{"id":9165,"date":"2020-04-23T04:29:57","date_gmt":"2020-04-23T01:29:57","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/antitrombina-antitrombina-iii\/"},"modified":"2025-07-01T07:56:53","modified_gmt":"2025-07-01T04:56:53","slug":"antitrombina-antitrombina-iii","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/antitrombina-antitrombina-iii\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0442\u0440\u043e\u043c\u0431\u0438\u043d III"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong><em>\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Antitrombina (antitrombina III, dup\u0103 denumirea mai veche) este un inhibitor potent al reac\u0163iilor din cascada coagul\u0103rii. De\u015fi numele \u201eantitrombin\u0103\u201d ar implica o ac\u0163iune numai la nivelul trombinei, de fapt acest anticoagulant natural inhib\u0103 \u00eentr-o oarecare m\u0103sur\u0103 toate enzimele coagul\u0103rii. Principalele enzime inhibate sunt: factor Xa, IXa \u015fi trombina (factor IIa); de asemenea antitrombina exercit\u0103 ac\u0163iuni inhibitorii asupra factorilor XIIa, XIa \u015fi a complexului factor VIIa \u015fi factor tisular<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Antitrombina a fost descoperit\u0103 \u00een 1939 ca o substan\u0163\u0103 prezent\u0103 \u00een plasm\u0103 ce ac\u0163ioneaz\u0103 \u00eempreun\u0103 cu heparina pentru a preveni apari\u0163ia trombozelor. De fapt, ac\u0163iunea de sine st\u0103t\u0103toare a antitrombinei este relativ ineficient\u0103, dar atunci c\u00e2nd se combin\u0103 cu heparina viteza reac\u0163iei de inhibare a factorilor de coagulare este puternic accelerat\u0103, ceea ce face din complexul antitrombin\u0103-heparin\u0103 un component vital al mecanismului anticoagulant \u015fi st\u0103 la baza indica\u0163iilor terapeutice ale preparatelor de heparin\u0103<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Gena antitrombinei, localizat\u0103 pe cromozomul 1, codific\u0103 o glicoprotein\u0103 cu greutatea molecular\u0103 de 58 kDa ce este sintetizat\u0103 \u00een ficat \u015fi este prezent\u0103 \u00een plasm\u0103 \u00eentr-o concentra\u0163ie relativ ridicat\u0103 (aproximativ 2.3 \u03bcmol\/L)<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Deficitul de antitrombin\u0103 a c\u0103rui inciden\u0163\u0103 \u00een popula\u0163ie este raportat\u0103 ca fiind cuprins\u0103 \u00eentre 0.02% \u015fi 1% poate fi congenital sau dob\u00e2ndit \u015fi se asociaz\u0103 cu un risc crescut de tromboembolism recurent<sup>1;3<\/sup>. Prevalen\u0163a deficitului ereditar de antitrombin\u0103 la pacien\u0163ii cu tromboze venoase este de 1-2%. Dintre trombofiliile ereditare, deficitul de antitrombin\u0103 prezint\u0103 cea mai mare penetran\u0163\u0103 (riscul cel mai mare de tromboembolism venos). Tromboza arterial\u0103 (AVC, infarct miocardic) a fost ocazional raportat\u0103 \u00een asociere cu deficitul de antitrombin\u0103<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Din punct de vedere al defectului implicat exist\u0103 2 tipuri principale de deficit de antitrombin\u0103:<\/p>\n<ul style=\"text-align: justify;\">\n<li>tipul I (cantitativ) caracterizat printr-o cantitate inadecvat\u0103 de antitrombin\u0103 ce este normal\u0103 din punct de vedere func\u0163ional (sunt sc\u0103zute at\u00e2t activitatea c\u00e2t \u015fi antigenul antitrombinei III);<\/li>\n<li>tipul II (calitativ) asociat cu o cantitate normal\u0103 de antitrombin\u0103 III, care \u00eens\u0103 nu este capabil\u0103 s\u0103-\u015fi exercite func\u0163ia de inhibitor al coagul\u0103rii (antigenul antitrombinei III este normal cantitativ dar activitatea este sc\u0103zut\u0103)<sup>1;3;4<\/sup>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong><em>Recomand\u0103ri pentru determinarea antitrombinei <\/em><\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>investigarea unor complica\u0163ii tromboembolice neexplicabile, \u00een special la pacien\u0163i &lt;50 ani \u015fi cu istoric familial pozitiv de evenimente trombotice<sup>5<\/sup>;<\/li>\n<li>investigarea unor episoade de tromboz\u0103 venoas\u0103 cu localiz\u0103ri neobi\u015fnuite (ex. tromboza venelor mezenterice)<sup>3<\/sup>;<\/li>\n<li>monitorizarea tratamentului afec\u0163iunilor \u00eenso\u0163ite de deficit de antitrombin\u0103, inclusiv administrarea concentratelor terapeutice de antitrombin\u0103<sup>2<\/sup>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong><em>Preg\u0103tire pacient<\/em><\/strong> \u2013 \u00e0 jeun; tratamentul cu heparin\u0103 va fi \u00eentrerupt cu 2 zile \u00eenaintea recolt\u0103rii<sup>4;5<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Specimen recoltat <\/em><\/strong>\u2013 s\u00e2nge venos<sup>5<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Recipient de recoltare <\/em><\/strong>\u2013 vacutainer cu citrat de Na 0.105 M (1\/9) (capac bleu\/verde)<sup>5<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Cantitatea recoltat\u0103 <\/em><\/strong>\u2013 c\u00e2t permite vacuumul<sup>5<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Cauze de respingere a probei:<\/em><\/strong><\/p>\n<ul>\n<li style=\"text-align: justify;\">specimen hemolizat;<\/li>\n<li>specimen coagulat;<\/li>\n<li>vacutainer care nu este plin;<\/li>\n<li>specimen contaminat cu heparin\u0103<sup>5<\/sup>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong> \u2013 se separ\u0103 plasma prin centrifugare \u015fi se lucreaz\u0103 imediat; dac\u0103 acest lucru nu este posibil, plasma se poate stoca la -20\u00b0C; probele de plasm\u0103 recoltate \u00een afara laboratorului vor fi transportate \u00een recipientul destinat probelor congelate<sup>5<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Stabilitate prob\u0103<\/em><\/strong> \u2013 plasma separat\u0103 este stabil\u0103 <em>8 ore<\/em> la 18-25\u00b0 C; <em>1 lun\u0103<\/em> la -20C<sup>4<\/sup>; se va evita decongelarea\/recongelarea<sup>5<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Metod\u0103 <\/em><\/strong><em>- <\/em><u>cromogen\u0103<\/u> (test de activitate) bazat\u0103 pe inhibarea FIIa (trombin\u0103); plasma diluat\u0103 a pacientului este incubat\u0103 cu un exces de FIIa uman \u00een prezen\u0163a heparinei; va rezulta un complex antitrombin\u0103-trombin\u0103-heparin\u0103 iar FIIa rezidual va cliva un substrat cromogen \u015fi va induce o schimbare de culoare; absorban\u0163a m\u0103surat\u0103 la 405 nm va fi invers propor\u0163ional\u0103 cu activitatea antitrombinei din plasma pacientului<sup>5<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Valori de referin\u0163\u0103<\/em><\/strong><sup>5<\/sup>:<\/p>\n<table class=\"wp-block-table w-100\" style=\"height: 334px;\" border=\"1\" width=\"606\">\n<tbody>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\"><strong>\u0412\u043e\u0437\u0440\u0430\u0441\u0442<\/strong><\/td>\n<td width=\"295\"><strong>Activitate antitrombin\u0103 (%)<\/strong><\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">Prematuri: zilele 1-3<\/td>\n<td width=\"295\">20-51<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">Prematuri: zilele 4-6<\/td>\n<td width=\"295\">21-51<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">Prematuri: ziua 7<\/td>\n<td width=\"295\">40-54<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">Nou n\u0103scut: zilele 1-6<\/td>\n<td width=\"295\">44-84<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">Nou-n\u0103scut: dup\u0103 ziua 7<\/td>\n<td width=\"295\">34-70<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">2-10 ani<\/td>\n<td width=\"295\">67-120<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">11-18 ani<\/td>\n<td width=\"295\">81-120<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">Adul\u0163i<\/td>\n<td width=\"295\">80-120<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\"><strong><em>\u00a0<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\"><strong><em>Interpretarea rezultatelor <\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Testul detecteaz\u0103 ambele tipuri (I si II) de deficit, dar nu permite diferen\u0163ierea lor. De aceea, \u00een cazul ob\u0163inerii unei activit\u0103\u0163i sc\u0103zute a antitrombinei se recomand\u0103 determinarea antigenului<sup>2;5<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><em>Sc\u0103derea activit\u0103\u0163ii antitrombinei se asociaz\u0103 cu:<\/em><\/p>\n<ul style=\"text-align: justify;\">\n<li>deficit congenital (ereditar);<\/li>\n<li>transplant hepatic, ciroz\u0103, insuficien\u0163\u0103 hepatic\u0103;<\/li>\n<li>boal\u0103 trombotic\u0103 activ\u0103 (tromboza venelor profunde);<\/li>\n<li>CID, afec\u0163iuni \u00eenso\u0163ite de fibrinoliz\u0103;<\/li>\n<li>infarct miocardic acut;<\/li>\n<li>embolism pulmonar;<\/li>\n<li>carcinoame, traumatisme, inflama\u0163ii severe<\/li>\n<li>boli asociate cu pierderi de proteine;<\/li>\n<li>e\u015fec al tratamentului cu heparin\u0103.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><em>Cre\u015fterea activit\u0103\u0163ii antitrombinei se asociaz\u0103 cu:<\/em><\/p>\n<ul style=\"text-align: justify;\">\n<li>hepatit\u0103 acut\u0103;<\/li>\n<li>transplant renal;<\/li>\n<li>inflama\u0163ii (VSH crescut);<\/li>\n<li>hiperglobulinemie<sup>4<\/sup>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">\u00cen cazul deficitului heterozigot se \u00eenregistreaz\u0103 valori ale activit\u0103\u0163ii antitrombinei cuprinse \u00eentre 40 \u015fi 70%<sup>2<\/sup>. Riscul de a dezvolta evenimente tromboembolice depinde de subtipul de deficit de antitrombin\u0103. Astfel, \u00een cazul deficitului de tip I a fost estimat un risc de tromboz\u0103 de 1% pe an, \u00eencep\u00e2nd cu v\u00e2rsta de 15 ani \u015fi un risc total de tromboz\u0103 pe durata vie\u0163ii de 50-85%. \u00cen deficitul de tip II riscul de tromboz\u0103 variaz\u0103 \u00eentre 6 \u015fi 20% \u00een func\u0163ie de localizarea defectului genetic, fiind mai mare \u00een cazul afect\u0103rii situsului reactiv al antitrombinei.<\/p>\n<p style=\"text-align: justify;\">Se pare c\u0103 deficitul de tip I homozigot este incompatibil cu via\u0163a iar deficitul de tip II homozigot se asociaz\u0103 cu un debut precoce al manifest\u0103rilor trombotice.<\/p>\n<p style=\"text-align: justify;\">Cel mai frecvent se dezvolt\u0103 tromboza venelor profunde ale membrelor inferioare complicat\u0103 \u00een unele cazuri cu embolia pulmoar\u0103. Mai pot s\u0103 apar\u0103: tromboze recurente dup\u0103 \u00eentreruperea tratamentului anticogulant, tromboza venelor abdominale, pelvine, retiniene sau a sinusurilor cerebrale. Evenimentele trombotice pot surveni spontan sau pot fi precipitate de sarcin\u0103, perioada post-partum, administrarea contraceptivelor orale, traumatisme, interven\u0163ii chirurgicale, etc. Exist\u0103 riscul de moarte subit\u0103 \u00een situa\u0163iile \u00een care nu se efectueaz\u0103 o profilaxie adecvat\u0103 a episoadelor trombotice.<\/p>\n<p style=\"text-align: justify;\">Rareori, se dezvolt\u0103 tromboza arterial\u0103 ca prim\u0103 manifestare a deficitului de antitrombin\u0103.<\/p>\n<p style=\"text-align: justify;\">De asemenea, au fost descrise complica\u0163ii obstetricale la gravidele cu deficit de antitrombin\u0103: pierderi recurente de sarcin\u0103, sindrom HELLP<sup>6<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Nou-n\u0103scu\u0163ii prezint\u0103 o activitate sc\u0103zut\u0103 a antitrombinei<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Folosirea contraceptivelor orale, statusul postoperator, imobilizarea prelungit\u0103 la pat si tratamentul cu L-asparaginaz\u0103 se pot asocia de asemenea cu o reducere a activit\u0103\u0163ii antitrombinei. Rezultatele nu sunt concludente \u00een ultimul trimestru de sarcin\u0103 \u015fi imediat post-partum<sup>4<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Nu se recomand\u0103 testarea \u00een cursul unui proces trombotic acut deoarece nivelul antitrombinei poate fi sc\u0103zut<sup>6<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Activitatea crescut\u0103 a antitrombinei nu prezint\u0103 o semnifica\u0163ie clinic\u0103 definit\u0103<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Prezen\u0163a inhibitorilor de trombin\u0103 (hirudin sau argatroban) \u00een plasma testat\u0103 poate interfera cu testul<sup>3<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><u>Influen<\/u><u>\u0163a tratamentului anticoagulant asupra determin\u0103rii antitrombinei<\/u><\/p>\n<ul style=\"text-align: justify;\">\n<li><strong>heparina nefrac\u0163ionat\u0103<\/strong> influen\u0163eaz\u0103 determinarea activit\u0103\u0163ii antitrombinei ca urmare a reducerii nvelurilor sale plasmatice; de aceea nu se recomand\u0103 testarea sub aceast\u0103 terapie<sup>2;7<\/sup>;<\/li>\n<li><strong>heparinele cu greutate molecular\u0103 mic\u0103<\/strong> nu influen\u0163eaz\u0103 testarea, totu\u015fi se recomand\u0103 ca recoltarea probei s\u0103 se efectueze la 12 ore de la ultima administrare sau imediat \u00eenaintea administr\u0103rii urm\u0103toarei doze<sup>5;7<\/sup>;<\/li>\n<li>tratamentul cu <strong>fondaparinux<\/strong> nu influen\u0163eaz\u0103 testarea<sup>7<\/sup>;<\/li>\n<li>rezultatele vor trebui interpretate cu pruden\u0163\u0103 la pacien\u0163ii afla\u0163i sub <strong>anticoagulante orale<\/strong>, \u0163in\u00e2ndu-se cont de faptul c\u0103 aceste medicamente pot normaliza nivelul de antitrombin\u0103 \u00een unele subtipuri de deficit heterozigot<sup>6<\/sup>;<\/li>\n<li><strong>dabigatranul <\/strong>(inhibitor de trombin\u0103) influen\u0163eaz\u0103 determinarea activit\u0103\u0163ii antitrombinei prin metoda cromogen\u0103 bazat\u0103 pe FIIa prin inducerea unor valori fals crescute; de aceea nu se recomand\u0103 testarea sub aceast\u0103 terapie;<\/li>\n<li>inhibitorii direc\u0163i de factor Xa (<strong>rivaroxaban<\/strong> \u0438\u043b\u0438 <strong>apixaban<\/strong>) nu influen\u0163eaz\u0103 determinarea activit\u0103\u0163ii antitrombinei prin metoda cromogen\u0103 bazat\u0103 pe FIIa<sup>7<\/sup>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 10pt;\">\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n<ol>\n<li style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">Antithrombin Deficiency. <a href=\"http:\/\/www.med.uiuc.edu\/hematology.com\" rel=\"nofollow noopener\" target=\"_blank\">med.uiuc.edu\/hematology<\/a><\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">Mayo Clinic, Mayo Medical Laboratories. Antithrombin Activity, Plasma. \/www.mayomedicallaboratories.com\/test-catalog. 2015. Ref Type: Internet Communication.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">Jennings I, Cooper P. Screening for Thrombophilia: A Laboratory Perspective. In <em>British Journal of Biomedical Science<\/em>, 2003, 60(1):39-51.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">Fischbach F. Blood Studies; Hematology and Coagulation. In <em>A Manual of Laboratory and Diagnostic Tests.<\/em> Lippincott Williams &amp; Wilkins, USA, 8 ed. 2009, 181-182.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">Laborator Synevo. Referin\u0163e specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">Mitton BA, Steineck A. Antithrombin Deficiency. Medscape. http\/\/emedicine.medscape.com. 2014. Ref Type: \u00a0Internet C<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">Funk DM. Coagulation assays and anticoagulant monitoring. American Society of Hematology. 2012.<\/span><\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>\u0410\u043d\u0442\u0438\u0442\u0440\u043e\u043c\u0431\u0438\u043d III \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043c\u043e\u0449\u043d\u044b\u043c \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u043e\u043c \u043a\u043e\u0430\u0433\u0443\u043b\u044f\u0446\u0438\u043e\u043d\u043d\u044b\u0445 \u043a\u0430\u0441\u043a\u0430\u0434\u043d\u044b\u0445 \u0440\u0435\u0430\u043a\u0446\u0438\u0439. \u0425\u043e\u0442\u044f \u043d\u0430\u0437\u0432\u0430\u043d\u0438\u0435 \u00ab\u0430\u043d\u0442\u0438\u0442\u0440\u043e\u043c\u0431\u0438\u043d\u00bb \u043f\u043e\u0434\u0440\u0430\u0437\u0443\u043c\u0435\u0432\u0430\u0435\u0442 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0442\u043e\u043b\u044c\u043a\u043e \u043d\u0430 \u0443\u0440\u043e\u0432\u043d\u0435 \u0442\u0440\u043e\u043c\u0431\u0438\u043d\u0430, \u043d\u0430 \u0441\u0430\u043c\u043e\u043c \u0434\u0435\u043b\u0435 \u044d\u0442\u043e\u0442 \u043f\u0440\u0438\u0440\u043e\u0434\u043d\u044b\u0439 \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442 \u0432 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u043e\u0439 \u0441\u0442\u0435\u043f\u0435\u043d\u0438 \u0438\u043d\u0433\u0438\u0431\u0438\u0440\u0443\u0435\u0442 \u0432\u0441\u0435 \u0444\u0435\u0440\u043c\u0435\u043d\u0442\u044b \u043a\u043e\u0430\u0433\u0443\u043b\u044f\u0446\u0438\u0438. \u041e\u0441\u043d\u043e\u0432\u043d\u044b\u043c\u0438 \u0438\u043d\u0433\u0438\u0431\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u043c\u0438 \u0444\u0435\u0440\u043c\u0435\u043d\u0442\u0430\u043c\u0438 \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f: \u0444\u0430\u043a\u0442\u043e\u0440 Xa, IXa\u00a0 \u0438 \u0442\u0440\u043e\u043c\u0431\u0438\u043d (\u0444\u0430\u043a\u0442\u043e\u0440 IIa); \u0430\u043d\u0442\u0438\u0442\u0440\u043e\u043c\u0431\u0438\u043d \u0442\u0430\u043a\u0436\u0435 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\u043b\u043e\u043a\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u044f\u043c\u0438 (\u043d\u0430\u043f\u0440\u0438\u043c\u0435\u0440, \u0442\u0440\u043e\u043c\u0431\u043e\u0437 \u0431\u0440\u044b\u0436\u0435\u0435\u0447\u043d\u043e\u0439 \u0432\u0435\u043d\u044b) 1.<\/li>\n<\/ul>\n<p><strong>\u041f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/strong> &#8211; \u043d\u0430\u0442\u043e\u0449\u0430\u043a; \u0435\u0441\u043b\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442 \u043f\u043e\u043b\u0443\u0447\u0430\u0435\u0442 \u043f\u0435\u0440\u043e\u0440\u0430\u043b\u044c\u043d\u0443\u044e \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u043d\u0443\u044e \u0442\u0435\u0440\u0430\u043f\u0438\u044e, \u043e\u043d \u0431\u0443\u0434\u0435\u0442 \u043e\u0442\u043c\u0435\u043d\u0435\u043d \u0437\u0430 2 \u043d\u0435\u0434\u0435\u043b\u0438 \u0434\u043e \u0441\u0431\u043e\u0440\u0430 \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430; \u041a\u0440\u043e\u043c\u0435 \u0442\u043e\u0433\u043e, \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0433\u0435\u043f\u0430\u0440\u0438\u043d\u043e\u043c \u0431\u0443\u0434\u0435\u0442 \u043f\u0440\u0435\u043a\u0440\u0430\u0449\u0435\u043d\u043e \u0437\u0430 2 \u0434\u043d\u044f \u0434\u043e \u0441\u0431\u043e\u0440\u0430 \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430 3; 4.<br \/>\n<strong>\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/strong> &#8211; \u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c 3.<br \/>\n<strong>\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f \u0441\u0440\u0435\u0434\u0430, \u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/strong> &#8211; \u0432\u0430\u043a\u0443\u0443\u043c\u043d\u044b\u0439 \u043a\u043e\u043d\u0442\u0435\u0439\u043d\u0435\u0440 \u0441 0,105 \u041c (1\/9) \u0446\u0438\u0442\u0440\u0430\u0442\u0430 \u043d\u0430\u0442\u0440\u0438\u044f (\u0441\u0438\u043d\u0435-\u0437\u0435\u043b\u0435\u043d\u0430\u044f \u043a\u0440\u044b\u0448\u043a\u0430) 3.<br \/>\n<strong>\u041e\u0431\u044a\u0435\u043c \u043e\u0431\u0440\u0430\u0437\u0446\u0430<\/strong> &#8211; \u0441\u0442\u043e\u043b\u044c\u043a\u043e, \u0441\u043a\u043e\u043b\u044c\u043a\u043e \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u0432\u0430\u043a\u0443\u0443\u043c 3.<\/p>\n<p><strong>\u041f\u0440\u0438\u0447\u0438\u043d\u044b \u043e\u0442\u043a\u0430\u0437\u0430 \u043e\u0442 \u043f\u0440\u043e\u0431\u044b<\/strong><\/p>\n<ul>\n<li>\u0433\u0435\u043c\u043e\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0435\u0446<\/li>\n<li>\u043a\u043e\u0430\u0433\u0443\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0435\u0446;<\/li>\n<li>\u0432\u0430\u043a\u0442\u0435\u0439\u043d\u0435\u0440, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u043d\u0435 \u043f\u043e\u043b\u043d\u044b\u0439;<\/li>\n<li>\u0437\u0430\u0440\u0430\u0436\u0435\u043d\u043d\u044b\u0435 \u0433\u0435\u043f\u0430\u0440\u0438\u043d\u043e\u043c 3.<\/li>\n<\/ul>\n<p><strong>\u041e\u0431\u0440\u0430\u0431\u043e\u0442\u043a\u0430, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0430\u044f \u043f\u043e\u0441\u043b\u0435 \u0441\u0431\u043e\u0440\u0430 \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430<\/strong> &#8211; \u043e\u0442\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u043f\u043b\u0430\u0437\u043c\u044b \u0446\u0435\u043d\u0442\u0440\u0438\u0444\u0443\u0433\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u0438 \u043d\u0435\u043c\u0435\u0434\u043b\u0435\u043d\u043d\u0430\u044f \u0440\u0430\u0431\u043e\u0442\u0430; \u0435\u0441\u043b\u0438 \u044d\u0442\u043e \u043d\u0435\u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e, \u043f\u043b\u0430\u0437\u043c\u0443 \u043c\u043e\u0436\u043d\u043e \u0445\u0440\u0430\u043d\u0438\u0442\u044c \u043f\u0440\u0438 -20 \u00b0 \u0421; \u043e\u0431\u0440\u0430\u0437\u0446\u044b \u043f\u043b\u0430\u0437\u043c\u044b, \u0441\u043e\u0431\u0440\u0430\u043d\u043d\u044b\u0435 \u0432 \u0434\u0440\u0443\u0433\u0438\u0445 \u0446\u0435\u043d\u0442\u0440\u0430\u0445, \u043a\u0440\u043e\u043c\u0435 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0438\u0438 \u0432 \u0413\u0440\u043e\u0437\u043e\u0432\u0438\u0447\u0430\u0445, \u0431\u0443\u0434\u0443\u0442 \u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u0430\u0442\u044c\u0441\u044f \u0432 \u043a\u043e\u043d\u0442\u0435\u0439\u043d\u0435\u0440 \u0434\u043b\u044f \u0437\u0430\u043c\u043e\u0440\u043e\u0436\u0435\u043d\u043d\u044b\u0445 \u043e\u0431\u0440\u0430\u0437\u0446\u043e\u04323.<\/p>\n<p><strong>\u0421\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u043e\u0431\u0440\u0430\u0437\u0446\u0430<\/strong> &#8211; \u043e\u0442\u0434\u0435\u043b\u044c\u043d\u0430\u044f \u043f\u043b\u0430\u0437\u043c\u0430 \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u0430 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 8 \u0447\u0430\u0441\u043e\u0432 \u043f\u0440\u0438 18-25 \u00b0 \u0421; 1 \u043c\u0435\u0441\u044f\u0446 \u043f\u0440\u0438 -20\u0421 4; \u0440\u0430\u0437\u043c\u043e\u0440\u0430\u0436\u0438\u0432\u0430\u043d\u0438\u044f \/ \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u043e\u0433\u043e \u0437\u0430\u043c\u043e\u0440\u0430\u0436\u0438\u0432\u0430\u043d\u0438\u044f \u0431\u0443\u0434\u0435\u0442 \u0438\u0437\u0431\u0435\u0433\u0430\u0442\u044c\u0441\u044f 3.<\/p>\n<p>\u0425\u0440\u043e\u043c\u043e\u0433\u0435\u043d\u043d\u044b\u0439 \u043c\u0435\u0442\u043e\u0434 (\u0442\u0435\u0441\u0442 \u043d\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c) 3.<\/p>\n<p style=\"text-align: justify;\"><strong><em>\u0420\u0435\u0444\u0435\u0440\u0435\u043d\u0441\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f<\/em><\/strong><sup>5<\/sup>:<\/p>\n<table class=\"wp-block-table w-100\" style=\"height: 334px;\" border=\"1\" width=\"606\">\n<tbody>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\"><strong>\u0412\u043e\u0437\u0440\u0430\u0441\u0442<\/strong><\/td>\n<td width=\"295\"><strong>\u0410\u043d\u0442\u0438\u0442\u0440\u043e\u043c\u0431\u0438\u043d\u043e\u0432\u0430\u044f \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c (%)<\/strong><\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">\u041d\u0435\u0434\u043e\u043d\u043e\u0448\u0435\u043d\u043d\u044b\u0435: \u0434\u043d\u0438 1-3<\/td>\n<td width=\"295\">20-51<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">\u041d\u0435\u0434\u043e\u043d\u043e\u0448\u0435\u043d\u043d\u044b\u0435: \u0434\u043d\u0438 4-6<\/td>\n<td width=\"295\">21-51<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">\u041d\u0435\u0434\u043e\u043d\u043e\u0448\u0435\u043d\u043d\u044b\u0435: \u0434\u0435\u043d\u044c 7<\/td>\n<td width=\"295\">40-54<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">\u041d\u043e\u0432\u043e\u0440\u043e\u0436\u0434\u0435\u043d\u043d\u044b\u0435: \u0434\u0435\u043d\u044c 1-6<\/td>\n<td width=\"295\">44-84<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">\u041d\u043e\u0432\u043e\u0440\u043e\u0436\u0434\u0435\u043d\u043d\u044b\u0435: \u043f\u043e\u0441\u043b\u0435 7 \u0434\u043d\u044f<\/td>\n<td width=\"295\">\u00a034-70<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">2-10 \u043b\u0435\u0442<\/td>\n<td width=\"295\">67-120<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">11-18 \u043b\u0435\u0442<\/td>\n<td width=\"295\">81-120<\/td>\n<\/tr>\n<tr style=\"border-color: #000000;\">\n<td width=\"295\">\u0412\u0437\u0440\u043e\u0441\u043b\u044b\u0435<\/td>\n<td width=\"295\">80-120<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\"><strong><em>\u00a0<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\"><strong><em>\u0420\u0430\u0441\u0448\u0438\u0444\u0440\u043e\u0432\u043a\u0430 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/em><\/strong><\/p>\n<p>\u0422\u0435\u0441\u0442 \u0432\u044b\u044f\u0432\u043b\u044f\u0435\u0442 \u043e\u0431\u0430 \u0442\u0438\u043f\u0430 (I \u0438 II) \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0430, \u043d\u043e \u043d\u0435 \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u0438\u0445 \u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0440\u043e\u0432\u0430\u0442\u044c. \u041f\u043e\u044d\u0442\u043e\u043c\u0443, \u0432 \u0441\u043b\u0443\u0447\u0430\u0435 \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0438\u044f \u043d\u0438\u0437\u043a\u043e\u0439 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0430\u043d\u0442\u0438\u0442\u0440\u043e\u043c\u0431\u0438\u043d\u0430 III, \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0443\u0435\u0442\u0441\u044f \u043f\u0440\u043e\u0432\u0435\u0440\u0438\u0442\u044c \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u043d\u0443\u044e \u0444\u0440\u0430\u043a\u0446\u0438\u044e 3.<\/p>\n<p>\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0430\u043d\u0442\u0438\u0442\u0440\u043e\u043c\u0431\u0438\u043d\u0430 III \u0441\u0432\u044f\u0437\u0430\u043d\u043e \u0441:<\/p>\n<ul>\n<li>\u0432\u0440\u043e\u0436\u0434\u0435\u043d\u043d\u044b\u043c \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u043e\u043c (\u043d\u0430\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439);<\/li>\n<li>\u043f\u0435\u0440\u0435\u0441\u0430\u0434\u043a\u043e\u0439 \u043f\u0435\u0447\u0435\u043d\u0438, \u0446\u0438\u0440\u0440\u043e\u0437 \u043f\u0435\u0447\u0435\u043d\u0438, \u043f\u0435\u0447\u0435\u043d\u043e\u0447\u043d\u0430\u044f \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u044c;<\/li>\n<li>\u0430\u043a\u0442\u0438\u0432\u043d\u044b\u043c \u0442\u0440\u043e\u043c\u0431\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435\u043c (\u0442\u0440\u043e\u043c\u0431\u043e\u0437 \u0433\u043b\u0443\u0431\u043e\u043a\u0438\u0445 \u0432\u0435\u043d);<\/li>\n<li>CID, \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435\u043c, \u0441\u043e\u043f\u0440\u043e\u0432\u043e\u0436\u0434\u0430\u044e\u0449\u0438\u043c\u0441\u044f \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043b\u0438\u0437\u043e\u043c;<\/li>\n<li>\u043e\u0441\u0442\u0440\u044b\u043c \u0438\u043d\u0444\u0430\u0440\u043a\u0442\u043e\u043c \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430;<\/li>\n<li>\u043b\u0435\u0433\u043e\u0447\u043d\u043e\u0439 \u044d\u043c\u0431\u043e\u043b\u0438\u0435\u0439;<\/li>\n<li>\u043a\u0430\u0440\u0446\u0438\u043d\u043e\u043c\u043e\u0439, \u0442\u0440\u0430\u0432\u043c\u043e\u0439, \u0441\u0438\u043b\u044c\u043d\u044b\u043c \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u0435\u043c;<\/li>\n<li>\u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435\u043c, \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u044b\u043c \u0441 \u043f\u043e\u0442\u0435\u0440\u0435\u0439 \u0431\u0435\u043b\u043a\u0430;<\/li>\n<li>\u043d\u0435\u0443\u0434\u0430\u0447\u043d\u044b\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u0435\u043c \u0433\u0435\u043f\u0430\u0440\u0438\u043d\u043e\u043c.<\/li>\n<\/ul>\n<p>\u0423\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u0435 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0430\u043d\u0442\u0438\u0442\u0440\u043e\u043c\u0431\u0438\u043d\u0430 III \u0441\u0432\u044f\u0437\u0430\u043d\u043e \u0441:<\/p>\n<ul>\n<li>\u043e\u0441\u0442\u0440\u044b\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c;<\/li>\n<li>\u0442\u0440\u0430\u043d\u0441\u043f\u043b\u0430\u043d\u0442\u0430\u0446\u0438\u0435\u0439 \u043f\u043e\u0447\u043a\u0438;<\/li>\n<li>\u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u0435\u043c (\u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 \u0421\u041e\u042d);<\/li>\n<li>\u0433\u0438\u043f\u0435\u0440\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u0435\u043c\u0438\u0435\u0439;<\/li>\n<li>\u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u043f\u0435\u0440\u043e\u0440\u0430\u043b\u044c\u043d\u044b\u0445 \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u043e\u04321.<\/li>\n<\/ul>\n<p><strong>\u041f\u0440\u0435\u0434\u0435\u043b\u044b \u0438 \u0438\u043d\u0442\u0435\u0440\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u044f<\/strong><\/p>\n<p>\u0423 \u043d\u043e\u0432\u043e\u0440\u043e\u0436\u0434\u0435\u043d\u043d\u044b\u0445 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\u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0435\u043c \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0430\u043d\u0442\u0438\u0442\u0440\u043e\u043c\u0431\u0438\u043d\u0430 III. \u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u043d\u0435\u0443\u0431\u0435\u0434\u0438\u0442\u0435\u043b\u044c\u043d\u044b \u0432 \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0435\u043c \u0442\u0440\u0438\u043c\u0435\u0441\u0442\u0440\u0435 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u0438 \u0441\u0440\u0430\u0437\u0443 \u043f\u043e\u0441\u043b\u0435 \u0440\u043e\u0434\u043e\u0432 1.<\/p>\n<p>\u041f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435 \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u043e\u0432 \u0442\u0440\u043e\u043c\u0431\u0438\u043d\u0430 (\u0433\u0438\u0440\u0443\u0434\u0438\u043d\u0430 \u0438\u043b\u0438 \u0430\u0440\u0433\u0430\u0442\u0440\u043e\u0431\u0430\u043d\u0430) \u0432 \u0442\u0435\u0441\u0442\u0438\u0440\u0443\u0435\u043c\u043e\u0439 \u043f\u043b\u0430\u0437\u043c\u0435 \u043c\u043e\u0436\u0435\u0442 \u043c\u0435\u0448\u0430\u0442\u044c \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u0438\u044e \u0442\u0435\u0441\u0442\u0430 4.<\/p>\n<p>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<br \/>\n1. Frances Fischbach. Blood Studies; Hematology and Coagulation. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams &amp; Wilkins, USA, 8 ed. 2009, 181-182.<br \/>\n2. Ian Jennings, Peter Cooper. Screening for Thrombophilia: A Laboratory Perspective. In British Journal of Biomedical Science, 2003.<br \/>\n3. \u041b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0438\u044f Synevo. \u041a\u043e\u043d\u043a\u0440\u0435\u0442\u043d\u044b\u0435 \u0441\u0441\u044b\u043b\u043a\u0438 \u043d\u0430 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0440\u0430\u0431\u043e\u0442\u044b \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u044b 2010. Ref Type: Catalog<br \/>\n4. Laboratory Corporation of America.Directory of Services and Interpretive Guide. Antithrombin Activity www.labcorp.com 2010. Ref Type: Internet Communication<br \/>\n5. Antithrombin Deficiency. www.med.uiuc.edu\/hematolog<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[952],"product_tag":[],"class_list":{"0":"post-9165","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-de-trombofilie","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9165"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9165"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9165"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9165"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}