{"id":9279,"date":"2020-04-23T04:33:29","date_gmt":"2020-04-23T01:33:29","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/osteocalcin\/"},"modified":"2025-07-01T07:57:40","modified_gmt":"2025-07-01T04:57:40","slug":"osteocalcin","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/osteocalcin\/","title":{"rendered":"\u041e\u0441\u0442\u0435\u043e\u043a\u0430\u043b\u044c\u0446\u0438\u043d"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/span><\/p>\n

Osteocalcinul (denumit \u015fi proteina G1a a osului) \u2013 principala protein\u0103 necolagenic\u0103 a \u0163esutului osos \u2013 este produs exclusiv de osteoblaste, de aceea este un marker relevant al procesului de formare osoas\u0103. Are o greutate molecular\u0103 de aproximativ 5800 daltoni \u015fi este alc\u0103tuit din 49 aminoacizi, ce includ trei resturi de acid gama-carboxiglutamic. Este specific osului \u015fi dentinei, iar sinteza sa implic\u0103 prezen\u0163a vitaminelor K \u015fi D3. O parte din osteocalcin este eliberat \u00een s\u00e2nge, iar restul (peste 80%) intr\u0103\u00a0\u00een componen\u0163a matricei osoase al\u0103turi de colagen2;<\/sup>4;6<\/sup>. Osteocalcinul are rol \u00een mineralizarea osoas\u0103 unde, datorit\u0103 afinit\u0103\u0163ii sale deosebite pentru calciu, ar putea constitui situsul depunerii cristalelor de hidroxiapatita8<\/sup>.<\/span><\/p>\n

In circula\u0163ie sunt prezente at\u00e2t osteocalcinul intact (49 aminoacizi) c\u00e2t \u015fi fragmentul mare N-MID (43 aminoacizi). Osteocalcinul intact este instabil datorit\u0103 clivajului proteazic \u00eentre aminoacizii 43 \u015fi 44,\u00a0\u00een timp ce fragmentul N-MID rezultat\u00a0\u00een urma clivajului este mult mai stabil5<\/sup>. Osteocalcinul este metabolizat \u00een principal\u00a0\u00een rinichi \u015fi mai pu\u0163in la nivel hepatic; are un timp de \u00eenjum\u0103t\u0103\u0163ire de aproximativ 5 minute8<\/sup>.\u00a0<\/span><\/p>\n

Nivelurile de osteocalcin sunt influen\u0163ate de v\u00e2rst\u0103 (perioada de cre\u015ftere rapid\u0103), sex (mai mari la b\u0103rba\u0163i) \u015fi cresc o dat\u0103 cu instalarea menopauzei2<\/sup>. <\/span>Valori crescute ale osteocalcinului se \u00eenregistreaz\u0103\u00a0\u00een afec\u0163iuni \u00eenso\u0163ite de cre\u015fterea turn-over-ului osos8<\/sup>.<\/span><\/p>\n

Recomand\u0103ri pentru determinarea osteocalcinului <\/em><\/strong><\/span><\/p>\n

\u2013 osteoporoza: monitorizarea terapiei antiresorbtive (tratament de substitu\u0163ie hormonal\u0103, bifosfona\u0163i, calcitonina, modulatori selectivi ai receptorilor de estrogeni) \u015fi estimarea riscului de fracturi; evaluarea altor afec\u0163iuni osoase (inclusiv procese maligne)1;6<\/sup>;7<\/sup>.<\/span><\/p>\n

Preg\u0103tire pacient <\/em><\/strong>\u2013 \u00e0 jeun5<\/sup>.<\/span><\/p>\n

Specimen recoltat <\/em><\/strong>\u2013 s\u00e2nge venos5<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/em><\/strong>\u2013 vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator5<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>\u2013 se separ\u0103 serul prin centrifugare5<\/sup>.<\/span><\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser5<\/sup>.<\/span><\/p>\n

Cauze de respingere a probei <\/em><\/strong>\u2013 specimen hemolizat5<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>\u2013 serul separat este stabil 8 ore<\/em> la temperatura camerei; 3 zile<\/em> la 2-8\u00b0C; 1 luna<\/em> la -20\u00b0C; se va evita decongelarea\/recongelarea5<\/sup>.<\/span><\/p>\n

Metod\u0103 <\/em><\/strong>- imunochimic\u0103 cu detec\u0163ie prin electrochemiluminiscen\u0163\u0103 (ECLIA);<\/span> testul folose\u015fte 2 anticorpi monoclonali indrepta\u0163i impotriva epitopilor de pe fragmentul N-MID \u015fi de pe fragmentul \u0163N-terminal; sunt detecta\u0163i astfel at\u00e2t fragmentul N-MID stabil c\u00e2t \u015fi osteocalcinul r\u0103mas intact; astfel, testul nu este dependent de fragmentul C-terminal (aminoacizii 43-49) al moleculei de osteocalcin, asigur\u00e2nd determin\u0103ri constante \u00een condi\u0163ii de rutin\u01035<\/sup>;7<\/sup>.<\/span><\/p>\n

Valori de referin\u0163\u0103<\/em><\/strong><\/span><\/p>\n

Femei: <\/span><\/p>\n

\u2013 premenopauz\u0103: 11-43 ng\/mL<\/span><\/div>\n
\u2013 postmenopauz\u0103 (f\u0103r\u0103 tratament hormonal de substitu\u0163ie): 15-46 ng\/mL<\/span><\/div>\n

B\u0103rba\u0163i:<\/span><\/p>\n

\u2013 18-30 ani: 24-70 ng\/mL<\/span><\/div>\n
\u2013 30-50 ani: 14-42 ng\/mL<\/span><\/div>\n
\u2013 >50 ani: 14-46 ng\/mL5<\/sup><\/span><\/div>\n

Limita de detec\u0163ie <\/em><\/strong>\u2013 0.5 ng\/mL5<\/sup>.<\/span><\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/span><\/p>\n\n\n\n\n\n\n
\n

Cre\u015fteri<\/em><\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u2022 hiperparatiroidism \u2022 acromegalie \u2022 fracturi (condi\u0163ii asociate cu un turnover osos crescut)2<\/sup>\u00a0<\/em><\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Sc\u0103deri<\/em><\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u2022 hipoparatiroidism \u2022 deficit de hormon de cre\u015ftere \u2022 medicamente (corticosteroizi, bifosfona\u0163i \u015fi calcitonina)2<\/sup><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Frecven\u0163a test\u0103rii la pacien\u0163ii sub tratament antiresorbtiv:<\/span><\/p>\n

\u2022 \u00eenainte de ini\u0163ierea tratamentului (concentra\u0163ia bazal\u0103)<\/span><\/div>\n
\u2022 la 3 luni (reducerea concentra\u0163iei cu minimum 20-40% indic\u0103 succes terapeutic)<\/span><\/div>\n
\u2022 continuarea monitoriz\u0103rii la fiecare 6-12 luni1<\/sup>;3;7<\/sup><\/span><\/div>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/p>\n

Repausul prelungit la pat determin\u0103 cre\u015fteri ale osteocalcinului2<\/sup>. <\/span>Func\u0163ia renal\u0103 influen\u0163eaz\u0103 concentra\u0163ia de osteocalcin; astfel nivelul seric de osteocalcin cre\u015fte la pacien\u0163ii cu afec\u0163iuni renale5<\/sup>.<\/span><\/p>\n

\u2022 Interferen\u0163e analitice<\/span><\/p>\n

Pot produce interferen\u0163e cu unele componente ale kit-ului \u015fi conduce la rezultate neconcludente urm\u0103toarele:<\/span><\/p>\n

\u2013 tratamentul cu biotin\u0103 \u00een doze mari (>5 mg\/zi); de aceea se recomand\u0103 ca recoltarea de s\u00e2nge s\u0103 se\u00a0<\/span>fac\u0103 dup\u0103 minimum 8 ore de la ultima administrare<\/span><\/div>\n
\u2013 titrurile foarte crescute de anticorpi anti-streptavidina \u015fi anti-ruteniu<\/span><\/div>\n
\u2013 anticorpii monoclonali proveni\u0163i de la \u015foarece administra\u0163i la unii pacien\u0163i \u00een scop diagnostic sau terapeutic5<\/sup><\/span><\/div>\n

\u00a0\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/span><\/strong><\/p>\n

1. Delmas PD, Eastell R, Garnero P, et.al. The use of biochemical markers of bone turnover in osteoporosis. In Osteoporosis Int. IOF Recommendations, 11 (Suppl 6):S2-S17, 2000. Ref Type: Journal (Full).<\/span><\/div>\n
2. Frances Fischbach. Chemistry Studies. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 Ed., 2009, 382-383.<\/span><\/div>\n
3. Hermien W. Goderie-Plomp, Marjolein van der Klift, Willem de Ronde, et.al. Endogenous Sex Hormones, Sex Hormone-Binding Globulin and the Risk of Incident Vertebral Fractures in Elderly Men and Women: The Rotterdam Study. In The Journal of Clinical Endocrinology & Metabolism, 8:3261-3269, 2004. Ref Type: Journal (Full).<\/span><\/div>\n
4. Johnell O, Kanis JA, Od\u00e9n A, et.al. Mortality after osteoporotic fractures. In Osteoporosis Int , 15:38-42, 2004. Ref Type: Journal (Full).<\/span><\/div>\n
5. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog.<\/span><\/div>\n
6. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Osteocalcin, Serum. www.labcorp.com. 2010. Ref Type: Internet Communication.<\/span><\/div>\n
7. Mayo Clinic. Mayo Medical Laboratories. Test Catalog: Osteocalcin, Serum. www.mayomedicallaboratories.com<\/a>. Ref Type: Internet Communication.<\/span><\/div>\n
8. Richard A. Mc.Pherson, Mattew R. Pincus. Biochemical markers of bone metabolism. In Henry\u00b4S.Clinical Diagnosis and Management By Laboratory Methods, Ed.Saunders, 2007, 181.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

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\u041f\u0440\u0430\u0432\u0438\u043b\u0430 \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438 \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e:<\/p>\n

    \n
  • \u0421\u0442\u0440\u043e\u0433\u043e \u043d\u0430\u0442\u043e\u0449\u0430\u043a \u043f\u043e\u0441\u043b\u0435 \u043d\u043e\u0447\u043d\u043e\u0433\u043e \u043f\u0435\u0440\u0438\u043e\u0434\u0430 \u0433\u043e\u043b\u043e\u0434\u0430\u043d\u0438\u044f \u043e\u0442 8 \u0434\u043e 14 \u0447\u0430\u0441\u043e\u0432.<\/li>\n<\/ul>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[927],"product_tag":[],"class_list":{"0":"post-9279","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-ososi","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9279","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9279"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9279"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9279"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9279"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}