{"id":9148,"date":"2020-04-23T03:29:29","date_gmt":"2020-04-23T00:29:29","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/anticorpi-anti-jo-1\/"},"modified":"2025-07-01T07:57:19","modified_gmt":"2025-07-01T04:57:19","slug":"anticorpi-anti-jo-1","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-jo-1\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a Jo-1"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Anticorpii anti-Jo-1 sunt \u00eendrepta\u0163i \u00eempotriva enzimei histidil-ARNt sintetaz\u0103 cu localizare citoplasmatic\u0103, determin\u00e2nd in vivo <\/em>inhibarea activit\u0103\u0163ii enzimatice.<\/p>\n

Anticorpii anti-Jo-1 constituie un marker serologic pentru dermatomiozit\u0103\/polimiozit\u0103, av\u00e2nd o prevalen\u0163\u0103 de 20-40%. Prezen\u0163a acestor autoanticorpi se asociaz\u0103 cu o form\u0103 mai sever\u0103 de boal\u0103, cu un prognostic rezervat \u015fi rec\u0103deri mai frecvente.<\/p>\n

Pacien\u0163ii la care se depisteaz\u0103 anti-Jo-1 prezint\u0103 urm\u0103toarea triad\u0103 clinic\u0103:<\/p>\n

\u2022 polimiozita (sl\u0103biciune muscular\u0103, atrofie muscular\u0103, semne biochimice \u015fi electromiografice de afectare muscular\u0103, modific\u0103ri histologice caracteristice)<\/div>\n
\u2022 polisinovita (artralgii, artrita non-eroziv\u0103, tenosinovita)<\/div>\n
\u2022 alveolita fibrozant\u0103 sau fibroza pulmonar\u0103<\/div>\n
Anticorpii apar precoce \u00een evolu\u0163ia bolii care debuteaz\u0103 adesea mono- sau oligosimptomatic. La copiii cu dermatomiozit\u0103, anti-Jo-1 se depisteaz\u0103 extrem de rar3<\/sup>.<\/div>\n

Recomand\u0103ri pentru deterninarea anticorpilor anti-Jo-1<\/em><\/strong><\/p>\n

Suspiciune de:<\/p>\n

\u2022 polimiozit\u0103 sau dermatomiozit\u0103<\/div>\n
\u2022 alveolita fibrozant\u01032;3<\/sup><\/div>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>\u00e0 jeun (pe nem\u00e2ncate) sau postprandial (dup\u0103 mese)1<\/sup>\u00a0<\/em><\/strong><\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c1<\/sup>\u00a0<\/em><\/strong><\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator1<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare1<\/sup>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser1<\/sup>.<\/p>\n

Cauze de respingere<\/em><\/strong> a probei <\/em><\/strong>- <\/em>ser intens hemolizat, lipemic sau puternic contaminat bacterian1<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>\u2013 serul separat este stabil 7 zile la 4\u00b0C; timp mai \u00eendelungat<\/em> la -20\u00b0C3<\/sup><\/em>.<\/p>\n

Metod\u0103 <\/em><\/strong>- imunoenzimatic\u0103 cu detec\u0163ie prin fluorescen\u0163\u0103 (FEIA<\/span>)1<\/sup>.<\/p>\n

Reactivul folosit este histidil-ARNt sintetaza uman\u0103 recombinat\u01031<\/sup>.<\/p>\n

Valori de referin\u0163\u0103:<\/em><\/strong><\/p>\n

\u00a0\u00a0 <7 U\/mL\u00a0: negativ<\/div>\n
7-10 U\/mL\u00a0: echivoc<\/div>\n
\u00a0>10 U\/mL : pozitiv1<\/sup><\/div>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog<\/span><\/span><\/div>\n
2. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Anti-Jo-1. www.labcorp.com 2010. Ref Type: Internet Communication<\/span><\/div>\n
3. Rudolf Mierau, Ekkehard Genth. Autoantibodies in Systemic Rheumatic Diseases. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. Lothar Thomas. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany,1 ed. 1998, 831.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430\u00a0\u043a\u00a0Jo-1\u00a0\u043e\u0442\u043d\u043e\u0441\u044f\u0442\u0441\u044f\u00a0\u043a\u00a0ANA.<\/p>\n

Jo-1 (\u0433\u0438\u0441\u0442\u0438\u0434\u0438\u043b-\u0442\u0420\u041d\u041a \u0441\u0438\u043d\u0442\u0435\u0442\u0430\u0437\u0430) \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u0441\u043e\u0431\u043e\u0439 \u0446\u0438\u0442\u043e\u043f\u043b\u0430\u0437\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0444\u0435\u0440\u043c\u0435\u043d\u0442, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u043a\u0430\u0442\u0430\u043b\u0438\u0437\u0438\u0440\u0443\u0435\u0442 \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u043d\u0438\u0435 \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442\u044b \u0433\u0438\u0441\u0442\u0438\u0434\u0438\u043d\u0430 \u0441 \u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u043e\u0439 \u0420\u041d\u041a (\u0442\u0420\u041d\u041a) \u0432 \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0435 \u0431\u0438\u043e\u0441\u0438\u043d\u0442\u0435\u0437\u0430 \u0431\u0435\u043b\u043a\u0430. \u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u0430\u043d\u0442\u0438-Jo-1 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u0434\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0438\u0434\u0438\u043e\u043f\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043c\u0438\u043e\u0437\u0438\u0442\u0430 \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u0434\u043e 30% \u0443 \u0432\u0437\u0440\u043e\u0441\u043b\u044b\u0445, \u0430 \u0434\u043b\u044f \u043f\u043e\u043b\u0438\u043c\u0438\u043e\u0437\u0438\u0442\u0430 \u043e\u043d\u0430 \u0434\u043e\u0441\u0442\u0438\u0433\u0430\u0435\u0442 46%. \u0412 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u043f\u043e\u043b\u043e\u0436\u043d\u043e\u0441\u0442\u044c \u044d\u0442\u043e\u043c\u0443 \u043f\u0440\u0438 \u044e\u0432\u0435\u043d\u0438\u043b\u044c\u043d\u043e\u0439 \u0444\u043e\u0440\u043c\u0435 \u043c\u0438\u043e\u0437\u0438\u0442\u0430 \u0430\u043d\u0442\u0438-Jo-1 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043d\u0430\u0445\u043e\u0434\u044f\u0442 \u043d\u0430\u043c\u043d\u043e\u0433\u043e \u0440\u0435\u0436\u0435. \u0418\u0445 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u044c \u0434\u043b\u044f \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0433\u043e \u043c\u0438\u043e\u0437\u0438\u0442\u0430 \u0434\u043e\u0441\u0442\u0438\u0433\u0430\u0435\u0442 \u043f\u043e\u0447\u0442\u0438 100%.<\/p>\n

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\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c<\/b><\/td>\n\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/b><\/td>\n<\/tr>\n
\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n
\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0433\u0435\u043b\u0435\u0432\u043e\u0439\u00a0\u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n
\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n
\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/b><\/td>\n<\/tr>\n
\u041c\u0430\u0440\u043a\u0435\u0440\u00a0\u043c\u0438\u043e\u0437\u0438\u0442\u0430\u00a0(\u0434\u0435\u0440\u043c\u0430\u0442\u043e\u043c\u0438\u043e\u0437\u0438\u0442\/\u043f\u043e\u043b\u0438\u043c\u0438\u043e\u0437\u0438\u0442)<\/b><\/p>\n

\u00b7\u00a0\u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430\u00a0\u043c\u0438\u043e\u0437\u0438\u0442\u0430<\/td>\n<\/tr>\n

\u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f\u00a0\u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/b><\/td>\n<\/tr>\n
\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/b><\/td>\n<\/tr>\n
\u00b7\u00a0\u041c\u0438\u043e\u0437\u0438\u0442\u00a0(\u0434\u0435\u0440\u043c\u0430\u0442\u043e\u043c\u0438\u043e\u0437\u0438\u0442\/\u043f\u043e\u043b\u0438\u043c\u0438\u043e\u0437\u0438\u0442);<\/p>\n

\u00b7\u00a0\u0441\u0438\u0441\u0442\u0435\u043c\u043d\u0430\u044f\u00a0\u043a\u0440\u0430\u0441\u043d\u0430\u044f\u00a0\u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0430\u00a0\u0432\u00a0\u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0439\u00a0\u0444\u043e\u0440\u043c\u0435\u00a0(\u0434\u043e\u00a098-100%);<\/p>\n

\u00b7\u00a0\u0431\u043e\u043b\u0435\u0437\u043d\u044c\u00a0\u041a\u0440\u043e\u043d\u0430\u00a0(\u0432\u00a05-20%);<\/p>\n

\u00b7\u00a0\u043d\u0435\u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0439\u00a0\u044f\u0437\u0432\u0435\u043d\u043d\u044b\u0439\u00a0\u043a\u043e\u043b\u0438\u0442\u00a0(50-80%);<\/p>\n

\u00b7\u00a0\u0441\u0438\u0441\u0442\u0435\u043c\u043d\u0430\u044f\u00a0\u0441\u043a\u043b\u0435\u0440\u043e\u0434\u0435\u0440\u043c\u0438\u044f;<\/p>\n

\u00b7\u00a0\u0441\u0438\u043d\u0434\u0440\u043e\u043c\u00a0\u0428\u0435\u0433\u0440\u0435\u043d\u0430;<\/p>\n

\u00b7\u00a0\u0431\u043e\u043b\u0435\u0437\u043d\u044c\u00a0\u0420\u0435\u0439\u043d\u043e;<\/p>\n

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