{"id":9206,"date":"2020-04-23T04:31:19","date_gmt":"2020-04-23T01:31:19","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/creatinkinaza-ck\/"},"modified":"2026-02-19T01:08:58","modified_gmt":"2026-02-18T23:08:58","slug":"creatinkinaza-ck","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/creatinkinaza-ck\/","title":{"rendered":"\u041a\u0440\u0435\u0430\u0442\u0438\u043d\u043a\u0438\u043d\u0430\u0437\u0430 (\u0421\u041a)"},"content":{"rendered":"

Sinonime <\/em><\/strong>\u2013 creatinfosfokinaza (CPK)4<\/sup>.<\/p>\n

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Creatinkinaza este o enzima ce se gaseste in concentratii crescute in miocard si muschii scheletici si, in concentratii mult mai mici, la nivelul creierului1<\/sup>. CK are o structura dimerica si apare sub 4 forme: izoenzima mitocondriala si izoenzimele citosolice cu 3 fractiuni: CK-MM (musculara), CK-MB (miocardica), CK-BB (cerebrala)5<\/sup>.<\/p>\n

La indivizii sanatosi, nivelul creatinkinazei totale este dat, aproape in totalitate, de izoenzima MM.<\/p>\n

Recomandari pentru determinarea creatinkinazei <\/em><\/strong>\u2013 diagnosticul infarctului miocardic acut si al diverselor afectiuni musculare1<\/sup>.<\/p>\n

Pregatire pacient <\/em><\/strong>\u2013 \u00e0 jeun (pe nemancate) sau postprandial; inainte de recoltare pacientul nu va face exercitii fizice3<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>\u2013 sange venos3<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer fara anticoagulant cu\/fara gel separator3<\/sup>.\u00a0<\/em><\/strong><\/p>\n

Prelucrare necesara dupa recoltare <\/em><\/strong>\u2013 se separa serul prin centrifugare3<\/sup>.<\/p>\n

Volum proba<\/em><\/strong> \u2013 minim 0.5 mL ser3<\/sup>.<\/p>\n

Cauze de respingere<\/em><\/strong> a probei <\/em><\/strong>\u2013 specimen hemolizat3<\/sup>.<\/p>\n

Stabilitate proba <\/em><\/strong>- <\/em>serul separat este stabil 2 zile<\/em> la temperatura camerei; 7 zile <\/em>la 4-8\u00b0C; 1 luna<\/em> la -20\u00b0C3<\/sup>.<\/p>\n

Metoda <\/em><\/strong>- spectrofotometrica (kinetica)<\/span>3<\/sup>.<\/p>\n

Valori de referinta<\/em><\/strong>\u00a0<\/strong><\/p>\n\n\n\n\n\n
\n

Sex<\/em><\/strong><\/p>\n<\/td>\n

\n

Valori ( U\/L)<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Femei<\/em><\/strong>3<\/sup><\/p>\n<\/td>\n

\n

<192 \u00a0<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Barbati<\/em><\/strong>3<\/sup><\/p>\n<\/td>\n

\n

<308<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/em>Factor de conversie:U\/L x 0.0167=<\/em>m<\/em>kat\/L<\/em><\/p>\n

Limita de detectie<\/em><\/strong> - <\/em>0.05 \u00b5kat\/L (3 U\/L)3<\/sup>.<\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/p>\n\n\n\n\n
\n

Cresteri<\/em><\/strong><\/p>\n<\/td>\n

\n

Scaderi<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

\u2022 infarct miocardic acut (la 4-6 ore de la debut); \u2022 miocardita severa; \u2022 dupa interventie chirurgicala deschisa pe cord si defribilare electrica \u2022 distrofie musculara Duchenne, polimiozita\/dermatomiozita, traumatisme musculare;<\/p>\n

\u2022 rabdomioliza in cadrul intoxicatiei cu cocaina; \u2022 sindromul mialgie-eozinofilie; \u2022 hipertermie maligna \u2022 convulsii, \u2022 ischemie,<\/p>\n

\u2022 hemoragie subarahnoidiana; \u2022 sindrom Reye1<\/sup>;4<\/sup>.<\/p>\n<\/td>\n

\n

\u2022 reflecta de obicei reducerea masei musculare asociata cu tumori in stadiu metastatic, corticoterapie, boala alcoolica a ficatului, colagenoze1<\/sup>;4<\/sup>.<\/p>\n

\u00a0<\/em><\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Limite si interferente<\/em><\/strong><\/p>\n

In infarctul miocardic acut determinarea creatinkinazei MB ofera indicatii mult mai precise despre afectarea miocardica decat creatinkinaza totala1<\/sup>.<\/p>\n

Uneori, CK total este normal, in prezenta unei valori crescute de CK-MB4<\/sup>.<\/p>\n

Efortul fizic sustinut, ridicarea de greutati sau travaliul pot determina cresteri de CK1<\/sup>.<\/p>\n

Injectiile intramusculare pot determina ocazional cresteri variabile de 2-6 ori peste valoarea normala4<\/sup>.<\/p>\n

\u2022 Medicamente<\/p>\n

Cresteri:<\/strong><\/span> acid aminocaproic, amfotericina B, captopril, carbenoxolona, carteolol, clindamicina, clorpromazina, clofibrat, clonidina, colchicina, ciclopropan, danazol, diclofenac, digoxin, gemfibrozil, haloperidol, inhibitori ai 3-hidroxi 3-metilglutaril CoA reductazei (ex: lovastatin), insulina, izotretinoin, labetalol, lamivudina, levamisol, lidocaina, litiu, D-penicilamina, pindolol, proclorperazina, propranolol, streptokinaza, trimetroprim, zalcitabin2<\/sup>.<\/p>\n

Scaderi:<\/strong> <\/span>acid ascorbic, amikacin, aspirina, dantrolen, prednison2<\/sup><\/p>\n

\u2022 Interferente analitice<\/p>\n

Hemoliza poate determina cresteri ale enzimei CK1;3<\/sup>.<\/p>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/p>\n

1. Frances Fischbach.Chemistry Studies. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 ed. 2009, 423-426.<\/span><\/p>\n

2. Frances Fischbach.Effects of Drugs on Laboratory Tests. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 ed. 2009, 1235.<\/span><\/p>\n

3. Laborator Synevo. Referinte specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog<\/span><\/p>\n

4. Laboratory Corporation of America.Directory of Services and Interpretive Guide. Creatine Kinase (CK),Serum. www.labcorp.com . 2003. Ref Type: Internet Communication<\/span><\/p>\n

5. Lothar Thomas.Cardiac diseases. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany,1 ed. 1998, 102.<\/span><\/p>\n

\u00a0<\/span><\/p>","protected":false},"excerpt":{"rendered":"

\u041a\u0440\u0435\u0430\u0442\u0438\u043d\u0444\u043e\u0441\u0444\u043e\u043a\u0438\u043d\u0430\u0437\u0430 (\u041a\u0424\u041a), \u043a\u0440\u0435\u0430\u0442\u0438\u043d\u043a\u0438\u043d\u0430\u0437\u0430 (\u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0444\u0435\u0440\u043c\u0435\u043d\u0442\u043e\u043c, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u043d\u0430\u0445\u043e\u0434\u0438\u0442\u0441\u044f \u0432 \u0432\u044b\u0441\u043e\u043a\u043e\u0439 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u0432 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0435 \u0438 \u0441\u043a\u0435\u043b\u0435\u0442\u043d\u044b\u0445 \u043c\u044b\u0448\u0446\u0430\u0445 \u0438, \u0432 \u0433\u043e\u0440\u0430\u0437\u0434\u043e \u0431\u043e\u043b\u0435\u0435 \u043d\u0438\u0437\u043a\u0438\u0445 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f\u0445, \u0432 \u0433\u043e\u043b\u043e\u0432\u043d\u043e\u043c \u043c\u043e\u0437\u0433\u0435. \u041e\u0431\u043b\u0430\u0434\u0430\u0435\u0442 \u0434\u0438\u043c\u0435\u0440\u043d\u043e\u0439 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043e\u0439 \u0438 \u043d\u0430\u0445\u043e\u0434\u0438\u0442\u0441\u044f \u0432 4-\u0445 \u0444\u043e\u0440\u043c\u0430\u0445: \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0438\u0437\u043e\u0444\u0435\u0440\u043c\u0435\u043d\u0442\u0430 \u0438 \u0446\u0438\u0442\u043e\u0437\u043e\u043b\u044c\u043d\u044b\u0445 \u0438\u0437\u043e\u0444\u0435\u0440\u043c\u0435\u043d\u0442\u043e\u0432 \u0441 3-\u043c\u044f \u0444\u0440\u0430\u043a\u0446\u0438\u044f\u043c\u0438: \u041a\u0424\u041a-\u041c\u041c (CK-\u041c\u041c, \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0433\u043e); \u041a\u0424\u041a-\u041c\u0412 (CK-MB, \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e); \u041a\u0424\u041a-\u0412\u0412 (CK-BB, \u043c\u043e\u0437\u0433\u043e\u0432\u043e\u0433\u043e).<\/p>\n

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\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c<\/b><\/td>\n\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/b><\/td>\n<\/tr>\n
\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n
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*\u0414\u043e\u00a0\u0432\u0437\u044f\u0442\u0438\u044f\u00a0\u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u00a0\u043d\u0435\u00a0\u0434\u043e\u043b\u0436\u0435\u043d\u00a0\u043f\u043e\u0434\u0432\u0435\u0440\u0433\u0430\u0442\u044c\u0441\u044f<\/p>\n

\u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u00a0\u043d\u0430\u0433\u0440\u0443\u0437\u043a\u0430\u043c<\/td>\n<\/tr>\n

\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0433\u0435\u043b\u0435\u0432\u043e\u0439\u00a0\u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n
\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
\u041c\u0435\u0442\u043e\u0434\u00a0\u0442\u0435\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f<\/b><\/td>\n\u041a\u0438\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
\u0418\u043d\u0442\u0435\u0440\u0444\u0435\u0440\u0438\u0440\u0443\u044e\u0449\u0438\u0435\u00a0\u0444\u0430\u043a\u0442\u043e\u0440\u044b.\u00a0\u041c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u044b<\/b><\/td>\n<\/tr>\n
\u041f\u043e\u0432\u044b\u0448\u0430\u044e\u0442<\/b><\/td>\n\u0421\u043d\u0438\u0436\u0430\u044e\u0442<\/b><\/td>\n<\/tr>\n
\u0410\u043c\u0438\u043d\u043e\u043a\u0430\u043f\u0440\u043e\u043d\u043e\u0432\u0430\u044f\u00a0\u043a\u0438\u0441\u043b\u043e\u0442\u0430,\u00a0\u0430\u043c\u0444\u043e\u0442\u0435\u0440\u0438\u0446\u0438\u043d\u00a0\u0412,\u00a0\u043a\u0430\u043f\u0442\u043e\u043f\u0440\u0438\u043b,\u00a0\u043a\u043b\u0438\u043d\u0434\u0430\u043c\u0438\u0446\u0438\u043d,<\/p>\n

\u0434\u0438\u043a\u043b\u043e\u0444\u0435\u043d\u0430\u043a,\u00a0\u0434\u0438\u0433\u043e\u043a\u0441\u0438\u043d,\u00a0\u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u044b\u00a03-\u0433\u0438\u0434\u0440\u043e\u043a\u0441\u0438-3-\u043c\u0435\u0442\u0438\u043b\u0433\u043b\u0443\u0442\u0430\u0440\u0438\u043b-\u041a\u043e\u0410\u00a0\u0440\u0435\u0434\u0443\u043a\u0442\u0430\u0437\u044b,\u00a0\u0438\u043d\u0441\u0443\u043b\u0438\u043d,\u00a0\u043b\u0438\u0434\u043e\u043a\u0430\u0438\u043d,\u00a0\u043f\u0440\u043e\u043f\u0440\u0430\u043d\u043e\u043b\u043e\u043b,\u00a0\u0441\u0442\u0440\u0435\u043f\u0442\u043e\u043a\u0438\u043d\u0430\u0437\u0430\u00a0\u0438\u00a0\u0434\u0440.<\/td>\n

\u0410\u0441\u043a\u043e\u0440\u0431\u0438\u043d\u043e\u0432\u0430\u044f\u00a0\u043a\u0438\u0441\u043b\u043e\u0442\u0430,\u00a0\u0430\u043c\u0438\u043a\u0430\u0446\u0438\u043d,\u00a0\u0430\u0441\u043f\u0438\u0440\u0438\u043d,\u00a0\u043a\u043e\u0440\u0442\u0438\u043a\u043e\u0441\u0442\u0435\u0440\u043e\u0438\u0434\u044b\u00a0\u0438\u00a0\u0434\u0440.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n
\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/b><\/td>\n<\/tr>\n
\u00b7\u00a0\u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430\u00a0\u0438\u043d\u0444\u0430\u0440\u043a\u0442\u0430\u00a0\u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430;<\/p>\n

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\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/b><\/td>\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/b><\/td>\n<\/tr>\n
\u00b7\u00a0\u041e\u0441\u0442\u0440\u044b\u0439\u00a0\u0438\u043d\u0444\u0430\u0440\u043a\u0442\u00a0\u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430;<\/p>\n

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\u044d\u043b\u0435\u043a\u0442\u0440\u0438\u0447\u0435\u0441\u043a\u043e\u0439\u00a0\u0434\u0435\u0444\u0438\u0431\u0440\u0438\u043b\u043b\u044f\u0446\u0438\u0438;<\/p>\n

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