{"id":9238,"date":"2020-04-23T04:32:17","date_gmt":"2020-04-23T01:32:17","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/folati-serici\/"},"modified":"2025-07-01T07:56:47","modified_gmt":"2025-07-01T04:56:47","slug":"folati-serici","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/folati-serici\/","title":{"rendered":"\u0424\u043e\u043b\u0438\u0435\u0432\u0430\u044f \u043a\u0438\u0441\u043b\u043e\u0442\u0430(\u0444\u043e\u043b\u0430\u0442\u044b) \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043a\u0440\u043e\u0432\u0438"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f <\/em><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Acidul folic (acidul pteroilmonoglutamic) este substan\u0163\u0103 comun\u0103 din care sunt produ\u015fi fola\u0163ii, un grup de compu\u015fi cu structura asem\u0103n\u0103toare, care constau dintr-un inel pteridinic, paraaminobenzoat \u015fi unul sau mai multe lan\u0163uri glutamice laterale. Formele poliglutamice sunt cele care predomin\u0103 intracelular \u015fi sunt mai eficiente \u00een reac\u0163iile enzimatice. Formele metabolic active sunt 5-metiltetrahidrofolatul (form\u0103 major\u0103 din organism), 10-formiltetrahidrofolatul \u015fi tetrahidrofolatul (care func\u0163ioneaz\u0103 c\u0103 donor\/acceptor de grupuri cu un atom de carbon \u00een reac\u0163ii din metabolismul unor aminoacizi \u015fi al nucleotidelor, respectiv sintez\u0103 ADN). Metabolismul folatului este legat de cel al vitaminei B12: cobalamin\u0103 este implicat\u0103 \u00een preluarea celular\u0103 de 5-metiltetrahidrofolat monoglutamat \u015fi transformarea intracelular\u0103 \u00een poliglutamat.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Folatul este ubicuitar, g\u0103sindu-se \u00een aproape toate clasele de alimente, \u00een primul r\u00e2nd \u00een legumele cu frunze verzi, dar \u015fi \u00een carne, organe, produse lactate, cereale. Folatul alimentar este poliglutamat \u015fi necesit\u0103 conversie \u00een monoglutamat pentru a fi absorbit, fiind mai pu\u0163in biodisponibil dec\u00e2t acidul folic de sintez\u0103. Folatul este absorbit at\u00e2t prin intermediul unui carrier, care predomin\u0103 \u00een intestinul sub\u0163ire proximal (proces saturabil), c\u00e2t \u015fi printr-un proces nonsaturabil, care predomin\u0103 la nivelul ileonului. Folatul alimentar \u015fi folatul biliar reabsorbit intr\u0103 \u00een circula\u0163ie, unde se leag\u0103 nespecific \u015fi cu afinitate mic\u0103 de albumina; o treime circul\u0103 \u00een form\u0103 liber\u0103 \u015fi numai o frac\u0163iune foarte mic\u0103 se leag\u0103 specific de protein\u0103 de legare a folatului derivat\u0103 din membran\u0103 celular\u0103; folatul circulant monoglutamat este preluat rapid la nivel celular via receptorul pentru folat sau prin difuzie pasiv\u0103, este convertit \u00een folat poliglutamat la nivel citosolic \u015fi apoi transportat la nivelul organitelor (35% din folatul intracelular se g\u0103se\u015fte \u00een mitocondrii). Organismul uman con\u0163ine 5-10 mg de fola\u0163i, iar cea mai mare parte (50%) este depozitat\u0103 la nivelul ficatului. Excre\u0163ia are loc prin materiile fecale (reciclarea enterohepatica este important\u0103) \u015fi urin\u0103 (filtrare glomerular\u0103, reabsorb\u0163ie \u015fi secre\u0163ie tubular\u0103). De asemenea, fola\u0163ii sunt sintetiza\u0163i de c\u0103tre bacteriile intestinale<sup> 1;2<\/sup>. <\/span><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Un deficit semnificativ de fola\u021bi se asociaz\u0103 \u00een mod caracteristic cu macrocitoz\u0103 \u0219i anemie megaloblastic\u0103. Acesta se datoreaz\u0103 \u00een principal unui aport alimentar insuficient \u0219i este cel mai frecvent \u00eent\u00e2lnit la gravide \u0219i alcoolici.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Un nivel seric de fola\u021bi sub limita inferioar\u0103 a intervalului de referin\u021b\u0103 a fost descris la pacien\u021bi cu tulbur\u0103ri neuropsihice, la gravidele ale c\u0103ror fe\u021bi prezint\u0103 defecte de tub neural, precum \u0219i la femeile cu avorturi sponatne recente<sup>3<\/sup>.<span style=\"color: #000000;\"><br \/>\n<\/span><\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Recomandari pentru determinarea folatului seric<\/em><\/strong><sup>2<\/sup>:<\/span><\/div>\n<ul style=\"text-align: justify;\">\n<li style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Diagnosticul diferen\u0163ial al anemiei megaloblastice;<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Alcoolismul cronic;<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Femei care inten\u0163ioneaz\u0103 s\u0103 aib\u0103 o sarcin\u0103, mai ales dac\u0103 au avut un copil cu defect de tub neural;<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Monitorizarea tratamentului cu anticonvulsivante, antifola\u0163i (metotrexat), pirimetamina (antimalaric), sulfasalazina (pentru boli inflamatorii intestinale), contraceptive orale;<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Sindroame de malabsorb\u0163ie;<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Boli hepatice cronice;<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">V\u00e2rstnici cu malnutri\u0163ie.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Se pot determina at\u00e2t folatul seric (care reflect\u0103 modific\u0103ri recente \u00een aportul alimentar \u015fi absorb\u0163ia intestinal\u0103 de folat), c\u00e2t \u015fi folatul eritrocitar (adev\u0103ratul indicator al folatului tisular). Folatul eritrocitar nu face distinc\u0163ia \u00eentre deficitul de folat \u015fi cel de vitamina B12: 63% din pacien\u0163ii cu deficit de vitamina B12 prezint\u0103 niveluri sc\u0103zute de fola\u0163i. Pe de alt\u0103 parte folatul seric este crescut la 30% din pacien\u0163ii cu deficit de vitamina B12; de aceea determin\u0103rile de folat \u015fi vitamina B12 trebuie efectuate simultan<sup>2<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Preg\u0103tire pacient \u2013 <\/em><\/strong>\u00e0 jeun (pe nem\u00e2ncate), \u00eenaintea unor eventuale injec\u0163ii cu vitamina B12, administr\u0103rii de transfuzii sau \u00eenceperii tratamentului cu folat<sup>4<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Specimen recoltat <\/em><\/strong><em>-<\/em> \u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>5<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Recipient de recoltare <\/em><\/strong><em>-<\/em> vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator<sup>5<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong><em>-<\/em> se separ\u0103 serul prin centrifugare<sup>5<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Volum prob\u0103<\/em><\/strong> \u2013 minim 1 mL ser<sup>5<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Cauze de respingere a probei <\/em><\/strong><em>-<\/em> ser hemolizat<sup>5<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Stabilitate prob\u0103 <\/em><\/strong><em>-<\/em> serul separat este stabil\u00a0<em>7 zile<\/em> la 2-8\u00b0C;\u00a0<em>3 luni<\/em> la -20\u00b0C; se protejeaz\u0103 de lumin\u0103<sup>3;5<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Metod\u0103 de determinare <\/em><\/strong><em>-<\/em> <span style=\"text-decoration: underline;\">imunochimic\u0103 cu detec\u0163ie prin electrochemiluminiscen\u0163\u0103 (ECLIA)<\/span><sup>5<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Valori de referin\u0163\u0103 <\/em><\/strong>-\u00a0<\/span>4.6 \u2013 34.8 ng\/mL<span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u00a0(pentru popula\u0163ia european\u0103)<sup>5<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><em>Factori de conversie: nmol\/L x 0.44 = ng\/mL; ng\/mL x 2.27 = nmol\/L.<\/em><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Limita de detec\u0163ie<\/em><\/strong><em> - <\/em>&lt; 0.640 ng\/mL (&lt; 1.45nmol\/L)<sup>5<\/sup>.<em>\u00a0<\/em><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Interpretarea rezultatelor<\/em><\/strong><\/span><\/p>\n<table class=\"wp-block-table w-100\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"600\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Deficitul de folat <\/em><\/strong>poate fi clasificat \u00een 4 stadii:<\/span><\/p>\n<p style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u2022 o balan\u0163\u0103 negativ\u0103 de folat determin\u0103 ini\u0163ial sc\u0103derea folatului seric, dar cu depozite normale<\/span><\/p>\n<p style=\"padding-left: 30px;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u2022 ulterior scade folatul eritrocitar<\/span><\/p>\n<p style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u2022 apoi apare alterarea eritropoiezei cu VEM si HEM crescute \u015fi apari\u0163ia neutrofilelor cu nucleu hipersegmentat<\/span><\/p>\n<p style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u2022 iar in final, deficit de fola\u0163i clinic manifest cu anemie megaloblastic\u0103<sup>7<\/sup>; spre deosebire de deficitul de vitamina B12, manifest\u0103rile neurologice sunt rare<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Dup\u0103 \u00eentreruperea aportului, sc\u0103derea folatului seric survine dup\u0103 ~1 lun\u0103, iar\u00a0deple\u0163ia depozitelor de folat la un nivel care nu poate sus\u0163ine hematopoiez\u0103 normal\u0103 are loc \u00een 3-6 luni<sup>2<\/sup>.<\/span><\/p>\n<p><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><span style=\"text-decoration: underline;\">Cauzele deficitului de folat sunt<\/span>:<\/span><\/p>\n<p style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u2022 Diet\u0103 deficitar\u0103: abuzul de alcool, copii cu diete exclusiv lactate f\u0103r\u0103 suplimentare cu folat, diet\u0103 restrictiv\u0103 din fenilcetonurie, v\u00e2rstnici cu malnutri\u0163ie, anorexie nervoas\u0103<\/span><\/p>\n<p style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u2022 Malabsorb\u0163ie: sprue tropical, boala celiac\u0103, boala Crohn, dermatit\u0103 herpetiform\u01031, by-pass jejuno-ileal, rezec\u0163ii intestinale<\/span><\/p>\n<p style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u2022 Nevoi crescute: sarcin\u0103, lacta\u0163ie, nou-n\u0103scu\u0163i prematuri, adolescen\u0163i, anemie hemolitic\u0103 cronic\u0103, boli mieloproliferative, carcinom metastatic, hipertiroidism, dermatite exfoliative<sup>2<\/sup><\/span><\/p>\n<p style=\"padding-left: 30px;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u2022 Pierderi crescute: dializa cronic\u0103<\/span><\/p>\n<p style=\"padding-left: 30px;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u2022 Boli hepatice cronice (ciroz\u0103, hepatom)<sup>2;4<\/sup><\/span><\/p>\n<p style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u2022 Medicamente \u015fi toxice: alcool, sulfasalazina, anticonvulsivante (hidantoine, acid valproic), antifola\u0163i (metotrexat), trimetoprim-sulfametoxazol, pirimetamina, contraceptive orale, antiacide\/blocan\u0163i de receptori H2 \u00een exces<sup>4;6<\/sup><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">De obicei, deficitul de fola\u0163i este multifactorial. Deficitul de fola\u0163i \u00een sarcin\u0103 poate duce la apari\u0163ia defectelor de tub neural.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: justify;\" valign=\"top\" width=\"600\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Folat crescut<\/em><\/strong><em>: <\/em>\u2022 vegetarieni <em>\u2022<\/em> deficit de vitamina B12<em> \u2022<\/em> sindrom de an\u015f\u0103 oarb\u0103 (cre\u0219terea sintezei bacteriene de fola\u0163i)<sup>4;6<\/sup><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u00cen mod obi\u0219nuit, evaluarea anemiilor macrocitare necesit\u0103 determinarea simultan\u0103 de fola\u021bi serici \u0219i vitamin\u0103 B12. Pentru diferen\u021bierea deficitului de vitamin\u0103 B12 \u0219i fola\u021bi se pot efectua suplimentar homocisteina plasmatic\u0103 \u0219i acidul metilmalonic seric. \u00cen defictul de fola\u021bi nivelul homocisteinei este crescut iar cel de acid malonic este normal, pe c\u00e2nd \u00een defictul de vitamin\u0103 B12 sunt crescute at\u00e2t homocisteina plasmatic\u0103 c\u00e2t \u0219i acidul metilmalonic seric<sup>3<\/sup>.<\/span><\/p>\n<p><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong><em>Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Deficitul sever de fier poate determina cre\u015fteri ale folatului printr-un mecanism necunoscut<sup>2<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u2022 Medicamente<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><span style=\"text-decoration: underline;\"><strong>Sc\u0103deri<\/strong><\/span>:\u00a0 acid aminosalicilic,\u00a0 ampicilina,\u00a0 antiacide,\u00a0 anticonvulsivante,\u00a0 barbiturice,\u00a0 cloramfenicol,\u00a0 colistiramina,\u00a0 eritromicina,\u00a0 fier,\u00a0 izoniazida,\u00a0 levodopa,\u00a0 lincomicina, metformin,\u00a0 metotrexat,\u00a0 nitrofurantoin, contraceptive orale,\u00a0 penicilina,\u00a0 pentamidina, primidona,\u00a0 pirimetamina,\u00a0 rifampicina,\u00a0 sulfasalazina,\u00a0 sulfisoxazol, tetraciclina, triamteren, trimetoprim<sup>7<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u2022 Interferen\u0163e analitice<\/span><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u00cen prezen\u0163a unui ser hemolizat pot ap\u0103rea false cre\u015fteri (eliberarea folatului eritrocitar).<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">La pacien\u0163ii care primesc tratament cu doze mari de biotin\u0103 (&gt;5mg\/zi), recoltarea probei trebuie f\u0103cut\u0103 la cel pu\u0163in 8 ore dup\u0103 ultima doz\u0103 de biotin\u0103. Nu se recomand\u0103 dozarea \u00een cursul tratamentului cu metotrexat\/leucovorin (interac\u0163ioneaz\u0103 cu proteina de legare a folatului folosit\u0103 pentru testare)<sup>2<\/sup>.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">Hiperproteinemia marcat\u0103 &gt;16 g\/dL (macroglobulinemia Waldenstr\u00f6m) interfer\u0103 cu testul (formare de gel proteic \u00een cupa de testare)<sup>5<\/sup>.<\/span><\/div>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\"><strong>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/span><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">1. Carmel R. Megalobastic Anemias: Disorders of Impaired DNA Synthesis. In Wintrobe\u2019s Clinical Hematology. Lippincott, Williams &amp; Wilkins, USA, 11 Ed., 2004, 1367-1388.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">2. Lothar Thomas. Folates. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998, 431-435.<\/span><\/div>\n<div style=\"text-align: left;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">3. Mayo Clinic. Mayo Medical Laboratories. Folate, Serum. www.mayomedicallaboratories.com. 2017. Ref Type: Internet Communication.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">4. Frances Fischbach. Blood Studies: Hematology and Coagulation. In A Manual of Laboratory and Diagnostic Tests. Lippincott, Williams &amp; Wilkins, USA, 8 Ed., 2009, 141-143.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">5.\u00a0Laborator Synevo. Referin\u0163e specifice tehnologiei de lucru utilizate 2017. Ref Type: Catalog.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">6. DeMott W, Tilzer L, et al. Hematology.In Laboratory Test Handbook. Lexi-Comp Inc. Jaffe, USA, 3 Ed., 1994, 545-546.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-family: times new roman,times,serif; font-size: 12pt;\">7. Frances Fischbach. Effects of the Most Commonly Used Drugs on Frequently Ordered Laboratory Tests. In A Manual of Laboratory and Diagnostic Tests. Lippincott, Williams &amp; Wilkins, USA, 8 Ed., 2009, 1238.<\/span><\/div>","protected":false},"excerpt":{"rendered":"<p>\u0424\u043e\u043b\u0438\u0435\u0432\u0430\u044f \u043a\u0438\u0441\u043b\u043e\u0442\u0430 (\u0432\u0438\u0442\u0430\u043c\u0438\u043d \u04129) \u043e\u0442\u043d\u043e\u0441\u0438\u0442\u0441\u044f \u043a \u0432\u0438\u0442\u0430\u043c\u0438\u043d\u0430\u043c \u0433\u0440\u0443\u043f\u043f\u044b \u0412. \u041e\u043d\u0430 \u0432\u044b\u0441\u0442\u0443\u043f\u0430\u0435\u0442 \u043f\u0440\u0435\u0434\u0448\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u0438\u043a\u043e\u043c \u0442\u0435\u0442\u0440\u0430\u0433\u0438\u0434\u0440\u043e\u0444\u043e\u043b\u0438\u0435\u0432\u043e\u0439 \u043a\u0438\u0441\u043b\u043e\u0442\u044b (\u0422\u0413\u0424\u041a), \u043a\u043e\u0442\u043e\u0440\u0430\u044f, \u0432 \u0441\u0432\u043e\u044e \u043e\u0447\u0435\u0440\u0435\u0434\u044c, \u0432\u044b\u043f\u043e\u043b\u043d\u044f\u0435\u0442 \u0444\u0443\u043d\u043a\u0446\u0438\u0438 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\u0437\u0435\u0440\u043d\u043e\u0432\u044b\u0435, \u043c\u0443\u043a\u0430 \u0433\u0440\u0443\u0431\u043e\u0433\u043e \u043f\u043e\u043c\u043e\u043b\u0430) \u0438 \u0436\u0438\u0432\u043e\u0442\u043d\u043e\u0433\u043e (\u043f\u0435\u0447\u0435\u043d\u044c, \u043c\u044f\u0441\u043e) \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u044f. \u041e\u0434\u043d\u0430\u043a\u043e \u0442\u0435\u0440\u043c\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u043a\u0430 \u0432\u044b\u0437\u044b\u0432\u0430\u0435\u0442 \u0431\u044b\u0441\u0442\u0440\u043e\u0435 \u0440\u0430\u0437\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u0444\u043e\u043b\u0430\u0442\u043e\u0432 \u2012 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u043d\u044b\u0445 \u0444\u043e\u043b\u0438\u0435\u0432\u043e\u0439 \u043a\u0438\u0441\u043b\u043e\u0442\u044b.<br \/>\n\u041f\u043e\u0441\u043b\u0435 \u0432\u0441\u0430\u0441\u044b\u0432\u0430\u043d\u0438\u044f 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\u043f\u0438\u0449\u0438.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[926],"product_tag":[],"class_list":{"0":"post-9238","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-anemie","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9238","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9238"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9238"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9238"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9238"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9238"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}