{"id":9237,"date":"2020-04-23T04:32:15","date_gmt":"2020-04-23T01:32:15","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/fibrinogen\/"},"modified":"2026-02-19T01:33:41","modified_gmt":"2026-02-18T23:33:41","slug":"fibrinogen","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/fibrinogen\/","title":{"rendered":"\u0424\u0438\u0431\u0440\u0438\u043d\u043e\u0433\u0435\u043d"},"content":{"rendered":"

\u00a0\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong>\u00a0<\/em><\/span><\/p>\n

Fibrinogenul (factorul I al coagularii) este o glicoproteina dimerica cu greutate moleculara de aproximativ 340kD, prezenta in plasma si in \u03b1-granulele plachetare. Este sintetizat in ficat la o rata de 1.7-5 g\/zi1<\/sup>. Fiecare din cele doua subunitati contine trei lanturi polipeptidice: A\u03b1, B\u03b2 si \u03b3. Fibrinogenul are o structura trinodulara, domeniul central globular fiind denumit domeniul E, care cuprinde capetele N-terminale ale celor sase lanturi polipeptidice, iar domeniile D contin capetele C-terminale ale celor trei lanturi. Timpul de injumatatire al fibrinogenului este de 3-5zile8<\/sup>.<\/span><\/p>\n

Fibrinogenul constituie substratul de actiune atat pentru trombina, ultima enzima din cascada coagularii, cat si pentru plasmina, enzima a sistemului fibrinolitic. Trombina se leaga la domeniul central al fibrinogenului si elibereaza cate doua fibrinopeptide A si B de la nivelul fiecarei molecule, expunand astfel situsurile de legare din domeniul E complementare situsurilor din domeniile D ale altor monomeri de fibrina. Aceste situsuri de legare complementare duc la formarea initial a protofibrilelor de fibrina, care agrega in fibre groase, iar acestea se ramifica intr-o retea de fibre interconectate. FXIIIa stabilizeaza polimerul de fibrina prin formarea de legaturi incrucisate.<\/span><\/p>\n

Plasmina cliveaza atat fibrinogenul cat si fibrina. In urma actiunii plasminei asupra fibrinogenului sunt eliberate fragmentele X, Y, D si E. Fragmente similare sunt eliberate in urma digestiei fibrinei, precum si D-dimeri si alti produsi de degradare care prezinta legaturi covalente incrucisate. Desi fragmentul X poate inca polimeriza intr-un cheag slab, fragmente Y si D inhiba polimerizarea monomerilor de fibrina8<\/sup>.<\/span><\/p>\n

In plus fibrinogenul apartine grupului proteinelor de faza acuta (valori crescute apar dupa 24-48 ore de la producerea evenimentului)1<\/sup>.<\/span><\/p>\n

Recomandari pentru determinarea fibrinogenului <\/em><\/strong>\u00a0<\/em><\/strong><\/span><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/em>\u2013 detectarea deficitului congenital sau dobandit al fibrinogenului (a-\/hipo-\/disfibrinogenemii);\u00a0<\/em><\/span><\/p>\n

\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/em>\u2013 monitorizarea terapiei trombolitice;\u00a0<\/em><\/span><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0<\/em>\u2013 ca indicator al reactiilor consumptive cu\/fara fibrin(ogen)oliza;\u00a0<\/em><\/span><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u2013 evaluarea riscului de aparitie a evenimentelor trombotice cardiovasculare (de ex. IMA, AVC);\u00a0<\/em><\/span><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/em>\u2013 procese inflamatorii acute1;2;6<\/sup>.\u00a0<\/em><\/span><\/p>\n

Pregatire pacient<\/em><\/strong> \u2013 \u00e0 jeun (pe nemancate)5<\/sup>.<\/span><\/p>\n

Specimen recoltat<\/em><\/strong> \u2013 sange venos5<\/sup>.<\/span><\/p>\n

Recipient de recoltare<\/em><\/strong> \u2013 vacutainer cu citrat de Na 0.105M (raport citrat de sodiu \u2013 sange=1\/9)<\/span><\/p>\n

Presiunea realizata de garou trebuie sa fie intre valoarea presiunii sistolice si cea a presiunii diastolice si nu trebuie sa depaseasca 1 minut. Daca punctia venoasa a esuat, o noua tentativa pe aceeasi vena nu se poate face decat dupa 10 minute5<\/sup>.<\/span><\/p>\n

Cantitate recoltata<\/em><\/strong> \u2013 cat permite vacuumul; pentru a preveni coagularea partiala a probei se va asigura amestecul corect al sangelui cu anticoagulantul, prin miscari de inversiune a tubului5<\/sup>.<\/span><\/p>\n

Cauze de respingere a probei<\/em><\/strong> - <\/em>vacutainer care nu este plin cel putin 90%; proba intens hemolizata, intens lipemica sau coagulata5,6<\/sup>.<\/span><\/p>\n

Prelucrare necesara dupa recoltare <\/em><\/strong>\u2013 proba va fi centrifugata 15 minute la 2500g5<\/sup>.<\/span><\/p>\n

Stabilitate proba<\/em><\/strong> \u2013 proba este stabila 4 ore<\/em> la temperatura camerei, iar plasma separata cateva luni<\/em> la -20\u00baC5<\/sup>.<\/span><\/p>\n

Metoda <\/strong>- coagulometrica (Clauss<\/span>): in prezenta unui exces de trombina, timpul de coagulare al unei plasme citratate, diluate (1\/10), saraca in trombocite este invers proportional cu concentratia de fibrinogen. Testul determina nivelul functional de fibrinogen (activitatea) 5<\/sup>.<\/span><\/p>\n

In laboratorul nostru se foloseste ca reactiv trombina umana ce contine un inhibitor pentru heparina. Ca urmare se poate folosi si pentru pacientii aflati in tratament cu heparina5<\/sup>.<\/span><\/p>\n

Valori de referinta <\/em><\/strong>\u2013 variaza in functie de varsta5<\/sup>:<\/span><\/p>\n\n\n\n\n\n\n\n
\n

Varsta<\/strong><\/span><\/p>\n<\/td>\n

\n

Valori de referinta (mg\/dL)<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

0-1 an<\/strong><\/span><\/p>\n<\/td>\n

\n

160-390<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2-10 ani<\/strong><\/span><\/p>\n<\/td>\n

\n

140-360<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

11-18 ani<\/strong><\/span><\/p>\n<\/td>\n

\n

160-390<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

> 18 ani<\/strong><\/span><\/p>\n<\/td>\n

\n

200-400<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Valori critice <\/strong>- <\/em><100mg\/dL<\/strong>2<\/sup><\/span><\/p>\n

! <\/strong>La valori <50mg\/dL<\/strong> pot aparea evenimente hemoragice dupa interventii chirurgicale traumatice.<\/span><\/p>\n

Valorile >700mg\/dL <\/strong>(determinari repetate\u00a0 dupa remiterea procesului inflamator acut) indica un risc crescut pentru aparitia bolilor coronariene si cerebrovasculare2<\/sup>.<\/span><\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/span><\/p>\n

Sc<\/span>aderi<\/span>:<\/span><\/p>\n

\u2022 Cresterea consumului de fibrinogen:<\/em> in CID si in reactiile de hiperfibrinoliza din cancere metastatice, leucemie acuta promielocitara, complicatii obstetricale. Consumul de fibrinogen poate incepe foarte rapid, de aceea dozarea acestuia trebuie facuta la intervale scurte de timp. Cand CID se suprapune peste raspunsul de faza acuta, fibringenul poate fi fals crescut.<\/span><\/p>\n

\u2022 Scaderea sintezei de fibrinogen<\/em>: in afectiuni hepatice severe insotite de scaderea parenchimului hepatic (ciroza hepatica, intoxicatie cu ciuperci), in afectiuni insotite de irigare hepatica anormala (insuficienta cardiaca dreapta).<\/span><\/p>\n

\u2022 Terapia trombolitica:<\/em> scaderea concentratiei de fibrinogen depinde de doza si de tipul medicatiei administrate: streptokinaza si urokinaza determina scaderea pronuntata a fibrinogenului (valori < 10mg\/dL); activatorul tisular al plasminogenului (t-PA) si prourokinaza determina scaderea moderata a fibrinogenului.<\/span><\/p>\n

\u2022 Terapia cu L-asparaginaza<\/em>6;7<\/sup>.<\/span><\/p>\n

\u2022 Afibrinogenemia congenitala<\/em>, caracterizata prin lipsa completa a fibrinogenului, este una din cele mai rare deficiente de factori ai coagularii, este mostenita autosomal recesiv si apare la homozigoti sau dublu heterozigoti pentru mutatiile respective. PT si aPTT sunt prelungite la infinit datorita incapacitatii de a produce fibrina6<\/sup>.<\/span><\/p>\n

\u2022 Indivizii heterozigoti pentru deficienta congenitala de fibrinogen (hipofibrinogemia<\/em>) sunt asimptomatici daca nivelul fibrinogenului este >50 mg\/dL, iar atat nivelul functional (activitatea) cat si cel antigenic sunt scazute6<\/sup>.<\/span><\/p>\n

Deficienta severa de fibrinogen trebuie considerata la un pacient cu istoric hemoragic si care are PT si aPTT prelungite. Deficientele usoare pot sa nu prelungeasca nici PT nici aPTT, astfel fibrinogenul trebuie masurat la pacienti cu tendinta hemoragica chiar atunci cand PT si aPTT sunt normale6<\/sup>.<\/span><\/p>\n

\u2022 La pacientii cu disfibrinogenemie congenitala <\/em>\u00a0fibrinogenul coagulabil este scazut, iar concentratia plasmatica a acestuia este normala sau scazuta1;6<\/sup>. Disfibrinogenemia congenitala este mostenita autosomal dominant, aproximativ 50% din pacienti sunt asimptomatici fiind descoperiti la testarile de laborator de rutina datorita timpilor de coagulare prelungiti (tipic, TT este prelungit), unul din patru pacienti prezinta sangerare prelungita postoperator, iar 20% prezinta tendinta spre tromboza6;7<\/sup>.<\/span><\/p>\n

\u2022 Consumul moderat de alcool scade nivelul de fibrinogen.4<\/sup><\/span><\/p>\n

Cresteri:<\/span><\/p>\n

\u2022 Cresterea sintezei de fibrinogen<\/em>: <\/em><\/span><\/p>\n

\u2013 in cadrul raspunsului de faza acuta din infectii, inflamatii, tumori, traumatisme, arsuri. In cazul distructiei celulare intinse (de ex. interventii chirurgicale, infarct miocardic, radioterapie) fibrinogenul revine la normal dupa raspunsul de faza acuta, spre deosebire de procesele inflamatorii cronice active din afectiuni reumatismale si boli de colagen, in care nivelul acestuia ramane crescut pe durate lungi de timp.<\/span><\/p>\n

\u2013 ca raspuns compensator la pierderea de proteine (in special a albuminei) la pacientii cu sindrom nefrotic, mielom multiplu;<\/span><\/p>\n

\u2013 boala hepatica, ciroza, tratament cu estrogeni, coagulare intravasculara compensata7<\/sup>;<\/span><\/p>\n

\u2013 hipertensiune, diabet, obezitate4;7<\/sup>.<\/span><\/p>\n

Disfibrinogenemia dobandita apare in asociere cu boli hepatice, renale si se asociaza de obicei cu niveluri crescute de fibrinogen7<\/sup>.<\/span><\/p>\n

Nivelurile crescute de fibrinogen se asociaza cu risc crescut de boala cardiovasculara aterosclerotica (de ex. IMA si AVC) 6<\/sup>. Concentratia plasmatica a fibrinogenului pare a fi reglata de un joc complex intre factorii genetici si de mediu1;2;4<\/sup>. Totusi ramane de stabilit daca fibrinogenul crescut actioneaza ca factor patogenic al trombozei arteriale sau reflecta inflamatia asociata cu ateroscleroza, fiind un marker pentru boala precoce silentioasa clinic4;6<\/sup>.<\/span><\/p>\n

Limite si interferente<\/em><\/strong>\u00a0<\/em><\/span><\/p>\n

La nou nascuti concentratia fibrinogenului poate fi scazuta datorita imaturitatii sistemului hemostatic si atinge nivelul de la adulti pana la 21 zile postnatal7<\/sup>.<\/span><\/p>\n

La gravide fibrinogenul este crescut in mod fiziologic2<\/sup>. Niveluri crescute pot fi intalnite la fumatori6<\/sup>.<\/span><\/p>\n

Determinarea fibrinogenului la pacientii aflati sub terapie trombolitica se face dupa adaugarea in plasma de testat a unei mixturi anticoagulante ce contine un inhibitor pentru plasmina.<\/span><\/p>\n

Rezultatul analizei nu este influentat de: prezenta PDF (<130\u00b5g\/mL), hirudina (<3\u00b5g\/mL), heparina (<2UI\/mL).<\/span><\/p>\n

\u00a0\u2022 Medicamente<\/span><\/p>\n

Cresteri<\/span>: contraceptive orale si estrogeni, aspirina, chimioterapice, pirazinamida, uleiul de peste. Scaderi<\/span>: nivele crescute ale antitrombinei III, steroizi anabolizanti, androgeni, L-asparaginaza, activatori ai plasminogenului, acid valproic, atenolol, pentoxifilin, cefamandol, preparate cu fier, 5-fluorouracil, clofibrat, danazol, kanamicina, medroxiprogesteron, prednison, ticlopidina1,3<\/sup>.<\/span><\/p>\n

\u00a0<\/span>\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span>
\n1. Dati F, Wagner C. \u201cHemostasis\u201d, Lothar Thomas\u2019 Clinical Laboratory Diagnostics, 1st ed, Frankfurt, Germany, 1998, 609-612.<\/span><\/p>\n

2. Fischbach F. \u201cBlood Studies. Hematology and Coagulation\u201d, A Manual of Laboratory and Diagnostic Test 8th ed, Philadelphia, 2009, 177-178.<\/span><\/p>\n

3. Fischbach F, \u201cAPPENDIX J-Effects of the Most Commonly Used Drugs\u201d, A Manual of Laboratory and Diagnostic Test, 8th ed, Philadelphia, 2009, 1238.<\/span><\/p>\n

4. Hantgan R, Lord S, \u201cFibrinogen Structure and Physiology\u201d, Hemostasis and Thrombosis. Basic Principles and Clinical Practice, Colman R, Marder V, Clowes A, George J, Goldheber S, 5th Ed, Lippincott Williams & Wilkins, 2006, 306-7<\/span><\/p>\n

5. Laborator Synevo. Referintele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog.<\/span><\/p>\n

6. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Fibrinogen Activity. www.labcorp.com. 2010. Ref Type: Internet Communication.<\/span><\/p>\n

7. Mayo Clinic, Mayo Medical Laboratories. Reference Laboratory Services for Health Care Organizations. Fibrinogen, Plasma. www.mayomedicallaboratories.com. 2009. Ref Type: Internet Communication.<\/span><\/p>\n

8. Roberts H, Monroe III D, Hoffman M, \u201cMolecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis\u201d, Wintrobe`s Clinical Hematology, Greer J, Foerster J, Lukens J, Rodgers G, Pareskevas F, Glader B, 11th ed, Lippincott Williams & Wilkins, 2004, 1680-82<\/span><\/p>","protected":false},"excerpt":{"rendered":"

\u0424\u0438\u0431\u0440\u0438\u043d\u043e\u0433\u0435\u043d \u043f\u043e \u043c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u043e\u0439 \u043d\u043e\u043c\u0435\u043d\u043a\u043b\u0430\u0442\u0443\u0440\u0435 \u2013 \u0444\u0430\u043a\u0442\u043e\u0440 I (\u043f\u0435\u0440\u0432\u044b\u0439) \u0441\u0432\u0435\u0440\u0442\u044b\u0432\u0430\u044e\u0449\u0435\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u043f\u043b\u0430\u0437\u043c\u044b \u043a\u0440\u043e\u0432\u0438. \u041e\u043d \u0432\u044b\u0440\u0430\u0431\u0430\u0442\u044b\u0432\u0430\u0435\u0442\u0441\u044f \u043f\u0435\u0447\u0435\u043d\u044c\u044e \u0438 \u0432\u044b\u0431\u0440\u0430\u0441\u044b\u0432\u0430\u0435\u0442\u0441\u044f \u0432 \u043a\u0440\u043e\u0432\u044c \u0432\u043c\u0435\u0441\u0442\u0435 \u0441 \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u0438\u043c\u0438 \u0434\u0440\u0443\u0433\u0438\u043c\u0438 \u0432\u0435\u0449\u0435\u0441\u0442\u0432\u0430\u043c\u0438, \u0432\u043b\u0438\u044f\u044e\u0449\u0438\u043c\u0438 \u043d\u0430 \u0435\u0435 \u0441\u0432\u0435\u0440\u0442\u044b\u0432\u0430\u043d\u0438\u0435.<\/p>\n

\u0415\u0441\u043b\u0438 \u043a\u0440\u043e\u0432\u0435\u043d\u043e\u0441\u043d\u044b\u0439 \u0441\u043e\u0441\u0443\u0434 \u0438\u043b\u0438 \u0442\u043a\u0430\u043d\u044c \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u044b, \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0435 \u043d\u0430\u0447\u0438\u043d\u0430\u0435\u0442\u0441\u044f \u0433\u0435\u043c\u043e\u0441\u0442\u0430\u0437, \u0438\u043b\u0438 \u0441\u0432\u0435\u0440\u0442\u044b\u0432\u0430\u043d\u0438\u0435 \u043a\u0440\u043e\u0432\u0438, \u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0438\u0435\u043c \u0447\u0435\u0433\u043e \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043f\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u0435 \u043a\u0440\u043e\u0432\u044f\u043d\u043e\u0433\u043e \u0441\u0433\u0443\u0441\u0442\u043a\u0430 (\u0442\u0440\u043e\u043c\u0431\u0430), \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0441\u043f\u043e\u0441\u043e\u0431\u0441\u0442\u0432\u0443\u0435\u0442 \u0437\u0430\u043c\u0435\u0434\u043b\u0435\u043d\u0438\u044e, \u0430 \u0437\u0430\u0442\u0435\u043c \u0438 \u043f\u0440\u0435\u043a\u0440\u0430\u0449\u0435\u043d\u0438\u044e \u043a\u0440\u043e\u0432\u043e\u0442\u0435\u0447\u0435\u043d\u0438\u044f. \u0412 \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0435 \u044d\u0442\u043e\u0433\u043e \u0432\u043e\u0437\u043d\u0438\u043a\u0430\u044e\u0442 \u043d\u0438\u0442\u0438 \u0431\u0435\u043b\u043a\u0430, \u043d\u0430\u0437\u044b\u0432\u0430\u0435\u043c\u044b\u0435 \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043c. \u041e\u043d\u0438 \u043f\u0435\u0440\u0435\u043f\u043b\u0435\u0442\u0430\u044e\u0442\u0441\u044f, \u043e\u0431\u0440\u0430\u0437\u0443\u044f \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u0432\u0443\u044e \u0441\u0435\u0442\u043a\u0443, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u0432\u043c\u0435\u0441\u0442\u0435 \u0441 \u0442\u0440\u043e\u043c\u0431\u043e\u0446\u0438\u0442\u0430\u043c\u0438 \u0441\u043f\u043e\u0441\u043e\u0431\u0441\u0442\u0432\u0443\u0435\u0442 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044e \u0442\u0440\u043e\u043c\u0431\u0430, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u043e\u0441\u0442\u0430\u0435\u0442\u0441\u044f \u043d\u0430 \u043c\u0435\u0441\u0442\u0435 \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u044f \u0441\u043e\u0441\u0443\u0434\u0430 \u0434\u043e \u0435\u0433\u043e \u043f\u043e\u043b\u043d\u043e\u0433\u043e \u0437\u0430\u0436\u0438\u0432\u043b\u0435\u043d\u0438\u044f.<\/p>\n

\u041f\u0440\u0438 \u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u043c \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435 \u0442\u0440\u043e\u043c\u0431\u043e\u0446\u0438\u0442\u043e\u0432 \u043a\u0430\u0436\u0434\u044b\u0439 \u0438\u0437 \u043a\u043e\u0430\u0433\u0443\u043b\u044f\u0446\u0438\u043e\u043d\u043d\u044b\u0445 \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432 \u0434\u043e\u043b\u0436\u0435\u043d \u0434\u0435\u0439\u0441\u0442\u0432\u043e\u0432\u0430\u0442\u044c \u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u043e \u0434\u043b\u044f \u0442\u043e\u0433\u043e, \u0447\u0442\u043e\u0431\u044b \u043e\u0431\u0435\u0441\u043f\u0435\u0447\u0438\u0442\u044c \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0433\u043e \u043a\u0440\u043e\u0432\u044f\u043d\u043e\u0433\u043e \u0441\u0433\u0443\u0441\u0442\u043a\u0430. \u041d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0435 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e \u0438\u043b\u0438 \u043d\u0435\u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u043e\u0435 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u044d\u0442\u0438\u0445 \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432 \u043c\u043e\u0436\u0435\u0442 \u043f\u0440\u0438\u0432\u0435\u0441\u0442\u0438 \u043a \u043a\u0440\u043e\u0432\u043e\u0442\u0435\u0447\u0435\u043d\u0438\u044e \u0438\u043b\u0438 \u043a \u0442\u0440\u043e\u043c\u0431\u043e\u0437\u0443.<\/p>\n

\u0410\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u0433\u0435\u043d \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c \u0432 \u043f\u0440\u0435\u0434\u043e\u043f\u0435\u0440\u0430\u0446\u0438\u043e\u043d\u043d\u043e\u043c \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438, \u043f\u0440\u0435\u043d\u0430\u0442\u0430\u043b\u044c\u043d\u043e\u0439 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435, \u043f\u0440\u0438 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0438 \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445.<\/p>\n

\u0424\u0438\u0431\u0440\u0438\u043d\u043e\u0433\u0435\u043d \u0442\u0430\u043a\u0436\u0435 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043e\u0434\u043d\u0438\u043c \u0438\u0437 \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432 \u043a\u0440\u043e\u0432\u0438, \u0438\u0437\u0432\u0435\u0441\u0442\u043d\u044b\u0445 \u043f\u043e\u0434 \u043d\u0430\u0437\u0432\u0430\u043d\u0438\u0435\u043c “\u0440\u0435\u0432\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u043e\u0431\u044b”. \u0423\u0440\u043e\u0432\u043d\u0438 \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u0433\u0435\u043d\u0430 \u0438 \u0434\u0440\u0443\u0433\u0438\u0445 \u0440\u0435\u0432\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432 \u0440\u0435\u0437\u043a\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430\u044e\u0442 \u0432 \u043a\u0440\u043e\u0432\u0438 \u043f\u0440\u0438 \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u0438 \u0438\u043b\u0438 \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0438 \u0442\u043a\u0430\u043d\u0438.<\/p>\n

\u0423\u0440\u043e\u0432\u0435\u043d\u044c \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u0433\u0435\u043d\u0430 \u0432 \u043a\u0440\u043e\u0432\u0438 \u043f\u043e\u0432\u044b\u0448\u0430\u0435\u0442\u0441\u044f \u043f\u0440\u0438 \u043e\u0441\u0442\u0440\u044b\u0445 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445, \u0430\u00a0\u0442\u0430\u043a\u0436\u0435 \u043f\u0440\u0438 \u043e\u0442\u043c\u0438\u0440\u0430\u043d\u0438\u0438 \u0442\u043a\u0430\u043d\u0435\u0439. \u0412\u00a0\u043e\u0441\u0442\u0430\u043b\u044c\u043d\u044b\u0445 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u043e\u043d\u043e \u043c\u043e\u0436\u0435\u0442 \u043e\u0437\u043d\u0430\u0447\u0430\u0442\u044c \u043e\u0441\u0442\u0440\u044b\u0435 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0435 \u0438 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u0438\u043d\u0441\u0443\u043b\u044c\u0442\u044b, \u0438\u043d\u0444\u0430\u0440\u043a\u0442 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430, \u0433\u0438\u043f\u043e\u0442\u0438\u0440\u0435\u043e\u0437, \u0430\u043c\u0438\u043b\u043e\u0438\u0434\u043e\u0437, \u043f\u043d\u0435\u0432\u043c\u043e\u043d\u0438\u044e, \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0435 \u043e\u043f\u0443\u0445\u043e\u043b\u0438. \u041f\u0440\u0438\u0447\u0438\u043d\u043e\u0439 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u044f \u0443\u0440\u043e\u0432\u043d\u044f \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u0433\u0435\u043d\u0430 \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u043f\u0435\u0440\u0435\u043d\u0435\u0441\u0435\u043d\u043d\u044b\u0435 \u043e\u043f\u0435\u0440\u0430\u0446\u0438\u0438, \u043e\u0436\u043e\u0433\u0438, \u043f\u0440\u0438\u0435\u043c \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u043c \u044d\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u043e\u0432 \u0438\u043b\u0438\u00a0\u043e\u0440\u0430\u043b\u044c\u043d\u044b\u0445 \u043a\u043e\u043d\u0442\u0440\u0430\u0446\u0435\u043f\u0442\u0438\u0432\u043e\u0432.<\/p>\n

\u0421\u0442\u043e\u0438\u0442 \u043e\u0442\u043c\u0435\u0442\u0438\u0442\u044c, \u0447\u0442\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043f\u0440\u0438 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u043e\u043c \u0443\u0440\u043e\u0432\u043d\u0435 \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u0433\u0435\u043d\u0430 \u043c\u043e\u0436\u0435\u0442 \u043d\u0435 \u043f\u043e\u043d\u0430\u0434\u043e\u0431\u0438\u0442\u044c\u0441\u044f \u0432 \u0434\u0432\u0443\u0445 \u0441\u043b\u0443\u0447\u0430\u044f\u0445: \u043f\u0440\u0438 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u0438 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u043c \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0435. \u0422\u043e\u0433\u0434\u0430 \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0438 \u0443\u0440\u043e\u0432\u043d\u044f \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u0433\u0435\u043d\u0430 \u0432 \u043a\u0440\u043e\u0432\u0438 \u043f\u0440\u0438\u0445\u043e\u0434\u044f\u0442 \u0432 \u043d\u043e\u0440\u043c\u0443 \u0441\u0430\u043c\u0438, \u043a\u043e\u0433\u0434\u0430 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0435 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430 \u0441\u0442\u0430\u0431\u0438\u043b\u0438\u0437\u0438\u0440\u0443\u0435\u0442\u0441\u044f.<\/p>\n

\u0414\u043b\u044f \u0447\u0435\u0433\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n

\u0427\u0442\u043e\u0431\u044b \u043e\u0446\u0435\u043d\u0438\u0442\u044c \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u043e\u0441\u0442\u044c \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430 \u043a \u0442\u0440\u043e\u043c\u0431\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044e \u0438 \u0432\u044b\u044f\u0432\u0438\u0442\u044c \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u044b\u0435 \u0441 \u044d\u0442\u0438\u043c \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f,\u00a0\u043d\u0430\u043f\u0440\u0438\u043c\u0435\u0440 \u043d\u0430\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u0443\u044e \u0430\u0444\u0438\u0431\u0440\u0438\u043d\u043e\u0433\u0435\u043c\u0438\u044e \u0438\u043b\u0438 \u0433\u0438\u043f\u043e\u0444\u0438\u0431\u0440\u0438\u043d\u043e\u0433\u0435\u043c\u0438\u044e, \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u043f\u0435\u0447\u0435\u043d\u0438, \u0438\u0441\u0442\u043e\u0449\u0435\u043d\u0438\u0435 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430, \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u043f\u0440\u043e\u0446\u0435\u0441\u0441.<\/p>\n

\u041a\u043e\u0433\u0434\u0430 \u043d\u0430\u0437\u043d\u0430\u0447\u0430\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n

    \n
  • \u041f\u0440\u0438 \u043a\u0440\u043e\u0432\u043e\u0442\u0435\u0447\u0435\u043d\u0438\u0438 \u0438\u043b\u0438 \u0442\u0440\u043e\u043c\u0431\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u044d\u043f\u0438\u0437\u043e\u0434\u0435.<\/li>\n
  • \u041f\u0440\u0438 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0433\u043e \u0447\u0430\u0441\u0442\u0438\u0447\u043d\u043e\u0433\u043e \u0442\u0440\u043e\u043c\u0431\u043e\u043f\u043b\u0430\u0441\u0442\u0438\u043d\u043e\u0432\u043e\u0433\u043e \u0432\u0440\u0435\u043c\u0435\u043d\u0438 (\u0410\u0427\u0422\u0412) \u0438\u043b\u0438 \u0442\u0440\u043e\u043c\u0431\u0438\u043d\u043e\u0432\u043e\u0433\u043e \u0432\u0440\u0435\u043c\u0435\u043d\u0438 (\u0422\u0412).<\/li>\n
  • \u0412 \u0441\u043b\u0443\u0447\u0430\u0435 \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0449\u0435\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043f\u0435\u0447\u0435\u043d\u0438.<\/li>\n<\/ul>\n

    \u041a\u0430\u043a \u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u043e \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u0438\u0442\u044c\u0441\u044f \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e?<\/strong><\/p>\n

      \n
    • \u0414\u0435\u0442\u044f\u043c \u0432 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 \u0434\u043e 1 \u0433\u043e\u0434\u0430 \u043d\u0435 \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0442\u044c \u043f\u0438\u0449\u0443 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 30-40 \u043c\u0438\u043d\u0443\u0442 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n
    • \u0414\u0435\u0442\u044f\u043c \u0432 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 \u043e\u0442 1 \u0434\u043e 5 \u043b\u0435\u0442 \u043d\u0435 \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0442\u044c \u043f\u0438\u0449\u0443 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 2-3 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n
    • \u041d\u0435 \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0442\u044c \u043f\u0438\u0449\u0443 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 12 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f, \u043c\u043e\u0436\u043d\u043e \u043f\u0438\u0442\u044c \u0447\u0438\u0441\u0442\u0443\u044e \u043d\u0435\u0433\u0430\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u0443\u044e \u0432\u043e\u0434\u0443.<\/li>\n
    • \u0418\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0438 \u044d\u043c\u043e\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0435 \u043f\u0435\u0440\u0435\u043d\u0430\u043f\u0440\u044f\u0436\u0435\u043d\u0438\u0435 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 30 \u043c\u0438\u043d\u0443\u0442 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n
    • \u041d\u0435 \u043a\u0443\u0440\u0438\u0442\u044c \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 30 \u043c\u0438\u043d\u0443\u0442 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n<\/ul>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[951],"product_tag":[],"class_list":{"0":"post-9237","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-de-hemostaza","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9237"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9237"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9237"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9237"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}