{"id":9395,"date":"2020-04-23T03:36:45","date_gmt":"2020-04-23T00:36:45","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/fibrotest-actitest\/"},"modified":"2025-07-01T07:56:30","modified_gmt":"2025-07-01T04:56:30","slug":"fibrotest-actitest","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/fibrotest-actitest\/","title":{"rendered":"\u0424\u0438\u0431\u0440\u043e\u0422\u0435\u0441\u0442 - \u0410\u043a\u0442\u0438\u0422\u0435\u0441\u0442"},"content":{"rendered":"<p><strong><em>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><strong> <em>si recomandari<\/em><\/strong><\/p>\n<p>In mod traditional, biopsia hepatica reprezinta metoda \u201cgold-standard\u201d pentru evaluarea leziunilor histologice ale ficatului si in consecinta pentru stabilirea gradului afectarii hepatice. Cu toate acestea biopsia prezinta mai multe incoveniente:<\/p>\n<p style=\"padding-left: 30px;\">-datorita caracterului invaziv nu este acceptata de toti pacientii;<\/p>\n<p style=\"padding-left: 30px;\">-poate asocia complicatii minore (circa 30% din pacienti prezinta durere) sau severe pana la deces (in 0.03% din cazuri);<\/p>\n<p style=\"padding-left: 30px;\">-erori semnificative de esantionaj (pana la 40% in stadializarea fibrozei);<\/p>\n<p style=\"padding-left: 30px;\">-variabilitate importanta intra- si inter-examinator<sup>6<\/sup>.<\/p>\n<p>Investigatia FibroTest-ActiTest (FT\/AT), dezvoltata de BioPredictive, constituie o alternativa non-invaziva la biopsia hepatica care a fost validata clinic la pacienti cu hepatita cronica B si C, hepatopatie indusa de etanol si steatoza hepatica non-alcoolica. Are la baza un algoritm care combina rezultatele obtinute la determinarea unor markeri biochimici serici in scopul evaluarii gradului de fibroza si a activitatii necroinflamatorii. Astfel, FT masoara gradul fibrozei prin combinarea urmatorilor markeri: alfa-2macroglobulina, haptoglobina, apolipoproteina A1, bilirubina totala, gamaglutamiltranspeptidaza-GGT, iar AT estimeaza gradul de activitate (necroza si inflamatie) prin asocierea alanin-aminotransferazei-ALT la markerii de mai sus. Rezultatele testului includ un scor de fibroza si unul de activitate necro-inflamatorie, ale caror valori sunt cuprinse in intervalul 0-1 (de la absenta bolii sau o afectare minima pana la fibroza sau activitate necroinflamatorie severa). Algoritmul ajusteaza rezultatele in functie de varsta si sex<sup>3;5<\/sup>.<\/p>\n<p>De la lansarea sa in 2002, validarea si standardizarea analitica a FT\/AT au fost realizate de-a lungul a 50 studii clinice. La ora actuala aceasta strategie diagnostica este folosita in 33 tari de pe intreg globul.<\/p>\n<p>Conform studiilor efectuate, AT\/FT are o valoare diagnostica mai mare decat alti markeri hepatici non-invazivi si, spre deosebire de biopsia hepatica, furnizeaza o evaluare non-invaziva a stadiului de fibroza si a gradului de activitate necroinflamatorie corespunzatoare stadiilor F0-F4 si gradelor A0-A3 ale scorului Metavir. Se recomanda ca testul sa fie repetat la fiecare 6 luni in cazul fibrozei moderate si anual daca fibroza este minima.<\/p>\n<p>Un studiu prospectiv care a inclus 537 pacienti cu hepatita C si care a comparat rezultatele biopsiei hepatice cu cele obtinute la FT\/AT a indicat o discordanta intre cele 2 metode la 29% din pacienti, intr-un procent de 16% pentru stadiile fibrozei si 17% pentru gradele de activitate. Discordanta a fost atribuita esecului FT\/AT in 2.4% din cazuri si a biopsiei hepatice la 18.1% din pacienti<sup>1;6<\/sup>.<\/p>\n<p>O centralizare a rezultatelor obtinute la 8540 de FT\/AT a evidentiat faptul ca scorurile medii obtinute la aceasta investigatie non-ivaziva s-au asociat intr-un mod linear cu stadiile fibrozei si gradele activitatii necroinflamatorii. Astfel, valoarea diagnostica a testului a fost aceeasi atat pentru stadiile moderate de fibroza si activitate necro-inflamatorie cat si pentru cele extreme. In cazul infectiei cu virusul hepatitei B FT\/AT isi mentine aceeasi valoare diagnostica independent de originea etnica, sex, prezenta\/absenta AgHBe si valoarea transaminazelor; de asemenea scorurile de fibroza si activitate necroinflamatorie au valoare predictiva in ceea ce priveste dezvoltarea complicatiilor in urmatorii 4 ani (intr-un studiu prospectiv s-a constatat ca la scoruri de fibroza &lt; 0.27 si la cele de activitate necroinflamatorie &lt; 0.29 nu a aparut nici o complicatie in decurs de 4 ani). In cazul infectiei cu virusul hepatitei C FT\/AT isi mentine aceeasi valoare diagnostica independent de originea etnica, sex, genotip, incarcatura virala si alte co-morbiditati ; de asemenea scorurile de fibroza au valoare predictiva in ceea ce priveste dezvoltarea complicatiilor in urmatorii 5 ani (intr-un studiu prospectiv s-a constatat ca la scoruri de fibroza &lt; 0.32 nu a aparut nici o complicatie in decurs de 5 ani).<\/p>\n<p>Testul a fost validat si pentru urmatoarele categorii de pacienti: copii, subiecti &gt;65 ani, pacienti cu insuficienta renala, transplant renal, hemofilie sau boli inflamatorii cronice.<\/p>\n<p>Cercetatorii au concluzionat ca FT\/AT constituie o alternativa eficienta din punct de vedere al costului la biopsia hepatica<sup>1;2;5;6<\/sup>.<\/p>\n<p><strong><em>Pregatire pacient<\/em><\/strong> \u2013 \u00e0 jeun (de preferat)<sup>4<\/sup>.<\/p>\n<p><strong><em>Specimen recoltat <\/em><\/strong>\u2013 sange venos<sup>4<\/sup>.<strong>\u00a0<\/strong><\/p>\n<p><strong><em>Recipient de recoltare <\/em><\/strong>\u2013 vacutainer fara anticoagulant cu\/fara gel separator<sup>4<\/sup>.<\/p>\n<p><strong><em>Prelucrare necesara dupa recoltare<\/em><\/strong> \u2013 se separa serul prin centrifugare; se lucreaza in aceeasi zi; daca acest lucru nu este posibil, serul se poate stoca la 2-8\u00b0C sau la -20\u00b0C<sup>4<\/sup>.<\/p>\n<p><strong><em>Cauze de respingere a probei<\/em><\/strong> \u2013 specimene hemolizate sau lipemice<sup>4<\/sup>.<\/p>\n<p><strong><em>Volum proba <\/em><\/strong>\u2013 minim 3 mL ser<sup>4<\/sup><strong>\u00a0<\/strong><\/p>\n<p><strong><em>Stabilitate proba <\/em><\/strong>\u2013 serul separat este stabil\u00a0 <em>3 zile<\/em> la 2-8\u00b0 C si protejat de lumina (pentru bilirubina); <em>timp indelungat <\/em>\u00a0la -20\u00b0 C<sup>4<\/sup>.<\/p>\n<p><strong><em>Metoda <\/em><\/strong><em>- <\/em>in laboratorul Synevo dozarea celor sase\u00a0 markeri biochimici se realizeaza prin metode standardizate in conformitate cu recomandarile tehnice furnizate de BioPredictive:<\/p>\n<p style=\"padding-left: 30px;\">\u2022 <span style=\"text-decoration: underline;\">metoda imunoturbidimetrica<\/span> pentru alfa-2macroglobulina, haptoglobina si apolipoproteina A1;<\/p>\n<p style=\"padding-left: 30px;\">\u2022 <span style=\"text-decoration: underline;\">metoda enzimatica cu piridoxal fosfat standardizata in conformitate cu IFCC<\/span> pentru ALT;<\/p>\n<p style=\"padding-left: 30px;\">\u2022 <span style=\"text-decoration: underline;\">metoda enzimatica standardizata in raport cu metoda Szasz<\/span> pentru GGT;<\/p>\n<p style=\"padding-left: 30px;\">\u2022 <span style=\"text-decoration: underline;\">metoda colorimetrica (reactie diazo)<\/span> pentru bilirubina totala<sup>4<\/sup>.<\/p>\n<p><strong><em>Interpretarea rezultatelor<\/em><\/strong><\/p>\n<p>Rezultatele obtinute la markerii serici sunt introduse, cu ajutorul unui cod de acces, pe site-ul BioPredictive unde se va genera un raport cu scorurile de fibroza si activitate necroinflamatorie pentru fiecare pacient testat<sup>4<\/sup>.<\/p>\n<p><strong><em>Limite si interferente<\/em><\/strong><\/p>\n<p>Aceasta investigatie <strong>nu<\/strong> este recomandata la pacienti cu hepatita acuta (cresc valorile ALT), hemoliza acuta (scad valorile haptoglobinei), stari inflamatorii acute (cresc valorile alfa2-macroglobulinei) sau colestaza extrahepatica.<\/p>\n<p>La pacientii cu hemoliza cronica sau sindrom Gilbert se va solicita consultul unui specialist pentru interpretarea rezultatelor<sup>6<\/sup>.<\/p>\n<p><span style=\"font-size: small;\">\u00a0<\/span><\/p>\n<p><span style=\"font-size: small;\">\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/p>\n<p><span style=\"font-size: small;\">1. Gilles Morali, Yaacov Maor, Rachel Klar, Marius Braun, Ziv Ben, Yoram Bujanove, Eli Zuckerman, Sarah Boger, Philippe Halfon. Fibrotest-Actitest\u2122: The Biochemical Marker of Liver Fibrosis \u2013The Israeli Experience. In IMAJ 2007;9:588\u2013591.<\/span><\/p>\n<p><span style=\"font-size: small;\">2. Halfon P., Bourlier M., Deydier R. et al. Independent prospective multicentric validation of biochemical markers (FibroTest-ActiTest) for prediction of liver fibrosis and activity in patients with chronic hepatitis C: the Fibropaca study. In Am J Gastroenterol 2006; 101: 547-55.<\/span><\/p>\n<p><span style=\"font-size: small;\">3. Ioan Sporea, Alina Popescu. Biopsia sau markerii non-invazivi pentru evaluarea hepatopatiilor cronice difuze. In Gastro.ro nr.6, 2007.<\/span><\/p>\n<p><span style=\"font-size: small;\">4. Laborator Synevo. Referintele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/p>\n<p><span style=\"font-size: small;\">5. Thierry Poynard; Rachel Morra; Philippe Halfon; Laurent Castera; Vlad Ratziu; Fran\u00e7oise Imbert-Bismut; Sylvie Naveau; Dominique Thabut; Didier Lebrec; Fabien Zoulim; Marc Bourliere; Patrice Cacoub; Djamila Messous; Mona Munteanu; Victor de Ledinghen. Meta-Analyses of FibroTest Diagnostic Value in Chronic Liver Disease In BMJ Gastroenterology, 2007.<\/span><\/p>\n<p><span style=\"font-size: small;\">6. www.biopredictive.com. Reference Type: Internet Communication.<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>\u0410\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0433\u043e \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0430 \u0438 \u0441\u0442\u0435\u043f\u0435\u043d\u044c \u0444\u0438\u0431\u0440\u043e\u0437\u0430 \u2013 \u044d\u0442\u043e \u043e\u0434\u043d\u0438 \u0438\u0437 \u0441\u0430\u043c\u044b\u0445 \u0432\u0430\u0436\u043d\u044b\u0445 \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432, \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u044e\u0449\u0438\u0445 \u0442\u0430\u043a\u0442\u0438\u043a\u0443 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u043c\u0438 \u043f\u0435\u0447\u0435\u043d\u0438. \u0412 \u043d\u0430\u0441\u0442\u043e\u044f\u0449\u0435\u0435 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\u0443\u0447\u0435\u043d\u044b\u0435 \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u0430\u043b\u0438 \u043d\u043e\u0432\u044b\u0435, \u043d\u0435\u0438\u043d\u0432\u0430\u0437\u0438\u0432\u043d\u044b\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u043e\u0446\u0435\u043d\u043a\u0438 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u044f \u043f\u0435\u0447\u0435\u043d\u0438: \u0410\u043a\u0442\u0438\u0422\u0435\u0441\u0442 \u0438 \u0424\u0438\u0431\u0440\u043e\u0422\u0435\u0441\u0442. \u0410\u043a\u0442\u0438\u0422\u0435\u0441\u0442 \u043f\u0440\u0435\u0434\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d \u0434\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u044f. \u0424\u0438\u0431\u0440\u043e\u0422\u0435\u0441\u0442 \u043f\u0440\u0435\u0434\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d \u0434\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u0444\u0438\u0431\u0440\u043e\u0437\u0430.<\/p>\n<p>\u0414\u043b\u044f \u0440\u0430\u0441\u0447\u0435\u0442\u0430 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u0410\u043a\u0442\u0438\u0422\u0435\u0441\u0442\u0430 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u044e\u0442\u0441\u044f 6 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0445 \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432:<\/p>\n<ul>\n<li>\u03b1-2 \u043c\u0430\u043a\u0440\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d;<\/li>\n<li>\u0433\u0430\u043f\u0442\u043e\u0433\u043b\u043e\u0431\u0438\u043d;<\/li>\n<li>\u0430\u043f\u043e\u043b\u0438\u043f\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d \u04101;<\/li>\n<li>\u043e\u0431\u0449\u0438\u0439 \u0431\u0438\u043b\u0438\u0440\u0443\u0431\u0438\u043d;<\/li>\n<li>\u0433\u0430\u043c\u043c\u0430-\u0433\u043b\u0443\u0442\u0430\u043c\u0438\u043b\u0442\u0440\u0430\u043d\u0441\u043f\u0435\u043f\u0442\u0438\u0434\u0430\u0437\u0430 (\u0433\u0430\u043c\u043c\u0430-\u0413\u0422);<\/li>\n<li>\u0430\u043b\u0430\u043d\u0438\u043d\u0430\u043c\u0438\u043d\u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0430\u0437\u0430 (\u0410\u041b\u0422). \u041f\u0440\u0438 \u0440\u0430\u0441\u0447\u0435\u0442\u0435 \u0442\u0430\u043a\u0436\u0435 \u0443\u0447\u0438\u0442\u044b\u0432\u0430\u044e\u0442\u0441\u044f \u0432\u043e\u0437\u0440\u0430\u0441\u0442 \u0438 \u043f\u043e\u043b \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430.<\/li>\n<\/ul>\n<p>\u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442 \u0410\u043a\u0442\u0438\u0422\u0435\u0441\u0442\u0430 \u043c\u043e\u0436\u0435\u0442 \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0442\u044c \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u043e\u0442 0,00 \u0434\u043e 1,00 \u0438 \u0441\u043e\u043e\u0442\u043d\u043e\u0441\u0438\u0442\u0441\u044f \u0441 \u043f\u0440\u0438\u043d\u044f\u0442\u043e\u0439 \u0433\u0438\u0441\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043a\u043b\u0430\u0441\u0441\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u0435\u0439 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0433\u043e \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0430 A0-A3 (\u0448\u043a\u0430\u043b\u0430 METAVIR: \u04100 \u2013 \u043d\u0435\u0442 \u043d\u0435\u043a\u0440\u043e\u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438, \u04101 \u2013 \u043c\u0438\u043d\u0438\u043c\u0430\u043b\u044c\u043d\u0430\u044f \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c, \u04102 \u2013 \u0443\u043c\u0435\u0440\u0435\u043d\u043d\u0430\u044f \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c, \u04103 \u2013 \u0432\u044b\u0441\u043e\u043a\u0430\u044f \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c).<\/p>\n<p>\u0414\u043b\u044f \u0440\u0430\u0441\u0447\u0435\u0442\u0430 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u0424\u0438\u0431\u0440\u043e\u0422\u0435\u0441\u0442\u0430 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u044e\u0442\u0441\u044f 5 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0445 \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432:<\/p>\n<ul>\n<li>\u03b1-2 \u043c\u0430\u043a\u0440\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d;<\/li>\n<li>\u0433\u0430\u043f\u0442\u043e\u0433\u043b\u043e\u0431\u0438\u043d;<\/li>\n<li>\u0430\u043f\u043e\u043b\u0438\u043f\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d \u04101;<\/li>\n<li>\u043e\u0431\u0449\u0438\u0439 \u0431\u0438\u043b\u0438\u0440\u0443\u0431\u0438\u043d;<\/li>\n<li>\u0433\u0430\u043c\u043c\u0430-\u0433\u043b\u0443\u0442\u0430\u043c\u0438\u043b\u0442\u0440\u0430\u043d\u0441\u043f\u0435\u043f\u0442\u0438\u0434\u0430\u0437\u0430 (\u0433\u0430\u043c\u043c\u0430-\u0413\u0422). \u041f\u0440\u0438 \u0440\u0430\u0441\u0447\u0435\u0442\u0435 \u0442\u0430\u043a\u0436\u0435 \u0443\u0447\u0438\u0442\u044b\u0432\u0430\u044e\u0442\u0441\u044f \u0432\u043e\u0437\u0440\u0430\u0441\u0442 \u0438 \u043f\u043e\u043b \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430.<\/li>\n<\/ul>\n<p>\u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442 \u0424\u0438\u0431\u0440\u043e\u0422\u0435\u0441\u0442\u0430 \u043c\u043e\u0436\u0435\u0442 \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0442\u044c \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u043e\u0442 0,00 \u0434\u043e 1,00 \u0438 \u0441\u043e\u043e\u0442\u043d\u043e\u0441\u0438\u0442\u0441\u044f \u0441 \u043f\u0440\u0438\u043d\u044f\u0442\u043e\u0439 \u0433\u0438\u0441\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043a\u043b\u0430\u0441\u0441\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u0435\u0439 \u0444\u0438\u0431\u0440\u043e\u0437\u0430 F0-F4 (\u0448\u043a\u0430\u043b\u0430 METAVIR: F0 \u2013 \u043d\u0435\u0442 \u0444\u0438\u0431\u0440\u043e\u0437\u0430, F1 \u2013 \u043f\u043e\u0440\u0430\u0442\u043b\u044c\u043d\u044b\u0439 \u0444\u0438\u0431\u0440\u043e\u0437 \u0431\u0435\u0437 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u0441\u0435\u043f\u0442, F2 \u2013 \u043f\u043e\u0440\u0442\u0430\u043b\u044c\u043d\u044b\u0439 \u0444\u0438\u0431\u0440\u043e\u0437 \u0441 \u0435\u0434\u0438\u043d\u0438\u0447\u043d\u044b\u043c\u0438 \u0441\u0435\u043f\u0442\u0430\u043c\u0438, F3 \u2013 \u043f\u043e\u0440\u0442\u0430\u043b\u044c\u043d\u044b\u0439 \u0444\u0438\u0431\u0440\u043e\u0437 \u0441 \u043c\u043d\u043e\u0436\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c\u0438 \u0441\u0435\u043f\u0442\u0430\u043c\u0438 \u0431\u0435\u0437 \u0446\u0438\u0440\u0440\u043e\u0437\u0430, F4 \u2013 \u0446\u0438\u0440\u0440\u043e\u0437).<\/p>\n<p>\u0412\u0438\u0434\u043d\u043e, \u0447\u0442\u043e \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u044e\u0449\u0438\u0435 \u0410\u043a\u0442\u0438\u0422\u0435\u0441\u0442\u0430 \u0438 \u0424\u0438\u0431\u0440\u043e\u0422\u0435\u0441\u0442\u0430 \u043f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0438 \u043e\u0434\u043d\u0438 \u0438 \u0442\u0435 \u0436\u0435. \u0414\u0435\u0439\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e, \u0440\u0430\u0437\u043d\u0438\u0446\u0430 \u044d\u0442\u0438\u0445 \u0442\u0435\u0441\u0442\u043e\u0432 \u0437\u0430\u043a\u043b\u044e\u0447\u0430\u0435\u0442\u0441\u044f \u043f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u0432 \u0430\u043b\u0433\u043e\u0440\u0438\u0442\u043c\u0435 \u0440\u0430\u0441\u0447\u0435\u0442\u0430, \u0430 \u043d\u0435 \u0432 \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u044e\u0449\u0438\u0445. \u041a\u0440\u043e\u043c\u0435 \u0442\u043e\u0433\u043e, \u0432\u0438\u0434\u043d\u043e, \u0447\u0442\u043e \u043f\u0440\u0438 \u0440\u0430\u0441\u0447\u0435\u0442\u0435 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u044e\u0442\u0441\u044f &#8220;\u043d\u0435\u043f\u0440\u044f\u043c\u044b\u0435&#8221; \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0435 \u043c\u0430\u0440\u043a\u0435\u0440\u044b. \u041d\u0435\u043f\u0440\u044f\u043c\u044b\u043c\u0438 \u043d\u0430\u0437\u044b\u0432\u0430\u044e\u0442\u0441\u044f \u043c\u0430\u0440\u043a\u0435\u0440\u044b, \u043e\u0442\u0440\u0430\u0436\u0430\u044e\u0449\u0438\u0435 \u043f\u043e\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0438\u044f \u0440\u0430\u0437\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u0442\u043a\u0430\u043d\u0438 \u043f\u0435\u0447\u0435\u043d\u0438. \u0418\u0445 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