{"id":9258,"date":"2020-04-23T03:32:53","date_gmt":"2020-04-23T00:32:53","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/insulina\/"},"modified":"2026-02-19T00:15:55","modified_gmt":"2026-02-18T22:15:55","slug":"insulina","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/insulina\/","title":{"rendered":"\u0418\u043d\u0441\u0443\u043b\u0438\u043d"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Insulina este un hormon polipeptidic produs de celulele \u03b2 ale insulelor Langerhans pancreatice. Molecula de insulin\u0103 este alc\u0103tuit\u0103 din 2 lan\u0163uri polipeptidice: lan\u0163ul \u03b1 cu 21 aminoacizi \u015fi lan\u0163ul \u03b2 cu 30 aminoacizi, unite prin dou\u0103 pun\u0163i disulfidice4<\/sup>. Insulina \u015fi peptidul C sunt produse de pancreas ca rezultat al cliv\u0103rii proteolitice a proinsulinei3;6<\/sup>.<\/p>\n

Reglarea secre\u0163iei de insulin\u0103 se face predominant prin nivelul glicemiei. Secre\u0163ia de insulin\u0103 este stimulat\u0103 de hiperglicemie, unii aminoacizi, hormoni ca glucagonul, gastrina, secretina, colecistokinina3;5;6<\/sup>. Secre\u0163ia insulinic\u0103 este inhibat\u0103 de hipoglicemie, somatostatina, adrenalina \u015fi noradrenalina3;5<\/sup>.<\/p>\n

Ac\u0163iunea insulinei este mediat\u0103 de receptori specifici \u015fi const\u0103 \u00een principal din facilitarea asimil\u0103rii glucozei la nivelul celulelor hepatice, adipoase \u015fi musculare; aceasta constituie baza ac\u0163iunii hipoglicemiante3;4;6<\/sup>.<\/p>\n

Prin activarea at\u00e2t a proceselor de stocare a glucozei sub form\u0103 de glicogen, c\u00e2t \u015fi a sintezei lipidelor \u015fi proteinelor pe seama glucidelor alimentare, precum \u015fi prin inhibarea proceselor de gluconeogenez\u0103 hepatic\u0103, insulina de\u0163ine al\u0103turi de al\u0163i hormoni anabolizan\u0163i un important rol fiziologic \u00een cre\u015fterea rezervelor energetice ale organismului3<\/sup>.<\/p>\n

Reglarea secre\u0163iei de insulin\u0103 se realizeaz\u0103 \u015fi printr-un mecanism neuro-reflex, cu participarea centrilor glicoreglatori hipotalamici \u015fi a nervilor insulinosecretori vago-simpatici3<\/sup>.<\/p>\n

Mecanismul de ac\u0163iune al insulinei asupra celor 3 metabolisme este complex \u015fi diferit de la un \u0163esut la altul. Captarea \u015fi stocarea glucozei \u00een ficat presupune inhibarea glicogenfosforilazei \u015fi activarea fosfofructokinazei \u015fi glicogensintetazei de c\u0103tre insulin\u0103. La nivel muscular \u015fi adipos, insulina faciliteaz\u0103 transportul glucozei cu ajutorul unei proteine transportoare prin mecanismul difuziunii active3<\/sup>. Insulina se combin\u0103 cu o protein\u0103-receptor care activeaz\u0103 sistemul de transport membranar \u015fi echipamentul enzimatic necesar degrad\u0103rii glucozei la nivel celular. Acest receptor insulinic este o protein\u0103 format\u0103 din dou\u0103 subunit\u0103\u0163i glicoproteice \u03b1 \u015fi alte dou\u0103 subunit\u0103\u0163i \u03b2 unite prin pun\u0163i disulfidice. Subunit\u0103\u0163ile \u03b1 sunt extracelulare, iar cele \u03b2 sunt transmembranare, cu activitate tirozinkinazic\u01033;6<\/sup>. Creierul este singurul \u0163esut\u00a0permeabil la glucoz\u0103 f\u0103r\u0103 participarea insulinei, de aceea sc\u0103derea glucozei \u00een s\u00e2nge la valori sub 50 mg\/dL provoac\u0103 ame\u0163eli, convulsii, eventual com\u0103 hipoglicemic\u01033<\/sup>.<\/p>\n

Un dezechilibru\u00a0\u00een metabolismul insulinic duce la influen\u0163area masiv\u0103 a unui num\u0103r semnificativ de procese metabolice. O concentra\u0163ie prea sc\u0103zuta de insulin\u0103 liber\u0103, biologic activ\u0103, poate duce la dezvoltarea diabetului zaharat. Posibile cauze ale acestuia includ:<\/p>\n

\u2022 distrugerea celulelor beta (diabetul de tip I)<\/div>\n
\u2022 reducerea efectului insulinei sau a sintezei pancreatice (diabetul de tip II)<\/div>\n
\u2022 existen\u0163a anticorpilor circulan\u0163i antiinsulinici<\/div>\n
\u2022 eliberarea \u00eent\u00e2rziat\u0103 a insulinei sau<\/div>\n
\u2022 absen\u0163a receptorilor celulari insulinici (sau receptori inadecva\u0163i)<\/div>\n

Pe de alt\u0103 parte, secre\u0163ia insulinic\u0103 autonom\u0103 neregulat\u0103 este \u00een general cauza hipoglicemiei. Aceast\u0103 condi\u0163ie este dat\u0103 de inhibarea gluconeogenezei, de exemplu ca rezultat al unei insuficien\u0163e renale sau hepatice, adenoamelor sau carcinoamelor de celule insulare. Exist\u0103 \u015fi situa\u0163ii \u00een care hipoglicemia poate fi provocat\u0103, deliberat (scop diagnostic sau terapeutic) sau accidental (supradozare insulin\u0103, hipoalimenta\u0163ie).<\/p>\n

Determinarea insulinei poate fi efectuat\u0103 \u00een asociere cu testul de toleran\u0163\u0103 la glucoz\u0103 sau cu glicemia bazal\u0103 (\u00e0 jeun)3;5;6<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea insulinei <\/em><\/strong>\u2013 evaluarea pacien\u0163ilor cu hipoglicemii \u00e0 jeun5;6<\/sup>.<\/p>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>\u00e0 jeun (pe nem\u00e2ncate) \u2013 minim 7 ore4<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c4<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator4<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul proasp\u0103t; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C sau la -20\u00b0C4<\/sup>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser4<\/sup>.<\/p>\n

Cauze de respingere<\/em><\/strong> a probei <\/em><\/strong>\u2013 specimen intens hemolizat4<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>serul separat este stabil 7 zile<\/em> la 2-8\u00b0C; 3 luni<\/em> la -20\u00b0C; nu decongela\u0163i\/recongela\u0163i4<\/sup>.<\/p>\n

Metod\u0103 <\/em><\/strong>- imunochimic\u0103 cu detec\u0163ie prin electrochemiluminiscen\u0163\u0103 (ECLIA)<\/span>4<\/sup>.<\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>- <\/em>2.6-24.9 \u00b5U\/mL4<\/sup>.<\/p>\n

Factor de conversie: \u00b5U\/mL= pmol\/L x 0.146; pmol\/L = \u00b5U\/mL x 6.84.<\/em><\/p>\n

Limita de detec\u0163ie<\/em><\/strong> - <\/em>0.20 \u03bcU\/mL (1.39 pmol\/L)4<\/sup>.\u00a0<\/em><\/p>\n

Valori de alert\u0103 clinic\u0103 <\/em><\/strong>\u2013 > 35 \u00b5U\/mL1<\/sup>.<\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/p>\n

Hipoglicemia \u00e0 jeun (< 45 mg\/dL) \u00een asociere cu niveluri crescute de insulin\u0103 este sugestiv\u0103 pentru diagnosticul de insulinom. Pentru cre\u015fterea sensibilit\u0103\u0163ii testului\u00a0\u00een depistarea tumorilor pancreatice secretante de insulin\u0103, glucoz\u0103 \u015fi insulin\u0103 se pot doza dup\u0103 o pauz\u0103 alimentar\u0103 mai mare (maximum 72 ore \u2013 perioada\u00a0\u00een care pacientul\u00a0 consum\u0103 doar lichide, f\u0103r\u0103 calorii sau cafein\u0103). Testul se efectueaz\u0103 numai\u00a0\u00een condi\u0163ii de spitalizare \u015fi este util pentru excluderea cazurilor de hipoglicemie reactiv\u01035<\/sup>.<\/p>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

Determinarea insulinei nu prezint\u0103 utilitate clinic\u0103 \u00een diagnosticul diabetului zaharat.<\/div>\n
In trimestrele II \u015fi III de sarcin\u0103 exist\u0103 o rezisten\u0163\u0103 relativ\u0103 la insulin\u0103, cu o cre\u015ftere a nivelului insulinei \u015fi hipoglicemie progresiv\u01035<\/sup>.<\/div>\n
La indivizii obezi nivelurile de insulin\u0103 \u00e0 jeun sunt mai mari dec\u00e2t la adul\u0163ii cu greutate normal\u0103.<\/div>\n

Hipoglicemia provocat\u0103 prin administrarea de insulin\u0103 poate mima un insulinom. \u00cen astfel de situa\u0163ii este util\u0103 dozarea peptidului C. Peptidul C rezult\u0103 prin clivarea proinsulinei \u00een celulele beta \u015fi nu se reg\u0103se\u015fte\u00a0\u00een insulina farmaceutic\u0103. Prin urmare,\u00a0\u00een cazurile de hipoglicemie provocat\u0103 se \u00eent\u00e2lnesc niveluri crescute de insulin\u0103 \u00eenso\u0163ite de niveluri sc\u0103zute de peptid C,\u00a0\u00een timp ce\u00a0\u00een insulinom se ob\u0163in valori crescute at\u00e2t pentru insulin\u0103 c\u00e2t \u015fi pentru peptidul C5<\/sup>.<\/p>\n

\u2022 Medicamente<\/p>\n

Cre\u015fteri<\/span>:<\/strong> acetohexamida, albuterol, aminoacizi, aspirina, beclometazona,\u00a0 clorpropamida, ciproheptadin (la persoane care nu au diabet), contraceptive orale, danazol, glipizid, gliburid, gluconat de calciu (la nou n\u0103scu\u0163i), hidroclorotiazida, hormon de cre\u015ftere, insulina, interferon alfa-2a, levodopa, lisinopril, medroxiprogesteron, niacina (doze mari), prednisolon, secretina (i.v.), spironolactona, streptozocin, sucroza, terbutalina, tolazamida, tolbutamida, verapamil2<\/sup>.<\/p>\n

Sc\u0103deri<\/strong><\/span>: blocan\u0163i betaadrenergici (ex.: propranolol), calcitonina, clorpropamida (c\u00e2nd nivelul ini\u0163ial este \u00eenalt), cimetidina, clofibrat, diazoxid, doxazosin, fenformin, fenobarbital, fenitoin, furosemid, metformin, nifedipin, tiazide, tolbutamida (la unii pacien\u0163i)2<\/sup>.<\/p>\n

\u2022 Interferen\u0163e analitice<\/p>\n

Pot produce interferen\u0163e cu unele componente ale kit-ului \u015fi conduce la rezultate neconcludente urm\u0103toarele:<\/p>\n

\u2013 tratamentul cu biotin\u0103 \u00een doze mari (>5 mg\/zi); de aceea se recomand\u0103 ca recoltarea de s\u00e2nge s\u0103 se fac\u0103 dup\u0103 minimum 8 ore de la ultima administrare;<\/div>\n
\u2013 titrurile foarte crescute de anticorpi anti-streptavidina \u015fi anti-ruteniu4<\/sup>.<\/div>\n

\u00a0<\/span>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/p>\n

1. Frances Fischbach. Chemistry Studies. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 Ed., 2009, 345-347.<\/span><\/div>\n
2. Frances Fischbach. Effects of the Most Commonly Used Drugs on Frequently Ordered Laboratory Tests. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 Ed., 2009, 1243-1244.<\/span><\/div>\n
3. Ion Haulica. Insulina. \u00cen Fiziologie uman\u0103. Editura Medical\u0103, Rom\u00e2nia, Ed. 2, 2002, 813-818.<\/span><\/div>\n
4. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog.<\/span><\/div>\n
5. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Insulin. www.labcorp.com 2010. <\/span>Ref Type: Internet Communication.<\/span><\/div>\n
6. Lothar Thomas. Insulin, C-peptide, proinsulin. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998, 153-154.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u041e\u0441\u043d\u043e\u0432\u043d\u043e\u0439 \u0443\u0447\u0430\u0441\u0442\u043d\u0438\u043a \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0440\u0435\u0430\u043a\u0446\u0438\u0438 \u043d\u0435\u043c\u0435\u0434\u043b\u0435\u043d\u043d\u043e\u0433\u043e \u0442\u0438\u043f\u0430 (1-\u0433\u043e \u0442\u0438\u043f\u0430) \u2013 \u0438\u043c\u043c\u0443\u043d\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d \u043a\u043b\u0430\u0441\u0441\u0430 \u0415 (IgE). \u0414\u043b\u044f \u043a\u0430\u0436\u0434\u043e\u0433\u043e \u0430\u043b\u043b\u0435\u0440\u0433\u0435\u043d\u0430 \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0443\u0435\u0442 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0438\u043c\u043c\u0443\u043d\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d \u0415.\u00a0 \u0426\u0435\u043b\u044c\u044e \u0434\u0430\u043d\u043d\u043e\u0433\u043e \u0442\u0435\u0441\u0442\u0430 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0440\u0435\u0430\u043a\u0446\u0438\u0438 \u043a \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0443 \u0447\u0435\u043b\u043e\u0432\u0435\u0447\u0435\u0441\u043a\u043e\u043c\u0443.<\/p>\n

\u0418\u043d\u0441\u0443\u043b\u0438\u043d \u2013 \u044d\u0442\u043e \u0431\u0435\u043b\u043a\u043e\u0432\u044b\u0439 \u0433\u043e\u0440\u043c\u043e\u043d, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0443\u0435\u0442 \u043e\u0431\u043c\u0435\u043d \u0443\u0433\u043b\u0435\u0432\u043e\u0434\u043e\u0432 \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0435, \u043e\u043d \u0432\u044b\u0440\u0430\u0431\u0430\u0442\u044b\u0432\u0430\u0435\u0442\u0441\u044f \u043a\u043b\u0435\u0442\u043a\u0430\u043c\u0438 \u043f\u043e\u0434\u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b. \u041f\u0440\u0438 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0438 \u0442\u0430\u043a\u043e\u0433\u043e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u043a\u0430\u043a \u0441\u0430\u0445\u0430\u0440\u043d\u044b\u0439 \u0434\u0438\u0430\u0431\u0435\u0442, \u0432\u0441\u0435 \u043a\u043b\u0435\u0442\u043a\u0438, \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u044b\u0435 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u044c \u0438\u043d\u0441\u0443\u043b\u0438\u043d, \u043f\u043e\u0433\u0438\u0431\u0430\u044e\u0442. \u042d\u0442\u043e \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0443 \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0435 \u0438 \u043d\u0435\u043a\u043e\u043d\u0442\u0440\u043e\u043b\u0438\u0440\u0443\u0435\u043c\u043e\u043c\u0443 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u044e \u0443\u0440\u043e\u0432\u043d\u044f \u0441\u0430\u0445\u0430\u0440\u0430 \u0432 \u043a\u0440\u043e\u0432\u0438. \u0412\u0432\u0435\u0434\u0435\u043d\u0438\u0435 \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0430 \u0438\u0437\u0432\u043d\u0435 \u043d\u0430 \u0441\u0435\u0433\u043e\u0434\u043d\u044f\u0448\u043d\u0438\u0439 \u0434\u0435\u043d\u044c \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0435\u0434\u0438\u043d\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c \u043c\u0435\u0442\u043e\u0434\u043e\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0434\u0430\u043d\u043d\u043e\u0433\u043e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f.<\/p>\n

\u0418\u0441\u0442\u043e\u0440\u0438\u0447\u0435\u0441\u043a\u0438 \u043f\u0435\u0440\u0432\u044b\u0435 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u044b \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0430 \u0434\u043b\u044f \u0437\u0430\u043c\u0435\u0441\u0442\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0441\u0430\u0445\u0430\u0440\u043d\u043e\u0433\u043e \u0434\u0438\u0430\u0431\u0435\u0442\u0430 \u043f\u043e\u043b\u0443\u0447\u0430\u043b\u0438 \u0438\u0437 \u044d\u043a\u0441\u0442\u0440\u0430\u043a\u0442\u043e\u0432 \u043f\u043e\u0434\u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u044b\u0445 \u0436\u0435\u043b\u0435\u0437 \u043a\u0440\u0443\u043f\u043d\u043e\u0433\u043e \u0440\u043e\u0433\u0430\u0442\u043e\u0433\u043e \u0441\u043a\u043e\u0442\u0430 \u0438 \u0441\u0432\u0438\u043d\u0435\u0439. \u041d\u043e \u0442\u0430\u043a \u043a\u0430\u043a \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u044b \u0436\u0438\u0432\u043e\u0442\u043d\u043e\u0433\u043e \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u044f \u043e\u0442\u043b\u0438\u0447\u0430\u043b\u0438\u0441\u044c \u043e\u0442 \u0447\u0435\u043b\u043e\u0432\u0435\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u043e \u0441\u043e\u0441\u0442\u0430\u0432\u0443 \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442, \u0430 \u0442\u0430\u043a\u0436\u0435 \u043f\u0440\u0438 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0439 \u043e\u0447\u0438\u0441\u0442\u043a\u0435 \u0441\u043e\u0434\u0435\u0440\u0436\u0430\u043b\u0438 \u043f\u0440\u0438\u043c\u0435\u0441\u0438, \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u044b\u0435 \u0432\u044b\u0437\u044b\u0432\u0430\u0442\u044c, \u0432 \u0442\u043e\u043c \u0447\u0438\u0441\u043b\u0435, \u0438 \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u0430\u043a\u0446\u0438\u0438, \u043e\u0442 \u0438\u0445 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u043f\u043e\u0441\u0442\u0435\u043f\u0435\u043d\u043d\u043e \u043e\u0442\u043a\u0430\u0437\u044b\u0432\u0430\u044e\u0442\u0441\u044f. \u0420\u0430\u0437\u0432\u0438\u0442\u0438\u0435 \u0433\u0435\u043d\u043d\u043e-\u0438\u043d\u0436\u0435\u043d\u0435\u0440\u043d\u044b\u0445 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0439 \u043f\u043e\u0437\u0432\u043e\u043b\u0438\u043b\u043e \u0438\u0441\u043a\u0443\u0441\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u0441\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442, \u043f\u043e\u043b\u043d\u043e\u0441\u0442\u044c\u044e \u0441\u043e\u043e\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0443\u044e\u0449\u0438\u0439 \u043f\u043e \u0441\u043e\u0441\u0442\u0430\u0432\u0443 \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442 \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0443 \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430.<\/p>\n

\u041e\u0434\u043d\u0430\u043a\u043e \u0438 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u0435 \u0433\u0435\u043d\u043d\u043e-\u0438\u043d\u0436\u0435\u043d\u0435\u0440\u043d\u043e\u0433\u043e \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0430 \u043f\u043e\u043b\u043d\u043e\u0441\u0442\u044c\u044e \u043d\u0435 \u0438\u0441\u043a\u043b\u044e\u0447\u0430\u0435\u0442 \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0440\u0435\u0430\u043a\u0446\u0438\u0439, \u0445\u043e\u0442\u044f \u043e\u043d\u0438 \u0438 \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u0435\u0442\u0441\u044f \u043d\u0430\u043c\u043d\u043e\u0433\u043e \u0440\u0435\u0436\u0435, \u0447\u0435\u043c \u043d\u0430 \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u044b \u0436\u0438\u0432\u043e\u0442\u043d\u043e\u0433\u043e \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u044f (\u043f\u043e \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u043c \u0434\u0430\u043d\u043d\u044b\u043c, \u043c\u0435\u043d\u0435\u0435 \u0447\u0435\u043c \u0443 1 % \u043d\u0430\u0447\u0430\u0432\u0448\u0438\u0445 \u0442\u0435\u0440\u0430\u043f\u0438\u044e \u0440\u0435\u043a\u043e\u043c\u0431\u0438\u043d\u0430\u043d\u0442\u043d\u044b\u043c \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u043c \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0435\u0442\u0441\u044f \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435 \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0440\u0435\u0430\u043a\u0446\u0438\u0439).<\/p>\n

\u041a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0435 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0445 IgE-\u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u043e\u0446\u0435\u043d\u0438\u0442\u044c \u0432\u0437\u0430\u0438\u043c\u043e\u0441\u0432\u044f\u0437\u044c \u043c\u0435\u0436\u0434\u0443 \u0443\u0440\u043e\u0432\u043d\u0435\u043c \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u044f\u043c\u0438 \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u0438. \u041d\u0438\u0437\u043a\u0438\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u044d\u0442\u043e\u0433\u043e \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044f \u0443\u043a\u0430\u0437\u044b\u0432\u0430\u044e\u0442 \u043d\u0430 \u043d\u0438\u0437\u043a\u0443\u044e \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e\u0441\u0442\u044c \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u0432 \u0442\u043e \u0432\u0440\u0435\u043c\u044f \u043a\u0430\u043a \u0432\u044b\u0441\u043e\u043a\u0438\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0438\u043c\u0435\u0435\u0442 \u0432\u044b\u0441\u043e\u043a\u0443\u044e \u043a\u043e\u0440\u0440\u0435\u043b\u044f\u0446\u0438\u044e \u0441 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u044f\u043c\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f. \u041f\u0440\u0438 \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u0438 \u0432\u044b\u0441\u043e\u043a\u0438\u0445 \u0443\u0440\u043e\u0432\u043d\u0435\u0439 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0445 IgE \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e \u043f\u0440\u0435\u0434\u0441\u043a\u0430\u0437\u0430\u0442\u044c \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435 \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u0438 \u0432 \u0431\u0443\u0434\u0443\u0449\u0435\u043c \u0438 \u0431\u043e\u043b\u0435\u0435 \u044f\u0440\u043a\u043e\u0435 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u0435 \u0435\u0435 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u0432. \u041e\u0434\u043d\u0430\u043a\u043e \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f IgE \u0432 \u043a\u0440\u043e\u0432\u0438 \u043d\u0435\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u0430. \u041e\u043d\u0430 \u043c\u0435\u043d\u044f\u0435\u0442\u0441\u044f \u0441 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435\u043c \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u0441 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e\u043c \u043f\u043e\u043b\u0443\u0447\u0430\u0435\u043c\u043e\u0439 \u0434\u043e\u0437\u044b \u0430\u043b\u043b\u0435\u0440\u0433\u0435\u043d\u043e\u0432, \u0430 \u0442\u0430\u043a\u0436\u0435 \u043d\u0430 \u0444\u043e\u043d\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u044f. \u0420\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0443\u0435\u0442\u0441\u044f \u043f\u043e\u0432\u0442\u043e\u0440\u0438\u0442\u044c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u043f\u0440\u0438 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0438 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u0432 \u0438 \u043f\u0440\u0438 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u0435 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u043c\u043e\u0433\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044f. \u041e \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e\u0441\u0442\u0438 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u043e\u0433\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043d\u0443\u0436\u043d\u043e \u043a\u043e\u043d\u0441\u0443\u043b\u044c\u0442\u0438\u0440\u043e\u0432\u0430\u0442\u044c\u0441\u044f \u0441 \u043b\u0435\u0447\u0430\u0449\u0438\u043c \u0432\u0440\u0430\u0447\u043e\u043c.<\/p>\n

\u0414\u043b\u044f \u0447\u0435\u0433\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n

\u0414\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0433\u0438\u043f\u0435\u0440\u0441\u0435\u043d\u0441\u0438\u0431\u0438\u043b\u0438\u0437\u0430\u0446\u0438\u0438 \u043a \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430\u043c \u0440\u0435\u043a\u043e\u043c\u0431\u0438\u043d\u0430\u043d\u0442\u043d\u043e\u0433\u043e \u0447\u0435\u043b\u043e\u0432\u0435\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0430.<\/p>\n

\u041a\u043e\u0433\u0434\u0430 \u043d\u0430\u0437\u043d\u0430\u0447\u0430\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n

\u041f\u0440\u0438 \u043d\u0430\u043b\u0438\u0447\u0438\u0438 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u0432 \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u0438, \u043f\u0440\u0435\u0434\u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u043e, \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u044b\u0445 \u0441 \u0442\u0435\u0440\u0430\u043f\u0438\u0435\u0439 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u043c \u0447\u0435\u043b\u043e\u0432\u0435\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0430.<\/p>\n

\u0427\u0442\u043e \u043e\u0437\u043d\u0430\u0447\u0430\u044e\u0442 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b?<\/strong><\/p>\n

\u0420\u0435\u0444\u0435\u0440\u0435\u043d\u0441\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f: < 0,35 \u043a\u0415\u0434\/\u043b.<\/p>\n

0 \u043a\u043b\u0430\u0441\u0441<\/strong> \u2013 0,1\u20130,34 \u043a\u0415\u0434\/\u043b (\u043e\u0447\u0435\u043d\u044c \u043d\u0438\u0437\u043a\u0438\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c);<\/p>\n

1-\u0439 \u043a\u043b\u0430\u0441\u0441<\/strong> \u2013 0,35\u20130,69 \u043a\u0415\u0434\/\u043b (\u043d\u0438\u0437\u043a\u0438\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c);<\/p>\n

2-\u0439 \u043a\u043b\u0430\u0441\u0441 \u2013 0,7\u20133,49 \u043a\u0415\u0434\/\u043b (\u0443\u043c\u0435\u0440\u0435\u043d\u043d\u044b\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c);<\/p>\n

3-\u0439 \u043a\u043b\u0430\u0441\u0441<\/strong> \u2013 3,5\u201317,49 \u043a\u0415\u0434\/\u043b (\u0432\u044b\u0441\u043e\u043a\u0438\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c);<\/p>\n

4-\u0439 \u043a\u043b\u0430\u0441\u0441<\/strong> \u2013 17,5\u201352,49 \u043a\u0415\u0434\/\u043b (\u043e\u0447\u0435\u043d\u044c \u0432\u044b\u0441\u043e\u043a\u0438\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c);<\/p>\n

5-\u0439 \u043a\u043b\u0430\u0441\u0441<\/strong> \u2013 52,5\u201399,99 \u043a\u0415\u0434\/\u043b (\u043e\u0447\u0435\u043d\u044c \u0432\u044b\u0441\u043e\u043a\u0438\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c);<\/p>\n

6-\u0439 \u043a\u043b\u0430\u0441\u0441<\/strong> \u2013 \u0431\u043e\u043b\u0435\u0435 99,99 \u043a\u0415\u0434\/\u043b (\u043e\u0447\u0435\u043d\u044c \u0432\u044b\u0441\u043e\u043a\u0438\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c).<\/p>\n

\u041f\u0440\u0438\u0447\u0438\u043d\u044b \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u043e\u0433\u043e \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0430:<\/strong><\/p>\n

\u0441\u0435\u043d\u0441\u0438\u0431\u0438\u043b\u0438\u0437\u0430\u0446\u0438\u044f \u043a \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0443 \u0447\u0435\u043b\u043e\u0432\u0435\u0447\u0435\u0441\u043a\u043e\u043c\u0443.<\/p>\n

\u041f\u0440\u0438\u0447\u0438\u043d\u044b \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0438\u043b\u0438 \u043f\u043e\u043d\u0438\u0436\u0435\u043d\u043d\u043e\u0433\u043e \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0430:<\/strong><\/p>\n

\u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435 \u0441\u0435\u043d\u0441\u0438\u0431\u0438\u043b\u0438\u0437\u0430\u0446\u0438\u0438 \u043a \u0434\u0430\u043d\u043d\u043e\u043c\u0443 \u0430\u043b\u043b\u0435\u0440\u0433\u0435\u043d\u0443;
\n\u0434\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u043e\u0433\u0440\u0430\u043d\u0438\u0447\u0435\u043d\u0438\u0435 \u0438\u043b\u0438 \u0438\u0441\u043a\u043b\u044e\u0447\u0435\u043d\u0438\u0435 \u043a\u043e\u043d\u0442\u0430\u043a\u0442\u0430 \u0441 \u0430\u043b\u043b\u0435\u0440\u0433\u0435\u043d\u043e\u043c.<\/p>\n

\u0412\u0430\u0436\u043d\u044b\u0435 \u0437\u0430\u043c\u0435\u0447\u0430\u043d\u0438\u044f<\/strong><\/p>\n

\u0422\u0430\u043a \u043a\u0430\u043a \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044b \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u0432 \u0440\u0430\u0437\u043d\u043e\u0433\u043e \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u044f \u0438\u043c\u0435\u044e\u0442 \u0432 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u043e\u0439 \u043c\u0435\u0440\u0435 \u0441\u0445\u043e\u0436\u0443\u044e \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442\u043d\u0443\u044e \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u0443, \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0436\u0438\u0432\u043e\u0442\u043d\u044b\u043c \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0430\u043c \u043c\u043e\u0433\u0443\u0442 \u043f\u0435\u0440\u0435\u043a\u0440\u0435\u0441\u0442\u043d\u043e \u0440\u0435\u0430\u0433\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u0438 \u0441 \u0447\u0435\u043b\u043e\u0432\u0435\u0447\u0435\u0441\u043a\u0438\u043c \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u043c (\u043f\u0435\u0440\u0435\u043a\u0440\u0435\u0441\u0442\u043d\u0430\u044f \u0440\u0435\u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c).<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[912,911],"product_tag":[],"class_list":{"0":"post-9258","1":"product","2":"type-product","3":"status-publish","5":"product_cat-hormoni-de-glicoreglare","6":"product_cat-markeri-endocrini","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9258"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9258"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9258"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9258"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}