{"id":9295,"date":"2020-04-23T04:33:56","date_gmt":"2020-04-23T01:33:56","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/coeficientul-de-saturatie-a-transferinei\/"},"modified":"2025-01-31T13:41:15","modified_gmt":"2025-01-31T11:41:15","slug":"coeficientul-de-saturatie-a-transferinei","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/coeficientul-de-saturatie-a-transferinei\/","title":{"rendered":"\u041a\u043e\u044d\u0444\u0444\u0438\u0446\u0438\u0435\u043d\u0442\u00a0\u043d\u0430\u0441\u044b\u0449\u0435\u043d\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d\u0430"},"content":{"rendered":"

ATEN\u021aIE!!! Testul con\u021bine Sideremie<\/strong> \u0438 <\/span>Transferin\u0103.\u00a0<\/span> <\/strong><\/p>\n

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Transferina reprezint\u0103 proteina de legare plasmatic\u0103 a fierului; este o glicoprotein\u0103 de 79.57 kD, gena sa fiind localizat\u0103 pe cromozomul 3q21; este generat\u0103 \u00een principal de celulele parenchimatoase hepatice, dar cantit\u0103\u0163i mai mici sunt sintetizate \u015fi\u00a0\u00een sistemul nervos central, ovar, testicul, celule T helper; rata de sintez\u0103 este invers propor\u0163ional\u0103 cu depozitele de fier. Transferina are dou\u0103 situsuri de legare a fierului, fiecare dintre acestea leg\u00e2nd un ion feric (Fe3+<\/sup>), iar \u00een s\u00e2nge exist\u0103 at\u00e2t transferina monoferic\u0103, c\u00e2t \u015fi diferic\u0103. 1g de transferin\u0103 poate lega 25.1 \u00b5mol sau 1.4 mg de fier. \u00cen mod normal, numai o treime din situsurile de legare ale transferinei sunt ocupate. Spre deosebire de sideremie, care prezint\u0103 varia\u0163ii diurne mari, nivelul transferinei serice este mult mai constant. Transferina furnizeaz\u0103 fier c\u0103tre precursorii eritroizi \u015fi alte celule prin legarea de receptori specifici de pe suprafa\u0163a celular\u0103. Cantitatea de fier furnizat\u0103 este reglat\u0103 printr-un mecanism de feedback negativ\u00a0\u00een func\u0163ie de nevoile celulare pentru sinteza de hemoglobin\u01031;7<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea transferinei<\/em><\/strong> (\u00een combina\u0163ie cu sideremia \u015fi feritina):<\/p>\n

\u2022 Diagnosticul diferen\u0163ial al anemiilor, \u00een special microcitare \u015fi\/sau hipocrome<\/div>\n
\u2022 Evaluarea anemiei feriprive, talasemiei, anemiei sideroblastice<\/div>\n
\u2022 Diagnosticul supra\u00eenc\u0103rc\u0103rii cu fier \u015fi hemocromatozei<\/div>\n

Preg\u0103tire pacient <\/em><\/strong>-<\/em> \u00e0 jeun (pe nem\u00e2ncate)6<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>-<\/em> \u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c6<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>-<\/em> vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator6<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>-<\/em> se separ\u0103 serul prin centrifugare6<\/sup>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser6<\/sup>.<\/p>\n

Cauze de respingere a probei <\/em><\/strong>-<\/em> specimen hemolizat6<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>-<\/em> serul separat este stabil 8 zile<\/em> la 15-25\u00b0C; 8 zile<\/em> la 2-8\u00b0C; 6 luni <\/em>la -206<\/sup>.<\/p>\n

Metod\u0103 <\/em><\/strong>- imunoturbidimetric\u0103<\/span>6<\/sup><\/span>.<\/span><\/p>\n

Satura\u0163ia transferinei poate fi calculat\u0103 conform formulei7<\/sup>:<\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Sideremia (\u00b5mol\/L)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Sideremia (\u00b5g\/dL)<\/em><\/p>\n

TfS (%) = \u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2013<\/span><\/em>\u2014\u2013<\/span><\/em> x 398\u00a0\u00a0 sau\u00a0\u00a0 TfS (%) = \u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014-<\/span> x 70.9 <\/em><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Transferina (mg\/dL)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Transferina (mg\/dL)<\/em><\/p>\n

Valori de referin\u0163\u0103<\/em><\/strong>6<\/sup><\/p>\n\n\n\n\n
\n

\u0422\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d\u00a0<\/em><\/strong><\/p>\n<\/td>\n

\n

2.0-3.6 g\/L sau 200-360 mg\/dL sau 25.2-45.4 \u00b5mol\/L\u00a0<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Satura\u0163ia transferinei\u00a0<\/em><\/strong><\/p>\n<\/td>\n

\n

16-45%\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Factori de conversie: mg\/dL x 0.126 = \u00b5mol\/L; \u00b5mol\/L x 7.96 = mg\/dL.<\/em><\/p>\n

Limita de detec\u0163ie<\/em><\/strong> - <\/em>0.1 g\/L (10mg\/dL; 1.26\u00b5mol\/L)6<\/sup>.<\/p>\n

\u00a0<\/em><\/strong><\/p>\n

Interpretarea rezultatelor \u2013 transferina<\/em><\/strong><\/p>\n\n\n\n\n\n\n
\n

Cre\u015fteri<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

\u2022 anemie feripriv\u0103 \u2022 sarcina \u2022 anticoncep\u0163ionale orale (TfS este normala)3<\/sup>\u00a0<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Scaderi<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

\u2022 anemia din bolile cronice (uneori, transferina poate fi normal\u0103) \u2022 anemiile sideroblastice (uneori, transferina poate fi normal\u0103) \u2022 anemii hemolitice (uneori, transferina poate fi normal\u0103) \u2022 deficit proteic: malnutri\u0163ie sau pierderi crescute (arsuri, sindrom nefrotic, boli hepatice) \u2022 boli hepatice acute \u2022 atransferinemia congenital\u0103 \u2022 sindroame de supra\u00eenc\u0103rcare cu fier, hemocromatoz\u0103 (u\u015for sc\u0103zut\u0103)3<\/sup>.<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/em><\/strong><\/p>\n

Interpretarea rezultatelor \u2013 satura\u0163ia transferinei<\/em><\/strong><\/p>\n\n\n\n\n\n\n
\n

Cre\u015fteri<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

\u2022 anemii sideroblastice \u2022 anemii hemolitice \u2022 talasemie \u2022 sindroame de supra\u00eenc\u0103rcare cu fier hemocromatoza (foarte crescut\u0103, \u00eenainte ca feritina s\u0103 fie foarte crescut\u0103)2;3<\/sup> \u2022 ingestie de fier (=\/>100%)5<\/sup><\/td>\n<\/tr>\n
Sc\u0103deri<\/em><\/strong><\/td>\n<\/tr>\n
\n

\u2022 anemii feriprive ( <10% \u00een deficitul instalat) \u2022 anemia din infec\u0163ii \u015fi boli cronice (uneori, poate fi normal\u0103)\u00a0<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/em><\/strong><\/p>\n

\u00a0<\/em><\/strong>Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

\u2022 Condi\u0163ii fiziologice<\/strong>: \u00een sarcin\u0103 sinteza transferinei este mai mare decat sc\u0103derea depozitelor de fier ale organismului7<\/sup>.<\/p>\n

\u2022 Condi\u0163ii patologice<\/strong>: sinteza transferinei este supresat\u0103 \u00een cursul reac\u0163iilor de faz\u0103 acut\u01037<\/sup>.<\/p>\n

\u00cen necroza hepatic\u0103 transferina este eliberat\u0103 din hepatocite \u00een plasm\u01037<\/sup>.<\/p>\n

\u2022 Interferen\u0163e analitice<\/p>\n

\u00cen cazuri foarte rare prezen\u0163a gamapatiei, \u00een special IgM (macroglobulinemia Waldenstr\u00f6m) poate determina rezultate eronate6<\/sup>.<\/p>\n

\u00a0<\/span><\/p>\n

\u00a0<\/span>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Andrews N. Iron Deficiency and Related Disorders. In Wintrobe\u2019s Clinical Hematology. Lippincott, Williams & Wilkins, USA, 11 Ed., 2004, 980-1004.<\/span><\/div>\n
2. Edwards C. Hemochromatosis. In Wintrobe\u2019s Clinical Hematology. Lippincott, Williams & Wilkins, USA, 11 Ed., 2004, 1036-1049.<\/span><\/div>\n
3. Finley P, Grady H, Olsowka E et al. Chemistry. In Laboratory Test Handbook. David S. Jacobs, Wayne R. DeMott, Paul R. Finley et al., LEXI-COMP. Inc., USA, 3 Ed., 1994, 262-264.<\/span><\/div>\n
4. Frances Fischbach. Blood Studies: Hematology and Coagulation. In A Manual of Laboratory and Diagnostic Tests. Lippincott, Williams & Wilkins, USA, 8 Ed., 2009, 121-123.<\/span><\/div>\n
5. Jacques Wallach. Afec\u0163iuni hematologice. \u00cen Interpretarea testelor de diagnostic. Editura Stiin\u0163elor Medicale, Rom\u00e2nia, 7 ed., 2001; 475.<\/span><\/div>\n
6. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n
7. Lothar Thomas. Transferrin Saturation. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998, 275-277.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0412\u041d\u0418\u041c\u0410\u041d\u0418\u0415!!! \u0422\u0435\u0441\u0442 \u0441\u043e\u0434\u0435\u0440\u0436\u0438\u0442 \u0421\u0438\u0434\u0435\u0440\u0435\u043c\u0438\u044e \u0438 \u0422\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0438\u043d.<\/span><\/p>\n

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

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\u0441\u043a\u043e\u0440\u043e\u0441\u0442\u044c \u0441\u0438\u043d\u0442\u0435\u0437\u0430 \u043e\u0431\u0440\u0430\u0442\u043d\u043e \u043f\u0440\u043e\u043f\u043e\u0440\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u0430 \u043e\u0442\u043b\u043e\u0436\u0435\u043d\u0438\u044f\u043c \u0436\u0435\u043b\u0435\u0437\u0430. \u0422\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d \u0438\u043c\u0435\u0435\u0442 \u0434\u0432\u0430 \u0441\u0430\u0439\u0442\u0430 \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u043d\u0438\u044f \u0436\u0435\u043b\u0435\u0437\u0430, \u043a\u0430\u0436\u0434\u044b\u0439 \u0438\u0437 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u0435\u0442 \u0438\u043e\u043d \u0436\u0435\u043b\u0435\u0437\u0430 (Fe3+), \u0438 \u0432 \u043a\u0440\u043e\u0432\u0438 \u0435\u0441\u0442\u044c \u043a\u0430\u043a \u043c\u043e\u043d\u043e\u0444\u0435\u0440\u043d\u044b\u0439, \u0442\u0430\u043a \u0438 \u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u044b\u0439 \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d. 1 \u0433 \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d\u0430 \u043c\u043e\u0436\u0435\u0442 \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u0442\u044c 25.1 \u043c\u043a\u043c\u043e\u043b\u044c \u0438\u043b\u0438 1.4 \u043c\u0433 \u0436\u0435\u043b\u0435\u0437\u0430. \u041e\u0431\u044b\u0447\u043d\u043e \u0437\u0430\u043d\u044f\u0442\u0430 \u0442\u043e\u043b\u044c\u043a\u043e \u0442\u0440\u0435\u0442\u044c \u0441\u0430\u0439\u0442\u043e\u0432 \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u043d\u0438\u044f \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d\u0430. \u0412 \u043e\u0442\u043b\u0438\u0447\u0438\u0435 \u043e\u0442 \u0441\u0438\u0434\u0435\u0440\u0435\u043c\u0438\u0438, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u043f\u043e\u043a\u0430\u0437\u044b\u0432\u0430\u0435\u0442 \u0431\u043e\u043b\u044c\u0448\u0438\u0435 \u0441\u0443\u0442\u043e\u0447\u043d\u044b\u0435 \u0432\u0430\u0440\u0438\u0430\u0446\u0438\u0438, \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d\u0430 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438 \u043d\u0430\u043c\u043d\u043e\u0433\u043e \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u0435\u0435. \u0422\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d \u0434\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u0436\u0435\u043b\u0435\u0437\u043e \u043f\u0440\u0435\u0434\u0448\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u0438\u043a\u0430\u043c \u044d\u0440\u0438\u0442\u0440\u043e\u0438\u0434\u043e\u0432 \u0438 \u0434\u0440\u0443\u0433\u0438\u043c \u043a\u043b\u0435\u0442\u043a\u0430\u043c, \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044f\u0441\u044c \u0441\u043e \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0430\u043c\u0438 \u043d\u0430 \u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0439 \u043f\u043e\u0432\u0435\u0440\u0445\u043d\u043e\u0441\u0442\u0438. \u041a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e \u043f\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u043c\u043e\u0433\u043e \u0436\u0435\u043b\u0435\u0437\u0430 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u043e\u043c \u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u043e\u0431\u0440\u0430\u0442\u043d\u043e\u0439 \u0441\u0432\u044f\u0437\u0438 \u0432 \u0441\u043e\u043e\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0438\u0438 \u0441 \u043f\u043e\u0442\u0440\u0435\u0431\u043d\u043e\u0441\u0442\u044f\u043c\u0438 \u043a\u043b\u0435\u0442\u043e\u043a \u0432 \u0441\u0438\u043d\u0442\u0435\u0437\u0435 \u0433\u0435\u043c\u043e\u0433\u043b\u043e\u0431\u0438\u043d\u0430 1; 7.<\/p>\n

\u0420\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438<\/strong> \u043f\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044e \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d\u0430 (\u0432 \u0441\u043e\u0447\u0435\u0442\u0430\u043d\u0438\u0438 \u0441 \u0441\u0438\u0434\u0435\u0440\u0435\u043c\u0438\u0435\u0439 \u0438 \u0444\u0435\u0440\u0440\u0438\u0442\u0438\u043d\u043e\u043c):<\/p>\n

    \n
  • \u0414\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u0430\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0430\u043d\u0435\u043c\u0438\u0439, \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e \u043c\u0438\u043a\u0440\u043e\u0446\u0438\u0442\u0430\u0440\u043d\u043e\u0439 \u0438 \/ \u0438\u043b\u0438 \u0433\u0438\u043f\u043e\u0445\u0440\u043e\u043c\u043d\u043e\u0439<\/li>\n
  • \u041e\u0446\u0435\u043d\u043a\u0430 \u0436\u0435\u043b\u0435\u0437\u043e\u0434\u0435\u0444\u0438\u0446\u0438\u0442\u043d\u043e\u0439 \u0430\u043d\u0435\u043c\u0438\u0438, \u0442\u0430\u043b\u0430\u0441\u0441\u0435\u043c\u0438\u0438, \u0441\u0438\u0434\u0435\u0440\u043e\u0431\u043b\u0430\u0441\u0442\u043d\u043e\u0439 \u0430\u043d\u0435\u043c\u0438\u0438<\/li>\n
  • \u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u043f\u0435\u0440\u0435\u0433\u0440\u0443\u0437\u043a\u0438 \u0436\u0435\u043b\u0435\u0437\u043e\u043c \u0438 \u0433\u0435\u043c\u043e\u0445\u0440\u043e\u043c\u0430\u0442\u043e\u0437\u0430<\/li>\n<\/ul>\n

    \u041f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430 <\/em><\/strong>-<\/em> \u00e0 jeun (\u043d\u0430\u0442\u043e\u0449\u0430\u043a)6<\/sup>.<\/p>\n

    \u0421\u043e\u0431\u0438\u0440\u0430\u0435\u043c\u044b\u0439 \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b <\/em><\/strong>-<\/em> \u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c6<\/sup>.<\/p>\n

    \u041a\u043e\u043d\u0442\u0435\u0439\u043d\u0435\u0440 \u0434\u043b\u044f \u0441\u0431\u043e\u0440\u0430 – vacutainer \u0431\u0435\u0437 \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430 \u0441 \/ \u0431\u0435\u0437 \u0441\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0440\u043d\u043e\u0433\u043e \u0433\u0435\u043b\u044f 6.<\/p>\n

    \u041d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0430\u044f \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u043a\u0430 \u043f\u043e\u0441\u043b\u0435 \u0441\u0431\u043e\u0440\u0430- \u043e\u0442\u0434\u0435\u043b\u044f\u0435\u043c \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0443 \u0446\u0435\u043d\u0442\u0440\u0438\u0444\u0443\u0433\u043e\u043c6.<\/p>\n

    \u041e\u0431\u044a\u0435\u043c \u043e\u0431\u0440\u0430\u0437\u0446\u0430-\u043c\u0438\u043d\u0438\u043c\u0443\u043c 0.5 \u043c\u043b 6.<\/p>\n

    \u041f\u0440\u0438\u0447\u0438\u043d\u044b \u043e\u0442\u0442\u043e\u0440\u0436\u0435\u043d\u0438\u044f \u043e\u0431\u0440\u0430\u0437\u0446\u0430-\u043e\u0431\u0440\u0430\u0437\u0435\u0446 \u0433\u0435\u043c\u043e\u043b\u0438\u0437\u0430\u04426.<\/p>\n

    \u0421\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u043e\u0431\u0440\u0430\u0437\u0446\u0430-\u043e\u0442\u0434\u0435\u043b\u044c\u043d\u0430\u044f \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0430 \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u0430 8 \u0434\u043d\u0435\u0439 \u043f\u0440\u0438 15-25\u00b0C; 8 \u0434\u043d\u0435\u0439 \u043f\u0440\u0438 2-8\u00b0c; 6 \u043c\u0435\u0441\u044f\u0446\u0435\u0432 \u043f\u0440\u0438 -206.<\/p>\n

    \u041c\u0435\u0442\u043e\u0434-\u0438\u043c\u043c\u0443\u043d\u043e\u0442\u0443\u0440\u0431\u0438\u0434\u0438\u043c\u0435\u0442\u0440\u0438\u0447\u0435\u0441\u043a\u0438\u0439 6.<\/p>\n

    \u041d\u0430\u0441\u044b\u0449\u0435\u043d\u0438\u0435 \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d\u0430 \u043c\u043e\u0436\u043d\u043e \u0440\u0430\u0441\u0441\u0447\u0438\u0442\u0430\u0442\u044c \u043f\u043e \u0444\u043e\u0440\u043c\u0443\u043b\u04357<\/sup>:<\/p>\n

    \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u0421\u0438\u0434\u0435\u0440\u0435\u043c\u0438\u044f (\u00b5mol\/L)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u0421\u0438\u0434\u0435\u0440\u0435\u043c\u0438\u044f (\u00b5g\/dL)<\/em><\/p>\n

    TfS (%) = \u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2013<\/span><\/em>\u2014\u2013<\/span><\/em> x 398\u00a0\u00a0\u0438\u043b\u0438\u00a0 \u00a0TfS (%) = \u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014-<\/span> x 70.9 <\/em><\/p>\n

    \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u0422\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0438\u043d (mg\/dL)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u0422\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0438\u043d (mg\/dL)<\/em><\/p>\n

    \u0417\u043d\u0430\u0447\u0435\u043d\u0438\u0435<\/em><\/strong>6<\/sup><\/p>\n\n\n\n\n
    \n

    \u0422\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0438\u043d<\/p>\n<\/td>\n

    		\n

    2.0-3.6 g\/L \u0438\u043b\u0438 200-360 mg\/dL \u0438\u043b\u0438 25.2-45.4 \u00b5mol\/L\u00a0<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

    \n

    \u041d\u0430\u0441\u044b\u0449\u0435\u043d\u0438\u0435 \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d\u0430<\/p>\n<\/td>\n

    		\n

    16-45%\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    \u041a\u043e\u044d\u0444\u0444\u0438\u0446\u0438\u0435\u043d\u0442\u044b \u043a\u043e\u043d\u0432\u0435\u0440\u0441\u0438\u0438: mg\/dL x 0.126 = \u00b5mol\/L; \u00b5mol\/L x 7.96 = mg\/dL.<\/em><\/p>\n

    \u041f\u0440\u0435\u0434\u0435\u043b \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u044f \u2013 <\/em>0.1 g\/L (10mg\/dL; 1.26\u00b5mol\/L)6<\/sup>.<\/p>\n

    \u00a0<\/em><\/strong><\/p>\n

    \u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432-\u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d<\/strong><\/p>\n\n\n\n\n\n\n
    \n

    \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

    \n

    \u2022 \u0436\u0435\u043b\u0435\u0437\u043e\u0434\u0435\u0444\u0438\u0446\u0438\u0442\u043d\u0430\u044f \u0430\u043d\u0435\u043c\u0438\u044f * \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u044c * \u043e\u0440\u0430\u043b\u044c\u043d\u044b\u0435 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0437\u0430\u0447\u0430\u0442\u043e\u0447\u043d\u044b\u0435 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0430 \u2022 TfS \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u044b\u043c3<\/sup>\u00a0<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

    \n

    \u041f\u043e\u043d\u0438\u0436\u0435\u043d\u0438\u0435<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

    \n

    * \u0430\u043d\u0435\u043c\u0438\u044f \u043f\u0440\u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445 (\u0438\u043d\u043e\u0433\u0434\u0430 \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u044b\u043c) \u2022 \u0441\u0438\u0434\u0435\u0440\u043e\u0431\u043b\u0430\u0441\u0442\u043d\u044b\u0435 \u0430\u043d\u0435\u043c\u0438\u0438 (\u0438\u043d\u043e\u0433\u0434\u0430 \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u044b\u043c) \u2022 \u0433\u0435\u043c\u043e\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0430\u043d\u0435\u043c\u0438\u0438 (\u0438\u043d\u043e\u0433\u0434\u0430 \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u044b\u043c) \u2022 \u0434\u0435\u0444\u0438\u0446\u0438\u0442 \u0431\u0435\u043b\u043a\u0430: \u043d\u0435\u0434\u043e\u0435\u0434\u0430\u043d\u0438\u0435 \u0438\u043b\u0438 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u0430\u044f \u043f\u043e\u0442\u0435\u0440\u044f (\u043e\u0436\u043e\u0433\u0438, \u043d\u0435\u0444\u0440\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c, \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435 \u043f\u0435\u0447\u0435\u043d\u0438) \u2022 \u043e\u0441\u0442\u0440\u044b\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u043f\u0435\u0447\u0435\u043d\u0438 \u2022 \u0432\u0440\u043e\u0436\u0434\u0435\u043d\u043d\u0430\u044f \u0430\u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0438\u043d\u0435\u043c\u0438\u044f \u2022 \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u044b \u043f\u0435\u0440\u0435\u0433\u0440\u0443\u0437\u043a\u0438 \u0436\u0435\u043b\u0435\u0437\u043e\u043c, \u0433\u0435\u043c\u043e\u0445\u0440\u043e\u043c\u0430\u0442\u043e\u0437 (\u043d\u0435\u043c\u043d\u043e\u0433\u043e \u043d\u0438\u0437\u043a\u0438\u0439)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    \u00a0<\/em><\/strong><\/h6>\n

    \u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432 – \u043d\u0430\u0441\u044b\u0449\u0435\u043d\u0438\u0435 \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d\u0430<\/strong><\/p>\n\n\n\n\n\n\n
    \n

    \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

    * \u0441\u0438\u0434\u0435\u0440\u043e\u0431\u043b\u0430\u0441\u0442\u043d\u044b\u0435 \u0430\u043d\u0435\u043c\u0438\u0438 \u2022 \u0433\u0435\u043c\u043e\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0430\u043d\u0435\u043c\u0438\u0438 \u2022 \u0442\u0430\u043b\u0430\u0441\u0441\u0435\u043c\u0438\u044f \u2022 \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u044b \u043f\u0435\u0440\u0435\u0433\u0440\u0443\u0437\u043a\u0438 \u0436\u0435\u043b\u0435\u0437\u043e\u043c \u0433\u0435\u043c\u043e\u0445\u0440\u043e\u043c\u0430\u0442\u043e\u0437 (\u043e\u0447\u0435\u043d\u044c \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u0439, \u0434\u043e \u0442\u043e\u0433\u043e, \u043a\u0430\u043a \u0444\u0435\u0440\u0440\u0438\u0442\u0438\u043d \u0431\u044b\u043b \u0441\u0438\u043b\u044c\u043d\u043e \u043f\u043e\u0432\u044b\u0448\u0435\u043d)2;3 \u2022 \u0443\u0441\u0432\u0430\u0438\u0432\u0430\u043d\u0438\u0435 \u0436\u0435\u043b\u0435\u0437\u0430 (=\/>100%)5<\/td>\n<\/tr>\n
    \u041f\u043e\u043d\u0438\u0436\u0435\u043d\u0438\u0435<\/em><\/strong><\/td>\n<\/tr>\n
    \n

    * \u0436\u0435\u043b\u0435\u0437\u043e\u0434\u0435\u0444\u0438\u0446\u0438\u0442\u043d\u044b\u0435 \u0430\u043d\u0435\u043c\u0438\u0438 (<10% \u043f\u0440\u0438 \u0443\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u043d\u043e\u043c \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0435) \u2022 \u0430\u043d\u0435\u043c\u0438\u044f \u043e\u0442 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0439 \u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 (\u0438\u043d\u043e\u0433\u0434\u0430 \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u043e\u0439)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    \u00a0<\/em><\/strong><\/p>\n

      \n
    • \u0424\u0438\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0443\u0441\u043b\u043e\u0432\u0438\u044f: \u043f\u0440\u0438 \u043d\u0430\u0433\u0440\u0443\u0437\u043a\u0435 \u0441\u0438\u043d\u0442\u0435\u0437 \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d\u0430 \u0431\u043e\u043b\u044c\u0448\u0435, \u0447\u0435\u043c \u0443\u043c\u0435\u043d\u044c\u0448\u0435\u043d\u0438\u0435 \u0437\u0430\u043f\u0430\u0441\u043e\u0432 \u0436\u0435\u043b\u0435\u0437\u0430 \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0435 7.<\/li>\n
    • \u041f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0443\u0441\u043b\u043e\u0432\u0438\u044f: \u0441\u0438\u043d\u0442\u0435\u0437 \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d\u0430 \u043f\u043e\u0434\u0430\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0432 \u0445\u043e\u0434\u0435 \u0440\u0435\u0430\u043a\u0446\u0438\u0439 \u043e\u0441\u0442\u0440\u043e\u0439 \u0444\u0430\u0437\u044b7.<\/li>\n<\/ul>\n

      \u041f\u0440\u0438 \u043d\u0435\u043a\u0440\u043e\u0437\u0435 \u043f\u0435\u0447\u0435\u043d\u0438 \u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0440\u0438\u043d \u0432\u044b\u0441\u0432\u043e\u0431\u043e\u0436\u0434\u0430\u0435\u0442\u0441\u044f \u0438\u0437 \u0433\u0435\u043f\u0430\u0442\u043e\u0446\u0438\u0442\u043e\u0432 \u0432 \u043f\u043b\u0430\u0437\u043c\u0443 7.<\/p>\n

      \u0410\u043d\u0430\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u043e\u043c\u0435\u0445\u0438<\/strong><\/p>\n

      \u0412 \u043e\u0447\u0435\u043d\u044c \u0440\u0435\u0434\u043a\u0438\u0445 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u043d\u0430\u043b\u0438\u0447\u0438\u0435 \u0433\u0430\u043c\u0430\u043f\u0430\u0442\u0438\u0438, \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e IgM (\u043c\u0430\u043a\u0440\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u0435\u043c\u0438\u044f \u0412\u0430\u043b\u044c\u0434\u0435\u043d\u0441\u0442\u0440\u0435\u043c\u0430) \u043c\u043e\u0436\u0435\u0442 \u0432\u044b\u0437\u0432\u0430\u0442\u044c \u043e\u0448\u0438\u0431\u043e\u0447\u043d\u044b\u0435 \u0438\u0441\u0445\u043e\u0434\u044b6.<\/p>\n

      \u00a0<\/span>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

      1. Andrews N. Iron Deficiency and Related Disorders. In Wintrobe\u2019s Clinical Hematology. Lippincott, Williams & Wilkins, USA, 11 Ed., 2004, 980-1004.<\/span><\/div>\n
      2. Edwards C. Hemochromatosis. In Wintrobe\u2019s Clinical Hematology. Lippincott, Williams & Wilkins, USA, 11 Ed., 2004, 1036-1049.<\/span><\/div>\n
      3. Finley P, Grady H, Olsowka E et al. Chemistry. In Laboratory Test Handbook. David S. Jacobs, Wayne R. DeMott, Paul R. Finley et al., LEXI-COMP. Inc., USA, 3 Ed., 1994, 262-264.<\/span><\/div>\n
      4. Frances Fischbach. Blood Studies: Hematology and Coagulation. In A Manual of Laboratory and Diagnostic Tests. Lippincott, Williams & Wilkins, USA, 8 Ed., 2009, 121-123.<\/span><\/div>\n
      5. Jacques Wallach. Afec\u0163iuni hematologice. \u00cen Interpretarea testelor de diagnostic. Editura Stiin\u0163elor Medicale, Rom\u00e2nia, 7 ed., 2001; 475.<\/span><\/div>\n
      6. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n
      7. Lothar Thomas. Transferrin Saturation. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998, 275-277.<\/span><\/div>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[953,954],"product_tag":[],"class_list":{"0":"post-9295","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-de-biochimie","6":"product_cat-proteine-specifice-in-ser-si-urina","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9295"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9295"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9295"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9295"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}