{"id":9198,"date":"2020-04-23T04:31:05","date_gmt":"2020-04-23T01:31:05","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/complement-c4\/"},"modified":"2026-02-18T23:42:33","modified_gmt":"2026-02-18T21:42:33","slug":"complement-c4","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/complement-c4\/","title":{"rendered":"\u04214\u00a0\u043a\u043e\u043c\u043f\u043e\u043d\u0435\u043d\u0442\u00a0\u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442\u0430"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

\u04124 <\/sub>este un alt component al sistemului complement sintetizat \u00een pl\u0103m\u00e2n \u015fi \u0163esutul osos1<\/sup>. C4 <\/sub>este utilizat doar pe calea clasic\u0103 de activare a complementului, astfel c\u0103 nivelul acestuia este normal \u00een condi\u0163iile asociate cu activarea doar a c\u0103ii alternative a complementului.<\/p>\n

Concentra\u0163iile serice de C4 <\/sub>reprezint\u0103 un indicator sensibil al gradului de activitate a bolii lupice.<\/p>\n

In angioedemul ereditar, lipsa inhibitorului C1<\/sub>-esterazei determin\u0103 liza frac\u0163iunilor C2<\/sub> \u015fi C4<\/sub> de c\u0103tre C1<\/sub>\u2013 esteraza, iar nivelul C4\u00a0 <\/sub>va fi astfel sc\u0103zut.<\/p>\n

Niveluri sc\u0103zute de C4 <\/sub>au mai fost descrise \u00eentr-o afec\u0163iune cu manifest\u0103ri clinice similare LES, dar f\u0103r\u0103 prezen\u0163a de celule lupice, cu depozite variabile de imunoglobuline sau C3 <\/sub>la biopsia cutanat\u0103 \u015fi cu purpura Henoch-Scholein sau glomerulonefrit\u0103. Aceast\u0103 condi\u0163ie este transmis\u0103 autozomal recesiv. Deficien\u0163a ereditar\u0103 de C4<\/sub> este asociat\u0103 cu un risc crescut de infec\u0163ii cu bacterii piogene5<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea C4<\/sub><\/em><\/strong><\/p>\n

\u2022 Suspiciune de deficit ereditar sau dob\u00e2ndit (asociat cu afec\u0163iuni imunologice ce induc un hipercatabolism al complementului: LES, boala serului, hepatita cronic\u0103 activ\u0103, anumite glomerulonefrite).<\/div>\n
\u2022 Evaluarea gradului de activitate a bolii \u00een LES.<\/div>\n
\u2022 Confirmarea diagnosticului de angioedem ereditar, atunci c\u00e2nd nivelul de C1<\/sub> inhibitor este sc\u0103zut1;3<\/sup>.<\/div>\n

Preg\u0103tire pacient<\/em><\/strong> \u2013 \u00e0 jeun (pe nem\u00e2ncate)4<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c4<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>-<\/em> vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator4<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare4<\/sup>.<\/p>\n

Volum prob\u0103 <\/em><\/strong>-<\/em> minim 0.5 mL ser4<\/sup>.<\/p>\n

Cauze\u00a0 de respingere a probei<\/em><\/strong> - <\/em>ser intens lipemic4<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>\u00a0serul separat este stabil: 2 zile<\/em> la temperatura camerei; 2\u00a0 zile<\/em> la 2-8\u00b0C4<\/sup>.<\/p>\n

Metod\u0103 <\/em><\/strong>- <\/em>imunoturbidimetric\u0103<\/span>4<\/sup>\u00a0<\/em><\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>-<\/em> 10-40 mg\/dL4<\/sup>.<\/p>\n

Limita de detec\u0163ie <\/em><\/strong>\u2013 1.5 mg\/dL (0.015 g\/L, 0.075 \u00b5mol\/L)4<\/sup>.\u00a0<\/em><\/strong><\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/p>\n\n\n\n\n
\n

Cre\u015fterea C4<\/sub> este asociat\u0103 cu:<\/em><\/strong><\/p>\n<\/td>\n

\n

Sc\u0103derea C4<\/sub> este asociat\u0103 cu:<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

\u2022 Condi\u0163ii maligne1;3<\/sup><\/p>\n

\n<\/td>\n

\n
\u2022 LES activ<\/div>\n
\u2022 glomerulonefrita acut\u0103<\/div>\n
\u2022 boli cu complexe imune<\/div>\n
\u2022 crioglobulinemie<\/div>\n
\u2022 deficit ereditar<\/div>\n
\u2022 angioedem ereditar1;3<\/sup><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

\u2022 Medicamente<\/p>\n

Cre\u015fteri<\/span>:<\/strong> ciclofosfamida, danazol, contraceptive orale2<\/sup>.<\/p>\n

Sc\u0103deri<\/strong><\/span>: dextran, metildopa, penicilamina2<\/sup>.<\/p>\n

\u2022 Interferen\u0163e analitice<\/p>\n

Gamapatiile monoclonale de tip Ig A sau Ig M pot interfera cu determinarea C4<\/sub>4<\/sup>. Lipemia excesiv\u0103 determin\u0103 cre\u015fteri semnificative ale nivelului C4<\/sub>5<\/sup>.<\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Frances Fischbach. Immunodiagnostic studies. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 ed., 2009, 6201.<\/span><\/div>\n
2. Frances Fischbach. Effects of the Most Commonly Used Drugs on Frequently Ordered Laboratory Tests. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 Ed., 2009; 1231.<\/span><\/div>\n
3. Jacques Wallach. Analize de sange. In Interpretarea testelor de diagnostic. Editura Stiintelor Medicale, Romania, Ed. 7, 2001, 49-121.<\/span><\/div>\n
4. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2015. Ref Type: Catalog.<\/span><\/div>\n
5. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Complement C4, serum. www.labcorp.com 2015. Ref Type: Internet Communication.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

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    \n
  1. \u0414\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0438 \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433\u0430 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0445 (\u0438\u043c\u043c\u0443\u043d\u043e\u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u044b\u0445) \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439.<\/li>\n
  2. \u0414\u043b\u044f \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044f \u0437\u0430 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c\u044e \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0432\u044b\u0448\u0435\u043d\u0430\u0437\u0432\u0430\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439.<\/li>\n
  3. \u0427\u0442\u043e\u0431\u044b \u0432\u044b\u044f\u0432\u0438\u0442\u044c \u043f\u0440\u0435\u0434\u0440\u0430\u0441\u043f\u043e\u043b\u043e\u0436\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u043a \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0439 \u043a\u0440\u0430\u0441\u043d\u043e\u0439 \u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0435.<\/li>\n
  4. \u0427\u0422\u043e\u0431\u044b \u043e\u0446\u0435\u043d\u0438\u0442\u044c \u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0439 \u0441\u0442\u0430\u0442\u0443\u0441 \u043f\u0440\u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445.<\/li>\n<\/ol>\n

    \u041a\u043e\u0433\u0434\u0430 \u043d\u0430\u0437\u043d\u0430\u0447\u0430\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/p>\n

      \n
    1. \u041f\u0440\u0438 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0445 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f\u0445.<\/li>\n
    2. \u041f\u0440\u0438 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u044b\u0445 \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f\u0445.<\/li>\n
    3. \u041f\u0440\u0438 \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043d\u043e\u0432\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f\u0445.<\/li>\n
    4. \u041f\u0440\u0438 \u043f\u043e\u0434\u043e\u0437\u0440\u0435\u043d\u0438\u0438 \u043d\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u0443\u044e \u043a\u0440\u0430\u0441\u043d\u0443\u044e \u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0443.<\/li>\n
    5. \u041f\u0440\u0438 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u0438\u0440\u0443\u044e\u0449\u0438\u0445 \u0442\u044f\u0436\u0435\u043b\u044b\u0445 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f\u0445.<\/li>\n<\/ol>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[953,954],"product_tag":[],"class_list":{"0":"post-9198","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-de-biochimie","6":"product_cat-proteine-specifice-in-ser-si-urina","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9198","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9198"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9198"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9198"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9198"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9198"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}