{"id":9207,"date":"2020-04-23T04:31:20","date_gmt":"2020-04-23T01:31:20","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/determinare-crioglobuline\/"},"modified":"2026-02-18T23:44:33","modified_gmt":"2026-02-18T21:44:33","slug":"determinare-crioglobuline","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/determinare-crioglobuline\/","title":{"rendered":"\u041e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u043a\u0440\u0438\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u0430"},"content":{"rendered":"
Proba se recolteaz\u0103 doar \u00een mun. Chi\u0219in\u0103u pe str. Testemi\u021banu 37!<\/span>
\n<\/strong><\/h5>\n

Informa\u0163ii<\/em><\/strong> generale<\/em><\/strong><\/p>\n

Crioglobulinele sunt proteine din clasa imunoglobulinelor care precipit\u0103 reversibil la temperaturi sc\u0103zute (0-4\u00baC) \u015fi se resolubilizeaz\u0103 la 37\u00baC. Studii recente au ar\u0103tat c\u0103 temperatura la care precipit\u0103 crioglobulinele variaz\u0103 \u00een func\u0163ie de concentra\u0163ia seric\u0103 a proteinelor; astfel cre\u015fterea concentra\u0163iei proteinelor determin\u0103 cre\u015fterea temperaturii la care precipit\u0103 crioglobulinele. De asemenea, exist\u0103 diferen\u0163e \u00een func\u0163ie de tipul imunoglobulinelor: IgM precipit\u0103 la temperaturi mai sc\u0103zute decat IgG.<\/p>\n

Ocazional, IgM prezint\u0103 2 propriet\u0103\u0163i: crioprecipitare \u015fi capacitatea de a aglutina hematiile prin anticorpi la rece (aglutinine la rece). Nu toate crioglobulinele sunt \u00eens\u0103 aglutinine la rece, deoarece nu de\u0163in unele din propriet\u0103\u0163ile acestor anticorpi.<\/p>\n

Sunt descrise 3 tipuri de crioglobuline:<\/p>\n

    \n
  • tip I: alc\u0103tuite dintr-un singur tip de imunoglobulin\u0103 (IgG sau IgM) omogen\u0103,\u00a0monoclonal\u0103 care formeaz\u0103 adesea un precipitat mare, \u00eentr-un interval de 24 ore de la plasarea serului \u00een frigider; de obicei concentra\u0163ia crioglobulinelor dep\u0103\u015fe\u015fte 5 mg\/mL;<\/li>\n
  • tip II: crioglobuline mixte alc\u0103tuite dintr-un component monoclonal (de obicei IgM care are activitate de factor reumatoid) \u015fi o component\u0103 policlonal\u0103 (IgG) care formeaz\u0103, \u00een majoritatea cazurilor, un precipitat mic la 4\u00baC \u00eentr-un interval de 1-7 zile; de obicei\u00a0 concentra\u0163ia crioglobulinelor este mai mare de 1 mg\/mL;<\/li>\n
  • tip III: crioglobuline mixte alc\u0103tuite din 2 sau mai multe imunoglobuline policlonale apar\u0163in\u00e2nd mai multor clase, care formeaz\u0103 la 4\u00baC precipitate foarte mici, adesea gelatinoase, \u00eentr-un interval de timp mai mare decat \u00een cazul celorlaltor tipuri de crioglobuline (p\u00e2n\u0103 la 7 zile); de obicei concentra\u0163ia crioglobulinelor este mai mic\u0103 de 1 mg\/mL3<\/sup>.<\/li>\n<\/ul>\n

    \u00cen urma precipit\u0103rii crioglobulinelor se produc obstruc\u0163ii ale vaselor mici care pot determina urm\u0103toarele manifest\u0103ri clinice: purpur\u0103, fenomene de tip Raynaud, necroz\u0103 a extremit\u0103\u0163ilor1<\/sup>.<\/p>\n

    Crioglobulinemiile pot fi esen\u0163iale (idiopatice) sau secundare. \u00cen tabelul de mai jos sunt men\u0163ionate afec\u0163iunile asociate celor 3 tipuri de crioglobuline3<\/sup>:<\/p>\n\n\n\n\n\n\n
    \n

    Tipul de crioglobuline<\/p>\n<\/td>\n

    		\n

    Afec\u0163iuni asociate<\/p>\n<\/td>\n<\/tr>\n

    \n

    Tip I<\/p>\n<\/td>\n

    		\n

    Boli limfoproliferative: boala Waldenstr\u00f6m, mielom multiplu, leucemie limfatic\u0103 cronic\u0103, leucemie cu celule p\u0103roase, limfomul angioimunoblastic<\/p>\n<\/td>\n<\/tr>\n

    \n

    Tip II<\/p>\n<\/td>\n

    		\n

    Infec\u0163ii, afec\u0163iuni hepatice (cel mai adesea, hepatita C), boli limfoproliferative, afec\u0163iuni autoimmune: lupus eritematos systemic, poliartrita reumatoid\u0103, sclerodermie, sindrom Sj\u00f6gren<\/p>\n<\/td>\n<\/tr>\n

    \n

    Tip III<\/p>\n<\/td>\n

    		\n

    Infec\u0163ii \u015fi afec\u0163iuni autoimune<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    <\/div>\n
    Pacien\u0163ii cu lupus eritematos sistemic \u015fi factor reumatoid negativ care prezint\u0103 crioglobuline dezvolt\u0103 mai frecvent afectare renal\u0103 dec\u00e2t cei cu factor reumatoid pozitiv \u015fi crioglobuline absente1<\/sup>.<\/div>\n
    Numeroase studii au ar\u0103tat c\u0103 multe cazuri (42-98%) de crioglobulinemie mixt\u0103 idiopatic\u0103 (tip II sau III) sunt de fapt secundare infec\u0163iei cu virusul hepatitei C3<\/sup>.<\/div>\n

    Recomand\u0103ri pentru determinarea crioglobulinelor <\/em><\/strong>\u2013 depistarea crioglobulinelor la pacien\u0163i cu simptome declan\u015fate \u00een urma expunerii la frig (purpura, urticarie, necroz\u0103 digital\u0103, fenomene Raynaud), infec\u0163ia cronic\u0103 cu virusul hepatitei C, macroglobulinemia Waldenstr\u00f6m, leucemia limfatic\u0103 cronic\u0103, colagenoze1;2<\/sup>.<\/p>\n

    Preg\u0103tire pacient <\/em><\/strong>\u2013 \u00e0 jeun (pe nem\u00e2ncate)2;3<\/sup>.<\/p>\n

    Specimen recoltat <\/em><\/strong>\u2013 s\u00e2nge venos2;3<\/sup>.<\/p>\n

    Recipient de recoltare <\/em><\/strong>\u2013 vacutainer f\u0103r\u0103 aditivi, pre\u00eenc\u0103lzit la 37 \u00baC; este exclus\u0103 utilizarea tubului cu gel separator 2;3<\/sup>.<\/p>\n

    Cantitate recoltat\u0103 <\/em><\/strong>\u2013 5 mL 2;3<\/sup><\/p>\n

    Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>\u2013 tubul de recoltare pre\u00eenc\u0103lzit la 37\u00baC se reintroduce imediat dup\u0103 prelevarea s\u00e2ngelui la 37\u00baC \u015fi se las\u0103 p\u00e2n\u0103 c\u00e2nd se produce coagularea; apoi, serul se separ\u0103 prin centrifugare, se decanteaz\u0103 \u015fi se transfer\u0103 \u00eentr-o eprubet\u0103 la 4\u00baC2;3<\/sup>.<\/p>\n

    Cauze de respingere a probei <\/em><\/strong>\u2013 specimen care nu a coagulat la 37\u00baC 2;3<\/sup>.<\/p>\n

    Metod\u0103 <\/em><\/strong>- precipitarea crioglobulinelor la 4\u00baC<\/span>1;2;3<\/sup><\/p>\n

    Valori de referin\u0163\u0103 <\/em><\/strong>\u2013 crioglobuline absente dup\u0103 7 zile de p\u0103strare a serului la 4\u00baC2;3<\/sup>.<\/p>\n

    Interpretarea rezultatelor<\/em><\/strong><\/p>\n

    Dup\u0103 24 ore, proba de ser p\u0103strat\u0103 la 4\u00baC se examineaz\u0103 pentru a se identifica eventuala formare a unui depozit albicios; dac\u0103 acesta este prezent, serul este \u00eenc\u0103lzit la 37\u00baC \u00eentr-o baie de ap\u0103 pentru a urm\u0103ri dizolvarea precipitatului \u015fi apoi va fi plasat din nou \u00een frigider, pentru a demonstra c\u0103 precipitatul se formeaz\u0103 \u00een mod repetat. Dac\u0103 dup\u0103 24 ore nu se observ\u0103 formarea precipitatului, proba este introdus\u0103 din nou la 4\u00baC \u015fi examinat\u0103 dup\u0103 7 zile2;3<\/sup>.<\/p>\n

    Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

    Testul, fiind calitativ, indic\u0103 doar prezen\u0163a sau absen\u0163a crioglobulinelor. Pentru analiza prezen\u0163ei componentelor monoclonale sau policlonale este necesar testul de imunofixare3<\/sup>.<\/div>\n
    Rezultate fals pozitive<\/span>\u00a0pot s\u0103 apar\u0103 \u00een cazul serurilor lipemice \u015fi \u00een situa\u0163ia \u00een care se folosesc la recoltarea probei vacutainere cu anticoagulant.<\/div>\n
    Rezultate fals negative<\/span> pot s\u0103 apar\u0103 dac\u0103 vacutainerul nu a fost pre\u00eenc\u0103lzit la 37\u00baC, proba nu a fost \u0163inut\u0103 la 37\u00baC p\u00e2n\u0103 la formarea coagulului, sau a fost centrifugat\u0103 la temperaturi mai mici de 37\u00baC2<\/sup>.<\/div>\n

    \u00a0<\/span><\/p>\n

    \u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

    1. Laboratory Corporation of America. Cryoglobulin, Qualitative, Serum. Directory of Services and Interpretive Guide, 2010. www.labcorp.com<\/span><\/div>\n
    2. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog<\/span><\/div>\n
    3. Mayo Reference Services. Cryoglobulinemia: Out in the Cold. In Communiqu\u00e9, vol.28. no. 11, nov.2003<\/span><\/div>","protected":false},"excerpt":{"rendered":"

    \u0410\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 \u043a\u0440\u0438\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u044b \u2013 \u044d\u0442\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0432 \u043a\u0440\u043e\u0432\u0438 \u0430\u043d\u043e\u043c\u0430\u043b\u044c\u043d\u044b\u0445 \u0431\u0435\u043b\u043a\u043e\u0432 \u0438\u043c\u043c\u0443\u043d\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u043e\u0432, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0441\u043b\u0438\u043f\u0430\u044e\u0442\u0441\u044f \u0438 \u0432\u044b\u043f\u0430\u0434\u0430\u044e\u0442 \u0432 \u043e\u0441\u0430\u0434\u043e\u043a \u043f\u0440\u0438 \u043f\u043e\u043d\u0438\u0436\u0435\u043d\u0438\u0438 \u0442\u0435\u043c\u043f\u0435\u0440\u0430\u0442\u0443\u0440\u044b \u043d\u0438\u0436\u0435 37 \u0433\u0440\u0430\u0434\u0443\u0441\u043e\u0432, \u0447\u0442\u043e \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a \u0441\u0433\u0443\u0449\u0435\u043d\u0438\u044e \u0438 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044e \u0442\u0435\u043a\u0443\u0447\u0435\u0441\u0442\u0438 \u043a\u0440\u043e\u0432\u0438, \u043f\u0440\u043e\u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u043e\u0447\u0430\u0433\u043e\u0432 \u0438\u0448\u0435\u043c\u0438\u0438.<\/p>\n

    \u0410\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 \u043a\u0440\u0438\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u044b \u043e\u043a\u0430\u0437\u044b\u0432\u0430\u0435\u0442 \u043f\u043e\u043c\u043e\u0449\u044c \u043f\u0440\u0438 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u043b\u0438\u043c\u0444\u043e\u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u044b\u0445, \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u044b\u0445, \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439. \u0412 \u043a\u0440\u043e\u0432\u0438 \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430 \u0446\u0438\u0440\u043a\u0443\u043b\u0438\u0440\u0443\u044e\u0442 \u0438\u043c\u043c\u0443\u043d\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u044b \u0410, \u041c, G. \u042d\u0442\u043e \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430.<\/p>\n

    \u041a\u0440\u0438\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u044b \u2013 \u044d\u0442\u043e \u0442\u0435 \u0436\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u044d\u0442\u0438\u0445 \u0442\u0440\u0435\u0445 \u043a\u043b\u0430\u0441\u0441\u043e\u0432, \u043d\u043e \u0441 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u043d\u044b\u043c\u0438 \u0441\u0432\u043e\u0439\u0441\u0442\u0432\u0430\u043c\u0438.<\/p>\n

    \u041a\u0440\u043e\u043c\u0435 \u0442\u043e\u0433\u043e, \u043e\u043d\u0438 \u0431\u044b\u0432\u0430\u044e\u0442:<\/p>\n

      \n
    • \u043c\u043e\u043d\u043e\u043a\u043b\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u043c\u0438, \u043a\u043e\u0433\u0434\u0430 \u043d\u0430 \u043e\u0434\u0438\u043d\u0430\u043a\u043e\u0432\u044b\u0435 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u044b \u0432\u044b\u0440\u0430\u0431\u0430\u0442\u044b\u0432\u0430\u044e\u0442\u0441\u044f \u043e\u0434\u0438\u043d\u0430\u043a\u043e\u0432\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430;<\/li>\n
    • \u043f\u043e\u043b\u0438\u043a\u043b\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u043c\u0438, \u0435\u0441\u043b\u0438 \u043d\u0430 \u043e\u0434\u0438\u043d\u0430\u043a\u043e\u0432\u044b\u0435 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u044b \u0441\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u0443\u044e\u0442\u0441\u044f \u0440\u0430\u0437\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430.<\/li>\n<\/ul>\n

      \u0421\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0435, \u043f\u0440\u0438 \u043a\u043e\u0442\u043e\u0440\u043e\u043c \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u044e\u0442 \u0432 \u043a\u0440\u043e\u0432\u0438 \u043a\u0440\u0438\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u044b, \u043d\u0430\u0437\u044b\u0432\u0430\u0435\u0442\u0441\u044f \u043a\u0440\u0438\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u0435\u043c\u0438\u0435\u0439.<\/p>\n

      \u0412 \u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0441\u0442\u0438 \u043e\u0442 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u044f \u043e\u0434\u043d\u043e\u0433\u043e \u0438\u043b\u0438 \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u0438\u0445 \u0442\u0438\u043f\u043e\u0432 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u043d\u044b\u0445 \u0438\u043c\u043c\u0443\u043d\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u043e\u0432 \u0440\u0430\u0437\u043b\u0438\u0447\u0430\u044e\u0442:<\/p>\n

        \n
      1. \u041f\u0440\u043e\u0441\u0442\u0443\u044e \u043a\u0440\u0438\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u0435\u043c\u0438\u044e, \u0438\u043b\u0438 \u043f\u0435\u0440\u0432\u043e\u0433\u043e \u0442\u0438\u043f\u0430, \u043f\u0440\u0438 \u043a\u043e\u0442\u043e\u0440\u043e\u0439 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u044e\u0442\u0441\u044f \u043c\u043e\u043d\u043e\u043a\u043b\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043e\u0434\u043d\u043e\u0433\u043e \u0438\u0437 \u0442\u0440\u0435\u0445 \u043a\u043b\u0430\u0441\u0441\u043e\u0432 (\u0410, \u041c, G). \u041d\u0430\u0438\u0431\u043e\u043b\u0435\u0435 \u0447\u0430\u0441\u0442\u043e \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u044e\u0449\u0443\u044e\u0441\u044f \u043f\u0440\u0438 \u043b\u0438\u043c\u0444\u043e\u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u044b\u0445 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u044f\u0445.<\/li>\n
      2. \u0421\u043c\u0435\u0448\u0430\u043d\u043d\u0443\u044e \u0432\u0442\u043e\u0440\u043e\u0433\u043e \u0442\u0438\u043f\u0430, \u0435\u0441\u043b\u0438 \u0432 \u043a\u0440\u043e\u0432\u0438 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u044e\u0442 \u043c\u043e\u043d\u043e\u043a\u043b\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u0410, \u041c \u0438\u043b\u0438 G, \u0438 \u043f\u043e\u043b\u0438\u043a\u043b\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0435, \u0447\u0430\u0449\u0435 \u0432\u0441\u0435\u0433\u043e G.<\/li>\n
      3. \u0421\u043c\u0435\u0448\u0430\u043d\u043d\u0443\u044e \u0442\u0440\u0435\u0442\u044c\u0435\u0433\u043e \u0442\u0438\u043f\u0430, \u043a\u043e\u0433\u0434\u0430 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u044e\u0442\u0441\u044f \u043f\u043e\u043b\u0438\u043a\u043b\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u0432\u0441\u0435\u0445 \u0442\u0438\u043f\u043e\u0432 \u0438\u043c\u043c\u0443\u043d\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u043e\u0432.<\/li>\n<\/ol>\n

        \u0412\u0442\u043e\u0440\u043e\u0439 \u0438 \u0442\u0440\u0435\u0442\u0438\u0439 \u0442\u0438\u043f \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u044e\u0442\u0441\u044f \u043d\u0430 \u0444\u043e\u043d\u0435 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u044b\u0445 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0439, \u0432\u0438\u0440\u0443\u0441\u043d\u044b\u0445 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u0432, \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0445 \u0431\u043e\u043b\u0435\u0437\u043d\u0435\u0439, \u043f\u0430\u0440\u0430\u0437\u0438\u0442\u0430\u0440\u043d\u044b\u0445 \u0438\u043d\u0432\u0430\u0437\u0438\u0439.<\/p>\n

        \u0414\u043b\u044f \u044d\u0442\u0438\u0445 \u0434\u0432\u0443\u0445 \u0442\u0438\u043f\u043e\u0432 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u044b \u0432 \u043f\u0435\u0440\u0432\u0443\u044e \u043e\u0447\u0435\u0440\u0435\u0434\u044c \u0442\u0430\u043a\u0438\u0435 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u044f, \u043a\u0430\u043a \u0432\u0430\u0441\u043a\u0443\u043b\u0438\u0442 (\u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u0435 \u0441\u043e\u0441\u0443\u0434\u043e\u0432) \u0438 \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u0435 \u0441\u0443\u0441\u0442\u0430\u0432\u043e\u0432. \u041a\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e \u043f\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u0435 \u0441\u043b\u0435\u0434\u0443\u044e\u0449\u0438\u0445 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u0432:<\/p>\n

          \n
        • \u0430\u0440\u0442\u0440\u0430\u043b\u0433\u0438\u0439 \u043e\u0434\u043d\u043e\u0433\u043e \u0438\u043b\u0438 \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u0438\u0445 \u0441\u0443\u0441\u0442\u0430\u0432\u043e\u0432;<\/li>\n
        • \u043a\u043e\u0436\u043d\u044b\u0445 \u0432\u044b\u0441\u044b\u043f\u0430\u043d\u0438\u0439 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u043e\u0439 \u043b\u043e\u043a\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u0438 \u0438 \u0438\u043d\u0442\u0435\u043d\u0441\u0438\u0432\u043d\u043e\u0441\u0442\u0438;<\/li>\n
        • \u0433\u0435\u043c\u043e\u0440\u0440\u0430\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u0439;<\/li>\n
        • \u043c\u044b\u0448\u0435\u0447\u043d\u044b\u0445 \u0431\u043e\u043b\u0435\u0439;<\/li>\n
        • \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u044f \u043f\u043e\u0447\u0435\u043a.<\/li>\n<\/ul>\n

          \u0414\u043b\u044f \u043f\u0435\u0440\u0432\u043e\u0433\u043e \u0442\u0438\u043f\u0430 \u0431\u043e\u043b\u0435\u0435 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u044b \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b, \u043f\u043e\u044f\u0432\u043b\u044f\u044e\u0449\u0438\u0435\u0441\u044f \u0432 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0435 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u044f \u0432\u044f\u0437\u043a\u043e\u0441\u0442\u0438 \u0438 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u0441\u0432\u0435\u0440\u0442\u044b\u0432\u0430\u043d\u0438\u044f \u043a\u0440\u043e\u0432\u0438:<\/p>\n

            \n
          • \u0441\u043a\u043b\u043e\u043d\u043d\u043e\u0441\u0442\u044c \u043a \u0442\u0440\u043e\u043c\u0431\u043e\u0437\u0430\u043c;<\/li>\n
          • \u043a\u0440\u043e\u0432\u043e\u0438\u0437\u043b\u0438\u044f\u043d\u0438\u044f \u0432 \u0441\u043b\u0438\u0437\u0438\u0441\u0442\u044b\u0435;<\/li>\n
          • \u043f\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u0435 \u043e\u0447\u0430\u0433\u043e\u0432 \u0438\u0448\u0435\u043c\u0438\u0438;<\/li>\n
          • \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0420\u0435\u0439\u043d\u043e (\u043f\u043e\u0445\u043e\u043b\u043e\u0434\u0430\u043d\u0438\u0435 \u0438 \u043e\u043d\u0435\u043c\u0435\u043d\u0438\u0435 \u043a\u043e\u043d\u0447\u0438\u043a\u043e\u0432 \u043f\u0430\u043b\u044c\u0446\u0435\u0432).<\/li>\n<\/ul>\n

            \u0410\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0430 \u0438 \u0442\u0438\u043f\u0430 \u043a\u0440\u0438\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u043e\u0432 \u043f\u043e\u043c\u043e\u0433\u0430\u0435\u0442 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0438\u0442\u044c, \u0447\u0442\u043e \u0442\u0430\u043a\u043e\u0435 \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0434\u0438\u0442 \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0435, \u0438 \u043f\u043e\u0434\u0441\u043a\u0430\u0437\u044b\u0432\u0430\u0435\u0442 \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u0438\u0435 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u043e\u0438\u0441\u043a\u0430.<\/p>\n

            \u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b<\/p>\n

            \u041e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435 \u044d\u0442\u0438\u0445 \u0431\u0435\u043b\u043a\u043e\u0432 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043d\u043e\u0440\u043c\u043e\u0439. \u041f\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u0435 \u0438\u0445 \u0441\u0432\u0438\u0434\u0435\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0443\u0435\u0442 \u043e \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f\u0445 \u0432 \u0440\u0430\u0431\u043e\u0442\u0435 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430 \u0438 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e\u0441\u0442\u0438 \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u0434\u043e\u043f\u043e\u043b\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043c\u0435\u0440\u043e\u043f\u0440\u0438\u044f\u0442\u0438\u0439. \u041a\u0440\u0430\u0442\u043a\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0435 \u0442\u0440\u0430\u043d\u0437\u0438\u0442\u043e\u0440\u043d\u043e\u0435 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435 \u043a\u0440\u0438\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u043e\u0432 \u0431\u044b\u0432\u0430\u0435\u0442 \u043f\u0440\u0438 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u043e\u0441\u0442\u0440\u044b\u0445 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445. \u041e\u043d\u0438 \u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0438\u0440\u0443\u044e\u0442\u0441\u044f \u0432 \u043e\u0441\u0442\u0440\u043e\u043c \u043f\u0435\u0440\u0438\u043e\u0434\u0435 \u0438 \u0438\u0441\u0447\u0435\u0437\u0430\u044e\u0442 \u0432 \u043f\u0435\u0440\u0438\u043e\u0434 \u0432\u044b\u0437\u0434\u043e\u0440\u043e\u0432\u043b\u0435\u043d\u0438\u044f.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[928,929],"product_tag":[],"class_list":{"0":"post-9207","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-boli-autoimune","6":"product_cat-markeri-pentru-afectiuni-reumatismale-si-vasculite","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9207","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9207"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9207"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9207"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9207"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9207"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}