{"id":9156,"date":"2020-04-23T03:29:42","date_gmt":"2020-04-23T00:29:42","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/anticorpi-anti-u1rnp\/"},"modified":"2025-07-01T07:57:16","modified_gmt":"2025-07-01T04:57:16","slug":"anticorpi-anti-u1rnp","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-u1rnp\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a U1RNP"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Anticorpii anti-U1RNP sunt \u00eendrepta\u0163i \u00eempotriva particulelor ribonucleoproteice nucleare mici (snRNPs); spre deosebire de anticorpii anti-Sm, ace\u015ftia recunosc numai ribonucleoproteinele din clasa U1. Anticorpii anti-U1RNP, de obicei \u00een concentra\u0163ie mare, constituie un marker serologic pentru boala mixt\u0103 de \u0163esut conjunctiv, prezen\u0163a lor fiind absolut necesar\u0103 pentru diagnostic (sensibilitate clinic\u0103 de100%). Aceast\u0103 afec\u0163iune se caracterizeaz\u0103 clinic prin prezen\u0163a simultan\u0103 de manifest\u0103ri asociate mai multor boli reumatismale: sclerodermie, LES, polimiozit\u0103 \u015fi poliartrit\u0103 reumatoid\u0103.<\/p>\n

\u00cen momentul depist\u0103rii anti-U1RNP, boala de \u0163esut conjunctiv este adesea nediferen\u0163iat\u0103.<\/p>\n

\u00cen cursul evolu\u0163iei bolii, pacien\u0163ii \u00eencep s\u0103 \u00eentruneasc\u0103 treptat criteriile de diagnostic ale uneia sau mai multora din bolile mai sus men\u0163ionate. La majoritatea pacien\u0163ilor cu nivele mari de anticorpi se reg\u0103sesc simptomele principale a dou\u0103 afec\u0163iuni; HLA-DR4 se asociaz\u0103 cu aceast\u0103 categorie. La pacien\u0163ii care au concentra\u0163ii mici de anticorpi, predomin\u0103 manifest\u0103rile de boal\u0103 lupic\u0103.<\/p>\n

Anti-U1RNP persist\u0103 \u00eendelungat, concentra\u0163ia lor fiind variabil\u0103, \u00een func\u0163ie de gradul de activitate a bolii. Acest tip de autoanticorpi mai poate ap\u0103rea cu prevalen\u0163\u0103 redus\u0103 (25-40%) \u015fi \u00een LES, adesea, \u00eempreun\u0103 cu anti-Sm. Pacien\u0163ii cu boal\u0103 lupic\u0103 care prezint\u0103 anti-U1RNP au o evolu\u0163ie clinic\u0103 mai u\u015foar\u0103, afectarea renal\u0103 fiind mai rar \u00eent\u00e2lnit\u01033<\/sup>.<\/p>\n

Recomandari pentru deterninarea anticorpilor anti-U1RNP<\/em><\/strong><\/p>\n

Suspiciune de:<\/p>\n

\u2022 boala mixt\u0103 de \u0163esut conjunctiv<\/div>\n
\u2022 LES<\/div>\n
\u2022 sclerodermie<\/div>\n
\u2022 poliartrit\u0103 reumatoid\u0103<\/div>\n
\u2022 polimiozit\u01032;3<\/sup><\/div>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>\u00e0 jeun (pe nem\u00e2ncate) sau postprandial (dup\u0103 mese)1<\/sup>.\u00a0<\/em><\/strong><\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c1<\/sup>\u00a0<\/em><\/strong><\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator1<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare1<\/sup>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser1<\/sup>.<\/p>\n

Cauze de respingere<\/em><\/strong> a probei <\/em><\/strong>- <\/em>ser intens hemolizat, lipemic sau puternic contaminat bacterian1<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>\u2013 serul separat este stabil 7 zile la 4\u00b0C; timp mai \u00eendelungat<\/em> la -20\u00b0C3<\/sup>.<\/em><\/p>\n

Metod\u0103 <\/em><\/strong>- imunoenzimatic\u0103 cu detec\u0163ie prin fluorescen\u0163\u0103 (FEIA<\/span>)1<\/sup>.<\/p>\n

Reactivii sunt reprezenta\u0163i de proteine umane recombinate de \u00eenalt\u0103 specificitate1<\/sup>.<\/p>\n

Valori de referin\u0163\u0103<\/em><\/strong><\/p>\n

<5 U\/mL\u00a0:\u00a0\u00a0\u00a0 negativ<\/div>\n
5-10 U\/mL\u00a0: echivoc<\/div>\n
>10 U\/mL:\u00a0\u00a0 pozitiv1<\/sup><\/div>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

De\u015fi sensibilitatea anticorpilor anti-U1RNP pentru boala mixt\u0103 de \u0163esut conjunctiv este de 100%, specificitatea clinic\u0103 este redus\u0103, \u00een special \u00een cazul concentra\u0163iilor mici. Unii pacien\u0163i, la care se depisteaz\u0103 anti-U1RNP nu \u00eentrunesc criteriile de diagnostic pentru boala mixt\u0103 de \u0163esut conjunctiv3<\/sup>.<\/p>\n

\u00a0<\/span>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog<\/span><\/span><\/div>\n
2. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Antiextractable nuclear antigens. www.labcorp.com . 2010 Ref Type: Internet Communication<\/span><\/div>\n
3. Rudolf Mierau, Ekkehard Genth. Autoantibodies in Systemic Rheumatic Diseases. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. Lothar Thomas. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany,1 ed. 1998, 831.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0410\u043d\u0442\u0438 RNP – \u044d\u0442\u043e \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u044d\u043a\u0441\u0442\u0440\u0430\u0433\u0438\u0440\u0443\u0435\u043c\u044b\u043c \u044f\u0434\u0435\u0440\u043d\u044b\u043c \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430\u043c – \u0440\u0438\u0431\u043e\u043d\u0443\u043a\u043b\u0435\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u043c (RNP). \u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a RNP \u043f\u0440\u0435\u0434\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u044b \u0434\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0421\u041a\u0412 \u0438 \u0441\u043c\u0435\u0448\u0430\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u0441\u043e\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438 (\u0421\u0417\u0421\u0422). \u042d\u0442\u0438 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043e\u0442\u043d\u043e\u0441\u044f\u0442\u0441\u044f \u043a \u0433\u0440\u0443\u043f\u043f\u0435 \u0430\u043d\u0442\u0438\u043d\u0443\u043a\u043b\u0435\u0430\u0440\u043d\u044b\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b (ANA). ANA-\u044d\u0442\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u043d\u044b\u0439 \u043a\u043b\u0430\u0441\u0441 \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u044b \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u0442\u044c \u0438 \u0440\u0430\u0437\u0440\u0443\u0448\u0430\u0442\u044c \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u043d\u044b\u0435 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u044b \u0432 \u044f\u0434\u0440\u0435 \u043a\u043b\u0435\u0442\u043e\u043a. \u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a RNP \u0438 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u0443 RNP\/Sm \u0441\u0432\u044f\u0437\u0430\u043d\u044b \u0441\u043e \u0441\u043c\u0435\u0448\u0430\u043d\u043d\u044b\u043c \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435\u043c \u0441\u043e\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438 \u0438 \u0421\u041a\u0412.<\/p>\n

\u041f\u0435\u0440\u0435\u043a\u0440\u0451\u0441\u0442\u043d\u044b\u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c (Overlap syndrome) –\u044d\u0442\u043e \u043e\u0431\u0449\u0438\u0439 \u0442\u0435\u0440\u043c\u0438\u043d, \u0441\u043e\u0437\u0434\u0430\u043d\u043d\u044b\u0439 \u0434\u043b\u044f \u0442\u043e\u0433\u043e, \u0447\u0442\u043e\u0431\u044b \u043e\u0431\u044a\u0435\u0434\u0438\u043d\u0438\u0442\u044c \u0440\u0430\u0437\u043d\u044b\u0435 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u0443\u044e\u0449\u0438\u0435\u0441\u044f \u043d\u0430\u043b\u043e\u0436\u0435\u043d\u0438\u0435\u043c \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u0432 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0439 \u043a\u0440\u0430\u0441\u043d\u043e\u0439 \u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0438 (\u0421\u041a\u0412), \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0449\u0435\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0439 \u0441\u043a\u043b\u0435\u0440\u043e\u0434\u0435\u0440\u043c\u0438\u0438 (\u041f\u0421\u0421), \u0434\u0435\u0440\u043c\u0430\u0442\u043e\/\u043f\u043e\u043b\u0438\u043c\u0438\u043e\u0437\u0438\u0442\u0430 (\u0414\u041c\/\u041f\u041c), \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0430\u0440\u0442\u0440\u0438\u0442\u0430 (\u0420\u0410) \u0438 \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430 \u0428\u0435\u0433\u0440\u0435\u043d\u0430.<\/p>\n

\u0421\u043c\u0435\u0448\u0430\u043d\u043d\u043e\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435 \u0441\u043e\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438 (MCTD, \u0421\u0417\u0421\u0422, \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0428\u0430\u0440\u043f\u0430) — \u0445\u043e\u0440\u043e\u0448\u043e \u0438\u0437\u0443\u0447\u0435\u043d\u043d\u044b\u0439 \u043f\u0435\u0440\u0435\u043a\u0440\u0451\u0441\u0442\u043d\u044b\u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c, \u0434\u043b\u044f \u043a\u043e\u0442\u043e\u0440\u043e\u0433\u043e \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u044b \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u0438\u0437\u043d\u0430\u043a\u0438, \u043d\u0430\u043b\u0438\u0447\u0438\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u043e\u0439 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u0438 \u0438 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u044b\u0439 \u0444\u0435\u043d\u043e\u0442\u0438\u043f HLA-\u0430\u043d\u0442\u0438\u0433\u0435\u043d\u043e\u0432 (\u0442.\u0435. DR2 \u0438 DR4). \u041a\u0440\u0430\u0439\u043d\u0435\u0435 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u0435 \u0421\u0417\u0421\u0422 — \u044d\u0442\u043e \u0444\u0435\u043d\u043e\u043c\u0435\u043d \u0420\u0435\u0439\u043d\u043e, \u0434\u043b\u044f \u043a\u043e\u0442\u043e\u0440\u043e\u0433\u043e \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u043c \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0439 \u043e\u0442\u0451\u043a \u043f\u0430\u043b\u044c\u0446\u0435\u0432 \u0438 \u0440\u0443\u043a. \u041a\u0440\u043e\u043c\u0435 \u044d\u0442\u043e\u0433\u043e, \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u044b \u0441\u0442\u0440\u0430\u0434\u0430\u044e\u0442 \u043e\u0442 \u0430\u0440\u0442\u0440\u0438\u0442\u0430. \u0423 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0421\u0417\u0421\u0422 \u0447\u0430\u0441\u0442\u043e \u043d\u0430\u0445\u043e\u0434\u044f\u0442 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0445 \u043f\u0435\u0440\u0435\u043a\u0440\u0451\u0441\u0442\u043d\u044b\u0445 \u0441\u043e\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e-\u0442\u043a\u0430\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439. \u041e\u0434\u043d\u0430\u043a\u043e \u043e\u043d\u0438 \u043c\u043e\u0433\u0443\u0442 \u043f\u0440\u043e\u044f\u0432\u0438\u0442\u044c\u0441\u044f \u043d\u0435 \u0443 \u0432\u0441\u0435\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432. \u0421\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438 \u0421\u0417\u0421\u0422 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u0443\u0435\u0442\u0441\u044f \u043d\u0430\u043b\u0438\u0447\u0438\u0435\u043c \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b, \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u043d\u044b\u0445 \u043f\u0440\u043e\u0442\u0438\u0432 \u0431\u0435\u043b\u043a\u0430 70 \u043a\u0414\u0430 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u0430 \u0441\u043f\u043b\u0430\u0439\u0441\u043e\u0441\u043e\u043c U1-snRNP. \u0414\u043e 100% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0421\u0417\u0421\u0422 \u0438\u043c\u0435\u044e\u0442 \u0432\u044b\u0441\u043e\u043a\u0438\u0435 \u0442\u0438\u0442\u0440\u044b \u0430\u043d\u0442\u0438-RNP-70 \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b. \u041f\u0430\u0446\u0438\u0435\u043d\u0442\u044b, \u0443 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0432\u044b\u044f\u0432\u043b\u044f\u044e\u0442 \u0442\u043e\u043b\u044c\u043a\u043e \u0430\u043d\u0442\u0438-RNP-70 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u0438\u0437 \u0432\u0441\u0435\u0433\u043e \u0440\u0430\u0437\u043d\u043e\u043e\u0431\u0440\u0430\u0437\u0438\u044f \u0430\u043d\u0442\u0438\u044f\u0434\u0435\u0440\u043d\u044b\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b, \u0438\u043c\u0435\u044e\u0442 \u043a\u043b\u0430\u0441\u0441\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0421\u0417\u0421\u0422.<\/p>\n

\u0414\u043e\u043f\u043e\u043b\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u0443 \u044d\u0442\u0438\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0447\u0430\u0441\u0442\u043e \u043d\u0430\u0445\u043e\u0434\u044f\u0442 \u0442\u0438\u043f\u0438\u0447\u043d\u044b\u0435 \u0434\u043b\u044f \u0421\u041a\u0412 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 (\u043d\u0430\u043f\u0440\u0438\u043c\u0435\u0440, \u0430\u043d\u0442\u0438-dsDNA, \u0430\u043d\u0442\u0438-Sm, \u0430\u043d\u0442\u0438\u0433\u0438\u0441\u0442\u043e\u043d\u043e\u0432\u044b\u0435). \u0412 \u044d\u0442\u0438\u0445 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u043a\u043b\u0430\u0441\u0441\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0421\u0417\u0421\u0422 \u0440\u0430\u0437\u043e\u0432\u044c\u0451\u0442\u0441\u044f \u0432 \u0421\u041a\u0412. U1-snRNP \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u0430 (\u0444\u0443\u043d\u043a\u0446\u0438\u044f \u043a\u043e\u0442\u043e\u0440\u043e\u0439 — \u0441\u043f\u043b\u0430\u0439\u0441\u0438\u043d\u0433 \u043f\u0440\u0435-\u043c\u0420\u041d\u041a) \u0441\u043e\u0441\u0442\u043e\u0438\u0442 \u0438\u0437 \u0443\u0440\u0438\u0434\u0438\u043d\u043e\u0432\u043e\u0433\u043e, \u0431\u043e\u0433\u0430\u0442\u043e\u0433\u043e \u0420\u041d\u041a \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u0430 \u0441 \u043a\u043b\u0430\u0441\u0441\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 RNP-\u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430\u043c\u0438, \u0442\u043e \u0435\u0441\u0442\u044c \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430 70 kDa, \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430 \u0410 (33 kDa) \u0438 \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430 C (22 kDa). \u0422\u0430\u043a\u0436\u0435 \u0441 \u044d\u0442\u043e\u0439 \u0420\u041d\u041a \u0441\u0432\u044f\u0437\u0430\u043d\u044b \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0435 Sm-\u0431\u0435\u043b\u043a\u0438. \u0410\u043d\u0442\u0438-Sm \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 — \u043f\u0430\u0442\u043e\u0433\u043d\u043e\u043c\u043e\u043d\u0438\u0447\u043d\u044b\u0435 \u0434\u043b\u044f \u0421\u041a\u0412 \u043c\u0430\u0440\u043a\u0451\u0440\u044b.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c<\/b><\/td>\n\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/b><\/td>\n<\/tr>\n
\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n
\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/b><\/td>\nC\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0433\u0435\u043b\u0435\u0432\u043e\u0439\u00a0\u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n
\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n
\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/b><\/td>\n<\/tr>\n
\u041c\u0430\u0440\u043a\u0435\u0440\u00a0\u0441\u043c\u0435\u0448\u0430\u043d\u043d\u044b\u0445\u00a0\u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439\u00a0\u0441\u043e\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439\u00a0\u0442\u043a\u0430\u043d\u0438\u00a0(\u0421\u0417\u0421\u0422)<\/b><\/p>\n

\u00b7\u00a0\u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430\u00a0\u0421\u0417\u0421\u0422;<\/p>\n

\u00b7\u00a0\u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430\u00a0\u0421\u041a\u0412<\/td>\n<\/tr>\n

\u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f\u00a0\u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/b><\/td>\n<\/tr>\n
\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/b><\/td>\n<\/tr>\n
\u00b7\u00a0\u0421\u0438\u0441\u0442\u0435\u043c\u043d\u044b\u0435\u00a0\u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u00a0\u0441\u043e\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439\u00a0\u0442\u043a\u0430\u043d\u0438;<\/p>\n

\u00b7\u00a0\u0441\u0438\u0441\u0442\u0435\u043c\u043d\u0430\u044f\u00a0\u043a\u0440\u0430\u0441\u043d\u0430\u044f\u00a0\u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0430;<\/p>\n

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