{"id":9256,"date":"2020-04-23T04:32:49","date_gmt":"2020-04-23T01:32:49","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/igf-i-somatomedin-c\/"},"modified":"2025-07-01T07:57:23","modified_gmt":"2025-07-01T04:57:23","slug":"igf-i-somatomedin-c","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/igf-i-somatomedin-c\/","title":{"rendered":"IGF-I (\u0421\u043e\u043c\u0430\u0442\u043e\u043c\u0435\u0434\u0438\u043d-\u0421)"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/i><\/b><\/p>\n

Insulin-like growth factor I (IGF-I) este un hormon polipeptidic, cu structur\u0103 similar\u0103 proinsulinei \u015fi insulinei \u015fi, de asemenea, provoc\u00e2nd efecte insulin-like; este sintetizat predominant \u00een ficat, dar \u015fi \u00een alte \u0163esuturi, sub influen\u0163a hormonului de cre\u015ftere (hGH). Acest factor mediaz\u0103 ac\u0163iunile metabolice \u015fi mitogene ale hormonului de cre\u015ftere. Deoarece IGF-I este un mediator al ac\u0163iunilor hGH este denumit \u015fi somatomedin.<\/p>\n

Concentra\u0163ia plasmatic\u0103 a IGF-I depinde \u00een mod direct de secre\u0163ia hGH \u015fi este un parametru important \u00een evaluarea clinic\u0103 a tulbur\u0103rilor legate de\u00a0 hormonul de cre\u015ftere.<\/p>\n

IGF-I este un bun test screening pentru evaluarea tulbur\u0103rilor de cre\u015ftere la copii. Este mai sensibil \u015fi mai specific dec\u00e2t determinarea hGH, deoarece nu prezint\u0103 varia\u0163ii diurne semnificative.<\/p>\n

Nivelurile serice de IGF-I sunt sc\u0103zute at\u00e2t \u00een deficien\u0163a primar\u0103 de hGH c\u00e2t \u015fi \u00een cazul sindroamelor de rezisten\u0163\u0103 periferic\u0103, par\u0163ial\u0103 sau total\u0103, la ac\u0163iunile hormonului de cre\u015ftere. Nanismul Laron, care are la baz\u0103 un defect calitativ \u015fi cantitativ al receptorului pentru hGH, se caracterizeaz\u0103 prin rezisten\u0163a total\u0103 la ac\u0163iunile hormonului de cre\u015ftere. Aceast\u0103 condi\u0163ie clinic\u0103 este asociat\u0103 cu un nivel bazal crescut al hormonului de cre\u015ftere, \u00eens\u0103 cu o concentra\u0163ie foarte sc\u0103zut\u0103 de IGF-I.<\/p>\n

Testul poate fi utilizat \u015fi \u00een monitorizarea r\u0103spunsului pe termen scurt sau lung la tratamentul cu hormon de cre\u015ftere.<\/p>\n

Nivelurile de IGF-I sunt crescute \u00een acromegalie \u015fi testul poate fi utilizat at\u00e2t \u00een scop diagnostic, c\u00e2t \u015fi pentru a monitoriza tratamentul4;5<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea IGF-I <\/i><\/b>\u2013 diagnosticul acromegaliei (at\u00e2t IGF-I c\u00e2t \u015fi hGH sunt crescute); evaluarea hipopituitarismului \u015fi a leziunilor hipotalamice la copii; monitorizarea terapiei \u00een deprivarea de hran\u01031<\/sup>.<\/p>\n

Preg\u0103tire pacient <\/i><\/b>- <\/b><\/i>\u00e0 jeun (pe nem\u00e2ncate)3<\/sup>.<\/p>\n

Specimen recoltat <\/i><\/b>- <\/i>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c3<\/sup>.<\/p>\n

Recipient de recoltare <\/i><\/b>- <\/i>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator3<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/i><\/b>- <\/b><\/i>se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul imediat; dac\u0103 acest lucru nu este posibil, serul se congeleaz\u01033<\/sup>.<\/p>\n

Volum prob\u0103<\/i><\/b> \u2013 minim 0.5 mL ser3<\/sup>.<\/p>\n

Cauze de respingere<\/i><\/b> a probei<\/i><\/b> \u2013 specimen intens hemolizat3<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/i><\/b>- <\/b>1 lun\u0103<\/i> la -20\u00b0C; nu decongela\u0163i\/recongela\u0163i3<\/sup>.<\/p>\n

Metod\u0103 <\/i><\/b>- imunochimic\u0103 cu detec\u0163ie prin chemiluminiscen\u0163\u0103 (CLIA)<\/span>3<\/sup><\/span>.<\/p>\n

Valori de referin\u0163\u0103<\/i><\/b> - <\/i>sunt dependente de v\u00e2rst\u0103 \u015fi de sex3<\/sup>;6<\/sup>:<\/p>\n

Sex feminin<\/span><\/b>\u00a0<\/i><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

V\u00e2rsta<\/i><\/p>\n<\/td>\n

\n

Valori ( ng\/mL)<\/i><\/p>\n<\/td>\n

\n

V\u00e2rsta<\/i><\/p>\n<\/td>\n

\n

Valori ( ng\/mL)<\/i><\/p>\n<\/td>\n<\/tr>\n

<1 ani<\/td>\n8-131<\/b><\/td>\n47-48 ani<\/td>\n62-243<\/b><\/td>\n<\/tr>\n
1-2 ani<\/td>\n9-146<\/b><\/td>\n48-49 ani<\/td>\n60-240<\/b><\/td>\n<\/tr>\n
2-3 ani<\/td>\n11-165<\/b><\/td>\n49-50 ani<\/td>\n59-238<\/b><\/td>\n<\/tr>\n
3-4 ani<\/td>\n13-187<\/b><\/td>\n50-51 ani<\/td>\n57-236<\/b><\/td>\n<\/tr>\n
4-5 ani<\/td>\n15-216<\/b><\/td>\n51-52 ani<\/td>\n55-235<\/b><\/td>\n<\/tr>\n
5-6 ani<\/td>\n19-251<\/b><\/td>\n52-53 ani<\/td>\n53-234<\/b><\/td>\n<\/tr>\n
6-7 ani<\/td>\n24-293<\/b><\/td>\n53-54 ani<\/td>\n52-233<\/b><\/td>\n<\/tr>\n
7-8 ani<\/td>\n30-342<\/b><\/td>\n54-55 ani<\/td>\n51-233<\/b><\/td>\n<\/tr>\n
8-9 ani<\/td>\n39-396<\/b><\/td>\n55-56 ani<\/td>\n49-234<\/b><\/td>\n<\/tr>\n
9-10 ani<\/td>\n49-451<\/b><\/td>\n56-57 ani<\/td>\n48-235<\/b><\/td>\n<\/tr>\n
10-11 ani<\/td>\n62-504<\/b><\/td>\n57-58 ani<\/td>\n47-236<\/b><\/td>\n<\/tr>\n
11-12 ani<\/td>\n76-549<\/b><\/td>\n58-59 ani<\/td>\n46-238<\/b><\/td>\n<\/tr>\n
12-13 ani<\/td>\n90-581<\/b><\/td>\n\u00a059-60 ani<\/td>\n\u00a044-240<\/b><\/td>\n<\/tr>\n
13-14 ani<\/td>\n\u00a0104-596<\/b><\/td>\n60-61 ani<\/td>\n43-241<\/b><\/td>\n<\/tr>\n
14-15 ani<\/td>\n115-591<\/b><\/td>\n61-62 ani<\/td>\n41-243<\/b><\/td>\n<\/tr>\n
15-16 ani<\/td>\n121-564<\/b><\/td>\n62-63 ani<\/td>\n40-244<\/b><\/td>\n<\/tr>\n
16-17 ani<\/td>\n122-524<\/b><\/td>\n63-64 ani<\/td>\n38-244<\/b><\/td>\n<\/tr>\n
17-18 ani<\/td>\n120-479<\/b><\/td>\n64-65 ani<\/td>\n36-244<\/b><\/td>\n<\/tr>\n
18-19 ani<\/td>\n117-436<\/b><\/td>\n65-66 ani<\/td>\n34-241<\/b><\/td>\n<\/tr>\n
19-20 ani<\/td>\n113-399<\/b><\/td>\n66-67 ani<\/td>\n32-238<\/b><\/td>\n<\/tr>\n
20-21 ani<\/td>\n109-372<\/b><\/td>\n67-68 ani<\/td>\n30-235<\/b><\/td>\n<\/tr>\n
21-22 ani<\/td>\n107-351<\/b><\/td>\n68-69 ani<\/td>\n28-231<\/b><\/td>\n<\/tr>\n
22-23 ani<\/td>\n105-337<\/b><\/td>\n69-70 ani<\/td>\n27-228<\/b><\/td>\n<\/tr>\n
23-24 ani<\/td>\n103-326<\/b><\/td>\n70-71 ani<\/td>\n26-226<\/b><\/td>\n<\/tr>\n
24-25 ani<\/td>\n102-317<\/b><\/td>\n71-72 ani<\/td>\n24-224<\/b><\/td>\n<\/tr>\n
25-26 ani<\/td>\n100-311<\/b><\/td>\n72-73 ani<\/td>\n24-222<\/b><\/td>\n<\/tr>\n
26-27 ani<\/td>\n98-305<\/b><\/td>\n73-74 ani<\/td>\n23-221<\/b><\/td>\n<\/tr>\n
27-28 ani<\/td>\n96-301<\/b><\/td>\n74-75 ani<\/td>\n22-220<\/b><\/td>\n<\/tr>\n
28-29 ani<\/td>\n93-297<\/b><\/td>\n75-76 ani<\/td>\n21-218<\/b><\/td>\n<\/tr>\n
29-30 ani<\/td>\n91-293<\/b><\/td>\n76-77 ani<\/td>\n20-216<\/b><\/td>\n<\/tr>\n
30-31 ani<\/td>\n89-290<\/b><\/td>\n77-78 ani<\/td>\n20-214<\/b><\/td>\n<\/tr>\n
31-32 ani<\/td>\n87-286<\/b><\/td>\n78-79 ani<\/td>\n19-210<\/b><\/td>\n<\/tr>\n
32-33 ani<\/td>\n85-283<\/b><\/td>\n79-80 ani<\/td>\n18-206<\/b><\/td>\n<\/tr>\n
33-34 ani<\/td>\n83-280<\/b><\/td>\n80-81 ani<\/td>\n18-200<\/b><\/td>\n<\/tr>\n
34-35 ani<\/td>\n82-279<\/b><\/td>\n81-82 ani<\/td>\n18-193<\/b><\/td>\n<\/tr>\n
35-36 ani<\/td>\n81-278<\/b><\/td>\n82-83 ani<\/td>\n17-186<\/b><\/td>\n<\/tr>\n
36-37 ani<\/td>\n80-277<\/b><\/td>\n83-84 ani<\/td>\n17-179<\/b><\/td>\n<\/tr>\n
37-38 ani<\/td>\n80-277<\/b><\/td>\n84-85 ani<\/td>\n17-173<\/b><\/td>\n<\/tr>\n
38-39 ani<\/td>\n79-276<\/b><\/td>\n\u226585 ani<\/td>\n17-167<\/b><\/td>\n<\/tr>\n
39-40 ani<\/td>\n78-274<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
40-41 ani<\/td>\n76-271<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
41-42 ani<\/td>\n75-267<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
42-43 ani<\/td>\n73-263<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
43-44 ani<\/td>\n71-258<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
44-45 ani<\/td>\n69-253<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
45-46 ani<\/td>\n66-249<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
46-47 ani<\/td>\n64-246<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/i><\/p>\n

\u00a0<\/i>Sex masculin<\/span><\/b>\u00a0<\/i><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

V\u00e2rsta<\/i><\/p>\n<\/td>\n

\n

Valori ( ng\/mL)<\/i><\/p>\n<\/td>\n

\n

V\u00e2rsta<\/i><\/p>\n<\/td>\n

\n

Valori ( ng\/mL)<\/i><\/p>\n<\/td>\n<\/tr>\n

<1 ani<\/td>\n11-100<\/b><\/td>\n47-48 ani<\/td>\n71-224<\/b><\/td>\n<\/tr>\n
1-2 ani<\/td>\n12-120<\/b><\/td>\n48-49 ani<\/td>\n69-224<\/b><\/td>\n<\/tr>\n
2-3 ani<\/td>\n13-143<\/b><\/td>\n49-50 ani<\/td>\n68-225<\/b><\/td>\n<\/tr>\n
3-4 ani<\/td>\n14-169<\/b><\/td>\n50-51 ani<\/td>\n67-225<\/b><\/td>\n<\/tr>\n
4-5 ani<\/td>\n15-200<\/b><\/td>\n51-52 ani<\/td>\n66-225<\/b><\/td>\n<\/tr>\n
5-6 ani<\/td>\n16-233<\/b><\/td>\n52-53 ani<\/td>\n65-222<\/b><\/td>\n<\/tr>\n
6-7 ani<\/td>\n17-269<\/b><\/td>\n53-54 ani<\/td>\n64-218<\/b><\/td>\n<\/tr>\n
7-8 ani<\/td>\n18-307<\/b><\/td>\n54-55 ani<\/td>\n62-214<\/b><\/td>\n<\/tr>\n
8-9 ani<\/td>\n20-347<\/b><\/td>\n55-56 ani<\/td>\n61-210<\/b><\/td>\n<\/tr>\n
9-10 ani<\/td>\n23-386<\/b><\/td>\n56-57 ani<\/td>\n59-206<\/b><\/td>\n<\/tr>\n
10-11 ani<\/td>\n29-424<\/b><\/td>\n57-58 ani<\/td>\n58-204<\/b><\/td>\n<\/tr>\n
11-12 ani<\/td>\n37-459<\/b><\/td>\n58-59 ani<\/td>\n56-203<\/b><\/td>\n<\/tr>\n
12-13 ani<\/td>\n49-487<\/b><\/td>\n\u00a059-60 ani<\/td>\n\u00a055-203<\/b><\/td>\n<\/tr>\n
13-14 ani<\/td>\n\u00a064-508<\/b><\/td>\n60-61 ani<\/td>\n53-206<\/b><\/td>\n<\/tr>\n
14-15 ani<\/td>\n83-519<\/b><\/td>\n61-62 ani<\/td>\n51-209<\/b><\/td>\n<\/tr>\n
15-16 ani<\/td>\n102-520<\/b><\/td>\n62-63 ani<\/td>\n49-214<\/b><\/td>\n<\/tr>\n
16-17 ani<\/td>\n119-511<\/b><\/td>\n63-64 ani<\/td>\n46-219<\/b><\/td>\n<\/tr>\n
17-18 ani<\/td>\n131-490<\/b><\/td>\n64-65 ani<\/td>\n43-225<\/b><\/td>\n<\/tr>\n
18-19 ani<\/td>\n137-461<\/b><\/td>\n65-66 ani<\/td>\n40-231<\/b><\/td>\n<\/tr>\n
19-20 ani<\/td>\n137-428<\/b><\/td>\n66-67 ani<\/td>\n37-236<\/b><\/td>\n<\/tr>\n
20-21 ani<\/td>\n133-395<\/b><\/td>\n67-68 ani<\/td>\n34-240<\/b><\/td>\n<\/tr>\n
21-22 ani<\/td>\n127-364<\/b><\/td>\n68-69 ani<\/td>\n31-243<\/b><\/td>\n<\/tr>\n
22-23 ani<\/td>\n120-338<\/b><\/td>\n69-70 ani<\/td>\n29-245<\/b><\/td>\n<\/tr>\n
23-24 ani<\/td>\n112-316<\/b><\/td>\n70-71 ani<\/td>\n27-246<\/b><\/td>\n<\/tr>\n
24-25 ani<\/td>\n105-298<\/b><\/td>\n71-72 ani<\/td>\n26-245<\/b><\/td>\n<\/tr>\n
25-26 ani<\/td>\n99-283<\/b><\/td>\n72-73 ani<\/td>\n25-242<\/b><\/td>\n<\/tr>\n
26-27 ani<\/td>\n94-271<\/b><\/td>\n73-74 ani<\/td>\n24-236<\/b><\/td>\n<\/tr>\n
27-28 ani<\/td>\n90-262<\/b><\/td>\n74-75 ani<\/td>\n23-229<\/b><\/td>\n<\/tr>\n
28-29 ani<\/td>\n87-255<\/b><\/td>\n75-76 ani<\/td>\n22-221<\/b><\/td>\n<\/tr>\n
29-30 ani<\/td>\n84-250<\/b><\/td>\n76-77 ani<\/td>\n22-212<\/b><\/td>\n<\/tr>\n
30-31 ani<\/td>\n83-246<\/b><\/td>\n77-78 ani<\/td>\n21-204<\/b><\/td>\n<\/tr>\n
31-32 ani<\/td>\n82-244<\/b><\/td>\n78-79 ani<\/td>\n20-196<\/b><\/td>\n<\/tr>\n
32-33 ani<\/td>\n82-243<\/b><\/td>\n79-80 ani<\/td>\n19-189<\/b><\/td>\n<\/tr>\n
33-34 ani<\/td>\n82-242<\/b><\/td>\n80-81 ani<\/td>\n18-184<\/b><\/td>\n<\/tr>\n
34-35 ani<\/td>\n82-242<\/b><\/td>\n81-82 ani<\/td>\n17-180<\/b><\/td>\n<\/tr>\n
35-36 ani<\/td>\n83-241<\/b><\/td>\n82-83 ani<\/td>\n16-177<\/b><\/td>\n<\/tr>\n
36-37 ani<\/td>\n83-240<\/b><\/td>\n83-84 ani<\/td>\n16-176<\/b><\/td>\n<\/tr>\n
37-38 ani<\/td>\n83-239<\/b><\/td>\n84-85 ani<\/td>\n16-176<\/b><\/td>\n<\/tr>\n
38-39 ani<\/td>\n83-238<\/b><\/td>\n\u226585 ani<\/td>\n15-177<\/b><\/td>\n<\/tr>\n
39-40 ani<\/td>\n83-238<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
40-41 ani<\/td>\n82-237<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
41-42 ani<\/td>\n81-236<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
42-43 ani<\/td>\n80-235<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
43-44 ani<\/td>\n78-233<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
44-45 ani<\/td>\n76-230<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
45-46 ani<\/td>\n74-227<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n
46-47 ani<\/td>\n72-225<\/b><\/td>\n<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/i>Factori de conversie: ng\/mL = \u00b5g\/L; 1nmol\/ = 1 ng\/mL x 0.131<\/i><\/p>\n

Limita de detec<\/i><\/b>\u0163ie<\/i><\/b> \u2013 3 ng\/mL3<\/sup>.<\/p>\n

Limite \u015fi interferen\u0163e<\/i><\/b><\/p>\n

Malnutri\u0163ia determin\u0103 niveluri sc\u0103zute de somatomedin C, \u00een prezen\u0163a unei concentra\u0163ii normale de hormon de cre\u015ftere circulant.<\/div>\n
Nivelul seric de IGF-I nu permite diferen\u0163ierea nanismului hipofizar de tulbur\u0103rile constitu\u0163ionale de cre\u015ftere \u015fi dezvoltare (este sc\u0103zut \u00een ambele condi\u0163ii).<\/div>\n
Valori sc\u0103zute de IGF-I mai pot fi \u00eent\u00e2lnite la persoane v\u00e2rstnice, \u00een afec\u0163iuni acute, hipotiroidism, pubertate \u00eent\u00e2rziat\u0103, anorexie nervoas\u0103, sindrom de deprivare matern\u0103, ciroz\u0103 hepatic\u0103, diabet zaharat decompensat.<\/div>\n
Valori crescute de IGF-I se \u00eent\u00e2lnesc \u00een sarcin\u0103, pubertate precoce, obezitate1;4<\/sup>.<\/div>\n

\u2022 Medicamente<\/p>\n

Cre\u015fteri<\/span>: aminoglutetimid, clonidin\u0103, dexametazon, goserelin, hormon de cre\u015ftere, medroxiprogesteron, prednisolon2<\/sup>.<\/div>\n
Sc\u0103deri<\/span>: contraceptive orale, estrogeni, etinil estradiol, metimazol2<\/sup>.<\/div>\n
Efecte variabile<\/span>: tamoxifen2<\/sup>.<\/div>\n

\u2022 Interferen\u0163e analitice<\/p>\n

Anticorpii heterofili prezen\u0163i \u00een serul pacien\u0163ilor pot interac\u0163iona cu imunoglobulinele incluse \u00een componentele din kit \u015fi da rezultate neconcludente3<\/sup>.<\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1.\u00a0\u00a0\u00a0 Frances Fischbach. Chemistry studies. <\/i>In A Manual of Laboratory and Diagnostic Tests.<\/i> Lippincott Williams & Wilkins, USA, 8 Ed., 2009, 398-399.<\/span><\/div>\n
2. \u00a0\u00a0 Frances Fischbach. Effects of the Most Commonly Used Drugs on Frequently Ordered Laboratory Tests. In\u00a0 A Manual of Laboratory and Diagnostic Tests.<\/i> Lippincott Williams & Wilkins, USA, 8 Ed., 2009, 1253.<\/span><\/div>\n
3. \u00a0\u00a0 Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog.<\/span><\/div>\n
4. \u00a0\u00a0 Laboratory Corporation of America. Directory of Services and Interpretive Guide. Insulin-Like Growth Factor 1 (IGF-1). www.labcorp.com<\/a> 2010. Ref Type: Internet Communication.<\/span><\/div>\n
5. \u00a0\u00a0 Lothar Thomas. Growth disorders. In\u00a0 Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results.<\/i> TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998, 1074-1077.<\/span><\/div>\n
6.\u00a0\u00a0\u00a0 2009 Pediatric Test Reference Values. Mayo Clinic, Mayo Medical Laboratories.<\/span><\/div>\n

","protected":false},"excerpt":{"rendered":"

\u0421\u043e\u043c\u0430\u0442\u043e\u043c\u0435\u0434\u0438\u043d \u0421 \u0441\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u043f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e (\u043d\u043e \u043d\u0435 \u0442\u043e\u043b\u044c\u043a\u043e) \u0432 \u043f\u0435\u0447\u0435\u043d\u0438, \u043f\u043e\u0434 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043c \u0441\u043e\u043c\u0430\u0442\u043e\u0442\u0440\u043e\u043f\u043d\u043e\u0433\u043e \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0438 \u043f\u0440\u0438\u0435\u043c\u0430 \u043f\u0438\u0449\u0438 \u0418\u0424\u0420-1 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0433\u043e\u0440\u043c\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u043c \u043f\u043e\u0441\u0440\u0435\u0434\u043d\u0438\u043a\u043e\u043c \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f \u043d\u0430 \u043a\u043b\u0435\u0442\u043a\u0438 \u0438 \u0442\u043a\u0430\u043d\u0438 \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0440\u043e\u0441\u0442\u0430.<\/p>\n

\u041e\u0434\u043d\u0438\u043c \u0438\u0437 \u0432\u0430\u0436\u043d\u044b\u0445 \u044d\u0444\u0444\u0435\u043a\u0442\u043e\u0432 \u0418\u0424\u0420-1 (\u0437\u0434\u0435\u0441\u044c \u0438 \u0434\u0430\u043b\u0435\u0435) \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0441\u0442\u0438\u043c\u0443\u043b\u044f\u0446\u0438\u044f \u0440\u043e\u0441\u0442\u0430 \u043a\u043e\u0441\u0442\u0435\u0439 \u0432 \u0434\u043b\u0438\u043d\u0443 \u0432 \u0434\u0435\u0442\u0441\u043a\u043e\u043c \u0438 \u043f\u043e\u0434\u0440\u043e\u0441\u0442\u043a\u043e\u0432\u043e\u043c \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435, \u0440\u043e\u0441\u0442 \u043a\u043e\u0441\u0442\u0435\u0439 \u043b\u0438\u0446\u0435\u0432\u043e\u0439 \u0447\u0430\u0441\u0442\u0438 \u0447\u0435\u0440\u0435\u043f\u0430, \u043a\u0438\u0441\u0442\u0435\u0439 \u0438 \u0441\u0442\u043e\u043f, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0445\u0440\u044f\u0449\u0435\u0439 \u0438 \u0432\u043d\u0443\u0442\u0440\u0435\u043d\u043d\u0438\u0445 \u043e\u0440\u0433\u0430\u043d\u043e\u0432 \u0432\u043e \u0432\u0437\u0440\u043e\u0441\u043b\u043e\u0439 \u0436\u0438\u0437\u043d\u0438.<\/p>\n

\u0410\u043d\u0430\u043b\u043e\u0433\u0438\u0447\u043d\u043e \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044e \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0430 \u0418\u0424\u0420-1 \u0441\u043f\u043e\u0441\u043e\u0431\u0435\u043d \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u0443\u0442\u0438\u043b\u0438\u0437\u0430\u0446\u0438\u044e \u0433\u043b\u044e\u043a\u043e\u0437\u044b \u0436\u0438\u0440\u043e\u0432\u043e\u0439 \u0438 \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u044f\u043c\u0438. \u0426\u0438\u0440\u043a\u0443\u043b\u0438\u0440\u0443\u044e\u0449\u0438\u0439 \u0418\u0424\u0420-1 \u043f\u043e\u0432\u044b\u0448\u0430\u0435\u0442 \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u043a \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0443. \u041f\u043e\u0441\u043a\u043e\u043b\u044c\u043a\u0443 \u0418\u0424\u0420-1 \u0438\u0433\u0440\u0430\u0435\u0442 \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u0443\u044e \u0440\u043e\u043b\u044c \u0432 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u0435 \u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0446\u0438\u043a\u043b\u0430 \u0438 \u0430\u043f\u043e\u043f\u0442\u043e\u0437\u0430 (\u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0430\u0445, \u0442\u0435\u0441\u043d\u043e \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u044b\u0445 \u0441 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0430\u043c\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u043e\u0433\u043e \u0440\u043e\u0441\u0442\u0430), \u0432 \u043d\u0430\u0441\u0442\u043e\u044f\u0449\u0435\u0435 \u0432\u0440\u0435\u043c\u044f \u0438\u043d\u0442\u0435\u043d\u0441\u0438\u0432\u043d\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u0443\u0435\u0442\u0441\u044f \u0435\u0433\u043e \u0440\u043e\u043b\u044c \u0432 \u043a\u0430\u043d\u0446\u0435\u0440\u043e\u0433\u0435\u043d\u0435\u0437\u0435.<\/p>\n

\u0412 \u043a\u0440\u043e\u0432\u0438 \u0446\u0438\u0440\u043a\u0443\u043b\u0438\u0440\u0443\u0435\u0442 \u0432 \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u043e\u043c \u0441 \u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u044b\u043c\u0438 \u0431\u0435\u043b\u043a\u0430\u043c\u0438 \u0432\u0438\u0434\u0435. \u0412\u0440\u0435\u043c\u044f \u0435\u0433\u043e \u043d\u0430\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u044f \u0432 \u043a\u0440\u043e\u0432\u0438 \u0434\u043e\u043b\u044c\u0448\u0435, \u0447\u0435\u043c \u0441\u043e\u043c\u0430\u0442\u043e\u0442\u0440\u043e\u043f\u043d\u043e\u0433\u043e \u0433\u043e\u0440\u043c\u043e\u043d\u0430, \u0438 \u043d\u0435 \u043c\u0435\u043d\u044f\u0435\u0442\u0441\u044f \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u0434\u043d\u044f \u0438 \u043f\u043e\u0441\u043b\u0435 \u0435\u0434\u044b. \u0423 \u043d\u043e\u0432\u043e\u0440\u043e\u0436\u0434\u0435\u043d\u043d\u044b\u0445 \u0418\u0424\u0420-1 \u0432 \u043f\u043b\u0430\u0437\u043c\u0435 \u0435\u0434\u0432\u0430 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u0435\u0442\u0441\u044f, \u0432 \u043f\u0435\u0440\u0438\u043e\u0434 \u0434\u0435\u0442\u0441\u0442\u0432\u0430 \u0435\u0433\u043e \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0433\u0440\u0430\u0434\u0443\u0430\u043b\u044c\u043d\u043e \u0440\u0430\u0441\u0442\u0435\u0442, \u0434\u043e\u0441\u0442\u0438\u0433\u0430\u044f \u043c\u0430\u043a\u0441\u0438\u043c\u0443\u043c\u0430 \u0432 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 \u043e\u0442 \u043f\u0443\u0431\u0435\u0440\u0442\u0430\u0442\u043d\u043e\u0433\u043e \u043f\u0435\u0440\u0438\u043e\u0434\u0430 \u0434\u043e \u043f\u0440\u0438\u0431\u043b\u0438\u0437\u0438\u0442\u0435\u043b\u044c\u043d\u043e 40 \u043b\u0435\u0442, \u043f\u043e\u0441\u043b\u0435 \u0447\u0435\u0433\u043e \u043f\u043b\u0430\u0432\u043d\u043e \u0441\u043d\u0438\u0436\u0430\u0435\u0442\u0441\u044f. \u0412\u043e \u0432\u0440\u0435\u043c\u044f \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0418\u0424\u0420-1 \u0432 \u043c\u0430\u0442\u0435\u0440\u0438\u043d\u0441\u043a\u043e\u0439 \u043a\u0440\u043e\u0432\u0438 \u0443\u0432\u0435\u043b\u0438\u0447\u0438\u0432\u0430\u0435\u0442\u0441\u044f.<\/p>\n

\u0421 \u043a\u0430\u043a\u043e\u0439 \u0446\u0435\u043b\u044c\u044e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u044e\u0442 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0421\u043e\u043c\u0430\u0442\u043e\u043c\u0435\u0434\u0438\u043d\u0430 \u0421 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438<\/p>\n

\u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u043d\u0430 \u0441\u043e\u043c\u0430\u0442\u043e\u043c\u0435\u0434\u0438\u043d \u0421 (\u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u043f\u043e\u0434\u043e\u0431\u043d\u044b\u0439 \u0444\u0430\u043a\u0442\u043e\u0440 \u0440\u043e\u0441\u0442\u0430 \u2013 1, \u0418\u0424\u0420-1) \u043f\u0440\u0438\u043c\u0435\u043d\u044f\u044e\u0442 \u043f\u0440\u0438 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0439 \u0440\u043e\u0441\u0442\u0430 \u0443 \u0434\u0435\u0442\u0435\u0439 \u0438 \u0430\u043a\u0440\u043e\u043c\u0435\u0433\u0430\u043b\u0438\u0438 \u0443 \u0432\u0437\u0440\u043e\u0441\u043b\u044b\u0445, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0434\u043b\u044f \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044f \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u044d\u0442\u0438\u0445 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0439. \u0418\u0424\u0420-1 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043b\u0443\u0447\u0448\u0438\u043c \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c \u0434\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0446\u0438\u0438 \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0440\u043e\u0441\u0442\u0430. \u041e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0418\u0424\u0420-1 \u0442\u0430\u043a\u0436\u0435 \u043f\u043e\u043b\u0435\u0437\u043d\u043e \u043f\u0440\u0438 \u043e\u0446\u0435\u043d\u043a\u0435 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0439 \u043e\u0431\u043c\u0435\u043d\u043d\u043e\u0433\u043e \u0441\u0442\u0430\u0442\u0443\u0441\u0430.<\/p>\n

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