{"id":9186,"date":"2020-04-23T04:30:41","date_gmt":"2020-04-23T01:30:41","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/ceruloplasmina\/"},"modified":"2025-07-01T07:56:51","modified_gmt":"2025-07-01T04:56:51","slug":"ceruloplasmina","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/ceruloplasmina\/","title":{"rendered":"\u0426\u0435\u0440\u0443\u043b\u043e\u043f\u043b\u0430\u0437\u043c\u0438\u043d"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Ceruloplasmina este o alfa2-globulin\u0103 ce con\u0163ine cupru. Aproximativ 70% din cuprul seric total este transportat de ceruloplasmina, 7% de o protein\u0103 cu greutate molecular\u0103 mare (transcupreina), 19% de albumin\u0103 \u015fi 2% de c\u0103tre unii aminoacizi3<\/sup>.<\/p>\n

Sinteza ceruloplasminei are loc \u00een hepatocite, la o rat\u0103 zilnic\u0103 de 6 mg\/kg corp. \u00cencorporarea cuprului \u00een ceruloplasmina (p\u00e2n\u0103 la maxim 8 atomi de cupru\/molecul\u0103) se produce \u00een cursul sintezei hepatice a acesteia, conferindu-i o culoare albastr\u0103. Dup\u0103 preluarea cuprului ceruloplasmina migreaz\u0103 c\u0103tre \u0163esuturile utilizatoare de cupru, unde acesta este eliberat, iar proteina este catabolizat\u0103. Eliminarea se face pe cale biliar\u0103.<\/p>\n

Pe l\u00e2nga transportul cuprului, ceruloplasmina mai de\u0163ine urm\u0103toarele func\u0163ii:<\/p>\n

\u2013 oxidarea Fe2+<\/sup> in Fe3+<\/sup> care permite transportul fierului de c\u0103tre transferin\u0103;<\/div>\n
\u2013 oxidarea catecolaminelor \u015fi serotoninei (rezultate in vitro<\/em>);<\/div>\n
\u2013 ac\u0163iune antioxidant\u0103, prevenind oxidarea lipidelor din membrana celular\u0103;<\/div>\n
\u2013 ac\u0163iune antiinflamatoare, prin inhibarea histaminazei serice.<\/div>\n

Concentra\u0163ii sc\u0103zute de ceruloplasmina se \u00eenregistreaz\u0103\u00a0\u00een boala Wilson (degenerescen\u0163\u0103 hepatolenticulara), o afec\u0163iune cu transmitere autozomal recesiv\u0103. Mecanismul patogenic al acestei boli, care este caracterizat\u0103 printr-o sintez\u0103 sc\u0103zut\u0103 de ceruloplasmina, este reprezentat de alterarea \u00eencorpor\u0103rii cuprului\u00a0\u00een molecula de ceruloplasmin\u0103 \u015fi a excre\u0163iei biliare a acestuia. Defectul genetic situat pe cromozomul 13q afecteaz\u0103 gena ATP-azei care transport\u0103 cuprul\u00a0\u00een ficat (ATP7B). Ca urmare, se produc depuneri patologice de cupru la nivel hepatic (cu dezvoltarea progresiv\u0103 a cirozei), cerebral (cu simptome neurologice), cornean (inelul Kayser-Fleischer) \u015fi renal (hematurie, proteinurie, aminoacidurie)1;2<\/sup>. Trebuie men\u0163ionat c\u0103 pentru stabilirea diagnosticului de boala Wilson nu este necesar ca manifest\u0103rile neurologice \u015fi hepatice s\u0103 fie prezente simultan. Din punct de vedere al testelor de laborator, modific\u0103rile caracteristice bolii Wilson includ: sc\u0103derea concentra\u0163iei serice a ceruloplasminei (marcat\u0103 la homozigo\u0163i, variabil\u0103, uneori absent\u0103 la heterozigoti), cre\u015fterea excre\u0163iei urinare a cuprului, cre\u015fterea cantit\u0103\u0163ii de cupru la nivel hepatic \u015fi anomalii ale func\u0163iei hepatice3<\/sup>.<\/p>\n

Sindromul Menkes, o afec\u0163iune genetic\u0103 rar\u0103 asociat\u0103 cu simptome neurodegenerative \u015fi anomalii ale \u0163esutului conjunctiv, are la baz\u0103 perturbarea absorb\u0163iei intestinale \u015fi utilizarea deficitar\u0103 a cuprului din diet\u0103, cu reducerea concomitent\u0103 a nivelului de ceruloplasmin\u0103.<\/p>\n

Printre cauzele dob\u00e2ndite de concentra\u0163ii reduse de ceruloplasmin\u0103 se num\u0103r\u0103 sindroamele \u00eenso\u0163ite de pierderi de proteine \u015fi insuficien\u0163\u0103 hepatic\u0103.<\/p>\n

Deoarece ceruloplasmina constituie un reactant de faz\u0103 acut\u0103, cre\u015fteri ale concentra\u0163iei sale se \u00eent\u00e2lnesc\u00a0\u00een cursul proceselor inflamatorii acute sau cronice (cre\u015fterile marcate pot determina colorarea serului\u00a0\u00een verde!)1;2;3<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea ceruloplasminei<\/em><\/strong><\/p>\n

\u2022 Suspiciune clinic\u0103 de boala Wilson: afec\u0163iuni hepatice la copii \u00een absen\u0163a etiologiei virale; afec\u0163iuni\u00a0neurologice (tulbur\u0103ri de coordonare a mi\u015fc\u0103rilor) de etiologie neclar\u0103;<\/div>\n
\u2022 Anemie microcitar\u0103 hipocrom\u0103 care nu r\u0103spunde la tratamentul cu preparate de fier (datorat\u0103\u00a0unui deficit de cupru);<\/div>\n
\u2022 Simptome neurodegenerative \u015fi anomalii ale \u0163esutului conjunctiv la copii (suspiciune de sindrom\u00a0Menkes)1;2;3<\/sup>.<\/div>\n

Preg\u0103tire pacient <\/em><\/strong>-<\/em> \u00e0 jeun (pe nem\u00e2ncate)2<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>-<\/em> \u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c2<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>-<\/em> vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator2<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>-<\/em> se separ\u0103 serul prin centrifugare2<\/sup>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser2<\/sup>.<\/p>\n

Cauze de respingere a probei <\/em><\/strong>-<\/em> specimen hemolizat2<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>-<\/em> serul separat este stabil 3 zile<\/em> la 2-8\u00b0C; 1 luna <\/em>la -20\u00b0C2<\/sup>.<\/p>\n

Metod\u0103 <\/em><\/strong>- imunoturbidimetrica2<\/sup><\/span>.<\/p>\n

Valori de referin\u0163\u0103 <\/em><\/strong>\u2013 sunt \u00een func\u0163ie de sex:<\/p>\n

B\u0103rba\u0163i: 15-30 mg\/dL<\/p>\n

Femei: 16-45 mg\/dL.<\/p>\n

Factor de conversie: mg\/dL x 0.0746 = \u03bcmol\/L2<\/sup>.<\/p>\n

Limita de detec\u0163ie<\/em><\/strong> \u2013 3 mg\/dL (0.03 g\/L; 0.22 \u00b5mol\/L)2<\/sup>.<\/p>\n

Interpretarea rezultatelor<\/em><\/strong><\/p>\n\n\n\n\n\n\n
\n

Sc\u0103deri <\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n
\u2022 boala Wilson (\u00een form\u0103 homozigot\u0103 <15 mg\/dL)<\/div>\n
\u2022 sindromul Menkes<\/div>\n
\u2022 deficit de cupru (anemie microcitar\u0103 hipocrom\u0103)<\/div>\n
\u2022 deficit ereditar de ceruloplasmin\u0103 (rar)<\/div>\n
\u2022 sindrom nefrotic<\/div>\n
\u2022 enteropatia cu pierdere de proteine<\/div>\n
\u2022 sindroame de malnutri\u0163ie \u015fi malabsorb\u0163ie<\/div>\n
\u2022 boli hepatice avansate2;3<\/sup>\u00a0<\/em><\/strong><\/div>\n<\/td>\n<\/tr>\n
\n

Cre\u015fteri<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n
\u2022 carcinoame<\/div>\n
\u2022 leucemii<\/div>\n
\u2022 boala Hodgkin<\/div>\n
\u2022 ciroza biliar\u0103 primitiv\u0103 (alterarea excre\u0163iei cuprului ca urmare a colestazei)<\/div>\n
\u2022 LES<\/div>\n
\u2022 poliartrita reumatoid\u01033<\/sup><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

La nou-n\u0103scut \u015fi sugar nivelurile de ceruloplasmin\u0103 sunt cu aproximativ 50% mai mici dec\u00e2t cele ale adultului (5-40 mg\/dL), de aceea acest test nu poate fi folosit pentru diagnosticul bolii Wilson \u00een cursul primului an de via\u0163\u0103.<\/div>\n
Concentra\u0163ii crescute sunt \u00eenregistrate\u00a0\u00een sarcin\u0103 \u015fi\u00a0\u00een cursul tratamentului cu anticoncep\u0163ionale orale1;2;3<\/sup>.<\/div>\n
Un nivel normal de ceruloplasmin\u0103 nu exclude diagnosticul de boala Wilson; trebuie efectuate suplimentar determin\u0103ri ale cuprului plasmatic \u015fi urinar.<\/div>\n
Tratamentul excesiv cu zinc poate induce blocarea absorb\u0163iei intestinale a cuprului cu instalarea unui sindrom de deficit de cupru caracterizat prin: anemie microcitar\u0103 hipocrom\u0103, leucopenie si\/sau neutropenie \u015fi un nivel marcat sc\u0103zut de ceruloplasmin\u0103. Revenirea la normal a concentra\u0163iei de ceruloplasmin\u0103 se produce lent, dup\u0103 eliminarea excesului de zinc3<\/sup>.<\/div>\n
<\/div>\n
\u2022 Interferen\u0163e analitice<\/div>\n
\u00cen cazuri foarte rare prezen\u0163a gamapatiei, \u00een special IgM (macroglobulinemia Waldenstr\u00f6m) poate determina rezultate eronate2<\/sup>.<\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/span><\/p>\n

1. Frances Fischbach. Protein Chemistry Testing\/Serum Proteins. In A Manual of Laboratory and Diagnostic Tests. Lippincott, Williams & Wilkins, USA, 8 Ed., 2009, 640-641.<\/span><\/div>\n
2. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2015. Ref Type: Catalog.<\/span><\/div>\n
3. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Ceruloplasmin. www.labcorp.com 2015. Ref Type: Internet Communication.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/strong><\/em><\/p>\n

\u0426\u0435\u0440\u0443\u043b\u043e\u043f\u043b\u0430\u0437\u043c\u0438\u043d \u2013 \u0433\u043b\u0430\u0432\u043d\u044b\u0439 \u043c\u0435\u0434\u044c\u0441\u043e\u0434\u0435\u0440\u0436\u0430\u0449\u0438\u0439 \u0431\u0435\u043b\u043e\u043a \u043a\u0440\u043e\u0432\u0438, \u0438\u0433\u0440\u0430\u044e\u0449\u0438\u0439 \u0432\u0430\u0436\u043d\u0443\u044e \u0440\u043e\u043b\u044c \u0432 \u043e\u0431\u043c\u0435\u043d\u0435 \u0436\u0435\u043b\u0435\u0437\u0430 \u0438 \u043e\u0442\u043d\u043e\u0441\u044f\u0449\u0438\u0439\u0441\u044f \u043a \u0430\u043b\u044c\u0444\u0430-2-\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u0430\u043c.<\/p>\n

\u0426\u0435\u0440\u0443\u043b\u043e\u043f\u043b\u0430\u0437\u043c\u0438\u043d \u2013 \u044d\u0442\u043e \u0444\u0435\u0440\u0440\u043e\u043a\u0441\u0438\u0434\u0430\u0437\u0430, \u0441\u043e\u0434\u0435\u0440\u0436\u0430\u0449\u0430\u044f \u043c\u0435\u0434\u044c, \u0443\u0447\u0430\u0441\u0442\u0432\u0443\u044e\u0449\u0430\u044f \u0432 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u043c\u0435 \u0436\u0435\u043b\u0435\u0437\u0430 \u0438 \u0432\u043e \u043c\u043d\u043e\u0433\u0438\u0445 \u043e\u043a\u0438\u0441\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e-\u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0440\u0435\u0430\u043a\u0446\u0438\u044f\u0445. \u041c\u0435\u0434\u044c \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0436\u0438\u0437\u043d\u0435\u043d\u043d\u043e \u0432\u0430\u0436\u043d\u044b\u043c \u043c\u0438\u043d\u0435\u0440\u0430\u043b\u043e\u043c, \u043f\u043e\u0441\u0442\u0443\u043f\u0430\u044e\u0449\u0438\u043c \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c \u0441 \u043f\u0438\u0449\u0435\u0439. \u041e\u043d\u0430 \u0432\u0441\u0430\u0441\u044b\u0432\u0430\u0435\u0442\u0441\u044f \u0432 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0435 \u0438 \u043f\u0435\u0440\u0435\u043d\u043e\u0441\u0438\u0442\u0441\u044f \u0432 \u043f\u0435\u0447\u0435\u043d\u044c, \u0433\u0434\u0435 \u043d\u0430\u043a\u0430\u043f\u043b\u0438\u0432\u0430\u0435\u0442\u0441\u044f \u0438\u043b\u0438 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0434\u043b\u044f \u0441\u0438\u043d\u0442\u0435\u0437\u0430 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0444\u0435\u0440\u043c\u0435\u043d\u0442\u043e\u0432. \u0412 \u043f\u0435\u0447\u0435\u043d\u0438 \u043c\u0435\u0434\u044c \u043f\u0440\u0438\u0441\u043e\u0435\u0434\u0438\u043d\u044f\u0435\u0442\u0441\u044f \u043a \u0430\u043f\u043e\u0446\u0435\u0440\u0443\u043b\u043e\u043f\u043b\u0430\u0437\u043c\u0438\u043d\u0443 \u0441 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044b \u0446\u0435\u0440\u0443\u043b\u043e\u043f\u043b\u0430\u0437\u043c\u0438\u043d\u0430, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u0432\u044b\u0445\u043e\u0434\u0438\u0442 \u0432 \u043e\u0431\u0449\u0438\u0439 \u043a\u0440\u043e\u0432\u043e\u0442\u043e\u043a. \u041e\u043a\u043e\u043b\u043e 95 % \u0432\u0441\u0435\u0439 \u043c\u0435\u0434\u0438 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430 \u043d\u0430\u0445\u043e\u0434\u0438\u0442\u0441\u044f \u0432 \u0441\u043e\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u0438 \u0441 \u0430\u043f\u043e\u0446\u0435\u0440\u0443\u043b\u043e\u043f\u043b\u0430\u0437\u043c\u0438\u043d\u043e\u043c, \u043f\u043e\u044d\u0442\u043e\u043c\u0443 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0430 \u0446\u0435\u0440\u0443\u043b\u043e\u043f\u043b\u0430\u0437\u043c\u0438\u043d\u0430 \u2013 \u043e\u0434\u0438\u043d \u0438\u0437 \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u0445 \u043c\u0435\u0442\u043e\u0434\u043e\u0432, \u043f\u043e\u043c\u043e\u0433\u0430\u044e\u0449\u0438\u0445 \u0432 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0412\u0438\u043b\u044c\u0441\u043e\u043d\u0430 \u2013 \u041a\u043e\u043d\u043e\u0432\u0430\u043b\u043e\u0432\u0430 \u0438 \u0432 \u043e\u0446\u0435\u043d\u043a\u0435 \u043e\u0431\u043c\u0435\u043d\u0430 \u043c\u0435\u0434\u0438. \u041f\u0440\u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0412\u0438\u043b\u044c\u0441\u043e\u043d\u0430 \u2013 \u041a\u043e\u043d\u043e\u0432\u0430\u043b\u043e\u0432\u0430 \u0438\u0437-\u0437\u0430 \u043d\u0438\u0437\u043a\u043e\u0439 \u043f\u0440\u043e\u0434\u0443\u043a\u0446\u0438\u0438 \u0446\u0435\u0440\u0443\u043b\u043e\u043f\u043b\u0430\u0437\u043c\u0438\u043d\u0430 \u0441\u0442\u0440\u0430\u0434\u0430\u0435\u0442 \u043c\u043e\u0431\u0438\u043b\u0438\u0437\u0430\u0446\u0438\u044f \u043c\u0435\u0434\u0438 \u0438\u0437 \u043f\u0435\u0447\u0435\u043d\u0438.<\/p>\n

\u0426\u0435\u0440\u0443\u043b\u043e\u043f\u043b\u0430\u0437\u043c\u0438\u043d \u0442\u0430\u043a\u0436\u0435 \u043e\u0442\u043d\u043e\u0441\u0438\u0442\u0441\u044f \u043a \u0433\u0440\u0443\u043f\u043f\u0435 \u0430\u043b\u044c\u0444\u0430-2-\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u043e\u0432, \u0442. \u0435. \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0431\u0435\u043b\u043a\u043e\u043c \u043e\u0441\u0442\u0440\u043e\u0439 \u0444\u0430\u0437\u044b \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u044f. \u0415\u0433\u043e \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430\u0435\u0442 \u043f\u0440\u0438 \u0441\u0442\u0440\u0435\u0441\u0441\u0435, \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438, \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0445 \u0438 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445.<\/p>\n\n\n\n\n\n\n\n\n\n
\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c<\/b><\/td>\n\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/b><\/td>\n<\/tr>\n
\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n
\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440 \u0441\/\u0431\u0435\u0437 \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430 \u0441\/\u0431\u0435\u0437 \u0433\u0435\u043b\u0435\u0432\u043e\u0439 \u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n
\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
\u041c\u0435\u0442\u043e\u0434\u00a0\u0442\u0435\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f<\/b><\/td>\n\u0418\u043c\u043c\u0443\u043d\u043e\u0442\u0443\u0440\u0431\u0438\u0434\u0438\u043c\u0435\u0442\u0440\u0438\u0447\u0435\u0441\u043a\u0438\u0439<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n
\u0418\u043d\u0442\u0435\u0440\u0444\u0435\u0440\u0438\u0440\u0443\u044e\u0449\u0438\u0435\u00a0\u0444\u0430\u043a\u0442\u043e\u0440\u044b.\u00a0\u041c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u044b<\/td>\n<\/tr>\n
\u041f\u043e\u0432\u044b\u0448\u0430\u044e\u0442<\/td>\n\u0421\u043d\u0438\u0436\u0430\u044e\u0442<\/td>\n<\/tr>\n
\u041e\u0440\u0430\u043b\u044c\u043d\u044b\u0435 \u043a\u043e\u043d\u0442\u0440\u0430\u0446\u0435\u043f\u0442\u0438\u0432\u044b, \u043a\u0430\u0440\u0431\u0430\u043c\u0430\u0437\u0435\u043f\u0438\u043d, \u0444\u0435\u043d\u043e\u0431\u0430\u0440\u0431\u0438\u0442\u0430\u043b, \u0444\u0435\u043d\u0438\u0442\u043e\u0438\u043d, \u0432\u0430\u043b\u044c\u043f\u0440\u043e\u0435\u0432\u0430\u044f \u043a\u0438\u0441\u043b\u043e\u0442\u0430, \u044d\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u044b,\u00a0\u043c\u0435\u0442\u0430\u0434\u043e\u043d,\u00a0\u0442\u0430\u043c\u043e\u043a\u0441\u0438\u0444\u0435\u043d<\/td>\nL-\u0430\u0441\u043f\u0430\u0440\u0430\u0433\u0438\u043d\u0430\u0437\u0430<\/td>\n<\/tr>\n
\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/td>\n<\/tr>\n
\n
    \n
  • \u0411\u043e\u043b\u0435\u0437\u043d\u044c \u0412\u0438\u043b\u044c\u0441\u043e\u043d\u0430-\u041a\u043e\u043d\u043e\u0432\u0430\u043b\u043e\u0432\u0430;<\/li>\n
  • \u043d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u043d\u0435\u044f\u0441\u043d\u043e\u0439 \u044d\u0442\u0438\u043e\u043b\u043e\u0433\u0438\u0438, \u043d\u0435\u0439\u0440\u043e\u0434\u0435\u0433\u0435\u043d\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u044b\u0435 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b \u0438 \u0430\u043d\u043e\u043c\u0430\u043b\u0438\u0438 \u0441\u043e\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438 \u0443 \u0434\u0435\u0442\u0435\u0439;<\/li>\n
  • \u043c\u0438\u043a\u0440\u043e\u0446\u0438\u0442\u0430\u0440\u043d\u0430\u044f \u0433\u0438\u043f\u043e\u0445\u0440\u043e\u043c\u043d\u0430\u044f \u0430\u043d\u0435\u043c\u0438\u044f, \u043d\u0435 \u0440\u0435\u0430\u0433\u0438\u0440\u0443\u044e\u0449\u0430\u044f \u043d\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430\u043c\u0438 \u0436\u0435\u043b\u0435\u0437\u0430;<\/li>\n
  • \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433 \u043f\u0440\u0438 \u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0438 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438, \u043f\u0440\u0438 \u0434\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u043c \u043f\u0430\u0440\u0435\u043d\u0442\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u043c \u043f\u0438\u0442\u0430\u043d\u0438\u0438<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f\u00a0\u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/td>\n<\/tr>\n
\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/td>\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/td>\n<\/tr>\n
\n
    \n
  • \u0417\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0435 \u043d\u043e\u0432\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f;<\/li>\n
  • \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u0425\u043e\u0434\u0436\u043a\u0438\u043d\u0430;<\/li>\n
  • \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u0436\u0435\u043b\u0447\u0435\u0432\u044b\u0432\u043e\u0434\u044f\u0449\u0435\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b, \u0441\u043e\u043f\u0440\u043e\u0432\u043e\u0436\u0434\u0430\u044e\u0449\u0438\u0435\u0441\u044f \u0445\u043e\u043b\u0435\u0441\u0442\u0430\u0437\u043e\u043c;<\/li>\n
  • \u0421\u041a\u0412, \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0430\u0440\u0442\u0440\u0438\u0442;<\/li>\n
  • \u043e\u0441\u0442\u0440\u044b\u0435 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u0442\u0440\u0430\u0432\u043c\u044b<\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • \u0411\u043e\u043b\u0435\u0437\u043d\u044c \u0412\u0438\u043b\u044c\u0441\u043e\u043d\u0430-\u041a\u043e\u043d\u043e\u0432\u0430\u043b\u043e\u0432\u0430 (\u043f\u0440\u0438 \u0433\u043e\u043c\u043e\u0437\u0438\u0433\u043e\u0442\u043d\u043e\u0439 \u0444\u043e\u0440\u043c\u0435<\/li>\n<\/ul>\n

    <\u00a015\u00a0\u043c\u0433\/\u0434\u043b),\u00a0\u0434\u0435\u0444\u0438\u0446\u0438\u0442\u00a0\u043c\u0435\u0434\u0438<\/p>\n

    (\u0433\u0438\u043f\u043e\u0445\u0440\u043e\u043c\u043d\u0430\u044f\u00a0\u043c\u0438\u043a\u0440\u043e\u0446\u0438\u0442\u0430\u0440\u043d\u0430\u044f\u00a0\u0430\u043d\u0435\u043c\u0438\u044f),\u00a0\u043d\u0430\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439\u00a0\u0434\u0435\u0444\u0438\u0446\u0438\u0442\u00a0\u0446\u0435\u0440\u0443\u043b\u043e\u043f\u043b\u0430\u0437\u043c\u0438\u043d\u0430,\u00a0\u043f\u0440\u0438\u00a0\u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0438\u00a0\u043f\u0438\u0442\u0430\u043d\u0438\u044f;<\/p>\n

      \n
    • \u043d\u0435\u0444\u0440\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c;<\/li>\n
    • \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u043c\u0430\u043b\u044c\u0430\u0431\u0441\u043e\u0440\u0431\u0446\u0438\u0438;<\/li>\n
    • \u0442\u044f\u0436\u0435\u043b\u044b\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u043f\u0435\u0447\u0435\u043d\u0438;<\/li>\n
    • \u0434\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u043f\u0430\u0440\u0435\u043d\u0442\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0435 \u043f\u0438\u0442\u0430\u043d\u0438\u0435<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[953,954],"product_tag":[],"class_list":{"0":"post-9186","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-de-biochimie","6":"product_cat-proteine-specifice-in-ser-si-urina","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9186"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9186"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9186"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9186"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}