{"id":9117,"date":"2020-04-23T04:28:34","date_gmt":"2020-04-23T01:28:34","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/adn-viral-hepatita-b-cantitativ\/"},"modified":"2025-07-01T07:56:00","modified_gmt":"2025-07-01T04:56:00","slug":"adn-viral-hepatita-b-cantitativ","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/adn-viral-hepatita-b-cantitativ\/","title":{"rendered":"\u0414\u041d\u041a \u0432\u0438\u0440\u0443\u0441\u0430 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412, \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439"},"content":{"rendered":"<p><strong><em>Informa\u0163ii generale \u015fi recomand\u0103ri<\/em><\/strong><\/p>\n<p>De\u015fi sunt disponibile vaccinuri eficiente \u00eenc\u0103 din 1982, infec\u0163ia cu virusul hepatitei B (VHB) continu\u0103 s\u0103 r\u0103m\u00e2n\u0103 o problem\u0103 grav\u0103 de s\u0103n\u0103tate public\u0103. Peste 2 miliarde de persoane din \u00eentreaga lume prezint\u0103 dovada serologic\u0103 a infec\u0163iei VHB (\u00een antecedente sau curent\u0103), dintre care aproximativ 257 milioane sunt \u00een stadiul de infec\u0163ie cronic\u0103 (definit prin prezen\u021ba AgHBs). \u00cen 2015 au fost \u00eenregistrate 887 000 decese cauzate \u00een principal de complica\u021biile infec\u021biei VHB (ciroza hepatic\u0103 \u0219i carcinomul hepatocelular)<sup>1<\/sup>.<\/p>\n<p>Au fost raportate 9 genotipuri VHB (notate cu majuscule de la A la I) \u0219i c\u00e2teva subgenotipuri, av\u00e2nd distribu\u0163ii geografice diferite<sup>2<\/sup>.<\/p>\n<p>Markerii serologici sunt folosi\u0163i adesea ca indicatori de diagnostic \u015fi\/sau prognostic ai infec\u0163iei HBV acute sau cronice. Dintre ace\u015ftia, AgHBe reprezint\u0103 un marker de infec\u0163iozitate \u015fi un indicator al replic\u0103rii virale active, asociat cu boal\u0103 hepatic\u0103 progresiv\u0103<sup>3<\/sup>. Totu\u015fi, existen\u0163a unor tulpini virale care fie produc AgHBe dar acesta nu este detectabil \u00een ser, fie \u015fi-au pierdut capacitatea de a produce AgHBe chiar \u00een prezen\u0163a unei infec\u0163ii active, limiteaz\u0103 utilitatea clinic\u0103 a acestui marker<sup>4<\/sup>.<\/p>\n<p>Cea mai eficient\u0103 \u015fi direct\u0103 metod\u0103, cu valoare prognostic\u0103 \u00een evolu\u0163ia infec\u0163iilor acute sau cronice, este detectarea cantitativ\u0103 a ADN-ului VHB din plasm\u0103 (viremie B), prin tehnologia PCR. \u00cen plus, aceast\u0103 metod\u0103 permite depistarea ADN-VHB \u00een cazurile de hepatit\u0103 cronic\u0103 B cu markeri serologici negativi<sup>5<\/sup>.<\/p>\n<p>ADN-ul VHB este detectat dup\u0103 aproximativ 30 zile de la contactul infec\u021bios, astfel c\u0103 poate fi util \u00een \u00een depistarea precoce a infec\u021biei acute la unele persoane cu risc crescut, \u00eenainte de apari\u021bia \u00een ser a AgHBs<sup>6<\/sup>.<\/p>\n<p>Determinarea viremiei este util\u0103 de asemenea pentru monitorizarea eficien\u0163ei terapiei antivirale. Studiile au demonstrat c\u0103 o sc\u0103dere rapid\u0103 \u015fi sus\u0163inut\u0103 a nivelului ADN-VHB la pacien\u0163ii afla\u0163i sub tratament cu \u03b1-interferon pegylat (PegINF\u03b1) sau cu analogi nucleozidici\/nucleotidici reprezint\u0103 un factor predictiv pentru un r\u0103spuns terapeutic favorabil. Pe de alt\u0103 parte, monitorizarea viremiei poate avea valoare predictiv\u0103 \u00een ceea ce prive\u015fte dezvoltarea rezisten\u0163ei la analogi nucleozidici\/nucleotidici<sup>5<\/sup>.<\/p>\n<p>Specimen recoltat \u2013 s\u00e2nge venos<sup>5<\/sup>.<\/p>\n<p>Recipient de recoltare\u00a0\u2013 vacutainer ce con\u0163ine EDTA ca anticoagulant<sup>5<\/sup>.<\/p>\n<p><strong><em>Cantitate recoltat\u0103 <\/em><\/strong>\u2013 c\u00e2t permite vacuumul<sup>5<\/sup>.<\/p>\n<p>Cauze de respingere <strong><em>a probei <\/em><\/strong>\u2013 folosirea heparinei ca anticoagulant<sup>5<\/sup>.<\/p>\n<p>Prelucrare necesar\u0103 dup\u0103 recoltare \u2013 se separ\u0103 plasma \u00een maxim 1 zi de la recoltare prin centrifugare la 800-1600 x g timp de 20 de minute la temperatura camerei, apoi se transfer\u0103 intr-o eprubet\u0103 de polipropilen (sunt necesari min. <strong>2mL<\/strong> de plasm\u0103)<sup> 5<\/sup>.<\/p>\n<p>Stabilitate prob\u0103 \u2013 plasma separat\u0103 poate fi p\u0103strat\u0103 timp de <em>72 de ore<\/em>\u00a0la temperatura camerei, <em>7 zile<\/em> la 2-8\u00b0C sau cel pu\u0163in <em>6 s\u0103pt\u0103m\u00e2ni<\/em> congelat\u0103 la\u00a0 -80\u00b0C. Probele pot fi congelate\/decongelate de maximum cinci ori f\u0103r\u0103 pierderea ADN-ului VHB<sup>5<\/sup>.<\/p>\n<p>Metod\u0103 \u2013 <u>Real-time PCR (TaqMan)<\/u>: reac\u0163ie de polimerizare \u00een lan\u0163 cu detec\u0163ie \u00een timp real a produsului PCR\u00a0 acumulat, prin m\u0103surarea fluorescen\u0163ei emise.<\/p>\n<p>Men\u0163iune: procesarea probelor se face automat<sup>5<\/sup>.<\/p>\n<p><em>Factor de conversie: <strong>\u00a0<\/strong>ADN-VHB (UI\/mL) x5.82 = ADN-VHB (copii\/mL).<\/em><\/p>\n<p><strong><em>Valori de referin\u0163\u0103 <\/em><\/strong>\u2013 ADN-VHB nedetectabil; limita de detec\u0163ie a metodei \u00een domeniul de linearitate (m\u0103surabil) este de 10 UI\/mL; sensibilitatea analitic\u0103: 4.4 UI\/mL. Un rezultat \u00abnedetectabil\u00bb semnific\u0103 faptul c\u0103 este vorba fie de o viremie foarte sc\u0103zut\u0103 (sub limita de cuantificare), fie de o viremie absent\u0103<sup>5<\/sup>. Un rezultat ADN-VHB &lt; 20 UI\/mL indic\u0103 o viremie detectabil\u0103, dar sub limita cuantific\u0103rii (testul poate fi repetat dup\u0103 1-2 luni \u00een func\u021bie de contextul clinic)<sup>5;6<\/sup>.<\/p>\n<p><strong><em>Raportarea \u0219i interpretarea rezultatelor<\/em><\/strong><\/p>\n<p>Rezultatele viremiei sunt exprimate at\u00e2t numeric (UI\/mL) c\u00e2t \u0219i sub form\u0103 logaritmic\u0103 (log<sub>10<\/sub> UI\/mL). O modificare cu 1 log<sub>10<\/sub> UI\/mL a viremiei fa\u021b\u0103 de nivelul bazal indic\u0103 o cre\u0219tere sau o sc\u0103dere de 10 ori<sup>5<\/sup>.<\/p>\n<p>Nivelul viremiei poate fi corelat cu markerii serologici, biochimici \u015fi cu rezultatele biopsiei hepatice, pentru a indica faza infec\u0163iei cronice VHB. Recent, European Association for the Study of Liver (EASL) a modificat denumirea fazelor infec\u021biei VHB (vezi tabelul de mai jos)<sup>7<\/sup>:<\/p>\n<table class=\"wp-block-table w-100\" width=\"847\">\n<tbody>\n<tr>\n<td width=\"251\"><strong>Faza infec\u0163iei<\/strong><\/p>\n<p><strong>(denumire nou\u0103)<\/strong><\/td>\n<td width=\"123\"><strong>Faza infec\u0163iei (denumire anterioar\u0103)<\/strong><\/td>\n<td width=\"104\"><strong>Nivel AgHBs cantitativ<\/strong><\/td>\n<td width=\"132\"><strong>Nivelul plasmatic ADN-VHB (UI\/mL)<\/strong><\/td>\n<td width=\"113\"><strong>Nivelul ALT<\/strong><\/td>\n<td width=\"123\"><strong>Examen histopatologic<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"251\"><strong>Infec\u021bie VHB cronic\u0103 AgHBe (+)<\/strong><\/td>\n<td width=\"123\">Faza de toleran\u0163\u0103 imun\u0103<\/td>\n<td width=\"104\">\u0412\u044b\u0441\u043e\u043a\u0438\u0439<\/td>\n<td width=\"132\">&gt;10<sup>7<\/sup><\/td>\n<td width=\"113\">Normal<\/td>\n<td width=\"123\">Normal sau inflama\u0163ie minim\u0103<\/td>\n<\/tr>\n<tr>\n<td width=\"251\"><strong>Hepatit\u0103 B cronic\u0103 AgHBe (+)<\/strong><\/td>\n<td width=\"123\">Faza de activitate imun\u0103<\/td>\n<td width=\"104\">Crescut\/<\/p>\n<p>Intermediar<\/td>\n<td width=\"132\">10<sup>4<\/sup>\u00a0\u2013 10<sup>7<\/sup><\/td>\n<td width=\"113\">\u0412\u044b\u0441\u043e\u043a\u0438\u0439<\/td>\n<td width=\"123\">Inflama\u0163ie cronic\u0103 moderat\u0103\/sever\u0103<\/td>\n<\/tr>\n<tr>\n<td width=\"251\"><strong>Infec\u021bie VHB cronic\u0103 AgHBe (-)<\/strong><\/p>\n<p>*Anti-HBe (+)<\/td>\n<td width=\"123\">Purt\u0103tor inactiv de AgHBs<\/td>\n<td width=\"104\">\u041d\u0438\u0436\u0435 \u043d\u043e\u0440\u043c\u044b<\/td>\n<td width=\"132\">&lt;2000<\/td>\n<td width=\"113\">Normal<\/td>\n<td width=\"123\">Normal<\/td>\n<\/tr>\n<tr>\n<td width=\"251\"><strong>Hepatit\u0103 B cronic\u0103 AgHBe (-)<\/strong><\/p>\n<p>*Anti-HBe (+) de obicei<\/td>\n<td width=\"123\">Acea\u0219i denumire<\/td>\n<td width=\"104\">Intermediar<\/td>\n<td width=\"132\">&gt; 2000<\/td>\n<td width=\"113\">\u0412\u044b\u0441\u043e\u043a\u0438\u0439<\/td>\n<td width=\"123\">Inflama\u0163ie cronic\u0103 moderat\u0103\/sever\u0103<\/td>\n<\/tr>\n<tr>\n<td width=\"251\"><strong>Faza AgHBs (-) sau Infec\u021bie VHB ocult\u0103<\/strong><\/p>\n<p>*Anti-HBc (+) \u00b1<\/p>\n<p>Anti-HBs (+)<\/td>\n<td width=\"123\">-<\/td>\n<td width=\"104\">Nedetectabil sau valori \u2193\u2193\u2193<\/td>\n<td width=\"132\">Nedetectabil de obicei (este detectat \u00een hepatocite)<\/td>\n<td width=\"113\">Normal<\/td>\n<td width=\"123\">Variabil (\u00een func\u021bie de momentul \u00een care s-a produs dispari\u021bia AgHBs)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><u style=\"font-size: 16px;\"><span style=\"font-size: 16px;\"><br \/>\n\u2192 R\u0103spuns virusologic: ADN-VHB nedetectabil<\/span><br \/>\nTerapia cu analogi nucleozidici\/nucleotidici<\/u><span style=\"font-size: 16px;\">:<\/span>\u021ainta terapiei antivirale este supresia pe termen lung a ADN-VHB.Conform ghidului EASL, r\u0103spunsul virusologic este definit \u00een func\u021bie de tipul tratamentului antiviral:<\/p>\n<p>\u2192 R\u0103spuns virusologic par\u021bial: ADN-VHB \u00eenregistreaz\u0103 o sc\u0103dere &gt; 1 log<sub>10<\/sub> UI\/mL dar este \u00eenc\u0103 detectabil dup\u0103 12 luni de tratament (\u00een cazul unui pacient compliant)<\/p>\n<p>\u2192 Lipsa r\u0103spunsului primar: ADN-VHB \u00eenregistreaz\u0103 o sc\u0103dere &lt; 1 log<sub>10<\/sub> UI\/mL dup\u0103 3 luni de tratament<\/p>\n<p>\u2192 Reapari\u0163ia viremiei (\u201ebreakthrough\u201d): ADN-VHB \u00eenregistreaz\u0103 o cre\u0219tere &gt; 1 log<sub>10<\/sub> UI\/mL comparativ cu valoarea cea mai sc\u0103zut\u0103 a viremiei ob\u021binut\u0103 \u00een cursul tratamentului<\/p>\n<p><u>Terapia cu PegINF\u03b1<\/u>:<\/p>\n<p>\u2192 R\u0103spuns virusologic: ADN-VHB &lt; 2000 UI\/mL (evaluat la 6 \u0219i 12 luni)<sup>7<\/sup>.<\/p>\n<p><u>R\u0103spuns virusologic sus\u021binut f\u0103r\u0103 tratament<\/u>: ADN-VHB &lt; 2000 UI\/mL men\u021binut cel pu\u021bin 12 luni de la \u00eencheierea terapiei (cu analogi nucleozidici\/nucleotidici sau cu PegINF\u03b1).<\/p>\n<ul>\n<li>Pentru prevenirea infec\u021biei perinatale, la pacientele gravide cu infec\u021bie VHB \u0219i ADN-VHB &gt; 200 000 UI\/mL se recomand\u0103 ini\u021bierea tratamentului antiviral profilactic \u00een s\u0103pt\u0103m\u00e2nile 24-28 de sarcin\u0103 \u0219i continuarea acestuia \u00een primele 12 s\u0103pt\u0103m\u00e2ni dup\u0103 na\u0219tere<sup>7<\/sup>.<\/li>\n<\/ul>\n<p><strong><em>Limite \u015fi interferen\u0163e: <\/em><\/strong>Acest tip de test a fost validat doar pentru plasma recoltat\u0103 pe EDTA. Analiza altor tipuri de probe poate duce la rezultate fals pozitive sau fals negative. Heparina inhib\u0103 metoda PCR<sup>5<\/sup>.<\/p>\n<p><strong>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/p>\n<ol>\n<li>World Health Organization. Hepatitis B. WHO Fact Sheet (updated April 2017).<\/li>\n<li>Kramvis A. Genotypes and genetic variability of hepatitis B virus. Intervirology. 2014;57(3-4):141-50.<\/li>\n<li>Niederau C, Heintges T, Lange S, Goldmann G, Niederau CM, Mohr L, H\u00e4ussinger D. Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B. N Engl J<\/li>\n<\/ol>\n<p>Med. 1996 May 30;334(22):1422-7.<\/p>\n<ol start=\"4\">\n<li>Brown JL, Carman WF, Thomas HC. The clinical significance of molecular variation within the hepatitis B virus genome.<\/li>\n<li>Laborator Synevo. Referintele specifice tehnologiei de lucru utilizate 2017. Ref TypeCatalog.<\/li>\n<li>Mayo Clinic. Mayo Medical Laboratories. Hepatitis B Virus (HBV) DNA Detection and Quantification by Real-Time PCR, Serum. <a href=\"http:\/\/www.myomedicallaboratories.com\" rel=\"nofollow noopener\" target=\"_blank\">www.myomedicallaboratories.com<\/a> 2017.<\/li>\n<li>European Association for the Study of the Liver. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol. 2017 Apr 18. pii: S0168-8278(17)30185-X. doi:<\/li>\n<\/ol>\n<p>10.1016\/j.jhep.2017.03.021. [Epub ahead of print].<\/p>","protected":false},"excerpt":{"rendered":"<p>\u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0434\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0432\u043e\u0437\u0431\u0443\u0434\u0438\u0442\u0435\u043b\u044f \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 B (HBV), \u0432 \u0445\u043e\u0434\u0435 \u043a\u043e\u0442\u043e\u0440\u043e\u0433\u043e \u0441 \u043f\u043e\u043c\u043e\u0449\u044c\u044e \u043c\u0435\u0442\u043e\u0434\u0430 \u043f\u043e\u043b\u0438\u043c\u0435\u0440\u0430\u0437\u043d\u043e\u0439 \u0446\u0435\u043f\u043d\u043e\u0439 \u0440\u0435\u0430\u043a\u0446\u0438\u0438 \u0432 \u0440\u0435\u0430\u043b\u044c\u043d\u043e\u043c \u0432\u0440\u0435\u043c\u0435\u043d\u0438 (\u0420\u0422-\u041f\u0426\u0420) \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u0435\u0442\u0441\u044f \u043d\u0430\u043b\u0438\u0447\u0438\u0435 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430 (\u0414\u041d\u041a) \u0432\u0438\u0440\u0443\u0441\u0430 \u0438 \u0435\u0433\u043e \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e (\u0432\u0438\u0440\u0443\u0441\u043d\u0430\u044f \u043d\u0430\u0433\u0440\u0443\u0437\u043a\u0430) \u0432 \u043e\u0431\u0440\u0430\u0437\u0446\u0435 \u043a\u0440\u043e\u0432\u0438.<\/p>\n<p>\u0412\u0438\u0440\u0443\u0441\u043d\u044b\u0439 \u0433\u0435\u043f\u0430\u0442\u0438\u0442 \u0412 (\u0412\u0413\u0412) \u2013 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u043e\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435 \u043f\u0435\u0447\u0435\u043d\u0438, \u0432\u044b\u0437\u0432\u0430\u043d\u043d\u043e\u0435 \u0414\u041d\u041a-\u0441\u043e\u0434\u0435\u0440\u0436\u0430\u0449\u0438\u043c \u0432\u0438\u0440\u0443\u0441\u043e\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412 (HBV). \u0421\u0440\u0435\u0434\u0438 \u0432\u0441\u0435\u0445 \u043f\u0440\u0438\u0447\u0438\u043d \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u043e\u0441\u0442\u0440\u043e\u0433\u043e \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0439 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 \u0432\u0438\u0440\u0443\u0441 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412 \u0441\u0447\u0438\u0442\u0430\u0435\u0442\u0441\u044f \u043e\u0434\u043d\u043e\u0439 \u0438\u0437 \u0441\u0430\u043c\u044b\u0445 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u043d\u044b\u0445 \u0432 \u043c\u0438\u0440\u0435. \u0414\u0435\u0439\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e \u0438\u043d\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u043d\u0435\u0438\u0437\u0432\u0435\u0441\u0442\u043d\u043e, \u0442\u0430\u043a \u043a\u0430\u043a \u0443 \u043c\u043d\u043e\u0433\u0438\u0445 \u043b\u044e\u0434\u0435\u0439 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f \u043f\u0440\u043e\u0442\u0435\u043a\u0430\u0435\u0442 \u0431\u0435\u0437 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u0432 \u0438 \u0437\u0430 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u043f\u043e\u043c\u043e\u0449\u044c\u044e \u043e\u043d\u0438 \u043d\u0435 \u043e\u0431\u0440\u0430\u0449\u0430\u044e\u0442\u0441\u044f. \u041d\u0435\u0440\u0435\u0434\u043a\u043e \u0432\u0438\u0440\u0443\u0441 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u044e\u0442 \u043f\u0440\u0438 \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u0438\u0438 \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439.<\/p>\n<p>\u0418\u043d\u043a\u0443\u0431\u0430\u0446\u0438\u043e\u043d\u043d\u044b\u0439 \u043f\u0435\u0440\u0438\u043e\u0434 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u2013 \u043e\u0442 4 \u043d\u0435\u0434\u0435\u043b\u044c \u0434\u043e 6 \u043c\u0435\u0441\u044f\u0446\u0435\u0432. \u0412\u0438\u0440\u0443\u0441\u043d\u044b\u0439 \u0433\u0435\u043f\u0430\u0442\u0438\u0442 \u0412 \u043c\u043e\u0436\u0435\u0442 \u043f\u0440\u043e\u0442\u0435\u043a\u0430\u0442\u044c \u043a\u0430\u043a \u0432 \u0432\u0438\u0434\u0435 \u043b\u0435\u0433\u043a\u0438\u0445 \u0444\u043e\u0440\u043c, \u0434\u043b\u044f\u0449\u0438\u0445\u0441\u044f \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u043e \u043d\u0435\u0434\u0435\u043b\u044c, \u0442\u0430\u043a \u0438 \u0432 \u0432\u0438\u0434\u0435 \u043c\u043d\u043e\u0433\u043e\u043b\u0435\u0442\u043d\u0435\u0439 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438. \u041e\u0441\u043d\u043e\u0432\u043d\u044b\u0435 \u043f\u0440\u0438\u0437\u043d\u0430\u043a\u0438 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430: \u0436\u0435\u043b\u0442\u0443\u0448\u043d\u043e\u0441\u0442\u044c \u043a\u043e\u0436\u043d\u044b\u0445 \u043f\u043e\u043a\u0440\u043e\u0432\u043e\u0432, \u043b\u0438\u0445\u043e\u0440\u0430\u0434\u043a\u0430, \u0442\u043e\u0448\u043d\u043e\u0442\u0430, \u0443\u0442\u043e\u043c\u043b\u044f\u0435\u043c\u043e\u0441\u0442\u044c, \u0432 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0445 \u0430\u043d\u0430\u043b\u0438\u0437\u0430\u0445 \u2013 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u044b \u0432\u0438\u0440\u0443\u0441\u0430 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412. \u041e\u0441\u0442\u0440\u043e\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435 \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0441\u0442\u0440\u043e \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442\u044c \u043a \u043b\u0435\u0442\u0430\u043b\u044c\u043d\u043e\u043c\u0443 \u0438\u0441\u0445\u043e\u0434\u0443, \u043f\u0435\u0440\u0435\u0445\u043e\u0434\u0438\u0442\u044c \u0432 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0443\u044e \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044e \u0438\u043b\u0438 \u0437\u0430\u043a\u0430\u043d\u0447\u0438\u0432\u0430\u0442\u044c\u0441\u044f \u043f\u043e\u043b\u043d\u044b\u043c \u0432\u044b\u0437\u0434\u043e\u0440\u043e\u0432\u043b\u0435\u043d\u0438\u0435\u043c. \u0421\u0447\u0438\u0442\u0430\u0435\u0442\u0441\u044f, \u0447\u0442\u043e \u043f\u043e\u0441\u043b\u0435 \u043f\u0435\u0440\u0435\u043d\u0435\u0441\u0435\u043d\u043d\u043e\u0433\u043e \u0412\u0413\u0412 \u0444\u043e\u0440\u043c\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0441\u0442\u043e\u0439\u043a\u0438\u0439 \u0438\u043c\u043c\u0443\u043d\u0438\u0442\u0435\u0442. \u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0432\u0438\u0440\u0443\u0441\u043d\u044b\u0439 \u0433\u0435\u043f\u0430\u0442\u0438\u0442 \u0412 \u0441\u0432\u044f\u0437\u0430\u043d \u0441 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435\u043c \u0446\u0438\u0440\u0440\u043e\u0437\u0430 \u0438 \u0440\u0430\u043a\u0430 \u043f\u0435\u0447\u0435\u043d\u0438.<\/p>\n<p><strong>\u0414\u043b\u044f \u0447\u0435\u0433\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n<ul>\n<li>\u0414\u043b\u044f \u043f\u0440\u043e\u0433\u043d\u043e\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0442\u0435\u0447\u0435\u043d\u0438\u044f \u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0433\u043e \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412.<\/li>\n<li>\u0414\u043b\u044f \u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0436\u0434\u0435\u043d\u0438\u044f \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0444\u043e\u0440\u043c\u044b \u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0433\u043e \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412.<\/li>\n<li>\u0414\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u043d\u043e\u0441\u0438\u0442\u0435\u043b\u0435\u0439 \u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0433\u043e \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412 \u0438 \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0440\u0430\u0437\u043c\u043d\u043e\u0436\u0435\u043d\u0438\u044f \u0432\u0438\u0440\u0443\u0441\u0430.<\/li>\n<li>\u0414\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0441\u043a\u0440\u044b\u0442\u044b\u0445 \u0438 \u043c\u0443\u0442\u0430\u043d\u0442\u043d\u044b\u0445 \u0448\u0442\u0430\u043c\u043c\u043e\u0432 \u0432\u0438\u0440\u0443\u0441\u0430 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412.<\/li>\n<li>\u0414\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412 \u0438 \u043f\u0440\u0438\u043d\u044f\u0442\u0438\u044f \u0440\u0435\u0448\u0435\u043d\u0438\u044f \u043e \u0434\u0430\u043b\u044c\u043d\u0435\u0439\u0448\u0435\u0439 \u0442\u0430\u043a\u0442\u0438\u043a\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u044f.<\/li>\n<\/ul>\n<p><strong>\u041a\u043e\u0433\u0434\u0430 \u043d\u0430\u0437\u043d\u0430\u0447\u0430\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n<ul>\n<li>\u041f\u0440\u0438 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u043c \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u0438 \u0414\u041d\u041a \u0432\u0438\u0440\u0443\u0441\u0430 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412.<\/li>\n<li>\u041f\u0440\u0438 \u043e\u0441\u0442\u0440\u043e\u043c \u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0432\u0438\u0440\u0443\u0441\u043d\u043e\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0435 \u0412.<\/li>\n<li>\u041f\u0440\u0438 \u043c\u0438\u043a\u0441\u0442-\u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430\u0445.<\/li>\n<li>\u0414\u043e \u0438 \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438.<\/li>\n<\/ul>\n<p><strong>\u0427\u0442\u043e \u043e\u0437\u043d\u0430\u0447\u0430\u044e\u0442 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b?<\/strong><\/p>\n<p>\u0420\u0435\u0444\u0435\u0440\u0435\u043d\u0441\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f<\/p>\n<p>\u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442: \u043d\u0435 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u043e.<\/p>\n<p>\u041a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f: \u043e\u0442 &lt; 1.0*10^2 \u0434\u043e &gt; 1.0*10^8 \u041c\u0415\/\u043c\u043b.<\/p>\n<p>\u041e\u0442 100 \u041c\u0415 \u0434\u043e 10^8 ME \u0414\u041d\u041a \u0412\u0413\u0412 \u2013 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u0435\u0442\u0441\u044f \u043a\u0430\u043a \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u0441 \u0443\u043a\u0430\u0437\u0430\u043d\u0438\u0435\u043c \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u043d\u043e\u0439 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u0414\u041d\u041a \u0412\u0413\u0412 \u0432 \u043e\u0431\u0440\u0430\u0437\u0446\u0435 (\u0432 \u041c\u0415\/\u043c\u043b).<\/p>\n<p>\u0411\u043e\u043b\u044c\u0448\u0435 10^8 \u041c\u0415 &#8211; \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0443\u0435\u0442\u0441\u044f \u0438\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u043a\u0430\u043a \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u0441 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0435\u0439 \u0414\u041d\u041a \u0412\u0413\u0412 &#8220;\u0431\u043e\u043b\u044c\u0448\u0435 10^8 \u041c\u0415\/ \u0432 \u043e\u0431\u044a\u0451\u043c\u0435 \u0432\u044b\u0434\u0435\u043b\u044f\u0435\u043c\u043e\u0439 \u043f\u0440\u043e\u0431\u044b.<\/p>\n<p>\u041c\u0435\u043d\u044c\u0448\u0435 100 \u041c\u0415 &#8211; \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0443\u0435\u0442\u0441\u044f \u0438\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u043a\u0430\u043a \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u0441 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0435\u0439 \u0414\u041d\u041a \u0412\u0413\u0412 &#8220;\u043c\u0435\u043d\u044c\u0448\u0435 100 \u041c\u0415 \u0432 \u043e\u0431\u044a\u0451\u043c\u0435 \u0432\u044b\u0434\u0435\u043b\u044f\u0435\u043c\u043e\u0439 \u043f\u0440\u043e\u0431\u044b&#8221;.<\/p>\n<p>\u0414\u0438\u0430\u043f\u0430\u0437\u043e\u043d \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u0435\u043c\u044b\u0445 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0439 \u2013 \u043e\u0442 100 \u0434\u043e 10^8 \u041c\u0415 \u0420\u041d\u041a \u0412\u0413\u0412.<\/p>\n<p><strong>\u0412\u0430\u0436\u043d\u044b\u0435 \u0437\u0430\u043c\u0435\u0447\u0430\u043d\u0438\u044f<\/strong><\/p>\n<p>\u041a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0435 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0414\u041d\u041a \u0432\u0438\u0440\u0443\u0441\u0430 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043e\u0431\u044f\u0437\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u043c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u0434\u043e \u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438. \u0412\u043e \u0432\u0440\u0435\u043c\u044f \u043a\u0443\u0440\u0441\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0430\u043d\u0430\u043b\u0438\u0437 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e \u043f\u043e\u0432\u0442\u043e\u0440\u0438\u0442\u044c \u0447\u0435\u0440\u0435\u0437 3-6 \u043c\u0435\u0441\u044f\u0446\u0435\u0432. \u0412\u0438\u0440\u0443\u0441\u043d\u044b\u0439 \u0433\u0435\u043f\u0430\u0442\u0438\u0442 \u0412 \u043d\u0435\u0440\u0435\u0434\u043a\u043e \u0441\u043e\u0447\u0435\u0442\u0430\u0435\u0442\u0441\u044f \u0441 \u0432\u0438\u0440\u0443\u0441\u043d\u044b\u043c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c D.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[968,971],"product_tag":[],"class_list":{"0":"post-9117","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-de-biologie-moleculara","6":"product_cat-teste-moleculare-pentru-diagnosticul-infectiilor","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9117","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9117"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9117"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9117"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9117"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9117"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}