{"id":9202,"date":"2020-04-23T03:31:12","date_gmt":"2020-04-23T00:31:12","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/cortizol-seric\/"},"modified":"2026-02-19T00:12:09","modified_gmt":"2026-02-18T22:12:09","slug":"cortizol-seric","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/cortizol-seric\/","title":{"rendered":"\u041a\u043e\u0440\u0442\u0438\u0437\u043e\u043b \u0432 \u043a\u0440\u043e\u0432\u0438"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Cortizolul este cel mai important glucocorticosteroid \u015fi este esen\u0163ial pentru men\u0163inerea mai multor func\u0163ii ale organismului. Ca \u015fi al\u0163i glucocorticosteroizi, cortizolul este sintetizat \u00een zona fasciculat\u0103 a cortico-suprarenalei dintr-un precursor comun cu colesterolul. \u00cen s\u00e2nge 90% din cortizol este legat de proteina de legare a corticosteroizilor (CBG \u2013 corticosteroid binding globulin) \u015fi de albumin\u0103. Doar o mic\u0103 parte din cortizol circul\u0103 nelegat\u0103,<\/strong> fiind liber\u0103 s\u0103 interac\u0163ioneze cu receptorii3;4;6;7;9<\/sup>.<\/p>\n

Cele mai importante efecte fiziologice ale cortizolului sunt cre\u015fterea glucozei sanguine (prin stimularea gluconeogenezei), precum \u015fi ac\u0163iunea antiinflamatorie \u015fi imunosupresiv\u01035;9<\/sup>.<\/p>\n

Sinteza \u015fi secre\u0163ia de cortizol sunt controlate prin feedback negativ de c\u0103tre axul hipotalamo-hipofizo-corticosuprarenalian. Dac\u0103 nivelul cortizolului este sc\u0103zut, hormonul de eliberare al corticotropinei (CRH-corticotropin releasing hormone) este secretat de hipotalamus, iar acesta determin\u0103 eliberarea de ACTH din hipofiz\u0103. ACTH stimuleaz\u0103 sinteza \u015fi secre\u0163ia de cortizol \u00een corticosuprarenal\u0103. Cortizolul \u00eensu\u015fi ac\u0163ioneaz\u0103 printr-un mecanism de feedback negativ asupra hipofizei \u015fi hipotalamusului. In plus, stresul determin\u0103 cre\u015fterea secre\u0163iei de cortizol4;6;7;9<\/sup>.<\/p>\n

\u00cen mod normal concentra\u0163ia seric\u0103 a cortizolului prezint\u0103 o varia\u0163ie diurn\u0103. Concentra\u0163iile maxime (pan\u0103 la 700nmol\/L) sunt observate diminea\u0163a, iar cele mai sc\u0103zute (care sunt aproximativ jum\u0103tate din cele matinale) se \u00eent\u00e2lnesc \u00eentre orele 16 \u015fi 20. De aceea pentru interpretarea rezultatelor este necesar\u0103 cunoa\u015fterea momentului recolt\u0103rii3;6;7;9<\/sup>.<\/p>\n

Pot fi efectuate \u015fi teste de stimulare sau supresie. Testul de supresie cu dexametazon\u0103 (\u00een cele 2 variante: 1 mg sau 8 mg) este utilizat pentru elucidarea cauzei unui nivel crescut de cortizol bazal. Testul de stimulare cu Cortrosyn (ACTH sintetic)\u00a0 detecteaz\u0103 insuficien\u0163a corticosuprarenalian\u01031<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea cortizolului<\/em><\/strong><\/p>\n

Dozarea cortizolului (bazal sau asociat cu teste de stimulare sau supresie) furnizeaz\u0103 informa\u0163ii asupra func\u0163ionalit\u0103\u0163ii corticosuprarenalei, hipofizei \u015fi hipotalamusului. De asemenea, nivelul cortizolului este util \u00een monitorizarea unor afec\u0163iuni care se \u00eenso\u0163esc de cre\u015fterea\u00a0 acestuia (ex.: sindromul Cushing) sau de sc\u0103derea lui (ex.: boala Addison). Este util \u015fi\u00a0\u00een monitorizarea unor tratamente (ex.: terapia de supresie cu dexametazon\u0103\u00a0\u00een sindromul Cushing sau terapia cu cortizol\u00a0\u00een boala Addison)3;9<\/sup>.<\/p>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>\u00e0 jeun (pe nem\u00e2ncate)8<\/sup>.<\/p>\n

NOTA<\/span>: nivelul cortizolului \u00een s\u00e2nge este mai mare \u00eentre orele 5-10 diminea\u0163a, comparativ cu intervalul orar 20-4. Recoltarea ideal\u0103 este dubl\u0103: ora 8 \u015fi ora 23 (unii prefer\u0103 ora 16 sau 18\u00a0\u00een loc de ora 23)8<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>-<\/em> s\u00e2nge venos; de\u015fi e\u015fantioanele de plasm\u0103 sunt cele recomandate curent, se ob\u0163in rezultate comparabile \u015fi din ser8<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator8<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul proasp\u0103t; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C sau la -20\u00b0C8<\/sup>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser8<\/sup>.<\/p>\n

Cauze de respingere<\/em><\/strong> a probei <\/em><\/strong>\u2013 specimen hemolizat, icteric sau lipemic8<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>\u2013 5 zile<\/em> la 2-8\u00b0C; 3 luni<\/em> la -20\u00b0C; nu decongela\u0163i\/recongela\u0163i8<\/sup>.<\/p>\n

Metod\u0103 <\/em><\/strong>- imunochimic\u0103 cu detec\u0163ie prin electrochemiluminiscen\u0163\u0103 (ECLIA)<\/span>8<\/sup>.<\/p>\n

Valori de referin\u0163\u0103<\/em><\/strong>1;8<\/sup><\/p>\n

\u2022 diminea\u0163a orele\u00a0 7-10: 172-497 nmol\/L;<\/div>\n
\u2022 dup\u0103-amiaz\u0103 orele 16-20:\u00a0 71.1-286 nmol\/L;<\/div>\n
\u2022 dup\u0103 stimulare: cre\u015ftere >20 mg\/dL (>552 nmol\/L) sau o cre\u015ftere de cel pu\u0163in 3x fa\u0163\u0103 de nivelul bazal;<\/div>\n
\u2022 dup\u0103 supresie: <5 mg\/dL (<138 nmol\/L) sau <50% fa\u0163\u0103 de nivelul bazal (ora 8 a.m.).<\/div>\n

Factori de conversie: nmol\/L x 0.03625 = \u00b5g\/dL;\u00a0 mg<\/em><\/em>\/dL x 27.586 = nmol\/L.<\/em><\/p>\n

Limita de detec\u0163ie<\/em><\/strong> \u2013 1<\/em>.5 nmol\/L8<\/sup>.<\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/p>\n

Testul de supresie cu doze mici de dexametazon\u0103<\/span>\u00a0 este un test de baz\u0103 pentru excluderea sindromului Cushing \u015fi pentru identificarea cazurilor ce necesit\u0103 investiga\u0163ii suplimentare. Pacien\u0163ii cu sindrom Cushing, indiferent de cauz\u0103, prezint\u0103 aproape \u00eentotdeauna o lips\u0103 a supresiei.<\/p>\n

Rezultate fals pozitive se pot ob\u0163ine \u00een boli acute sau cronice, alcoolism, depresie, precum \u015fi \u00een cazul utiliz\u0103rii unor medicamente: estrogeni, fenitoin, fenobarbital, primidona.<\/p>\n

Testul de supresie cu doze mari de dexametazon\u0103<\/span>\u00a0 este folosit pentru diferen\u0163ierea bolii Cushing asociat\u0103 cu tumori hipofizare (\u00een care se observ\u0103 doar o rezisten\u0163\u0103 relativ\u0103 la feedback-ul negativ produs de dexametazon\u0103) de tumorile suprarenaliene sau produc\u0163ia ectopic\u0103 de ACTH (de regul\u0103 rezisten\u0163a complet\u0103 \u2013 lipsa supresiei).<\/p>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

Deoarece cre\u015fteri \u015fi sc\u0103deri episodice ale concentra\u0163iei de cortizol apar at\u00e2t la pacien\u0163i cu boala Cushing sau cu produc\u0163ie ectopic\u0103 de ACTH, c\u00e2t \u015fi la persoanele normale, aceasta trebuie m\u0103surat\u0103 \u00een cel pu\u0163in dou\u0103 zile diferite3<\/sup>.<\/p>\n

\u00cen sarcin\u0103 pot ap\u0103rea valori crescute de cortizol1<\/sup>.<\/p>\n

\u2022 Medicamente<\/p>\n

Cre\u015fteri<\/strong><\/span>: anticonvulsivante, aspirina, atropina, benzodiazepine, clomipramina,\u00a0 corticotropina, contraceptive orale, cortizon, diazoxid, diclofenac, estrogeni, furosemid, gemfibrozil, gliburid, hidrocortizon, insulina, interferon (gama), litiu, metadona, metoxamina, metoclopramid, naloxon, ranitidina, spironolactona, vasopresina2<\/sup>.<\/p>\n

Sc\u0103deri<\/strong><\/span>: aminoglutetimid, barbiturice, beclometazona,\u00a0 danazol, dexametazona, efedrina, fenitoin, indometacin, ketoconazol, labetalol, levodopa, carbonat de litiu, magneziu, metilprednisolon, morfina, nifedipina, oxazepam, pravastatin, prednisolon, rifampicina, sumatriptan, trimipramina2<\/sup>.<\/p>\n

\u2022 Interferen\u0163e analitice<\/p>\n

Pot produce interferen\u0163e cu unele componente ale kit-ului \u015fi conduce la rezultate neconcludente urm\u0103toarele:<\/p>\n

-tratamentul cu biotin\u0103 \u00een doze mari (>5 mg\/zi); de aceea se recomand\u0103 ca recoltarea de s\u00e2nge s\u0103 se fac\u0103 dup\u0103 minimum 8 ore de la ultima administrare;<\/div>\n
-titrurile foarte crescute de anticorpi anti-streptavidina \u015fi anti-ruteniu8<\/sup>.<\/div>\n

\u00a0<\/span>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Frances Fischbach. Chemistry Studies. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 Ed., 2009, 390-391.<\/span><\/div>\n
2. Frances Fischbach. Effects of the Most Commonly Used Drugs on Frequently Ordered Laboratory Tests. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 Ed., 2009, 1234.<\/span><\/div>\n
3. Henry John Bernard. Evaluation of endocrine function. In Clinical Diagnosis and Management by Laboratory Methods. ASM Press, USA, 20 Ed., 1998, 99-346.<\/span><\/div>\n
4. Ion Teodorescu Exarcu. Corticosuprarenala. \u00cen Fiziologia \u015fi fiziopatologia sistemului endocrin. Editura Medical\u0103, Rom\u00e2nia, Ed. 1989, 680-699.<\/span><\/div>\n
5. Ion Teodorescu Exarcu. Fiziopatologia corticosuprarenalei. \u00cen Fiziologia \u015fi fiziopatologia sistemului endocrin. Editura Medical\u0103, Rom\u00e2nia, Ed. 1989, 699-727.<\/span><\/div>\n
6. Jacques Wallach. Afec\u0163iuni endocrine. \u00cen Interpretarea testelor de diagnostic. Editura Stiin\u0163elor Medicale, Rom\u00e2nia, Ed. 7, 2001, 866-868.<\/span><\/div>\n
7. Jacques Wallach. Afec\u0163iuni endocrine. \u00cen Interpretarea testelor de diagnostic. Editura Stiin\u0163elor Medicale, Rom\u00e2nia, ed. 7, 2001, 835-837.<\/span><\/div>\n
8. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2016. Ref Type: Catalog.<\/span><\/div>\n
9. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Cortisol. www.labcorp.com 2016. Ref Type: Internet Communication.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u041a\u043e\u0440\u0442\u0438\u0437\u043e\u043b \u2013 \u044d\u0442\u043e \u0433\u043e\u0440\u043c\u043e\u043d, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0443\u0435\u0442\u0441\u044f \u0432 \u043a\u043e\u0440\u0435 \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432. \u041e\u043d \u0437\u0430\u0449\u0438\u0449\u0430\u0435\u0442 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c \u043e\u0442 \u0441\u0442\u0440\u0435\u0441\u0441\u0430, \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0443\u0435\u0442 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0434\u0430\u0432\u043b\u0435\u043d\u0438\u044f, \u0443\u0447\u0430\u0441\u0442\u0432\u0443\u0435\u0442 \u0432 \u043e\u0431\u043c\u0435\u043d\u0435 \u0431\u0435\u043b\u043a\u043e\u0432, \u0436\u0438\u0440\u043e\u0432 \u0438 \u0443\u0433\u043b\u0435\u0432\u043e\u0434\u043e\u0432.<\/p>\n

\u0412\u044b\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0430\u0434\u0440\u0435\u043d\u043e\u043a\u043e\u0440\u0442\u0438\u043a\u043e\u0442\u0440\u043e\u043f\u043d\u044b\u043c \u0433\u043e\u0440\u043c\u043e\u043d\u043e\u043c (\u0410\u041a\u0422\u0413), \u0432\u044b\u0440\u0430\u0431\u0430\u0442\u044b\u0432\u0430\u044e\u0449\u0438\u043c\u0441\u044f \u0432 \u0433\u0438\u043f\u043e\u0444\u0438\u0437\u0435 \u2013 \u043d\u0435\u0431\u043e\u043b\u044c\u0448\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u0435, \u043d\u0430\u0445\u043e\u0434\u044f\u0449\u0435\u0439\u0441\u044f \u043d\u0430 \u043d\u0438\u0436\u043d\u0435\u0439 \u0447\u0430\u0441\u0442\u0438 \u0433\u043e\u043b\u043e\u0432\u043d\u043e\u0433\u043e \u043c\u043e\u0437\u0433\u0430. \u041a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u0410\u041a\u0422\u0413 \u0438 \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u0432 \u043a\u0440\u043e\u0432\u0438 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0443\u044e\u0442\u0441\u044f \u043f\u043e \u043c\u0435\u0442\u043e\u0434\u0443 \u043e\u0431\u0440\u0430\u0442\u043d\u043e\u0439 \u0441\u0432\u044f\u0437\u0438. \u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u043f\u043e\u0432\u044b\u0448\u0430\u0435\u0442 \u0432\u044b\u0440\u0430\u0431\u043e\u0442\u043a\u0443 \u0410\u041a\u0422\u0413, \u0432 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0435 \u0447\u0435\u0433\u043e \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0441\u0442\u0432\u043e \u044d\u0442\u043e\u0433\u043e \u0433\u043e\u0440\u043c\u043e\u043d\u0430 \u0434\u043e \u043c\u043e\u043c\u0435\u043d\u0442\u0430, \u043f\u043e\u043a\u0430 \u043e\u043d \u043d\u0435 \u043f\u0440\u0438\u0434\u0435\u0442 \u0432 \u043d\u043e\u0440\u043c\u0443. \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u0432 \u043a\u0440\u043e\u0432\u0438, \u043d\u0430\u043f\u0440\u043e\u0442\u0438\u0432, \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a \u0443\u043c\u0435\u043d\u044c\u0448\u0435\u043d\u0438\u044e \u0432\u044b\u0440\u0430\u0431\u043e\u0442\u043a\u0438 \u0410\u041a\u0422\u0413.<\/p>\n

\u041f\u043e\u044d\u0442\u043e\u043c\u0443 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u0432 \u043a\u0440\u043e\u0432\u0438 \u043c\u043e\u0436\u0435\u0442 \u043c\u0435\u043d\u044f\u0442\u044c\u0441\u044f \u043f\u0440\u0438 \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u0438 \u0438\u043b\u0438 \u0443\u043c\u0435\u043d\u044c\u0448\u0435\u043d\u0438\u0438 \u0432\u044b\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u043a\u0430\u043a \u0441\u0430\u043c\u043e\u0433\u043e \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u0432 \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u0430\u0445, \u0442\u0430\u043a \u0438 \u0410\u041a\u0422\u0413 \u0432 \u0433\u0438\u043f\u043e\u0444\u0438\u0437\u0435, \u043d\u0430\u043f\u0440\u0438\u043c\u0435\u0440 \u043f\u0440\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u0438 \u0433\u0438\u043f\u043e\u0444\u0438\u0437\u0430, \u0432\u044b\u0434\u0435\u043b\u044f\u044e\u0449\u0435\u0439 \u0410\u041a\u0422\u0413.<\/p>\n

\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u0432\u044b\u0440\u0430\u0431\u043e\u0442\u043a\u0438 \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u043c\u043e\u0436\u0435\u0442 \u0441\u043e\u043f\u0440\u043e\u0432\u043e\u0436\u0434\u0430\u0442\u044c\u0441\u044f \u043d\u0435\u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u044b\u043c\u0438 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0430\u043c\u0438: \u043f\u043e\u0445\u0443\u0434\u0435\u043d\u0438\u0435\u043c, \u0441\u043b\u0430\u0431\u043e\u0441\u0442\u044c\u044e, \u0443\u0441\u0442\u0430\u043b\u043e\u0441\u0442\u044c\u044e, \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0435\u043c \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0434\u0430\u0432\u043b\u0435\u043d\u0438\u044f, \u0431\u043e\u043b\u044c\u044e \u0432 \u0436\u0438\u0432\u043e\u0442\u0435. \u041f\u0440\u0438 \u0441\u043e\u0447\u0435\u0442\u0430\u043d\u0438\u0438 \u0441\u043d\u0438\u0436\u0435\u043d\u043d\u043e\u0439 \u043f\u0440\u043e\u0434\u0443\u043a\u0446\u0438\u0438 \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u0438 \u0441\u0438\u043b\u044c\u043d\u043e\u0433\u043e \u0441\u0442\u0440\u0435\u0441\u0441\u0430 \u0438\u043d\u043e\u0433\u0434\u0430 \u0440\u0430\u0437\u0432\u0438\u0432\u0430\u0435\u0442\u0441\u044f \u0430\u0434\u0440\u0435\u043d\u0430\u043b\u043e\u0432\u044b\u0439 \u043a\u0440\u0438\u0437, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0442\u0440\u0435\u0431\u0443\u0435\u0442 \u044d\u043a\u0441\u0442\u0440\u0435\u043d\u043d\u043e\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u043f\u043e\u043c\u043e\u0449\u0438.<\/p>\n

\u0418\u0437\u0431\u044b\u0442\u043e\u043a \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u044e \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0434\u0430\u0432\u043b\u0435\u043d\u0438\u044f \u0438 \u0443\u0440\u043e\u0432\u043d\u044f \u0441\u0430\u0445\u0430\u0440\u0430 \u0432 \u043a\u0440\u043e\u0432\u0438, \u043a \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u044e, \u0438\u0441\u0442\u043e\u043d\u0447\u0435\u043d\u0438\u044e \u043a\u043e\u0436\u0438 \u0438 \u043f\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u044e \u0444\u0438\u043e\u043b\u0435\u0442\u043e\u0432\u044b\u0445 \u0440\u0430\u0441\u0442\u044f\u0436\u0435\u043a \u043f\u043e \u0431\u043e\u043a\u0430\u043c \u0436\u0438\u0432\u043e\u0442\u0430.<\/p>\n

\u0414\u043b\u044f \u0447\u0435\u0433\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n

    \n
  • \u0414\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430 \u0438\u043b\u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0418\u0446\u0435\u043d\u043a\u043e \u2013 \u041a\u0443\u0448\u0438\u043d\u0433\u0430 \u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0410\u0434\u0434\u0438\u0441\u043e\u043d\u0430 \u2013 \u0441\u0435\u0440\u044c\u0435\u0437\u043d\u044b\u0445 \u044d\u043d\u0434\u043e\u043a\u0440\u0438\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439.<\/li>\n
  • \u0414\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430 \u0438\u043b\u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0418\u0446\u0435\u043d\u043a\u043e \u2013 \u041a\u0443\u0448\u0438\u043d\u0433\u0430 \u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0410\u0434\u0434\u0438\u0441\u043e\u043d\u0430.<\/li>\n<\/ul>\n

    \u041a\u043e\u0433\u0434\u0430 \u043d\u0430\u0437\u043d\u0430\u0447\u0430\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n

      \n
    • \u041f\u0440\u0438 \u043f\u043e\u0434\u043e\u0437\u0440\u0435\u043d\u0438\u0438 \u043d\u0430 \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0438\u043b\u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u0418\u0446\u0435\u043d\u043a\u043e \u2013 \u041a\u0443\u0448\u0438\u043d\u0433\u0430 (\u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b: \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0434\u0430\u0432\u043b\u0435\u043d\u0438\u044f, \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u0435, \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u044f \u043c\u044b\u0448\u0446, \u0440\u0430\u0441\u0442\u044f\u0436\u043a\u0438 \u043d\u0430 \u0436\u0438\u0432\u043e\u0442\u0435) \u0438\u043b\u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u0410\u0434\u0434\u0438\u0441\u043e\u043d\u0430 (\u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b: \u0441\u043b\u0430\u0431\u043e\u0441\u0442\u044c, \u0443\u0441\u0442\u0430\u043b\u043e\u0441\u0442\u044c, \u043f\u043e\u043d\u0438\u0436\u0435\u043d\u043d\u043e\u0435 \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0435 \u0434\u0430\u0432\u043b\u0435\u043d\u0438\u0435, \u043f\u0438\u0433\u043c\u0435\u043d\u0442\u0430\u0446\u0438\u044f \u043a\u043e\u0436\u0438).<\/li>\n
    • \u0412 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u043d\u0435\u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u043f\u043e\u043f\u044b\u0442\u043e\u043a \u043d\u043e\u0440\u043c\u0430\u043b\u0438\u0437\u043e\u0432\u0430\u0442\u044c \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u043e\u0435 \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0435 \u0434\u0430\u0432\u043b\u0435\u043d\u0438\u0435.<\/li>\n
    • \u0427\u0435\u0440\u0435\u0437 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u043d\u044b\u0435 \u043f\u0440\u043e\u043c\u0435\u0436\u0443\u0442\u043a\u0438 \u0432\u0440\u0435\u043c\u0435\u043d\u0438, \u043a\u043e\u0433\u0434\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442 \u043b\u0435\u0447\u0438\u0442\u0441\u044f \u043e\u0442 \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430\/\u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0418\u0446\u0435\u043d\u043a\u043e \u2013 \u041a\u0443\u0448\u0438\u043d\u0433\u0430 \u0438\u043b\u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0410\u0434\u0434\u0438\u0441\u043e\u043d\u0430.<\/li>\n<\/ul>\n

      \u0427\u0442\u043e \u043e\u0437\u043d\u0430\u0447\u0430\u044e\u0442 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b?<\/strong><\/p>\n

      \u0420\u0435\u0444\u0435\u0440\u0435\u043d\u0441\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f<\/p>\n

      \u0414\u043b\u044f \u043f\u0440\u043e\u0431, \u0432\u0437\u044f\u0442\u044b\u0445 \u0432 \u0443\u0442\u0440\u0435\u043d\u043d\u0438\u0435 \u0447\u0430\u0441\u044b (6-10 \u0447\u0430\u0441\u043e\u0432): 166 \u2013 507 \u043d\u043c\u043e\u043b\u044c\/\u043b.<\/p>\n

      \u0414\u043b\u044f \u043f\u0440\u043e\u0431, \u0432\u0437\u044f\u0442\u044b\u0445 \u0432 \u0432\u0435\u0447\u0435\u0440\u043d\u0438\u0435 \u0447\u0430\u0441\u044b (16-20 \u0447\u0430\u0441\u043e\u0432): 73,8 \u2013 291 \u043d\u043c\u043e\u043b\u044c\/\u043b.<\/p>\n

      \u0412 \u043d\u043e\u0440\u043c\u0435 \u0432\u0435\u0447\u0435\u0440\u043e\u043c \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u0441\u043d\u0438\u0436\u0435\u043d \u0438 \u0434\u043e\u0441\u0442\u0438\u0433\u0430\u0435\u0442 \u043c\u0430\u043a\u0441\u0438\u043c\u0443\u043c\u0430 \u043f\u043e\u0441\u043b\u0435 \u043f\u0440\u043e\u0431\u0443\u0436\u0434\u0435\u043d\u0438\u044f. \u0415\u0441\u043b\u0438 \u0447\u0435\u043b\u043e\u0432\u0435\u043a \u0447\u0430\u0441\u0442\u043e \u0440\u0430\u0431\u043e\u0442\u0430\u0435\u0442 \u0432 \u043d\u043e\u0447\u043d\u044b\u0435 \u0441\u043c\u0435\u043d\u044b \u0438\u043b\u0438 \u043d\u0435 \u0441\u043e\u0431\u043b\u044e\u0434\u0430\u0435\u0442 \u0440\u0435\u0436\u0438\u043c \u0441\u043d\u0430, \u0442\u043e \u044d\u0442\u043e\u0442 \u0440\u0438\u0442\u043c \u043c\u043e\u0436\u0435\u0442 \u0441\u0431\u0438\u0442\u044c\u0441\u044f. \u041a\u0430\u043a \u043f\u0440\u0430\u0432\u0438\u043b\u043e, \u043d\u0430\u0440\u0443\u0448\u0435\u043d \u043e\u043d \u0438 \u043f\u0440\u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0418\u0446\u0435\u043d\u043a\u043e \u2013 \u041a\u0443\u0448\u0438\u043d\u0433\u0430.<\/p>\n

      \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u0439 \u0438\u043b\u0438 \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u044b\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u0432 \u0443\u0442\u0440\u0435\u043d\u043d\u0438\u0445 \u043f\u0440\u043e\u0431\u0430\u0445 \u043f\u0440\u0438 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0438 \u0435\u0433\u043e \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u044f \u043a \u0432\u0435\u0447\u0435\u0440\u0443 \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u043f\u0440\u0435\u0434\u043f\u043e\u043b\u043e\u0436\u0438\u0442\u044c \u0438\u0437\u0431\u044b\u0442\u043e\u0447\u043d\u0443\u044e \u043f\u0440\u043e\u0434\u0443\u043a\u0446\u0438\u044e \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430. \u0427\u0430\u0441\u0442\u043e \u0438\u0437\u0431\u044b\u0442\u043e\u0447\u043d\u043e\u0435 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u0441\u0432\u044f\u0437\u0430\u043d\u043e \u0441 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u043e\u0439 \u043f\u0440\u043e\u0434\u0443\u043a\u0446\u0438\u0435\u0439 \u0410\u041a\u0422\u0413 \u0432 \u0433\u0438\u043f\u043e\u0444\u0438\u0437\u0435 \u2013 \u0431\u043e\u043b\u0435\u0437\u043d\u044c\u044e \u0418\u0446\u0435\u043d\u043a\u043e \u2013 \u041a\u0443\u0448\u0438\u043d\u0433\u0430. \u041e\u0431\u044b\u0447\u043d\u043e \u043f\u0440\u0438\u0447\u0438\u043d\u043e\u0439 \u044d\u0442\u043e\u0433\u043e \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0430\u0434\u0435\u043d\u043e\u043c\u0430 \u0433\u0438\u043f\u043e\u0444\u0438\u0437\u0430, \u0430 \u0442\u0430\u043a\u0436\u0435 \u043e\u043f\u0443\u0445\u043e\u043b\u0438, \u0432\u044b\u0440\u0430\u0431\u0430\u0442\u044b\u0432\u0430\u044e\u0449\u0438\u0435 \u0410\u041a\u0422\u0413 \u0432\u043d\u0435 \u0433\u0438\u043f\u043e\u0444\u0438\u0437\u0430.<\/p>\n

      \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u0430\u044f \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432 \u0438 \u0432\u044b\u0440\u0430\u0431\u043e\u0442\u043a\u0430 \u0438\u043c\u0438 \u0438\u0437\u0431\u044b\u0442\u043e\u0447\u043d\u044b\u0445 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432 \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u0430 \u2013 \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0418\u0446\u0435\u043d\u043a\u043e \u2013 \u041a\u0443\u0448\u0438\u043d\u0433\u0430 \u2013 \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u0441\u0432\u044f\u0437\u0430\u043d \u0441 \u0434\u043e\u0431\u0440\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u0438\u043b\u0438 \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u043e\u043f\u0443\u0445\u043e\u043b\u044c\u044e \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0441 \u0442\u0435\u043c, \u0447\u0442\u043e \u043f\u0430\u0446\u0438\u0435\u043d\u0442 \u0434\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u0432\u0440\u0435\u043c\u044f \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0435\u0442 \u0433\u043b\u044e\u043a\u043e\u043a\u043e\u0440\u0442\u0438\u043a\u043e\u0441\u0442\u0435\u0440\u043e\u0438\u0434\u044b, \u043a\u0430\u043a, \u043d\u0430\u043f\u0440\u0438\u043c\u0435\u0440, \u043f\u0440\u0438 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0439 \u043a\u0440\u0430\u0441\u043d\u043e\u0439 \u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0435 \u0438\u043b\u0438 \u0431\u0440\u043e\u043d\u0445\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0430\u0441\u0442\u043c\u0435.<\/p>\n

      \u041a\u0430\u043a \u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u043e \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u0438\u0442\u044c\u0441\u044f \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e?<\/strong><\/p>\n

        \n
      • \u041d\u0435 \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0442\u044c \u043f\u0438\u0449\u0443 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 12 \u0447\u0430\u0441\u043e\u0432 \u043f\u0435\u0440\u0435\u0434 \u0441\u0434\u0430\u0447\u0435\u0439 \u043a\u0440\u043e\u0432\u0438.<\/li>\n
      • \u0418\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u043f\u0440\u0438\u0435\u043c \u044d\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u043e\u0432, \u0430\u043d\u0434\u0440\u043e\u0433\u0435\u043d\u043e\u0432 \u0437\u0430 48 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n
      • \u0418\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0438 \u044d\u043c\u043e\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0435 \u043f\u0435\u0440\u0435\u043d\u0430\u043f\u0440\u044f\u0436\u0435\u043d\u0438\u0435 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 24 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n
      • \u041d\u0435 \u043a\u0443\u0440\u0438\u0442\u044c 3 \u0447\u0430\u0441\u0430 \u0441\u0434\u0430\u0447\u0438 \u043a\u0440\u043e\u0432\u0438.<\/li>\n<\/ul>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[911,917],"product_tag":[],"class_list":{"0":"post-9202","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-endocrini","6":"product_cat-markeri-suprarenalieni","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9202","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9202"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9202"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9202"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9202"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}