{"id":9339,"date":"2020-04-23T03:35:11","date_gmt":"2020-04-23T00:35:11","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/zinc-in-urina\/"},"modified":"2024-12-11T16:36:42","modified_gmt":"2024-12-11T14:36:42","slug":"zinc-in-urina","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/zinc-in-urina\/","title":{"rendered":"\u0426\u0438\u043d\u043a \u0432 \u043c\u043e\u0447\u0435"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong>\u00a0<\/em><\/strong><\/span><\/p>\n

Zincul este un oligoelement esen\u0163ial, component al mai multor sisteme enzimatice. Este stocat \u00een \u0163esutul osos \u015fi muscular; mobilizarea din aceste depozite se realizeaz\u0103 cu dificultate, chiar \u00een condi\u0163iile unui deficit de zinc. Absorb\u0163ia intestinal\u0103 cre\u015fte atunci c\u00e2nd se \u00eenregistreaz\u0103 o sc\u0103dere a depozitelor.<\/span><\/p>\n

Deficitul de zinc determin\u0103 inapeten\u0163\u0103, tulbur\u0103ri de cre\u015ftere (anomalii ale scheletului, alterarea sintezei colagenului), alopecie \u015fi \u00eent\u00e2rzierea procesului de vindecare a r\u0103nilor;\u00a0\u00een cazul unui deficit sever se instaleaz\u0103 hipogonadism \u015fi nanism care sunt ameliorate prin suplimentarea zincului1;2<\/sup>. Pe de alt\u0103 parte, trebuie men\u0163ionat faptul c\u0103 administrarea cronic\u0103 a preparatelor orale de zinc interfer\u0103 cu absorb\u0163ia cuprului \u015fi poate precipita deficitul acestuia4<\/sup>.<\/span><\/p>\n

Din punct de vedere industrial, zincul este un metal alb-alb\u0103strui, extras din minereuri \u015fi folosit \u00een aliaje, \u00een procesul de galvanizare a fierului pentru a preveni coroziunea \u015fi oxidarea, precum \u015fi \u00een numero\u015fi compu\u015fi utiliza\u0163i \u00een industria cosmeticelor \u015fi medicamentelor. La temperaturi apropiate de punctul de fierbere, zincul volatilizeaz\u0103 \u015fi genereaz\u0103 prin oxidare fumul de oxid de zinc.<\/span><\/p>\n

Expunerea acut\u0103 la oxid de zinc determin\u0103 irita\u0163ia tractului respirator, tuse, dureri toracice, cefalee, grea\u0163\u0103, febr\u0103 \u015fi mialgii2<\/sup>.<\/span><\/p>\n

Clorura de zinc este un alt compus produs\u00a0\u00een generatoarele de fum chimic4<\/sup>; inhalarea acestui material coroziv provoac\u0103 pneumonita chimic\u0103, obstruc\u0163ie bron\u015fic\u0103 \u015fi alveolar\u0103, uneori letale2<\/sup>.<\/span><\/p>\n

Recomand\u0103ri pentru determinarea zincului<\/em><\/strong><\/span><\/p>\n

\u2013 zincul\u00a0\u00een plasm\u0103: monitorizarea expunerii la zinc; evaluarea unui posibil deficit\u00a0\u00een caz de alimenta\u0163ie parenteral\u0103 prelungit\u0103, pacien\u0163i cu arsuri severe sau afec\u0163iuni cronice grave, alcoolici, diabetici, anorexici, diet\u0103 vegetarian\u0103, sindroame de malabsorb\u0163ie; confirmarea acrodermatitei enteropatice; monitorizarea administr\u0103rii orale de zinc\u00a0\u00een boala Wilson, monitorizarea administr\u0103rii intravenoase a zincului1;4<\/sup>;<\/span><\/p>\n

\u2013 zincul urinar: monitorizarea expunerii la zinc; evaluarea nivelurilor sc\u0103zute de zinc seric, precum \u015fi a complian\u0163ei la terapie a pacien\u0163ilor cu boala Wilson4<\/sup>.<\/span><\/p>\n

Preg\u0103tire pacient <\/em><\/strong>\u2013 \u00e0 jeun (pe nem\u00e2ncate)3;<\/sup>4<\/sup>.\u00a0<\/strong><\/span><\/p>\n

Specimen recoltat <\/em><\/strong>\u2013 1) s\u00e2nge venos; 2) urina din 24 ore sau 3) o prob\u0103 de urin\u0103 spontan\u01033;4<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/em><\/strong>\u2013 1) vacutainer pentru metale ce con\u0163ine EDTA sau heparinat de litiu ca anticoagulant; 2) vas de 2- 3 litri \u015fi pahar de plastic de unic\u0103 folosin\u0163\u0103, pentru urin\u0103, pe care se noteaz\u0103 cantitatea total\u0103 de urin\u0103 din 24 ore; nu se folosesc conservan\u0163i; 3) eprubeta pentru urin\u01033;4<\/sup>.<\/span><\/p>\n

Cantitatea recoltat\u0103 <\/em><\/strong>\u2013 1) cat permite vacuumul; 2), 3) aproximativ 10 mL3;4<\/sup>.\u00a0<\/strong><\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>\u2013 se separ\u0103 plasma prin centrifugare \u015fi se transfer\u0103 \u00eentr-un tub de plastic\u00a0\u00een vederea transportului (pe tub se va preciza tipul produsului: plasm\u0103)3<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>probele de plasm\u0103 \u015fi urin\u0103 se men\u0163in la temperatura camerei sau la frigider p\u00e2n\u0103 \u00een momentul lucrului3;4<\/sup>.\u00a0<\/em><\/span><\/p>\n

Metoda <\/em><\/strong>- <\/em>spectrometrie cu absorb\u0163ie atomic\u0103 (AAS)<\/span>3<\/sup>.<\/span><\/p>\n

Valori de referin\u0163\u0103:<\/em><\/strong><\/span><\/p>\n

Zincul plasmatic<\/strong>3;4<\/sup>:\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Zincul urinar<\/strong>3;4<\/sup>:\u00a0<\/strong><\/span><\/p>\n

< 4 luni: \u00a0\u00a065-137 \u03bcg\/dL;\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0150-1200 \u03bcg\/24h; 100-900 \u03bcg\/g creatinina.<\/span><\/p>\n

4-12 luni: \u00a065-130 \u03bcg\/dL;<\/span><\/p>\n

1-5 ani: \u00a0\u00a0\u00a065-118 \u03bcg\/dL;<\/span><\/p>\n

6-9 ani: \u00a0\u00a0\u00a078-105 \u03bcg\/dL;<\/span><\/p>\n

10-13 ani \u2013 F: 78-118 \u03bcg\/dL;<\/span><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u2013 B: 78-98 \u03bcg\/dL;<\/span><\/p>\n

14-19 ani \u2013 F: 59-98 \u03bcg\/dL;<\/span><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0 \u2013 B: 65-118 \u03bcg\/dL;<\/span><\/p>\n

Adul\u0163i: \u00a0\u00a0\u00a0\u00a0\u00a046-150 \u03bcg\/dL.<\/span><\/p>\n

Factor de conversie: <\/em>\u03bc<\/em>g\/dL x 0.153 = <\/em>\u03bc<\/em>mol\/L; <\/em>\u03bc<\/em>mol\/L x 6.54 = <\/em>\u03bc<\/em>g\/dL4<\/sup>.\u00a0 <\/em><\/span><\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/span><\/p>\n

Asocierea nivelului redus al zincului seric cu valori sc\u0103zute ale excre\u0163iei urinare confirm\u0103 deficitul de zinc4<\/sup>.<\/span><\/p>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/p>\n

Sc\u0103derea zincului seric se \u00eenregistreaz\u0103 \u00een st\u0103ri febrile, sepsis, stres, infarct miocardic, terapie cu estrogeni (se produce o mobilizare a zincului din ser \u00een ficat de c\u0103tre interleukine). Valori sc\u0103zute mai pot fi \u00eent\u00e2lnite \u00een uremie, f\u0103r\u0103 s\u0103 existe o reducere a nivelului tisular.<\/span><\/p>\n

Niveluri crescute ale zincului seric pot fi \u00eent\u00e2lnite \u00eentr-o afec\u0163iune familial\u0103, f\u0103r\u0103 s\u0103 existe semne de toxicitate sau depozite crescute.<\/span><\/p>\n

Deficitul de zinc este \u00eenso\u0163it de obicei de sc\u0103derea excre\u0163iei urinare; cu toate acestea deficitul se poate instala \u015fi\u00a0\u00een prezen\u0163a unor pierderi urinare excesive care pot s\u0103 apar\u0103\u00a0\u00een ciroz\u0103, anemii hemolitice, siclemie, alcoolism sau afec\u0163iuni renale cronice4<\/sup>.<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Frances Fischbach. Appendix G: Minerals in Human Nutrition. In A Manual of Laboratory and Diagnostic Tests.Lippincott Williams & Wilkins, USA, 7 Ed., 2004: 1161-1162.<\/span><\/div>\n
2. Jill C.Merill, et al. Metals. In Principles and Methods of Toxicology. Taylor & Francis, 4th Edition, 2001, 663.<\/span><\/div>\n
3. Laborator Synevo. Referin\u0163e specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n
4. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Zinc, Serum and Urine. www.labcorp.com. 2010. Ref Type: Internet Communication.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

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\u0441\u043d\u0438\u0436\u0430\u0442\u044c \u0434\u043e\u0431\u0430\u0432\u043a\u0438 \u0436\u0435\u043b\u0435\u0437\u0430. \u0421\u043b\u0443\u0447\u0430\u0438 \u0438\u0437\u0431\u044b\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u043f\u043e\u0441\u0442\u0443\u043f\u043b\u0435\u043d\u0438\u044f \u0446\u0438\u043d\u043a\u0430 \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0442 \u0441 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u0433\u0430\u043b\u044c\u0432\u0430\u043d\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u0435\u043c\u043a\u043e\u0441\u0442\u0435\u0439 \u0434\u043b\u044f \u043f\u0438\u0442\u044c\u0435\u0432\u044b\u0445 \u0436\u0438\u0434\u043a\u043e\u0441\u0442\u0435\u0439 (\u0440\u0435\u0434\u043a\u043e), \u0438\u0437\u0431\u044b\u0442\u043e\u043a \u0446\u0438\u043d\u043a\u0430 \u043c\u043e\u0436\u0435\u0442 \u0432\u044b\u0437\u044b\u0432\u0430\u0442\u044c \u0440\u0430\u0437\u0434\u0440\u0430\u0436\u0435\u043d\u0438\u0435 \u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e-\u043a\u0438\u0448\u0435\u0447\u043d\u043e\u0433\u043e \u0442\u0440\u0430\u043a\u0442\u0430. \u0410\u0431\u0441\u043e\u0440\u0431\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \u0446\u0438\u043d\u043a \u0432 \u043f\u0435\u0447\u0435\u043d\u0438 \u0430\u043a\u0442\u0438\u0432\u043d\u043e \u0432\u043a\u043b\u044e\u0447\u0430\u0435\u0442\u0441\u044f \u0432 \u043c\u0435\u0442\u0430\u043b\u043b\u043e\u0444\u0435\u0440\u043c\u0435\u043d\u0442\u044b \u0438 \u0431\u0435\u043b\u043a\u0438 \u043f\u043b\u0430\u0437\u043c\u044b.<\/p>\n

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\u0421\u043f\u0435\u0446\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438 \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e \u043d\u0435 \u0442\u0440\u0435\u0431\u0443\u0435\u0442\u0441\u044f.<\/p>\n

\u0410\u043b\u044c\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u043d\u044b\u0435 \u0435\u0434\u0438\u043d\u0438\u0446\u044b: \u043c\u043a\u0433\/\u043b.
\n\u041f\u0435\u0440\u0435\u0441\u0447\u0451\u0442 \u0435\u0434\u0438\u043d\u0438\u0446: \u043c\u043a\u0433\/\u043b \u0445 0,001=> \u043c\u043a\u0433\/\u043c\u043b.<\/p>\n

\u0420\u0435\u0444\u0435\u0440\u0435\u043d\u0441\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f: 0,2 – 1 \u043c\u043a\u0433\/\u043c\u043b.<\/p>\n

\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u0443\u0440\u043e\u0432\u043d\u044f:<\/p>\n

    \n
  • \u0433\u0438\u043f\u0435\u0440\u043f\u0430\u0440\u0430\u0442\u0438\u0440\u0435\u043e\u0438\u0434\u0438\u0437\u043c;<\/li>\n
  • \u0430\u043b\u043a\u043e\u0433\u043e\u043b\u0438\u0437\u043c;<\/li>\n
  • \u0441\u0435\u0440\u043f\u043e\u0432\u0438\u0434\u043d\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u0430\u044f \u0430\u043d\u0435\u043c\u0438\u044f;<\/li>\n
  • \u0432\u0438\u0440\u0443\u0441\u043d\u044b\u0435 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u044b;<\/li>\n
  • \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0435 \u043f\u043e\u0441\u043b\u0435 \u0445\u0438\u0440\u0443\u0440\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0432\u043c\u0435\u0448\u0430\u0442\u0435\u043b\u044c\u0441\u0442\u0432;<\/li>\n
  • \u043f\u0430\u0440\u0435\u043d\u0442\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0435 \u043f\u0438\u0442\u0430\u043d\u0438\u0435;<\/li>\n
  • \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u0435 \u0446\u0438\u0441\u043f\u043b\u0430\u0442\u0438\u043d\u0430, \u043f\u0435\u0442\u043b\u0435\u0432\u044b\u0445 \u0434\u0438\u0443\u0440\u0435\u0442\u0438\u043a\u043e\u0432, \u043d\u0430\u043f\u0440\u043e\u043a\u0441\u0435\u043d\u0430, \u0438\u0437\u043e\u0442\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0445\u043b\u043e\u0440\u0438\u0434\u0430 \u043d\u0430\u0442\u0440\u0438\u044f, \u0442\u0438\u0430\u0437\u0438\u0434\u043d\u044b\u0445 \u0434\u0438\u0443\u0440\u0435\u0442\u0438\u043a\u043e\u0432;<\/li>\n
  • \u043a\u0440\u0430\u0442\u043a\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0435 \u0433\u043e\u043b\u043e\u0434\u0430\u043d\u0438\u0435.<\/li>\n<\/ul>\n

    \u041f\u043e\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u0443\u0440\u043e\u0432\u043d\u044f:<\/p>\n

      \n
    • \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u0443\u0440\u043e\u0432\u043d\u044f \u043f\u043e\u0441\u0442\u0443\u043f\u043b\u0435\u043d\u0438\u044f \u0446\u0438\u043d\u043a\u0430;<\/li>\n
    • \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0435 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u043c\u0430 \u0446\u0438\u043d\u043a\u0430;<\/li>\n
    • \u0433\u0438\u043f\u043e\u0433\u043e\u043d\u0430\u0434\u0430\u043b\u044c\u043d\u044b\u0439 \u0434\u0432\u0430\u0440\u0444\u0438\u0437\u043c.<\/li>\n<\/ul>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[983],"product_tag":[],"class_list":{"0":"post-9339","1":"product","2":"type-product","3":"status-publish","5":"product_cat-metale","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9339","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9339"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9339"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9339"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9339"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9339"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}