{"id":9296,"date":"2020-04-23T03:33:57","date_gmt":"2020-04-23T01:33:57","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/scc-antigen-tumoral\/"},"modified":"2025-02-07T15:08:22","modified_gmt":"2025-02-07T13:08:22","slug":"scc-antigen-tumoral","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/scc-antigen-tumoral\/","title":{"rendered":"SCC (\u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0439 \u0430\u043d\u0442\u0438\u0433\u0435\u043d)"},"content":{"rendered":"

Informa\u0163ii generale \u015fi recomand\u0103ri pentru determinarea SCC<\/em><\/strong>\u00a0<\/em><\/strong><\/span><\/p>\n

Antigenul cancerului cu celule scuamoase (SCC) constituie un grup de glicoproteine ce apar\u0163in familiei inhibitorilor de serin\/cistein proteaze1<\/sup>.<\/span><\/p>\n

SCC este un marker serologic pentru carcinoamele cu celule scuamoase localizate la nivelul colului uterin, vulvei, pl\u0103m\u00e2nului, esofagului<\/em> \u0438 zonei cap-g\u00e2t<\/em>2<\/sup><\/em>.<\/span><\/p>\n

Utilitatea marker-ului \u00een func\u0163ie de localizarea carcinomului cu celule scuamoase:<\/span><\/p>\n

A. <\/em>Cancerul de col uterin<\/em><\/span><\/p>\n

Sensibilitatea clinic\u0103 a SCC este de 45-85% \u00een cancerul primar \u015fi de 66-84% \u00een cancerul recurent. <\/span>Concentra\u0163ia seric\u0103 de SCC se coreleaz\u0103 cu gradul de extindere a bolii (manifest\u0103ri clinice \u015fi afectare ganglionar\u0103). Nivelul pre-tratament constituie un indicator precoce al prognosticului. Dup\u0103 tratamentul chirurgical radical sau radioterapie concentra\u0163ia seric\u0103 de SCC se normalizeaz\u0103 de obicei in 2-7 zile. Persisten\u0163a nivelurilor anormale dup\u0103 2-6 s\u0103pt\u0103m\u00e2ni de la tratament se coreleaz\u0103 cu o rat\u0103 \u00eenalt\u0103 de recidive. Reapari\u0163ia nivelurilor crescute, dup\u0103 o normalizare ini\u0163ial\u0103, se asociaz\u0103 cu recidiva bolii, chiar\u00a0\u00een absen\u0163a manifest\u0103rilor clinice, marker-ul fiind astfel util\u00a0\u00een detectarea precoce a recuren\u0163elor tumorale. Din punct de vedere al sensibilit\u0103\u0163ii clinice, markerul CEA este inferior Ag SCC\u00a0\u00een cancerul de col uterin cu celule scuamose2;3<\/sup>.<\/span><\/p>\n

B. <\/em>Cancerul pulmonar<\/em><\/span><\/p>\n

In cancerul pulmonar cu celule scuamoase prevalen\u0163a concentra\u0163iilor crescute de SCC variaz\u0103 \u00eentre 39 \u015fi 78%. Nivelurile de SCC sunt crescute\u00a0\u00een direct\u0103 corela\u0163ie cu stadiul bolii \u015fi clasificarea TNM. Dup\u0103 2 zile de la rezec\u0163ia tumorii valorile SCC trebuie s\u0103 se normalizeze;\u00a0\u00een cazul tumorilor reziduale declinul valorilor se produce mai greu. Dac\u0103 dup\u0103 4-5 luni nivelul SCC va cre\u015fte semnificativ, aceasta indic\u0103 recidiv\u0103 tumoral\u0103. Dup\u0103 unele studii, determinarea combinat\u0103 de SCC \u015fi CEA cre\u015fte sensibilitatea clinic\u0103 pentru acest tip de cancer de la 35 la 50-82%2;3<\/sup>.<\/span><\/p>\n

C. <\/em>Carcinoamele din zona cap-g\u00e2t<\/em><\/span><\/p>\n

In aceste forme de cancer sensibilitatea clinic\u0103 a SCC variaz\u0103 de la 34 la 78%, fiind dependent\u0103 de stadiul bolii \u015fi clasificarea TNM. Rata de detec\u0163ie \u00een diverse tumori este: 49%\u00a0\u00een leziunile sinusului maxilar, 34%\u00a0\u00een leziunile cavit\u0103\u0163ii bucale, 23%\u00a0\u00een leziunile limbii, 19%\u00a0\u00een leziunile laringelui \u015fi 11-33%\u00a0\u00een leziunile faringelui. In ceea ce prive\u015fte detectarea recidivelor tumorale, se descrie o sensibilitate clinic\u0103 de 60-75%2<\/sup>.<\/span><\/p>\n

D. <\/em>Cancerul esofagian<\/em><\/span><\/p>\n

In cancerul de esofag sensibilitatea clinic\u0103 medie a SCC este de 30-39%, aceasta fiind dependent\u0103 de stadiul bolii. Dup\u0103 o interven\u0163ie chirurgical\u0103 reu\u015fit\u0103 nivelurile de SCC se normalizeaz\u0103. Persisten\u0163a nivelurilor crescute se asociaz\u0103 cu prezen\u0163a tumorilor reziduale, iar cre\u015fterea valorilor, dup\u0103 o normalizare ini\u0163ial\u0103, indic\u0103 recidiv\u0103 tumoral\u01032<\/sup>.<\/span><\/p>\n

E.\u00a0<\/em>Alte tumori genito-urinare<\/em><\/span><\/p>\n

In tumorile ginecologice (altele dec\u00e2t cancerul de col uterin) s-au descris sensibilit\u0103\u0163i clinice variate ale SCC: 8-30% \u00een cancerul de endometru, 4-20% \u00een cancerul ovarian, 19-42% \u00een cancerul vulvar \u015fi 17% \u00een cancerul vaginal.<\/span><\/p>\n

Valori crescute de SCC se \u00eenregistreaz\u0103 \u015fi la pacien\u0163ii av\u00e2nd carcinom metastatic cu celule scuamoase de penis \u015fi uretr\u0103\u00a0\u00een aproximativ 45% din cazuri2<\/sup>.<\/span><\/p>\n

Preg\u0103tire pacient <\/em><\/strong>\u2013 \u00e0 jeun (pe nem\u00e2ncate) sau postprandial1<\/sup>.<\/span><\/p>\n

Specimen recoltat <\/em><\/strong>\u2013 s\u00e2nge venos1<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/em><\/strong>\u2013 vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator1<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong> \u2013 se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul proasp\u0103t \u00een maxim 2 ore; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C, la -20\u00b0C sau la -70\u00b0C1<\/sup>.<\/span><\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser1<\/sup>.<\/span><\/p>\n

Cauze de respingere<\/em><\/strong> a probei<\/em><\/strong> \u00a0<\/em><\/strong><\/span><\/p>\n

\u2022 specimen hemolizat;<\/span><\/div>\n
\u2022 specimen expus la temperatur\u0103 ridicat\u0103;<\/span><\/div>\n
\u2022 specimen contaminat bacterian1<\/sup>.<\/span><\/div>\n

Stabilitate prob\u0103 <\/em><\/strong>\u2013 serul separat este stabil 1 zi<\/em> la 2-8\u00b0C; timp \u00eendelungat<\/em> la -20\u00b0C sau la -70\u00b0C1<\/sup>. Evita\u0163i decongelarea\/recongelarea1<\/sup>.<\/span><\/p>\n

Metod\u0103 <\/em><\/strong>- <\/span>imunochimic\u0103 cu detec\u0163ie prin electrochemilumiscen\u0163\u0103 (ECLIA)<\/u>1<\/sup>.<\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>\u2013 < 2.7 ng\/mL1<\/sup>.<\/span><\/p>\n

Limita de detec\u0163ie <\/em><\/strong>\u2013 0.1 ng\/mL1<\/sup>.<\/span><\/p>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/p>\n

Antigenul SCC este prezent \u00een epiteliile scuamoase normale astfel \u00eencat niveluri crescute pot fi \u00eent\u00e2lnite \u00een afec\u0163iuni cutanate asociate cu hiperkeratinizare (psoriazis, eczem\u0103). Concentra\u0163ii crescute mai pot s\u0103 apar\u0103 \u00een afec\u0163iuni inflamatorii pulmonare, insuficien\u0163\u0103 hepatic\u0103 sau renal\u0103.<\/span><\/p>\n

SCC nu<\/strong> trebuie utilizat \u00een screening-ul cancerului\u00a0 la pacien\u0163i asimptomatici1<\/sup>.<\/span><\/p>\n

\u2022 Interferen\u0163e analitice<\/span><\/p>\n

Antigenul SCC este prezent \u00een piele, sudoare \u015fi saliv\u0103, fiind distribuit cu u\u015furin\u0163\u0103 \u00een aerosoli (ca rezultat al str\u0103nutului). Pentru a evita valorile fals crescute datorit\u0103 contamin\u0103rii este obligatoriu s\u0103 se utilizeze bariere protectoare (ex. m\u0103nu\u015fi, masc\u0103) \u00een timpul efectu\u0103rii testului.<\/span><\/p>\n

Pot produce interferen\u0163e cu unele componente ale kit-ului \u015fi conduce la rezultate neconcludente urm\u0103toarele:<\/p>\n

\u2013 tratamentul cu biotin\u0103 \u00een doze mari (>5 mg\/zi); de aceea se recomand\u0103 ca recoltarea de s\u00e2nge s\u0103 se fac\u0103 dup\u0103 minimum 8 ore de la ultima administrare;<\/div>\n
\u2013 titrurile foarte crescute de anticorpi anti-streptavidin\u0103 \u015fi anti-ruteniu1<\/span><\/sup>.<\/div>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2016. Ref Type: Catalog.<\/span><\/div>\n
2. Lothar Thomas. Tumor Markers. In Clinical Laboratory Diagnostics, 1998, 986-989.<\/span><\/div>\n
3. The National Academy of Clinical Biochemistry. Practice Guidelines and Recommendations for Use of Tumor Markers in\u00a0 <\/span>the<\/span>\u00a0Clinic (Laboratory Medicine Practice Guidelines), 2002, 19.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0410\u043d\u0442\u0438\u0433\u0435\u043d \u043f\u043b\u043e\u0441\u043a\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0439 \u043a\u0430\u0440\u0446\u0438\u043d\u043e\u043c\u044b (SCC) \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u0441\u043e\u0431\u043e\u0439 \u0433\u043b\u0438\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d, \u043f\u0440\u0438\u043d\u0430\u0434\u043b\u0435\u0436\u0430\u0449\u0438\u0439 \u043a \u0433\u0440\u0443\u043f\u043f\u0435 \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u043e\u0432 \u0441\u0435\u0440\u0438\u043d\/\u0446\u0438\u0441\u0442\u0435\u0438\u043d\u043e\u0432\u044b\u0445 \u043f\u0440\u043e\u0442\u0435\u0430\u0437. \u0410\u043d\u0442\u0438\u0433\u0435\u043d SCC \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0441\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c \u043f\u043b\u043e\u0441\u043a\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0439, \u043b\u043e\u043a\u0430\u043b\u0438\u0437\u0443\u044e\u0449\u0438\u0445\u0441\u044f \u0432: \u0448\u0435\u0439\u043a\u0435 \u043c\u0430\u0442\u043a\u0438, \u0432\u0443\u043b\u044c\u0432\u0435, \u043b\u0435\u0433\u043a\u043e\u043c, \u043f\u0438\u0449\u0435\u0432\u043e\u0434\u0435 \u0438 \u043e\u0431\u043b\u0430\u0441\u0442\u0438 \u0433\u043e\u043b\u043e\u0432\u044b \u0438 \u0448\u0435\u0438.<\/p>\n

\u0420\u0430\u043a \u0448\u0435\u0439\u043a\u0438 \u043c\u0430\u0442\u043a\u0438<\/strong><\/em> – \u0427\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 45-85% \u043f\u0440\u0438 \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u043e\u0439 \u043e\u043f\u0443\u0445\u043e\u043b\u0438 \u0438 66-84% \u043f\u0440\u0438 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u0435 \u043e\u043f\u0443\u0445\u043e\u043b\u0438. \u041a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 SCC \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u043e\u0440\u0440\u0435\u043b\u0438\u0440\u0443\u0435\u0442 \u0441 \u0442\u044f\u0436\u0435\u0441\u0442\u044c\u044e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u0435\u043c \u043b\u0438\u043c\u0444\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0443\u0437\u043b\u043e\u0432 \u0438 \u043d\u0430\u043b\u0438\u0447\u0438\u0435\u043c \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0437\u043e\u0432. \u0418\u043d\u0434\u0435\u043a\u0441 \u0434\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0438\u043d\u0434\u0438\u043a\u0430\u0442\u043e\u0440\u043e\u043c \u043f\u0440\u043e\u0433\u043d\u043e\u0437\u0430 \u043f\u043e\u0441\u043b\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u044f. \u041a\u0430\u043a \u043f\u0440\u0430\u0432\u0438\u043b\u043e, \u0443\u0440\u043e\u0432\u043d\u0438 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 SCC \u043d\u043e\u0440\u043c\u0430\u043b\u0438\u0437\u0443\u044e\u0442\u0441\u044f \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 2-7 \u0434\u043d\u0435\u0439 \u043f\u043e\u0441\u043b\u0435 \u043e\u043f\u0435\u0440\u0430\u0446\u0438\u0438 \u0438\u043b\u0438 \u043b\u0443\u0447\u0435\u0432\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438.<\/p>\n

\u0421\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435 \u0432\u044b\u0441\u043e\u043a\u043e\u0433\u043e \u0431\u0430\u043b\u043b\u0430 \u0434\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 2-6 \u043d\u0435\u0434\u0435\u043b\u044c \u043f\u043e\u0441\u043b\u0435 \u043d\u0430\u0447\u0430\u043b\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0441\u0432\u0438\u0434\u0435\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0443\u0435\u0442 \u043e \u0432\u044b\u0441\u043e\u043a\u043e\u043c \u0440\u0438\u0441\u043a\u0435 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u0430. \u041f\u043e\u0441\u043b\u0435 \u043d\u043e\u0440\u043c\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u0438 \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0435\u0439 \u043f\u043e\u0441\u043b\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0432\u043e\u0437\u0432\u0440\u0430\u0449\u0435\u043d\u0438\u0435 \u043d\u0430 \u0432\u044b\u0441\u043e\u043a\u0438\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0441\u043d\u043e\u0432\u0430, \u043d\u0435\u0441\u043c\u043e\u0442\u0440\u044f \u043d\u0430 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043f\u0440\u0438\u0437\u043d\u0430\u043a\u043e\u0432, \u043c\u043e\u0436\u0435\u0442 \u0441\u0432\u0438\u0434\u0435\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u043e\u0432\u0430\u0442\u044c \u043e \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f. \u041f\u043e \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u0438 \u043a\u0430\u0440\u0446\u0438\u043d\u043e\u044d\u043c\u0431\u0440\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0439 \u0430\u043d\u0442\u0438\u0433\u0435\u043d \u0443\u0441\u0442\u0443\u043f\u0430\u0435\u0442 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0443 \u043f\u043b\u043e\u0441\u043a\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0440\u0430\u043a\u0430 \u0432 \u0441\u043e\u043e\u0442\u043d\u043e\u0448\u0435\u043d\u0438\u0438 2:3.<\/p>\n

\u0420\u0430\u043a \u043b\u0435\u0433\u043a\u0438\u0445<\/strong> <\/em>–\u00a0 \u041f\u0440\u0438 \u043f\u043b\u043e\u0441\u043a\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u043b\u0435\u0433\u043a\u043e\u0433\u043e \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u043f\u043b\u043e\u0441\u043a\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 39-78% \u0438 \u043a\u043e\u0440\u0440\u0435\u043b\u0438\u0440\u0443\u0435\u0442 \u0441\u043e \u0441\u0442\u0430\u0434\u0438\u0435\u0439 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u0438 \u043a\u043b\u0430\u0441\u0441\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u0435\u0439 TNM (\u0422 – \u0440\u0430\u0437\u043c\u0435\u0440 \u0438 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u0435 \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u043e\u0439 \u043e\u043f\u0443\u0445\u043e\u043b\u0438, \u041d – \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u0435 \u043b\u0438\u043c\u0444\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0443\u0437\u043b\u043e\u0432, \u041c – \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0437\u044b).<\/p>\n

\u0412 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 2 \u0434\u043d\u0435\u0439 \u043f\u043e\u0441\u043b\u0435 \u0440\u0435\u0437\u0435\u043a\u0446\u0438\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u0438 \u0443\u0440\u043e\u0432\u043d\u0438 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 SCC \u0434\u043e\u043b\u0436\u043d\u044b \u0432\u0435\u0440\u043d\u0443\u0442\u044c\u0441\u044f \u043a \u043d\u043e\u0440\u043c\u0435. \u0412 \u0441\u043b\u0443\u0447\u0430\u0435 \u0440\u0435\u0437\u0438\u0434\u0443\u0430\u043b\u044c\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0439 \u043e\u0437\u043da\u0447\u0430\u0435\u0442\u0435\u043b\u044c\u043d\u043e \u0441\u043b\u043e\u0436\u043d\u0435\u0435 \u043d\u043e\u0440\u043c\u0430\u043b\u0438\u0437\u043e\u0432\u0430\u0442\u044c \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u043d\u044b\u0435 \u043c\u0430\u0440\u043a\u0435\u0440\u044b \u041f\u041a\u0420. \u0423\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u0435 \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0435\u0439 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 SCC \u0447\u0435\u0440\u0435\u0437 4-5 \u043c\u0435\u0441 \u043f\u043e\u0441\u043b\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u0438 \u0441\u0432\u0438\u0434\u0435\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0443\u0435\u0442 \u043e \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u0435 \u043e\u043f\u0443\u0445\u043e\u043b\u0438. \u041f\u043e \u0434\u0430\u043d\u043d\u044b\u043c \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439, \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0435 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u043e\u0432 \u041f\u041a\u0420 \u0438 \u0421\u0415\u0410 (\u043a\u0430\u0440\u0446\u0438\u043d\u043e\u044d\u043c\u0431\u0440\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0445) \u043f\u043e\u0432\u044b\u0448\u0430\u0435\u0442 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0443\u044e \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u0441 35% \u0434\u043e 50-82%.<\/p>\n

\u041a\u0430\u0440\u0446\u0438\u043d\u043e\u043c\u0430 \u0433\u043e\u043b\u043e\u0432\u044b \u0438 \u0448\u0435\u0438<\/strong><\/em> \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 SCC \u0432 \u044d\u0442\u0438\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 34-78% \u0438 \u0437\u0430\u0432\u0438\u0441\u0438\u0442 \u043e\u0442 \u0441\u0442\u0430\u0434\u0438\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u0438 \u043a\u043b\u0430\u0441\u0441\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u0438 TNM.<\/p>\n

\u0427\u0430\u0441\u0442\u043e\u0442\u0430 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u044f SCC \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 \u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u0433\u043e\u043b\u043e\u0432\u044b \u0438 \u0448\u0435\u0438 \u0441\u043b\u0435\u0434\u0443\u044e\u0449\u0430\u044f: \u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u0432\u0435\u0440\u0445\u043d\u0435\u0439 \u0447\u0435\u043b\u044e\u0441\u0442\u0438 – 49%, \u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u043f\u043e\u043b\u043e\u0441\u0442\u0438 \u0440\u0442\u0430 34%, \u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u044f\u0437\u044b\u043a\u0430 23%, \u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u0441\u043b\u044e\u043d\u044b 19%, \u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u0433\u043b\u043e\u0442\u043a\u0438 11-33%.<\/p>\n

\u0412 \u0441\u043b\u0443\u0447\u0430\u0435 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u0438\u0440\u0443\u044e\u0449\u0435\u0433\u043e \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u044f \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 60-75%.<\/p>\n

\u041e\u043f\u0443\u0445\u043e\u043b\u0438 \u043f\u0438\u0449\u0435\u0432\u043e\u0434\u0430<\/strong> <\/em>– \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 SCC \u043f\u0440\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u043f\u0438\u0449\u0435\u0432\u043e\u0434\u0430 \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 30-39% \u0441 \u0443\u0447\u0435\u0442\u043e\u043c \u0441\u0442\u0430\u0434\u0438\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f. \u041f\u043e\u0441\u043b\u0435 \u0443\u0441\u043f\u0435\u0448\u043d\u043e\u0433\u043e \u0445\u0438\u0440\u0443\u0440\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0432\u043c\u0435\u0448\u0430\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0430 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 SCC \u0432\u043e\u0437\u0432\u0440\u0430\u0449\u0430\u0435\u0442\u0441\u044f \u043a \u043d\u043e\u0440\u043c\u0435. \u0414\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u0443\u0440\u043e\u0432\u043d\u044f \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 \u0432 \u0440\u0435\u0437\u0438\u0434\u0443\u0430\u043b\u044c\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u0438 \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u0435 \u043f\u043e\u0441\u043b\u0435 \u043d\u0430\u0447\u0430\u043b\u044c\u043d\u043e\u0439 \u043d\u043e\u0440\u043c\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u0438 \u0443\u043a\u0430\u0437\u044b\u0432\u0430\u044e\u0442 \u043d\u0430 \u0440\u0435\u0446\u0438\u0434\u0438\u0432 \u043e\u043f\u0443\u0445\u043e\u043b\u0438.<\/p>\n

\u0427\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 \u043f\u043b\u043e\u0441\u043a\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0440\u0430\u043a\u0430 \u043f\u0440\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u044d\u043d\u0434\u043e\u043c\u0435\u0442\u0440\u0438\u044f \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 8-30%, \u043f\u0440\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u044f\u0438\u0447\u043d\u0438\u043a\u043e\u0432 – 4-20%, \u043f\u0440\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u0432\u0443\u043b\u044c\u0432\u044b – 19-42%, \u043f\u0440\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u0448\u0435\u0439\u043a\u0438 \u043c\u0430\u0442\u043a\u0438 \u0438 \u0432\u043b\u0430\u0433\u0430\u043b\u0438\u0449\u0430 – 17%.<\/p>\n

\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u0443\u0440\u043e\u0432\u043d\u044f \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 SCC \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0435\u0442\u0441\u044f \u043f\u0440\u0438 \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043f\u043b\u043e\u0441\u043a\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445 \u043f\u043e\u043b\u043e\u0432\u044b\u0445 \u043f\u0443\u0442\u0435\u0439 \u0438 \u0443\u0440\u0435\u0442\u0440\u044b, \u043f\u0440\u0438\u043c\u0435\u0440\u043d\u043e \u043d\u0430 45%.<\/p>\n

\u041f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430: \u041f\u0440\u0435\u0434\u0432\u0430\u0440\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438 \u043d\u0435 \u0442\u0440\u0435\u0431\u0443\u0435\u0442\u0441\u044f.<\/p>\n

\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b \u0434\u043b\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f: \u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<\/p>\n

\u0412\u043e\u0437\u043c\u043e\u0436\u043d\u0430\u044f \u043f\u0440\u0438\u0447\u0438\u043d\u0430 \u043e\u0442\u043a\u043b\u043e\u043d\u0435\u043d\u0438\u044f \u043e\u0431\u0440\u0430\u0437\u0446\u0430: \u0433\u0435\u043c\u043e\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b, \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u0442\u0435\u043c\u043f\u0435\u0440\u0430\u0442\u0443\u0440\u043d\u043e\u0433\u043e \u0440\u0435\u0436\u0438\u043c\u0430 \u043e\u0431\u0440\u0430\u0437\u0446\u0430, \u0437\u0430\u0433\u0440\u044f\u0437\u043d\u0435\u043d\u0438\u0435 \u043e\u0431\u0440\u0430\u0437\u0446\u0430.<\/p>\n

\u0410\u043d\u0442\u0438\u0433\u0435\u043d SCC \u0432\u0445\u043e\u0434\u0438\u0442 \u0432 \u0441\u043e\u0441\u0442\u0430\u0432 \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u043f\u043b\u043e\u0441\u043a\u043e\u0433\u043e \u044d\u043f\u0438\u0442\u0435\u043b\u0438\u044f, \u043f\u043e\u044d\u0442\u043e\u043c\u0443 \u0435\u0433\u043e \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u043c\u043e\u0436\u0435\u0442 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0442\u044c\u0441\u044f \u043f\u0440\u0438 \u0442\u0430\u043a\u0438\u0445 \u043a\u043e\u0436\u043d\u044b\u0445 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f\u0445, \u043a\u0430\u043a \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u044b \u0441 \u0433\u0438\u043f\u0435\u0440\u043a\u0435\u0440\u0430\u0442\u043e\u0437\u043e\u043c: \u043f\u0441\u043e\u0440\u0438\u0430\u0437, \u044d\u043a\u0437\u0435\u043c\u0430. \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 SSC \u200b\u200b\u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0435\u0442\u0441\u044f \u0442\u0430\u043a\u0436\u0435 \u043f\u0440\u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445 \u043b\u0435\u0433\u043a\u0438\u0445, \u043f\u0435\u0447\u0435\u043d\u043e\u0447\u043d\u043e\u0439 \u0438 \u043f\u043e\u0447\u0435\u0447\u043d\u043e\u0439 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u0438.<\/p>\n

\u041e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430 SCC \u043d\u0435 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433\u043e\u0432\u044b\u043c \u0442\u0435\u0441\u0442\u043e\u043c \u0443 \u0431\u0435\u0441\u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043d\u044b\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[923],"product_tag":[],"class_list":{"0":"post-9296","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-tumorali","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9296","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9296"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9296"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9296"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9296"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}