{"id":9146,"date":"2020-04-23T03:29:25","date_gmt":"2020-04-23T00:29:25","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/anticorpi-anti-muschi-neted-asma\/"},"modified":"2025-07-01T07:57:04","modified_gmt":"2025-07-01T04:57:04","slug":"anticorpi-anti-muschi-neted-asma","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-muschi-neted-asma\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0433\u043b\u0430\u0434\u043a\u0438\u043c \u043c\u044b\u0448\u0446\u0430\u043c"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/p>\n

Anticorpii anti-mu\u0219chi neted (engl. anti-smooth muscle antibodies, ASMA) se asociaz\u0103 cu afec\u0163iuni autoimune ale ficatului \u015fi c\u0103ilor biliare. Prevalen\u0163a ASMA \u00een hepatita autoimun\u0103 de tip 1 este de aproximativ 70%, pe c\u00e2nd \u00een ciroza biliar\u0103 primitiv\u0103 este de 20-30%. Epitopii \u0163int\u0103 pentru ace\u015fti autoanticorpi sunt reprezenta\u0163i de actin\u0103 (86% din cazuri) dar \u015fi de alte componente ale citoscheletului cum arf fi tubulina, vimentina, desmina, troponina \u0219i tropomiozina (14% din cazuri).<\/p>\n

\u00cen hepatita autoimun\u0103 de tip 1, principala \u0163int\u0103 antigenic\u0103 pentru ASMA este forma filamentoas\u0103 a actinei (actina F). Prezen\u0163a anticorpilor anti-actin\u0103 este relevant\u0103 \u00een special la pacien\u0163ii pediatrici, unde pot fi singurul marker al bolii (chiar \u00een titruri mici). Studiile efectuate au ar\u0103tat c\u0103 acest tip de anticorpi este asociat cu un debut al bolii la o v\u00e2rst\u0103 mai t\u00e2n\u0103r\u0103, haplotipul HLA-A1-B8-DR3, o frecven\u0163\u0103 mai mare a e\u015fecului terapeutic \u015fi a mortalit\u0103\u0163ii prin boal\u0103 hepatic\u0103 \u015fi cu necesitatea efectu\u0103rii precoce a transplantului hepatic, \u00een compara\u0163ie cu pacientii care sunt diagnostica\u0163i cu hepatit\u0103 autoimun\u0103 tip 1, dar nu prezint\u0103 anticorpi anti-actin\u0103.<\/p>\n

\u00cen cursul terapiei imunosupresoare se constat\u0103 dispari\u0163ia ASMA la majoritatea pacien\u0163ilor; cu toate acestea statusul serologic nu poate avea valoare predictiv\u0103 asupra ratei de recaderi la \u00eentreruperea corticoterapiei. Mai mult, at\u00e2t titrul ini\u0163ial al anticorpilor c\u00e2t \u015fi dinamica lor \u00een cursul bolii nu reprezint\u0103 markeri de prognostic pentru hepatita autoimun\u0103 de tip 1.<\/p>\n

\u00cen concluzie, ASMA nu sunt implicati in patogenia bolii \u015fi de aceea determinarea lor are mai mult valoare diagnostic\u0103 dec\u00e2t prognostic\u0103.<\/p>\n

Performan\u021ba diagnostic\u0103 a ASMA se \u00eembun\u0103t\u0103\u021be\u0219te dac\u0103 sunt prezen\u021bi concomitent \u0219i anticorpii anti-nucleari (ANA)1;2;3;4;5;6<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea ASMA<\/em><\/strong> \u2013 suspiciune clinic\u0103 de hepatit\u0103 autoimun\u0103 activ\u0103 (hepatit\u0103 acut\u0103 sau cronic\u0103 de etiologie neprecizat\u0103, inclusiv \u00een cazul disfunc\u021biei grefei dup\u0103 transplantul hepatic).<\/p>\n

Men\u021biune: \u00cen 25-34% din cazuri hepatita autoimun\u0103 este asimptomatic\u0103, de aceea testarea autoanticorpilor trebuie luat\u0103 \u00een considerare \u00een prezen\u021ba unor modific\u0103ri u\u0219oare, recent depistate, ale activit\u0103\u021bii enzimelor hepatice. \u00cent\u00e2rzierea diagnosticului \u0219i \u00een consecin\u021b\u0103 a tratamentului adecvat poate conduce la sc\u0103derea ratei de supravie\u021buire la 10 ani, comparativ cu fomele severe de hepatit\u0103 autoimun\u0103 tratate corespunz\u0103tor3;4;5;6<\/sup>.<\/p>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>\u00e0 jeun (pe nem\u00e2ncate) sau postprandial (dup\u0103 mese)7<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c7<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator7<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare7<\/sup>.<\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser7<\/sup>.<\/p>\n

Cauze de respingere<\/em><\/strong> a probei <\/em><\/strong>- <\/em>ser intens hemolizat, lipemic sau puternic contaminat bacterian7<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>- <\/em>serul separat este stabil minim<\/em> 7 zile<\/em> la 2-8\u00b0C; timp mai \u00eendelungat<\/em> la -20\u00b0C7;8<\/sup>.<\/p>\n

Metod\u0103 <\/em><\/strong>- <\/em>ELISA<\/u>. Sunt determina\u021bi anticorpii anti-actin\u01037<\/sup>.<\/p>\n

Valori de referin\u0163\u0103<\/em><\/strong><\/p>\n

Rezultatele sunt exprimate \u00een unit\u0103\u0163i arbitrare (AU) \u015fi sunt interpretate astfel:<\/p>\n

<20 AU\/mL\u00a0: negativ<\/p>\n

20-30 AU\/mL\u00a0: slab pozitiv<\/p>\n

>30 AU\/mL: pozitiv7<\/sup>.<\/p>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

La fel ca \u0219i ANA, ASMA nu sunt \u00een totalitate specifici pentru hepatita autoimun\u0103, prezen\u021ba lor fiind \u00eenregistrat\u0103 la 20-40% dintre pacien\u021bii cu boal\u0103 hepatic\u0103 alcoolic\u0103, steatoz\u0103 hepatic\u0103 non-alcooolic\u0103, hepatit\u0103 viral\u0103 cronic\u0103 B sau C, ciroz\u0103 biliar\u0103 primitiv\u0103 sau colangit\u0103 sclerozant\u0103 primitiv\u0103. ASMA pot ap\u0103rea \u00een titruri sc\u0103zute la 3-18% din indivizii s\u0103n\u0103to\u015fi. De\u0219i anticorpii anti-actin\u0103 F prezint\u0103 specificitate mai mare pentru hepatita autoimun\u0103 comparativ cu ASMA, ace\u0219tia pot fi \u00eent\u00e2lni\u021bi \u0219i \u00een infec\u021bii virale, boli de colagen, boala celiac\u0103, boala Crohn, tiroidita autoimun\u0103, diabet1;2;3;4;5;6<\/sup>.<\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

    \n
  1. Czaja AJ. Diagnosis and Management of Autoimmune Hepatitis: Current Status and Future Directions. Gut Liver. 2016 Mar;10(2):177-203.<\/span><\/li>\n
  2. Kalliopi Zachou, et al. Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice. In Journal of\u00a0\u00a0<\/em>Autoimmune Diseases,<\/em> 2004, 2: 1740-1757.<\/span><\/li>\n
  3. Cancado EL, Abrantes-Lemos CP, Terrabuio DR. The importance of autoantibody detection in autoimmune hepatitis. Front\u00a0Immunol. 2015 May 13;6:222.<\/span><\/li>\n
  4. Gatselis NK, Zachou K, Koukoulis GK, Dalekos GN. Autoimmune hepatitis, one disease with many faces: etiopathogenetic,\u00a0clinico-laboratory and histological characteristics. World J Gastroenterol. 2015 Jan 7;21(1):60-83.<\/span><\/li>\n
  5. Himoto T, Nishioka M. Autoantibodies in liver disease: important clues for the diagnosis, disease activity and prognosis. Auto\u00a0Immun Highlights. 2013 Feb 22;4(2):39-53.<\/span><\/li>\n
  6. Liberal R, Vergani D, Mieli-Vergani G. Update on Autoimmune Hepatitis. J Clin Transl Hepatol. 2015 Mar;3(1):42-52.<\/span><\/li>\n
  7. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2017. Ref Type: Catalog<\/span><\/li>\n
  8. Laboratory Corporation of America.Directory of Services and Interpretive Guide. Actin (Smooth Muscle) Antibody. www.labcorp.com<\/a> 2017. Ref Type: Internet Communication<\/span><\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"

    \u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0433\u043b\u0430\u0434\u043a\u043e\u0439 \u043c\u0443\u0441\u043a\u0443\u043b\u0430\u0442\u0443\u0440\u0435 (SMA) \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u044e\u0442 \u0441\u043e\u0431\u043e\u0439 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0431\u0435\u043b\u043a\u0443 \u0430\u043a\u0442\u0438\u043d\u0443 \u0438\u043b\u0438 \u043d\u0435\u0430\u043a\u0442\u0438\u043d\u043e\u0432\u044b\u043c \u043a\u043e\u043c\u043f\u043e\u043d\u0435\u043d\u0442\u0430\u043c (\u0442\u0443\u0431\u0443\u043b\u0438\u043d\u0443, \u0432\u0438\u043c\u0435\u043d\u0442\u0438\u043d\u0443, \u0434\u0435\u0441\u043c\u0435\u043b\u0438\u043d\u0443 \u0438 \u0441\u043a\u0435\u043b\u0435\u0442\u0438\u043d\u0443) \u0438 \u043f\u043e\u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0432 \u043e\u0442\u0432\u0435\u0442 \u043d\u0430 \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u0433\u0435\u043f\u0430\u0442\u043e\u0446\u0438\u0442\u0430. SMA \u0432\u044b\u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0432 60-80% \u0441\u043b\u0443\u0447\u0430\u0435\u0432 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0433\u043e \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430, \u0432 50% \u0441\u043b\u0443\u0447\u0430\u0435\u0432 \u041f\u0411\u0426 \u0438 \u043d\u0435 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u044e\u0442 \u043f\u0440\u0438 \u0421\u041a\u0412 \u0438 \u0432\u043d\u0435\u043f\u0435\u0447\u0451\u043d\u043e\u0447\u043d\u044b\u0445 \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u044f\u0445 \u0436\u0435\u043b\u0447\u043d\u044b\u0445 \u043f\u0443\u0442\u0435\u0439. SMA \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u044e\u0442 \u0443 70% \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0430\u043a\u0442\u0438\u0432\u043d\u044b\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c.<\/p>\n

    \u041f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435\u00a0SMA\u00a0\u0438\u00a0ANA\u00a0\u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u043e\u00a0\u0434\u043b\u044f\u00a0\u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0433\u043e\u00a0\u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430\u00a01-\u0433\u043e\u00a0\u0442\u0438\u043f\u0430.<\/p>\n

    \u0412 \u0445\u043e\u0434\u0435 \u0438\u043c\u043c\u0443\u043d\u043e\u0441\u0443\u043f\u0440\u0435\u0441\u0441\u0438\u0432\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c 1 \u0432 \u0431\u043e\u043b\u044c\u0448\u0438\u043d\u0441\u0442\u0432\u0435 \u0441\u043b\u0443\u0447\u0430\u0435\u0432 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0435\u0442\u0441\u044f \u0438\u0441\u0447\u0435\u0437\u043d\u043e\u0432\u0435\u043d\u0438\u0435 SMA \u0438\/\u0438\u043b\u0438 ANA. \u041d\u043e \u0442\u0438\u0442\u0440\u044b \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043f\u0440\u0438 \u043f\u0435\u0440\u0432\u043e\u043d\u0430\u0447\u0430\u043b\u044c\u043d\u043e\u0439 \u043f\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043a\u0435 \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0441\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u0442\u0430\u0442\u0443\u0441 \u0432 \u0445\u043e\u0434\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u044f, \u043d\u0435 \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u044e\u0442 \u043f\u0440\u0435\u0434\u0441\u043a\u0430\u0437\u0430\u0442\u044c \u0438\u0441\u0445\u043e\u0434 \u043f\u043e\u0441\u043b\u0435 \u043f\u0440\u0435\u043a\u0440\u0430\u0449\u0435\u043d\u0438\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u0438. \u041f\u043e\u043b\u0430\u0433\u0430\u044e\u0442, \u0447\u0442\u043e SMA \u0438 ANA \u043d\u0435 \u0432\u043a\u043b\u044e\u0447\u0435\u043d\u044b \u043d\u0435\u043f\u043e\u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u0432 \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0437 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0433\u043e \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 1 \u0442\u0438\u043f\u0430, \u0438 \u0446\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u044d\u0442\u0438\u0445 \u0442\u0435\u0441\u0442\u043e\u0432 \u0441\u043a\u043e\u0440\u0435\u0435 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f, \u0447\u0435\u043c \u043f\u0440\u043e\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f. SMA \u0438\/\u0438\u043b\u0438 ANA \u043c\u043e\u0436\u043d\u043e \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0442\u044c \u0432 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412 \u0438 \u0421, \u043e\u0431\u044b\u0447\u043d\u043e \u0432 \u043d\u0435\u0432\u044b\u0441\u043e\u043a\u0438\u0445 \u0442\u0438\u0442\u0440\u0430\u0445.<\/p>\n

    SMA \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u044e\u0442\u0441\u044f \u043f\u0440\u0438 \u043e\u0441\u0442\u0440\u043e\u043c \u0432\u0438\u0440\u0443\u0441\u043d\u043e\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0435 \u0438 \u0438\u0441\u0447\u0435\u0437\u0430\u044e\u0442 \u043f\u0440\u0438 \u0432\u044b\u0437\u0434\u043e\u0440\u043e\u0432\u043b\u0435\u043d\u0438\u0438, \u0432 \u043d\u0438\u0437\u043a\u0438\u0445 \u0442\u0438\u0442\u0440\u0430\u0445 \u043c\u043e\u0433\u0443\u0442 \u0431\u044b\u0442\u044c \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u044b \u043f\u0440\u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u043e\u043c \u043c\u043e\u043d\u043e\u043d\u0443\u043a\u043b\u0435\u043e\u0437\u0435, \u0446\u0438\u0442\u043e\u043c\u0435\u0433\u0430\u043b\u043e\u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0439 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438, \u043c\u0438\u043a\u043e\u043f\u043b\u0430\u0437\u043c\u0435\u043d\u043d\u043e\u0439 \u043f\u043d\u0435\u0432\u043c\u043e\u043d\u0438\u0438, \u043b\u0438\u043c\u0444\u043e\u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445, \u043d\u0430\u0440\u043a\u043e\u043c\u0430\u043d\u0438\u0438, \u0443 \u0436\u0435\u043d\u0449\u0438\u043d, \u0441\u0442\u0440\u0430\u0434\u0430\u044e\u0449\u0438\u0445 \u0431\u0435\u0441\u043f\u043b\u043e\u0434\u0438\u0435\u043c, \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043d\u043e\u0432\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0439 \u0438 \u0438\u043d\u043e\u0433\u0434\u0430 \u043d\u0435\u0431\u043e\u043b\u044c\u0448\u0438\u0435 \u0442\u0438\u0442\u0440\u044b SMA (1:20-40) \u043c\u043e\u0433\u0443\u0442 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0442\u044c\u0441\u044f \u0432 \u043f\u043e\u043f\u0443\u043b\u044f\u0446\u0438\u0438 \u0437\u0434\u043e\u0440\u043e\u0432\u044b\u0445 \u0438\u043d\u0434\u0438\u0432\u0438\u0434\u0443\u0443\u043c\u043e\u0432.<\/p>\n\n\n\n\n\n\n\n\n\n\n
    \u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c<\/b><\/td>\n\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/b><\/td>\n<\/tr>\n
    \u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n
    \u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
    \u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0433\u0435\u043b\u0435\u0432\u043e\u0439\u00a0\u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n
    \u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
    <\/td>\n<\/td>\n<\/tr>\n
    <\/td>\n<\/td>\n<\/tr>\n
    <\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n
    \u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/b><\/td>\n<\/tr>\n
    \u041c\u0430\u0440\u043a\u0435\u0440\u00a0\u0410\u0418\u0413<\/b><\/p>\n
      \n
    • \u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0445 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u0432 (\u043f\u0440\u0438 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u043e\u043c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438);<\/li>\n
    • \u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433\u043e\u0432\u043e\u0435 \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c \u0412 \u0438 \u0421 \u043f\u0435\u0440\u0435\u0434 \u043d\u0430\u0447\u0430\u043b\u043e\u043c \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0438\u043d\u0442\u0435\u0440\u0444\u0435\u0440\u043e\u043d\u043e\u043c<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
    \u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f\u00a0\u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/b><\/td>\n<\/tr>\n
    \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/b><\/td>\n<\/tr>\n
    \n
      \n
    • \u0410\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0439 \u0433\u0435\u043f\u0430\u0442\u0438\u0442 1 \u0442\u0438\u043f\u0430 (70% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432, \u043e\u0431\u044b\u0447\u043d\u043e \u0432\u044b\u0441\u043e\u043a\u0438\u0435 \u0442\u0438\u0442\u0440\u044b);<\/li>\n
    • \u0432\u0438\u0440\u0443\u0441\u043d\u044b\u0435 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u044b;<\/li>\n
    • \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0439 \u043c\u043e\u043d\u043e\u043d\u0443\u043a\u043b\u0435\u043e\u0437;<\/li>\n
    • \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f;<\/li>\n
    • \u0440\u0435\u0434\u043a\u043e — \u0443 \u0437\u0434\u043e\u0440\u043e\u0432\u044b\u0445 \u043b\u044e\u0434\u0435\u0439 (\u043d\u0438\u0437\u043a\u0438\u0435 \u0442\u0438\u0442\u0440\u044b)<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[928,931],"product_tag":[],"class_list":{"0":"post-9146","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-boli-autoimune","6":"product_cat-markeri-pentru-afectiuni-hepatice-si-gastrointestinale-autoimune","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9146"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9146"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9146"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9146"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}