{"id":9118,"date":"2020-04-23T03:28:36","date_gmt":"2020-04-23T00:28:36","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/afp-alfa-feto-proteina\/"},"modified":"2026-02-19T00:24:59","modified_gmt":"2026-02-18T22:24:59","slug":"afp-alfa-feto-proteina","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/afp-alfa-feto-proteina\/","title":{"rendered":"\u0410\u0424\u041f (\u0410\u043b\u044c\u0444\u0430-\u0444\u0435\u0442\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d)"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Informa\u0163<\/em><\/strong><strong><em>ii generale<\/em><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">AFP este o glicoprotein\u0103 omoloag\u0103 albuminei, sintetizat\u0103 \u00een cursul perioadei fetale \u00een tractul gastrointestinal, ficat \u015fi sacul vitelin. In func\u0163ie de v\u00e2rsta gesta\u0163ional\u0103, AFP ajunge pe cale transplacentar\u0103 \u00een circula\u0163ia matern\u0103, ating\u00e2nd un maxim de concentra\u0163ie \u00een s\u0103pt\u0103m\u00e2nile 32-36.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Dup\u0103 na\u015ftere, nivelul seric de AFP scade progresiv, dar cu fluctua\u0163ii mari, astfel c\u0103 valori similare cu ale adultului normal sunt atinse abia dup\u0103 aproximativ 10 luni.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">La adult se \u00eent\u00e2lnesc concentra\u0163ii crescute de AFP- tranzitorii sau persistente \u2013\u00a0\u00een afec\u0163iuni hepatice benigne \u015fi\u00a0\u00een procese de regenerare hepatic\u0103; niveluri foarte crescute se asociaz\u0103 cu dezvoltarea carcinomului primitiv hepatic \u015fi cu tumori germinative de origine testicular\u0103, ovarian\u0103 sau extragonadal\u0103<sup>2<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Recomand\u0103ri pentru determinarea AFP<\/em><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"text-decoration: underline;\">Ca marker tumoral<\/span>:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><em><strong>Indica\u0163ii absolute:<\/strong><\/em><\/span><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">\u2022 suspiciune de carcinom hepatocelular;\u00a0\u00a0\u00a0\u00a0<\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">\u2022 tumori germinative non-seminomatoase de origine testicular\u0103, ovarian\u0103 sau extragonadal\u0103;<\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">\u2022 monitorizarea tratamentului la pacien\u0163i cu tumori germinative sau carcinom hepatocelular<sup>2<\/sup>.<\/span><\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">La pacien\u0163ii cu tumori germinative AFP trebuie determinat \u00eempreun\u0103 cu HCG total. In cancerul testicular ace\u015fti markeri trebuie evalua\u0163i \u00eenainte de orhiectomie \u015fi apoi m\u0103sura\u0163i seriat dup\u0103 interven\u0163ia chirurgical\u0103. Rata de reducere a nivelului seric trebuie comparat\u0103 cu rata normal\u0103 de dispari\u0163ie a AFP (timp de \u00eenjum\u0103t\u0103\u0163ire &lt; 7 zile) \u015fi HCG total (timp de \u00eenjum\u0103t\u0103\u0163ire &lt; 3 zile). Programul de monitorizare include determin\u0103ri lunare de AFP, HCG total \u015fi LDH \u00een decursul primului an \u015fi la 2 luni \u00een urm\u0103torii 2 ani.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Orice pacient cu examen histopatologic sugestiv pentru seminom pur, dar care prezint\u0103 AFP crescut trebuie considerat ca av\u00e2nd tumor\u0103 testicular\u0103 non-seminomatoas\u0103 \u015fi tratat corespunz\u0103tor. In plus AFP reprezint\u0103 un factor de prognostic independent pentru tumorile testiculare non-seminomatoase<sup>3<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><em><strong>Indica\u0163ii relative<\/strong><\/em><\/span><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">\u2022 monitorizarea pacien\u0163ilor cu ciroz\u0103 hepatic\u0103 pentru depistarea precoce a cancerului hepatic;<\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">\u2022 monitorizarea pacien\u0163ilor cu risc crescut de tumori germinative (criptorhidism, gemeni monozigo\u0163i, unul dintre ei av\u00e2nd cancer testicular)<sup>2<\/sup><\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 12pt; text-decoration: underline;\">Ca marker de monitorizare \u00een sarcin\u0103<\/span><\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Dac\u0103 scopul determin\u0103rii AFP este screening-ul prenatal pentru <em>depistarea afec\u0163iunilor de tip<\/em> anencefalie, spin\u0103 bifid\u0103, boala Langdon Down, trisomie 21, trisomie 18 etc., gravida va men\u0163iona exact v\u00e2rsta sarcinii stabilit\u0103 echografic sau data ultimei menstrua\u0163ii. Serul matern poate fi recoltat \u00eentre s\u0103pt\u0103m\u00e2nile 14-19 de sarcin\u0103, momentul ideal pentru recoltare fiind s\u0103pt\u0103m\u00e2nile 16-18 de sarcin\u0103. Dac\u0103 se ob\u0163ine o valoare crescut\u0103 pentru AFP, determinarea se va repeta dup\u0103 1 s\u0103pt\u0103m\u00e2n\u0103<sup>1;2<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Preg\u0103tire pacient <\/em><\/strong><em>- <\/em>\u00e0 jeun (pe nem\u00e2ncate)<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Specimen recoltat <\/em><\/strong><em>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Recipient de recoltare <\/em><\/strong><em>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong><em>- <\/em>se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul proasp\u0103t; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C sau la -20\u00b0C<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Volum prob\u0103<\/em><\/strong> \u2013 minim 0.5 mL ser<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Cauze de respingere<\/em><\/strong> <strong><em>a probei<\/em><\/strong><\/span><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">\u2022 specimen hemolizat;<\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">\u2022 specimen expus la temperatur\u0103 ridicat\u0103;<\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">\u2022 specimen contaminat bacterian.<\/span><\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><span style=\"text-decoration: underline;\">NOTA<\/span>: specimenul care prezint\u0103 turbiditate sau particule \u00een suspensie trebuie clarificat prin centrifugare<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Stabilitate prob\u0103 <\/em><\/strong><em>- <\/em>serul separat este stabil <em>7 zile<\/em> la 2-8\u00b0C; <em>timp \u00eendelungat<\/em> la -20\u00b0C sau la -70\u00b0C<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Metode<\/em><\/strong><\/span><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">a) <span style=\"text-decoration: underline;\">imunochimic\u0103 cu detec\u0163ie prin electrochemilumiscen\u0163\u0103 (ECLIA)<\/span><\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">b) <span style=\"text-decoration: underline;\">imunochimic\u0103 cu detec\u0163ie prin chemiluminiscen\u0163\u0103<\/span><sup>1<\/sup><\/span><\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Valori de referin\u0163\u0103<\/em><\/strong><sup>1<\/sup><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Pentru AFP ca marker tumoral valorile variaz\u0103 \u00een func\u0163ie de metoda de lucru:<\/span><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">a) &lt; 7.0 ng\/mL<\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">b) &lt; 6.0 ng\/mL<\/span><\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">La gravide rezultatele se interpreteaz\u0103 \u00een func\u0163ie de v\u00e2rsta gesta\u0163ional\u0103.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><em>Factor de conversie: UI\/mL x 1.21 = ng\/mL;<\/em><em> ng\/mL x 0.83 =UI\/mL.<\/em><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Limita de detec\u0163ie <\/em><\/strong>\u2013 0.2 UI\/mL (0.24 ng\/mL)<sup>1<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\"><strong><em>Limite \u015fi interferen\u0163e<\/em><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Nivelurile de AFP sunt rareori crescute \u00een tumorile testiculare aflate \u00een stadiul I de boal\u0103.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">De\u015fi cu o inciden\u0163\u0103 sc\u0103zut\u0103, cre\u015fteri ale AFP mai pot fi \u00eenregistrate \u015fi \u00een alte tumori: gastrointestinale, pancreatice, pulmonare.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Printre afec\u0163iunile benigne \u00een care pot ap\u0103rea niveluri crescute de AFP se num\u0103r\u0103: hepatita, ciroza, obstruc\u0163ia de c\u0103i biliare, sindromul ataxie-telangiectazie, tirozinemia ereditar\u0103.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Dup\u0103 amniocentez\u0103 valoarea ob\u0163inut\u0103 pentru AFP nu corespunde nivelului real<sup>2<\/sup>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">\u2022 Interferen\u0163e analitice<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12pt;\">Pot produce interferen\u0163e cu unele componente ale kit-ului \u015fi conduce la rezultate neconcludente urm\u0103toarele:<\/span><\/p>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">\u2013 tratamentul cu biotin\u0103 \u00een doze mari (&gt;5 mg\/zi); de aceea se recomand\u0103 ca recoltarea de s\u00e2nge s\u0103 se fac\u0103 dup\u0103 minimum 8 ore de la ultima administrare;<\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">\u2013 titrurile foarte crescute de anticorpi anti-streptavidina \u015fi anti-ruteniu;<\/span><\/div>\n<div style=\"text-align: justify; padding-left: 30px;\"><span style=\"font-size: 12pt;\">\u2013 anticorpii monoclonali proveni\u0163i de la \u015foarece administra\u0163i la unii pacien\u0163i \u00een scop diagnostic sau terapeutic<sup>1<\/sup>.<\/span><\/div>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 10pt;\">\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">1. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">2. Lothar Thomas. Tumor Markers. In Clinical Laboratory Diagnostics. 1998, 941-945.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">3. The National Academy of Clinical Biochemistry. Practice Guidelines and Recommendations for Use of Tumor Markers in the Clinic (Laboratory Medicine Practice Guidelines), 2002, 35-37.<\/span><\/div>","protected":false},"excerpt":{"rendered":"<p>\u0410\u043b\u044c\u0444\u0430-\u0444\u0435\u0442\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d \u2013 \u0433\u043b\u0438\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0432\u044b\u0440\u0430\u0431\u0430\u0442\u044b\u0432\u0430\u0435\u0442\u0441\u044f \u0432 \u044d\u043c\u0431\u0440\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u043c \u0436\u0435\u043b\u0442\u043e\u0447\u043d\u043e\u043c \u043c\u0435\u0448\u043a\u0435, \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u044d\u043f\u0438\u0442\u0435\u043b\u0438\u0438 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430 \u043f\u043b\u043e\u0434\u0430. \u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u043c\u0430\u0441\u0441\u0430 \u0431\u0435\u043b\u043a\u0430 \u2013 \u043e\u043a\u043e\u043b\u043e 70 000 \u0434\u0430\u043b\u044c\u0442\u043e\u043d, \u043f\u0435\u0440\u0438\u043e\u0434 \u0435\u0433\u043e \u043f\u043e\u043b\u0443\u0440\u0430\u0441\u043f\u0430\u0434\u0430 \u0441\u043e\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 5-7 \u0434\u043d\u0435\u0439. \u0412 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0435 \u043f\u043b\u043e\u0434\u0430 \u043e\u043d \u0432\u044b\u043f\u043e\u043b\u043d\u044f\u0435\u0442 \u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u0430\u043b\u044c\u0431\u0443\u043c\u0438\u043d\u0430 \u0432\u0437\u0440\u043e\u0441\u043b\u043e\u0433\u043e \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430: \u043e\u0441\u0443\u0449\u0435\u0441\u0442\u0432\u043b\u044f\u0435\u0442 \u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0432\u0435\u0449\u0435\u0441\u0442\u0432, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u044b\u0445 \u0434\u043b\u044f \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u043f\u043b\u043e\u0434\u0430, \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u0435\u0442 \u044d\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u044b, \u043e\u0433\u0440\u0430\u043d\u0438\u0447\u0438\u0432\u0430\u044f \u0438\u0445 \u0432\u043b\u0438\u044f\u043d\u0438\u0435 \u043d\u0430 \u0440\u0430\u0437\u0432\u0438\u0432\u0430\u044e\u0449\u0438\u0439\u0441\u044f \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c, \u0438 \u0437\u0430\u0449\u0438\u0449\u0430\u0435\u0442 \u043e\u0442 \u043d\u0435\u0433\u0430\u0442\u0438\u0432\u043d\u043e\u0433\u043e \u0432\u043e\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f \u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u043c\u0430\u0442\u0435\u0440\u0438.<\/p>\n<p>\u0410\u043b\u044c\u0444\u0430-\u0444\u0435\u0442\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0435\u0442 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0435 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\u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u0437\u0430\u043a\u043b\u0430\u0434\u043a\u0438 \u043d\u0435\u0440\u0432\u043d\u043e\u0439 \u0442\u0440\u0443\u0431\u043a\u0438, \u0430\u043d\u044d\u043d\u0446\u0435\u0444\u0430\u043b\u0438\u0438 (\u0442\u044f\u0436\u0435\u043b\u044b\u0439 \u043f\u043e\u0440\u043e\u043a \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f, \u043f\u0440\u0438 \u043a\u043e\u0442\u043e\u0440\u043e\u043c \u0443 \u043f\u043b\u043e\u0434\u0430 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u0435\u0442 \u0447\u0430\u0441\u0442\u044c \u0433\u043e\u043b\u043e\u0432\u043d\u043e\u0433\u043e \u043c\u043e\u0437\u0433\u0430), \u0445\u0440\u043e\u043c\u043e\u0441\u043e\u043c\u043d\u044b\u0445 \u0430\u043d\u043e\u043c\u0430\u043b\u0438\u0439.<\/li>\n<li>\u0414\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u043e\u0439 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\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/p>\n<ol>\n<li>\u041f\u0440\u0438 \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430 \u0441 \u0432\u044b\u0441\u043e\u043a\u0438\u043c \u0440\u0438\u0441\u043a\u043e\u043c \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u0438 (\u043f\u0440\u0438 \u0446\u0438\u0440\u0440\u043e\u0437\u0435 \u043f\u0435\u0447\u0435\u043d\u0438, \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0435, \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0435 \u0430\u043b\u044c\u0444\u0430-\u0430\u043d\u0442\u0438\u0442\u0440\u0438\u043f\u0441\u0438\u043d\u0430).<\/li>\n<li>\u041f\u0440\u0438 \u043f\u043e\u0434\u043e\u0437\u0440\u0435\u043d\u0438\u0438 \u043d\u0430 \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0439 \u0432 \u043f\u0435\u0447\u0435\u043d\u044c.<\/li>\n<li>\u041f\u0440\u0438 \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430 \u0441 \u043d\u043e\u0432\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u043f\u043e\u043b\u043e\u0432\u044b\u0445 \u0436\u0435\u043b\u0435\u0437.<\/li>\n<li>\u0414\u043e, \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u0438 \u043f\u043e\u0441\u043b\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0440\u0430\u043a\u043e\u0432\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439.<\/li>\n<li>\u041f\u0440\u0438 \u043d\u0430\u0431\u043b\u044e\u0434\u0435\u043d\u0438\u0438 \u0437\u0430 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0435\u043c \u0432 \u043f\u043e\u0441\u043b\u0435\u043e\u043f\u0435\u0440\u0430\u0446\u0438\u043e\u043d\u043d\u044b\u0439 \u043f\u0435\u0440\u0438\u043e\u0434 \u0431\u043e\u043b\u044c\u043d\u044b\u0445, \u043a\u043e\u0442\u043e\u0440\u044b\u043c \u0431\u044b\u043b\u0430 \u0443\u0434\u0430\u043b\u0435\u043d\u0430 \u043e\u043f\u0443\u0445\u043e\u043b\u044c.<\/li>\n<li>\u0412\u043e \u0432\u0442\u043e\u0440\u043e\u043c \u0442\u0440\u0438\u043c\u0435\u0441\u0442\u0440\u0435 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438 (\u043c\u0435\u0436\u0434\u0443 15-\u0439 \u0438 21-\u0439 \u043d\u0435\u0434\u0435\u043b\u044f\u043c\u0438 \u0433\u0435\u0441\u0442\u0430\u0446\u0438\u0438).<\/li>\n<li>\u041f\u0440\u0438 \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0445, \u0443 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u043b\u0438\u0441\u044c \u0430\u043c\u043d\u0438\u043e\u0446\u0435\u043d\u0442\u0435\u0437 \u0438 \u0431\u0438\u043e\u043f\u0441\u0438\u044f \u0445\u043e\u0440\u0438\u043e\u043d\u0430 \u0432 \u0440\u0430\u043d\u043d\u0438\u0439 \u043f\u0435\u0440\u0438\u043e\u0434 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438.<\/li>\n<\/ol>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[923],"product_tag":[],"class_list":{"0":"post-9118","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-tumorali","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9118"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9118"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9118"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9118"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}