{"id":9150,"date":"2020-04-23T03:29:32","date_gmt":"2020-04-23T00:29:32","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/anticorpi-anti-lkm1\/"},"modified":"2025-07-01T07:57:04","modified_gmt":"2025-07-01T04:57:04","slug":"anticorpi-anti-lkm1","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-lkm1\/","title":{"rendered":"\u0410\u043d\u0442\u0438-LKM1 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Anticorpii anti-LKM1<\/strong> (engl. liver-kidney microsome antibodies) sunt \u00eendrepta\u0163i \u00eempotriva antigenelor microzomale hepatice \u015fi renale \u015fi reprezint\u0103 un marker serologic pentru hepatita autoimun\u0103 tip 2, cea mai frecvent\u0103 form\u0103 de hepatit\u0103 autoimun\u0103 juvenil\u0103.<\/p>\n

Antigenul \u021bint\u0103 pentru anti-LKM1 este reprezentat de citocromul p450 2D6 (CYP2D6)\u00a0 de 50 kDa, antigen microsomal din reticulul endoplasmic ce include enzime (monooxigenaze) implicate \u00een prima faz\u0103 de metabolizare a xenobioticelor. Epitopii imunodominan\u021bi sunt situa\u021bi \u00eentre aminoacizii 263-270 ai CYP2D6. Expresia acestui antigen la suprafa\u0163a\u00a0 hepatocitelor ar putea sugera rolul patogenic al acestor anticorpi. Identificarea \u021bintei moleculare a condus la dezvoltarea unor metode imunoenzimatice \u0219i imunoblot ce utilizeaz\u0103 antigen \u00eenalt purificate sau recombinante \u0219i detecteaz\u0103 cu acurate\u021be ridicat\u0103 anti-LKM1.<\/p>\n

Anti-LKM1 sunt \u00eent\u00e2lni\u021bi la aproximativ 3% din adul\u021bii cu hepatit\u0103 autoimun\u0103, 14-38% din copiii cu hepatit\u0103 autoimun\u0103 \u0219i \u00een 90% din cazurile de hepatit\u0103 autoimun\u0103 de tip 2, fiind un marker cu specificitate \u00eenalt\u0103 pentru aceast\u0103 form\u0103 de boal\u0103. Prezen\u021ba anticorpilor este asociat\u0103 cu o evolu\u021bie mai sever\u0103, iar titrurile acestora pot fi utilizate \u00een monitorizarea activit\u0103\u021bii bolii \u0219i a r\u0103spunsului la tratament.<\/p>\n

Anti-LKM1 sunt prezen\u021bi \u00een 30-70% din cazurile de hepatit\u0103 autoimun\u0103 tip 2 av\u00e2nd serologie pozitiv\u0103 pentru anticorpii anti-LC1. Ocazional, a fost demonstrat\u0103 prezen\u021ba simultan\u0103 de anti-LKM1 \u0219i anticorpi antinucleari (ANA).<\/p>\n

Surprinz\u0103tor, p\u00e2n\u0103 la 10% din pacien\u021bii av\u00e2nd hepatit\u0103 cronic\u0103 cu virus C dezvolt\u0103, independent de genotipul implicat, anti-LKM1 direc\u021biona\u021bi \u00eempotriva aceluia\u0219i antigen\u00a0 ca \u0219i \u00een hepatita autoimun\u0103 de tip 2, suger\u00e2nd existen\u021ba unui mecanism de reactivitate \u00eencruci\u0219at\u0103, de\u0219i r\u0103spunsul autoanticorpilor fa\u021b\u0103 de epitopii imunodominan\u021bi este diferit. La pacien\u021bii italieni cu hepatit\u0103 cronic\u0103 C a fost identificat\u0103 o predispozi\u021bie genetic\u0103 \u2013 alela HLA DR7 \u2013 pentru apari\u021bia anti-LKM11;2;3;4;5;6<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea anticorpilor anti-LKM1 <\/em><\/strong><\/p>\n

\u2013 \u00a0suspiciune clinic\u0103 de hepatit\u0103 autoimun\u0103 activ\u0103 (hepatit\u0103 acut\u0103 sau cronic\u0103 de etiologie neprecizat\u0103, inclusiv \u00een cazul disfunc\u021biei grefei dup\u0103 transplantul hepatic).<\/p>\n

Men\u021biune: \u00cen 25-34% din cazuri hepatita autoimun\u0103 este asimptomatic\u0103, de aceea testarea autoanticorpilor trebuie luat\u0103 \u00een considerare \u00een prezen\u021ba unor modific\u0103ri u\u0219oare, recent depistate, ale activit\u0103\u021bii enzimelor hepatice. \u00cent\u00e2rzierea diagnosticului \u0219i \u00een consecin\u021b\u0103 a tratamentului adecvat poate conduce la sc\u0103derea ratei de supravie\u021buire la 10 ani, comparativ cu fomele severe de hepatit\u0103 autoimun\u0103 tratate corespunz\u0103tor3;4;5;6<\/sup>.<\/p>\n

\u2013 pacien\u021bi cu hepatit\u0103 cronic\u0103 C afla\u021bi sub tratament cu interferon alfa, deoarece \u00een prezen\u021ba unor rezultate pozitive exist\u0103 riscul ca aceast\u0103 terapie s\u0103 dema\u0219te sau s\u0103 induc\u0103 o hepatit\u0103 autoimun\u01036;7<\/sup>.<\/p>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>\u00e0 jeun (pe nem\u00e2ncate) sau postprandial (dup\u0103 mese)8<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c8<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator8<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare8<\/sup>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser8<\/sup>..<\/p>\n

Cauze de respingere<\/em><\/strong> a probei <\/em><\/strong>- <\/em>ser intens hemolizat, lipemic sau puternic contaminat bacterian8<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>serul separat este stabil 7 zile<\/em> la 2-8\u00b0C \u015fi\u00a0 timp \u00eendelungat <\/em>\u00a0la -20\u00b0C sau la -70\u00b0C. Nu decongela\u0163i\/recongela\u0163i8<\/sup>..<\/p>\n

Metod\u0103 <\/em><\/strong>-<\/em> ELISA <\/u>. Antigenul folosit este citocromul P4508<\/sup>.<\/p>\n

Valori de referin\u0163\u0103<\/em><\/strong><\/p>\n

<4\u00a0\u00a0\u00a0 U\/mL\u00a0: negativ<\/p>\n

4-5 U\/mL\u00a0: echivoc<\/p>\n

>5\u00a0 U\/mL: pozitiv8<\/sup>.<\/p>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

Un rezultat negativ nu exclude existen\u0163a hepatitei autoimune7<\/sup>.<\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/p>\n

    \n
  1. Czaja AJ. Diagnosis and Management of Autoimmune Hepatitis: Current Status and Future Directions. Gut Liver. 2016 Mar;10(2):177-203.<\/li>\n
  2. Kalliopi Zachou, et al. Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice. In Journal of<\/em>\u00a0Autoimmune Diseases,<\/em> 2004, 2: 1740-1757.<\/li>\n
  3. Cancado EL, Abrantes-Lemos CP, Terrabuio DR. The importance of autoantibody detection in autoimmune hepatitis. Front Immunol. 2015 May 13;6:222.<\/li>\n
  4. Gatselis NK, Zachou K, Koukoulis GK, Dalekos GN. Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics. World J Gastroenterol. 2015 Jan 7;21(1):60-83.<\/li>\n
  5. Himoto T, Nishioka M. Autoantibodies in liver disease: important clues for the diagnosis, disease activity and prognosis. Auto Immun Highlights. 2013 Feb 22;4(2):39-53.<\/li>\n
  6. Liberal R, Vergani D, Mieli-Vergani G. Update on Autoimmune Hepatitis. J Clin Transl Hepatol. 2015 Mar;3(1):42-52.<\/li>\n
  7. Laboratory Corporation of America.Directory of Services and Interpretive Guide. Liver-Kidney Microsomal (LKM) Antibodies.\u00a0www.labcorp.com<\/a>. \u00a02017. Ref Type: Internet Communication.<\/li>\n
  8. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2017. Ref Type: Catalog.<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"

    \u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u043c\u0438\u043a\u0440\u043e\u0441\u043e\u043c\u0430\u043b\u044c\u043d\u043e\u043c\u0443 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0443 \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u043f\u043e\u0447\u0435\u043a (LKM) \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u044e\u0442 \u0441\u043e\u0431\u043e\u0439 \u0433\u0435\u0442\u0435\u0440\u043e\u0433\u0435\u043d\u043d\u0443\u044e \u0433\u0440\u0443\u043f\u043f\u0443 \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0430\u043d\u0438\u0438 \u0438\u0445 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u043e\u0432-\u043c\u0438\u0448\u0435\u043d\u0435\u0439 \u0434\u0435\u043b\u0438\u0442\u0441\u044f \u043d\u0430 3 \u043f\u043e\u0434\u0442\u0438\u043f\u0430:<\/p>\n

      \n
    • \u0430\u043d\u0442\u0438-LKM-1,<\/li>\n
    • \u0430\u043d\u0442\u0438-LKM–2<\/li>\n
    • \u0430\u043d\u0442\u0438-LKM-3, \u0432 \u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0441\u0442\u0438 \u043e\u0442 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0430-\u043c\u0438\u0448\u0435\u043d\u0438.<\/li>\n<\/ul>\n

      \u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a LKM-1 \u0441\u043b\u0443\u0436\u0430\u0442 \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u043c \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c \u0410\u0418\u0413-2; \u044d\u0442\u043e \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u043c\u0438\u043a\u0440\u043e\u0441\u043e\u043c\u0430\u043b\u044c\u043d\u043e\u043c\u0443 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0443 \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u043f\u043e\u0447\u0435\u043a \u0441 \u043c.\u043c. 50 \u043a\u0414a, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0438\u0437\u0432\u0435\u0441\u0442\u0435\u043d \u043a\u0430\u043a \u0446\u0438\u0442\u043e\u0445\u0440\u043e\u043c\u043c\u043e\u043d\u043e\u043e\u043a\u0441\u0438\u0433\u0435\u043d\u0430\u0437\u0430 \u0420450 IID6. \u0421\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u0430 \u044d\u0442\u043e\u0433\u043e \u043f\u0435\u043f\u0442\u0438\u0434\u0430 \u0441\u0445\u043e\u0434\u043d\u0430 \u0441\u043e \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043e\u0439 \u0431\u0435\u043b\u043a\u0430 IEP-175 \u0432\u0438\u0440\u0443\u0441\u0430 \u043f\u0440\u043e\u0441\u0442\u043e\u0433\u043e \u0433\u0435\u0440\u043f\u0435\u0441\u0430 \u0442\u0438\u043f\u0430 1, \u0430 \u0442\u0430\u043a\u0436\u0435 \u044f\u0434\u0435\u0440\u043d\u043e\u0433\u043e \u0431\u0435\u043b\u043a\u0430 HCV. \u0414\u0430\u043d\u043d\u044b\u0439 \u043f\u0435\u043f\u0442\u0438\u0434 \u0440\u0430\u0441\u0441\u043c\u0430\u0442\u0440\u0438\u0432\u0430\u0435\u0442\u0441\u044f \u0432 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u0433\u043e \u044d\u043f\u0438\u0442\u043e\u043f\u0430, \u043a \u043a\u043e\u0442\u043e\u0440\u043e\u043c\u0443 \u0441\u0435\u043d\u0441\u0438\u0431\u0438\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u044b \u0422-\u0445\u0435\u043b\u043f\u0435\u0440\u044b I \u0442\u0438\u043f\u0430, \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0430\u044e\u0449\u0438\u0435 \u0433\u0435\u043f\u0430\u0442\u043e\u0446\u0438\u0442\u044b.<\/p>\n

      \u0418\u043c\u043c\u0443\u043d\u043e\u0441\u0443\u043f\u0440\u0435\u0441\u0441\u0438\u0432\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0441\u043d\u0438\u0436\u0430\u0435\u0442 \u0422-\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0439 \u043e\u0442\u0432\u0435\u0442 \u043d\u0430 \u0420450 IID6. \u041f\u043e\u043c\u0438\u043c\u043e \u0441\u0435\u043d\u0441\u0438\u0431\u0438\u043b\u0438\u0437\u0430\u0446\u0438\u0438 \u0422-\u043a\u043b\u0435\u0442\u043e\u043a, \u0430\u043d\u0442\u0438-LKM-1 \u043c\u043e\u0433\u0443\u0442 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442 \u0438\u043b\u0438 NK-\u043a\u043b\u0435\u0442\u043a\u0438 \u043f\u043e \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0443 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u043e\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0439 \u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0439 \u0446\u0438\u0442\u043e\u0442\u043e\u043a\u0441\u0438\u0447\u043d\u043e\u0441\u0442\u0438. \u041e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 LKM-1 \u0438\u043c\u0435\u0435\u0442 \u0431\u043e\u043b\u044c\u0448\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u0432 \u043f\u0435\u0434\u0438\u0430\u0442\u0440\u0438\u0438, \u0442\u0430\u043a \u043a\u0430\u043a \u0410\u0418\u0413-2 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0435\u0442\u0441\u044f \u043f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u0443 \u0434\u0435\u0442\u0435\u0439 2-14 \u043b\u0435\u0442. \u0412\u044b\u0440\u0430\u0431\u043e\u0442\u043a\u0430 LKM-1 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u0430 \u043d\u0435 \u0442\u043e\u043b\u044c\u043a\u043e \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u043c\u0438 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0430\u043c\u0438, \u043d\u043e \u0438 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u043c\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c\u0438 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430\u043c\u0438 (\u0442\u0438\u0435\u043d\u0430\u043c, \u0434\u0438\u0433\u0438\u0434\u0440\u0430\u043b\u0430\u0437\u0438\u043d, \u0433\u0430\u043b\u043e\u0442\u0430\u043d, \u0444\u0435\u043d\u0438\u0442\u043e\u0438\u043d, \u0444\u0435\u043d\u043e\u0431\u0430\u0440\u0431\u0438\u0442\u0430\u043b, \u043a\u0430\u0440\u0431\u0430\u043c\u0430\u0437\u0435\u043f\u0438\u043d). \u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a LKM-1 \u0442\u0430\u043a\u0436\u0435 \u043d\u0430\u0439\u0434\u0435\u043d\u044b \u0443 1-2% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c \u0421.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
      \u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c<\/b><\/td>\n\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/b><\/td>\n<\/tr>\n
      \u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n
      \u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
      \u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0433\u0435\u043b\u0435\u0432\u043e\u0439\u00a0\u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n
      \u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
      <\/td>\n<\/td>\n<\/tr>\n
      <\/td>\n<\/td>\n<\/tr>\n
      <\/td>\n<\/tr>\n
      \u0418\u043d\u0442\u0435\u0440\u0444\u0435\u0440\u0438\u0440\u0443\u044e\u0449\u0438\u0435\u00a0\u0444\u0430\u043a\u0442\u043e\u0440\u044b<\/b>.\u00a0<\/b>\u041c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u044b<\/b><\/td>\n<\/tr>\n
      \u041f\u043e\u0432\u044b\u0448\u0430\u044e\u0442<\/b><\/td>\n<\/tr>\n
      \u0422\u0438\u0435\u043d\u0430\u043c,\u00a0\u0434\u0438\u0433\u0438\u0434\u0440\u0430\u043b\u0430\u0437\u0438\u043d,\u00a0\u0433\u0430\u043b\u043e\u0442\u0430\u043d,\u00a0\u0444\u0435\u043d\u0438\u0442\u043e\u0438\u043d,\u00a0\u0444\u0435\u043d\u043e\u0431\u0430\u0440\u0431\u0438\u0442\u0430\u043b,\u00a0\u043a\u0430\u0440\u0431\u0430\u043c\u0430\u0437\u0435\u043f\u0438\u043d<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n
      \u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/b><\/td>\n<\/tr>\n
      \u041c\u0430\u0440\u043a\u0435\u0440\u00a0\u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0433\u043e\u00a0\u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430\u00a02\u00a0\u0442\u0438\u043f\u0430<\/b><\/p>\n
        \n
      • \u0412 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u043e\u043c \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 \u0434\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0445 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u0432 (\u043f\u0440\u0438 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0438 \u0443\u0440\u043e\u0432\u043d\u044f \u0442\u0440\u0430\u043d\u0441\u0430\u043c\u0438\u043d\u0430\u0437);<\/li>\n
      • \u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433\u043e\u0432\u043e\u0435 \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c \u0421 \u043f\u0435\u0440\u0435\u0434 \u043d\u0430\u0447\u0430\u043b\u043e\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0434\u043b\u044f \u0432\u044b\u0431\u043e\u0440\u0430 \u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0442\u0430\u043a\u0442\u0438\u043a\u0438<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
      \u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f\u00a0\u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/b><\/td>\n<\/tr>\n
      \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/b><\/td>\n<\/tr>\n
      \n
        \n
      • \u0410\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0439 \u0433\u0435\u043f\u0430\u0442\u0438\u0442 (2-\u0433\u043e \u0442\u0438\u043f\u0430) — \u0432 \u0431\u043e\u043b\u044c\u0448\u0435\u0439 \u0447\u0430\u0441\u0442\u0438 \u0441\u043b\u0443\u0447\u0430\u0435\u0432;<\/li>\n
      • \u0438\u043d\u043e\u0433\u0434\u0430 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0432\u0438\u0440\u0443\u0441\u043d\u044b\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c \u0421, D<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[928,931],"product_tag":[],"class_list":{"0":"post-9150","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-boli-autoimune","6":"product_cat-markeri-pentru-afectiuni-hepatice-si-gastrointestinale-autoimune","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9150"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9150"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9150"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9150"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}