0439\u00a0\u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n<td colspan=\"2\" width=\"361\">\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><\/td>\n<td colspan=\"2\" width=\"361\"><\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><\/td>\n<td colspan=\"2\" width=\"361\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" width=\"623\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" width=\"623\"><b>\u0418\u043d\u0442\u0435\u0440\u0444\u0435\u0440\u0438\u0440\u0443\u044e\u0449\u0438\u0435\u00a0\u0444\u0430\u043a\u0442\u043e\u0440\u044b.\u00a0\u041c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u044b<\/b><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" width=\"347\"><b>\u041f\u043e\u0432\u044b\u0448\u0430\u044e\u0442<\/b><\/td>\n<td width=\"276\"><b>\u0421\u043d\u0438\u0436\u0430\u044e\u0442<\/b><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" width=\"347\">\u0426\u0438\u043a\u043b\u043e\u0441\u043f\u043e\u0440\u0438\u043d,\u00a0\u044d\u0443\u0444\u0438\u043b\u043b\u0438\u043d,\u00a0\u0441\u0443\u043b\u044c\u0444\u0430\u0441\u0430\u043b\u0430\u0437\u0438\u043d,\u00a0\u043c\u0435\u0442\u043e\u0442\u0440\u0435\u043a\u0441\u0430\u0442,\u00a0\u043a\u0430\u0440\u0431\u0430\u043c\u0430\u0437\u0435\u043f\u0438\u043d,\u00a0\u0444\u0435\u043d\u0438\u0442\u043e\u0438\u043d,\u00a0\u0437\u0430\u043a\u0438\u0441\u044c\u00a0\u0430\u0437\u043e\u0442\u0430<\/td>\n<td width=\"276\">\u0412\u0438\u0442\u0430\u043c\u0438\u043d\u044b\u00a0\u0433\u0440\u0443\u043f\u043f\u044b\u00a0\u0412,\u00a0\u0444\u043e\u043b\u0438\u0435\u0432\u0430\u044f\u00a0\u043a\u0438\u0441\u043b\u043e\u0442\u0430<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table>\n<tbody>\n<tr>\n<td width=\"623\">\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/td>\n<\/tr>\n<tr>\n<td width=\"623\">\u00b7\u00a0\u041e\u0446\u0435\u043d\u043a\u0430\u00a0\u0440\u0438\u0441\u043a\u0430\u00a0\u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f\u00a0\u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445\u00a0\u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439:\u00a0\u0430\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445\u00a0\u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0439\u00a0\u0438\u00a0\u0440\u0438\u0441\u043a\u0430\u00a0\u0442\u0440\u043e\u043c\u0431\u043e\u0437\u0430;<\/p>\n<p>\u00b7\u00a0\u0432\u044b\u0440\u0430\u0436\u0435\u043d\u043d\u044b\u0435\u00a0\u0430\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435\u00a0\u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f\u00a0\u0441\u043e\u0441\u0443\u0434\u043e\u0432\u00a0\u043f\u0440\u0438\u00a0\u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u044b\u0445\u00a0\u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044f\u0445\u00a0\u043b\u0438\u043f\u0438\u0434\u043d\u043e\u0433\u043e\u00a0\u043e\u0431\u043c\u0435\u043d\u0430;<\/p>\n<p>\u00b7\u00a0\u0432\u0435\u0434\u0435\u043d\u0438\u0435\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432\u00a0\u0441\u00a0\u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u043c\u0438\u00a0\u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u043c\u0438\u00a0(\u041e\u0421\u041d,\u00a0\u0425\u0421\u041d,\u00a0\u0418\u0411\u0421,\u00a0\u0438\u043d\u0444\u0430\u0440\u043a\u0442\u00a0\u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430,\u00a0\u0438\u043d\u0441\u0443\u043b\u044c\u0442,<\/p>\n<p>\u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f\u00a0\u043c\u043e\u0437\u0433\u043e\u0432\u043e\u0433\u043e\u00a0\u043a\u0440\u043e\u0432\u043e\u043e\u0431\u0440\u0430\u0449\u0435\u043d\u0438\u044f,\u00a0\u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u0430\u044f\u00a0\u0433\u0438\u043f\u0435\u0440\u0442\u0435\u043d\u0437\u0438\u044f,\u00a0\u0434\u0440\u0443\u0433\u0438\u0435);<\/p>\n<p>\u00b7\u00a0\u0432\u0435\u0434\u0435\u043d\u0438\u0435\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432\u00a0\u0441\u00a0\u0442\u0440\u043e\u043c\u0431\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438\u00a0\u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u043c\u0438\u00a0(\u0422\u042d\u041b\u0410,\u00a0\u0442\u0440\u043e\u043c\u0431\u043e\u0437\u044b);<\/p>\n<p>\u00b7\u00a0\u0432\u00a0\u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u0435\u00a0\u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f\u00a0\u0436\u0435\u043d\u0449\u0438\u043d\u00a0\u0441\u00a0\u043d\u0435\u0432\u044b\u043d\u0430\u0448\u0438\u0432\u0430\u043d\u0438\u0435\u043c\u00a0\u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438\u00a0(\u043f\u043e\u0442\u0435\u0440\u044f\u00a0\u043f\u043b\u043e\u0434\u0430\u00a0\u043d\u0430\u00a0\u0440\u0430\u0437\u043d\u044b\u0445\u00a0\u0441\u0440\u043e\u043a\u0430\u0445\u00a0\u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438),<\/p>\n<p>\u043f\u0440\u0435\u044d\u043a\u043b\u0430\u043c\u043f\u0441\u0438\u0435\u0439\/\u044d\u043a\u043b\u0430\u043c\u043f\u0441\u0438\u0435\u0439,\u00a0\u041f\u041e\u041d\u0420\u041f;<\/p>\n<p>\u00b7\u00a0\u0432\u00a0\u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u0435\u00a0\u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f\u00a0\u043f\u0440\u0438\u00a0\u0433\u0438\u043f\u043e\u0442\u0438\u0440\u0435\u043e\u0437\u0435,\u00a0\u0441\u0430\u0445\u0430\u0440\u043d\u043e\u043c\u00a0\u0434\u0438\u0430\u0431\u0435\u0442\u0435;<\/p>\n<p>\u00b7\u00a0\u0434\u043b\u044f\u00a0\u043f\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043a\u0438\u00a0\u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430\u00a0\u0433\u043e\u043c\u043e\u0446\u0438\u0441\u0442\u0438\u043d\u0443\u0440\u0438\u0438<\/td>\n<\/tr>\n<tr>\n<td width=\"623\">\u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f\u00a0\u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/td>\n<\/tr>\n<tr>\n<td width=\"623\">\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/td>\n<\/tr>\n<tr>\n<td width=\"623\">\u00b7\u00a0\u041f\u0438\u0442\u0430\u043d\u0438\u0435\u00a0\u0431\u043e\u0433\u0430\u0442\u043e\u0435\u00a0\u0431\u0435\u043b\u043a\u0430\u043c\u0438;<\/p>\n<p>\u00b7\u00a0\u0434\u0435\u0444\u0438\u0446\u0438\u0442\u00a0\u0444\u043e\u043b\u0438\u0435\u0432\u043e\u0439\u00a0\u043a\u0438\u0441\u043b\u043e\u0442\u044b,\u00a0\u0432\u0438\u0442\u0430\u043c\u0438\u043d\u0430\u00a0\u04126,\u00a0\u041212;<\/p>\n<p>\u00b7\u00a0\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435\u00a0\u0434\u0435\u0444\u0435\u043a\u0442\u044b\u00a0\u0444\u0435\u0440\u043c\u0435\u043d\u0442\u043e\u0432,\u00a0\u0443\u0447\u0430\u0441\u0442\u0432\u0443\u044e\u0449\u0438\u0445\u00a0\u0432\u00a0\u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u043c\u0435\u00a0\u0433\u043e\u043c\u043e\u0446\u0438\u0441\u0442\u0435\u0438\u043d\u0430\u00a0(\u0434\u0435\u0444\u0435\u043a\u0442\u044b\u00a0MTHFR);<\/p>\n<p>\u00b7\u00a0\u043f\u043e\u0447\u0435\u0447\u043d\u0430\u044f\u00a0\u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u044c;<\/p>\n<p>\u00b7\u00a0\u043f\u0441\u043e\u0440\u0438\u0430\u0437;<\/p>\n<p>\u00b7\u00a0\u0433\u0438\u043f\u043e\u0442\u0438\u0440\u0435\u043e\u0437,\u00a0\u0441\u0430\u0445\u0430\u0440\u043d\u044b\u0439\u00a0\u0434\u0438\u0430\u0431\u0435\u0442;<\/p>\n<p>\u00b7\u00a0\u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f\u00a0\u0416\u041a\u0422,\u00a0\u0441\u043e\u043f\u0440\u043e\u0432\u043e\u0436\u0434\u0430\u044e\u0449\u0430\u044f\u0441\u044f\u00a0\u0434\u0435\u0444\u0438\u0446\u0438\u0442\u043e\u043c\u00a0\u0432\u0438\u0442\u0430\u043c\u0438\u043d\u043e\u0432;<\/p>\n<p>\u00b7\u00a0\u043a\u0443\u0440\u0435\u043d\u0438\u0435,\u00a0\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u0438\u0437\u043c,\u00a0\u043a\u043e\u0444\u0435\u00a0(\u043a\u043e\u0444\u0435\u0438\u043d);<\/p>\n<p>\u00b7\u00a0\u043f\u0440\u0438\u0435\u043c\u00a0\u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445\u00a0\u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[925],"product_tag":[],"class_list":{"0":"post-9397","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-cardiaci","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9397","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9397"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9397"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9397"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9397"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9397"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}