{"id":9142,"date":"2020-04-23T03:29:18","date_gmt":"2020-04-23T00:29:18","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/anticorpi-anti-adn-dublu-catenar\/"},"modified":"2025-07-01T07:57:04","modified_gmt":"2025-07-01T04:57:04","slug":"anticorpi-anti-adn-dublu-catenar","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-adn-dublu-catenar\/","title":{"rendered":"\u0414\u0432\u0443\u0445\u0446\u0435\u043f\u043e\u0447\u0435\u0447\u043d\u044b\u0435 \u0414\u041d\u041a-\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/span><\/p>\n

Lupusul eritematos sistemic (LES) este o boal\u0103 inflamatorie cronic\u0103 autoimun\u0103 care apare predominant la femei de v\u00e2rst\u0103 reproductiv\u0103. Anticorpii anti-ADN\u00a0dublu catenar (anti-ADNdc)\u00a0reprezint\u0103 marca acestei afec\u0163iuni.<\/span><\/p>\n

Detec\u0163ia\u00a0anticorpilor \u00eendrepta\u0163i \u00eempotriva ADN\u00a0 este\u00a0important\u0103 at\u00e2t \u00een diagnosticul\u00a0lupusului eritematos sistemic c\u00e2t \u015fi \u00een evaluarea activit\u0103\u0163ii bolii, \u00een special la pacien\u0163ii cu nefrit\u0103 lupic\u0103.<\/span><\/p>\n

Anticorpii anti-ADN sunt \u00eemp\u0103r\u0163i\u0163i \u00een 2 tipuri: anticorpi anti-ADNdc\u00a0(nativ) \u015fi anticorpi anti-ADN monocatenar (denaturat). Anticorpii anti ADNdc (nativ) recunosc \u00een principal epitopii stratului extern ai scheletului dezoxiriboza-fosfat din\u00a0dublul helix format de cele 2 catene polinucleotidice ale ADN-ului. Anticorpii anti-ADN monocatenar recunosc epitopii stratului intern\u00a0reprezentat de bazele azotate purinice \u015fi pirimidinice.<\/span><\/p>\n

Prevalen\u0163a anticorpilor\u00a0anti-ADNdc\u00a0la\u00a0pacien\u0163ii cu LES este de 60-90%, \u00een func\u0163ie de metoda de detec\u0163ie utilizat\u0103 \u015fi de gradul de activitate al bolii. Anticorpii anti-ADNdc pot fi detecta\u0163i ocazional \u015fi la pacien\u0163ii cu alte boli autoimune, \u00een infec\u0163ii (Epstein-Barr, hepatita B), dup\u0103 administrarea anumitor medicamente (hidralazina, interferon, inhibitori de TNF) \u015fi \u00een rare cazuri, la oamenii s\u0103n\u0103to\u015fi, 85% din ace\u015ftia put\u00e2nd dezvolta LES\u00a0 \u00een 5 ani de la detec\u0163ia ini\u0163ial\u0103 a anticorpilor anti-ADN3, 4, 5, 6<\/sup>.<\/span><\/p>\n

Anticorpii anti-nucleozomi sunt de asemenea un marker exclusiv de lupus eritematos sistemic. Studii clinice\u00a0au demonstrat\u00a0c\u0103\u00a0anticorpii anti-ADNdc sunt \u00eentotdeauna asocia\u0163i cu anticorpi anti-nucleozomi, iar anticorpii anti-nucleozomi apar \u00eenaintea anticorpilor anti-ADNdc.<\/span><\/p>\n

Pentru detec\u0163ia anticorpilor anti-ADNdc sunt utilizate \u00een mod curent 3 tipuri de metode: metoda imunoenzimatic\u0103, metoda RIA (testul Farr) \u015fi metoda imunofluorescen\u0163ei indirecte utiliz\u00e2nd ca substrat Crithidia luciliae<\/em> (CLIFT), metoda RIA fiind\u00a0considerat\u0103 gold-standard.<\/span><\/p>\n

Testul anti-ADNdc \u2013 nucleozomi ELISA utilizat \u00een laboratorul nostru\u00a0demonstreaz\u0103 o sensibilitate mai mare, p\u0103str\u00e2nd aceea\u015fi specificitate, \u00een compara\u0163ie cu tehnica gold-standard \u2013 testul Farr. Astfel, \u00eentr-un studiu de cohort\u0103 efectuat la Spitalul Universitar Charite din Berlin, serurile a 964 pacien\u0163i (207 pacien\u0163i cu SLE, 357 pacien\u0163i cu alte boli reumatismale \u2013 162 pacien\u0163i cu artrit\u0103 reumatoid\u0103, 88 pacien\u0163i cu sindrom Sjoegren, 81 pacien\u0163i cu scleroz\u0103 sistemic\u0103, 26 pacien\u0163i cu miozit\u0103 \u2013 \u015fi 400 donatori s\u0103n\u0103to\u015fi) au fost analizate utiliz\u00e2nd pentru detec\u0163ia anticorpilor anti-ADNdc 5 metode diferite: metoda RIA, anti-ADNdc ELISA, anti-nucleozomi ELISA, CLIFT (Crithidia luciliae immunofluorescence test<\/em>) \u015fi\u00a0anti-ADNdc-nucleozomi ELISA <\/b>3, 4, 5, 6<\/sup>.<\/span><\/p>\n

Compar\u00e2ndu-se\u00a0semnifica\u0163ia clinic\u0103 a acestei metode\u00a0cu tehnicile deja utilizate, inclusiv cu\u00a0metoda RIA considerata gold-standard, testul anti-ADNdc-nucleozomi ELISA a ar\u0103tat o sensibilitate superioar\u0103 (60.9%) fa\u0163\u0103 de metoda gold-standard (52%), cu o specificitate de 98.9% \u00een toate serurile analizate la un cut-off de 100 UI\/ml. Acest lucru se datoreaz\u0103 tehnicii inovative de cuplare a antigenului la microplac\u0103.\u00a0Studii efectuate recent\u00a0au ar\u0103tat faptul c\u0103, la pacien\u0163ii cu boli autoimune, nucleozomii, ce con\u0163in ADNdc (\u015fi nu ADN-ul izolat)\u00a0reprezint\u0103 principalul stimul imunogen in vivo.<\/em>\u00a0Din acest\u00a0motiv\u00a0substratul antigenic folosit, in vitro<\/em>, \u00een testul nostru este reprezentat de ADNdc cuplat la faza solid\u0103 cu frac\u0163iuni de nucleozomi \u00eenalt purifica\u0163i,\u00a0 \u00een contrast cu tehnicile conven\u0163ionale de detec\u0163ie a anticorpilor anti-ADNdc care utilizeaz\u0103 ca substan\u0163\u0103 de cuplare a antigenului la microplaca de reac\u0163ie protamina sau poli-L-lizina, ce pot\u00a0da reac\u0163ii nespecifice. Configurarea speciala a antigenului\u00a0\u00een testul anti-ADNdc \u2013 nucleozomi ELISA asigur\u0103 o prezentare autentic\u0103 a epitopilor majori relevan\u0163i \u015fi minimalizeaz\u0103 rezultatele fals-pozitive. In plus, testul are avantajul c\u0103\u00a0nu implic\u0103 o metod\u0103 radioactiv\u0103 3, 4, 5, 6<\/sup>.\u00a0<\/span><\/p>\n

O concentra\u0163ie crescut\u0103 de anticorpi anti-ADN dublu catenar-nucleozomi ELISA\u00a0este semnificativ\u0103 pentru diagnosticul de LES. S-a demonstrat c\u0103\u00a0testul\u00a0\u00a0anti-ADNdc-nucleozomi ELISA poate detecta peste 18% mai multe cazuri de LES decat testele conven\u0163ionale.<\/span><\/p>\n

Intr-o analiza\u0103 longitudinal\u0103 pe 20 pacien\u0163i, care au fost monitoriza\u0163i timp de 69 vizite, s-a demonstrat corelarea titrului anticorpilor anti-ADNdc \u2013nucleozomi ELISA cu gradul de activitate al bolii, respectiv cu scorul SLEDAI modificat 6<\/sup>.<\/span><\/p>\n

Recomand\u0103ri pentru determinarea ADNdc <\/em><\/strong>\u2013 suspiciune LES; monitorizarea pacien\u0163ilor cu boal\u0103 lupic\u01031;2<\/sup>.\u00a0<\/em><\/strong><\/span><\/p>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>\u00e0 jeun (pe nem\u00e2ncate) sau postprandial (dup\u0103 mese)1<\/sup>\u00a0<\/em><\/strong><\/span><\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c1<\/sup>\u00a0<\/em><\/strong><\/span><\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator1<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare1<\/sup>.<\/span><\/p>\n

Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser1<\/sup>.<\/span><\/p>\n

Cauze de respingere<\/em><\/strong> a probei <\/em><\/strong>- <\/em>ser intens hemolizat, lipemic sau puternic contaminat bacterian1<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>\u2013 serul separat este stabil 7 zile la 4\u00b0C; timp mai \u00eendelungat<\/em> la -20\u00b0C1<\/sup><\/em>.<\/span><\/p>\n

Metod\u0103 <\/em><\/strong>\u2013 FEIA \u2013 metoda enzimatica cu fluorescen\u0163\u01031<\/sup>.<\/span><\/p>\n

Antigenul este reprezentat de ADNdc complexat cu nucleozomi \u015fi cuplat la faza solid\u0103.<\/span><\/p>\n

Valori de referin\u0163\u0103:<\/em><\/strong><\/span>\u00a0<\/span><\/span><\/p>\n

\n

< 10: Negativ<\/p>\n

10 \u2013 15: Echivoc<\/p>\n

> 15: Pozitiv\u00a0<\/span>1<\/sup><\/p>\n<\/div>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/p>\n

Un rezultat negativ nu exclude boala lupic\u0103.<\/span><\/div>\n
Anticorpii anti-ADN dublu catenar mai pot ap\u0103rea, \u00eentr-un procent sc\u0103zut \u015fi \u00een alte boli reumatismale (<1% din cazurile de poliartrita reumatoid\u0103 \u015fi <10% din cazurile de sindrom Sj\u00f6gren primar \u015fi boala mixt\u0103 de \u0163esut conjunctiv), hepatita cronic\u0103 activ\u0103, ciroz\u0103 biliar\u0103, mononucleoz\u0103 infec\u0163ioas\u0103.<\/span><\/div>\n
Procainamida \u015fi hidralazina pot induce at\u00e2t anticorpi anti-histone (specifici pentru lupusul indus medicamentos) c\u00e2t \u015fi anticorpi anti-ADN2;3<\/sup>.<\/span><\/div>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2013. Ref Type: Catalog<\/span><\/span><\/div>\n
2. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Anti-dsDNA (Double-Stranded) Antibodies. www.labcorp.com 2013. Ref Type: Internet Communication<\/span><\/div>\n
3. Makowski GS, Ramsby ML. Selective detection of autoimmune antibodies to single- and double-stranded DNA by enzyme immunoassay. Ann Clin Lab Sci. 2003 Spring;33(2):142-8. 4. Rouquette AM, Desgruelles C.\u00a0 Detection of antibodies to dsDNA: an overview of laboratory assays. Lupus. 2006;15(7):403-7.<\/span><\/div>\n
5. Radice A, Sinico RA. A new oligonucleotide-based ELISA for the detection of anti-double-stranded DNA antibodies. Autoimmunity. 2006 Mar;39(2):113-9.<\/span><\/div>\n
6.\u00a0\u00a0Robert Biesen, Cornelia D\u00e4hnrich, Anke Rosemann, Fidan Barkhudarova, Thomas Rose, Olga Jakob, Anne Bruns, Marina Backhaus, Winfried St\u00f6cker, Gerd-R\u00fcdiger Burmester, Wolfgang Schlumberger, Karl Egerer and Falk Hiepe Anti-dsDNA-NcX ELISA: dsDNA-loaded nucleosomes improve diagnosis and monitoring of disease activity in systemic lupus erythematosus, Arthritis Research & Therapy 2011, 13:R26<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0434\u0432\u0443\u0445\u0441\u043f\u0438\u0440\u0430\u043b\u044c\u043d\u043e\u0439 \u0414\u041d\u041a.<\/b><\/p>\n

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\u042d\u0442\u0438\u00a0\u0410\u0422\u00a0\u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u044b\u00a0\u0434\u043b\u044f\u00a0\u0421\u041a\u0412\u00a0\u0438\u00a0\u043c\u043e\u0433\u0443\u0442\u00a0\u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u0442\u044c\u0441\u044f\u00a0\u043f\u0440\u0438\u0431\u043b\u0438\u0437\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u00a0\u0443\u00a040-70%\u00a0\u0431\u043e\u043b\u044c\u043d\u044b\u0445\u00a0\u0432\u00a0\u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0439\u00a0\u0444\u0430\u0437\u0435\u00a0(\u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0—\u00a091%,\u00a0\u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u044c\u00a0—\u00a096%).<\/p>\n

\u041e\u0434\u043d\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0435 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0430\u043d\u0442\u0438\u043d\u0443\u043a\u043b\u0435\u0430\u0440\u043d\u044b\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u0441 \u0438\u0445 \u0432\u044b\u0441\u043e\u043a\u043e\u0439 \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u044e \u0438 anti-dsDNA \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u0441 \u0438\u0445 \u0432\u044b\u0441\u043e\u043a\u043e\u0439 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u044c\u044e \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043d\u0430\u0438\u043b\u0443\u0447\u0448\u0435\u0439 \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u0435\u0439 \u0442\u0435\u0441\u0442\u043e\u0432 \u0434\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0421\u041a\u0412.<\/p>\n\n\n\n\n\n\n\n\n\n\n
\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c<\/b><\/td>\n\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/b><\/td>\n<\/tr>\n
\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n
\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0433\u0435\u043b\u0435\u0432\u043e\u0439\u00a0\u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n
\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n
\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/b><\/td>\n<\/tr>\n
\u041c\u0430\u0440\u043a\u0435\u0440\u00a0\u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0439\u00a0\u043a\u0440\u0430\u0441\u043d\u043e\u0439\u00a0\u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0438<\/b><\/p>\n
    \n
  • \u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0439 \u043a\u0440\u0430\u0441\u043d\u043e\u0439 \u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0438 (\u0421\u041a\u0412);<\/li>\n
  • \u043e\u0446\u0435\u043d\u043a\u0430 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0444\u0430\u0437\u044b \u0442\u0435\u0447\u0435\u043d\u0438\u044f \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f (\u0421\u041a\u0412);<\/li>\n
  • \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u043c\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f\u00a0\u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/b><\/td>\n<\/tr>\n
\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/b><\/td>\n<\/tr>\n
\n
    \n
  • \u0421\u0438\u0441\u0442\u0435\u043c\u043d\u0430\u044f \u043a\u0440\u0430\u0441\u043d\u0430\u044f \u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0430;<\/li>\n
  • \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0430\u0440\u0442\u0440\u0438\u0442;<\/li>\n
  • \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0428\u0435\u0433\u0440\u0435\u043d\u0430;<\/li>\n
  • \u0441\u043a\u043b\u0435\u0440\u043e\u0434\u0435\u0440\u043c\u0438\u044f;<\/li>\n
  • \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u043a\u0442\u0438\u0432\u043d\u044b\u0439 \u0433\u0435\u043f\u0430\u0442\u0438\u0442;<\/li>\n
  • \u0431\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u0439 \u0446\u0438\u0440\u0440\u043e\u0437;<\/li>\n
  • \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f, \u0432\u044b\u0437\u0432\u0430\u043d\u043d\u0430\u044f \u0432\u0438\u0440\u0443\u0441\u043e\u043c \u042d\u043f\u0448\u0442\u0435\u0439\u043d\u0430-\u0411\u0430\u0440\u0440\u0430 \u0438 \u0426\u041c\u0412 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[928,929],"product_tag":[],"class_list":{"0":"post-9142","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-boli-autoimune","6":"product_cat-markeri-pentru-afectiuni-reumatismale-si-vasculite","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9142"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9142"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9142"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9142"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}