{"id":9111,"date":"2020-04-23T04:28:24","date_gmt":"2020-04-23T01:28:24","guid":{"rendered":"https:\/\/www.synevo.ro\/product\/17-hidroxiprogesteron\/"},"modified":"2025-07-01T07:57:28","modified_gmt":"2025-07-01T04:57:28","slug":"17-hidroxiprogesteron","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/17-hidroxiprogesteron\/","title":{"rendered":"17-\u0433\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u043f\u0440\u043e\u0433\u0435\u0441\u0442\u0435\u0440\u043e\u043d"},"content":{"rendered":"

\u041e\u0431\u0449\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/em><\/strong><\/span><\/p>\n

ACTH (corticotropina) stimuleaz\u0103 sinteza \u015fi secre\u0163ia suprarenalian\u0103 de hormoni glucocorticoizi, mineralocorticoizi \u015fi androgeni. Sinteza\u00a0 celor 3 tipuri de hormoni\u00a0 porne\u015fte de la un precursor comun (pregnenolon). 17-hidroxiprogesteron reprezint\u0103 substratul pentru procesele de hidroxilare \u00een pozi\u0163iile 21 \u015fi 11 \u00een etapa de sintez\u0103 a cortizolului, un rol critic av\u00e2ndu-l enzimele 21-hidroxilaza \u015fi 11-beta-hidroxilaza. Dac\u0103 hidroxilarea nu poate avea loc datorit\u0103 unui deficit enzimatic, sinteza cortizolului se reduce foarte mult, fiind \u00eenso\u0163it\u0103 de cre\u015fterea ACTH1<\/sup>.<\/p>\n

Hiperplazia adrenal\u0103 congenital\u0103 sau sindromul adrenogenital include un grup de afec\u0163iuni caracterizate printr-o anomalie ereditar\u0103 \u00een sinteza cortizolului, transmis\u0103 autozomal recesiv, asociat\u0103 de obicei cu o cre\u015ftere a produc\u0163iei de androgeni. Cea mai frecvent\u0103 cauz\u0103 de sindrom adrenogenital (prezent\u0103 \u00een 95% din cazuri) este deficitul de 21-hidroxilaz\u0103. Datorit\u0103 perturb\u0103rii sintezei cortizolului, metabolismul steroizilor este redirec\u0163ionat c\u0103tre sinteza de androgeni; clinic apar semne de virilizare la nou-n\u0103scutul de sex feminin (hermafroditism) \u015fi pubertate precoce izosexual\u0103 la b\u0103ie\u0163i. Adeseori se asociaz\u0103 \u015fi deficitul de aldosteron. \u00cen peste 50% din cazuri debutul formei homozigote a bolii se \u00eenregistreaz\u0103 \u00een primele 3 s\u0103pt\u0103m\u00e2ni de via\u0163\u0103. Deficitul de 21-hidroxilaz\u0103 determin\u0103 acumularea de 17-hidroxiprogesteron, care \u00een mod normal este metabolizat, sub ac\u0163iunea acestei enzime, \u00een 11-deoxicortizol. Este posibil \u015fi un diagnostic prenatal al fe\u0163ilor afecta\u0163i, prin detectarea unor concentra\u0163ii crescute de 17-hidroxiprogesteron \u00een lichidul amniotic, \u00een s\u0103pt\u0103m\u00e2nile 14-16 de sarcin\u0103.<\/p>\n

Pe l\u00e2ng\u0103 sindromul adrenogenital clasic, mai exist\u0103 deficitul de 21-hidroxilaz\u0103 cu debut tardiv \u015fi forma heterozigot\u0103 de hiperplazie adrenal\u0103, care se manifest\u0103 clinic \u00een perioada peripubertar\u0103 sub form\u0103 de tulbur\u0103ri menstruale \u015fi hirsutism sau direct la adult sub form\u0103 de hirsutism. \u00cen aceste cazuri, nivelul bazal de 17-hidroxiprogesteron poate fi normal sau u\u015for crescut, de aceea se va efectua un test de stimulare cu ACTH. La 60 minute dup\u0103 administrarea de 0.25 mg de ACTH se \u00eenregistreaz\u0103 o cre\u015ftere de peste 10 ng\/mL2<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea 17-hidroxiprogesteronului <\/em><\/strong>\u2013 diagnosticul deficitului de 21-hidroxilaz\u0103; evaluarea hirsutismului \u015fi\/sau infertilit\u0103\u0163ii; evaluarea anumitor tumori suprarenaliene sau ovariene cu activitate endocrin\u01031<\/sup>.<\/p>\n

Preg\u0103tire pacient <\/em><\/strong>- <\/em>datorit\u0103 unor fluctua\u0163ii diurne importante \u015fi dependen\u0163ei de etapele ciclulului menstrual, se recomand\u0103 ca recoltarea s\u0103 se fac\u0103 diminea\u0163a \u015fi \u00een faza folicular\u01031<\/sup>.<\/p>\n

Specimen recoltat <\/em><\/strong>- <\/em>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c3<\/sup>.<\/p>\n

Recipient de recoltare <\/em><\/strong>- <\/em>vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator3<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>- <\/em>se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul proasp\u0103t; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C sau la -20\u00b0C3<\/sup>.<\/p>\n

Volum prob\u0103 <\/em><\/strong>\u2013 minim 0.5 mL ser3<\/sup>.<\/p>\n

Cauze de respingere a probei<\/em><\/strong> \u2013 specimen hemolizat, intens lipemic sau cu particule \u00een suspensie3<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/em><\/strong>\u2013\u00a07 zile\u00a0<\/em>\u00a0la 2-8\u00b0C; 1 lun\u0103 <\/em>la -20\u00b0C; nu decongela\u0163i\/recongela\u0163i1;3<\/sup>.<\/p>\n

Metod\u0103 <\/em><\/strong>- ELISA<\/u>3<\/sup>.<\/p>\n

Interval\u00a0de referin\u0163\u0103 <\/em><\/strong>-\u00a0<\/em>este dependent de v\u00e2rsta \u015fi sex3<\/sup>:<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
V\u00e2rst\u0103 \u015fi sex<\/strong><\/td>\nValori de referin\u0163\u0103<\/strong><\/td>\n<\/tr>\n
(ng\/mL)<\/strong><\/td>\n<\/tr>\n
Fete >13 ani \u0219i Femei perioada fertil\u0103:<\/strong><\/td>\n<\/td>\n<\/tr>\n
\u2013 faza folicular\u0103<\/td>\n0.44 \u2013 1.6<\/td>\n<\/tr>\n
\u2013 faza ovulatorie<\/td>\n0.49 \u2013 2.32<\/td>\n<\/tr>\n
\u2013 faza luteal\u0103<\/td>\n0.9 \u2013 4.06<\/td>\n<\/tr>\n
\u2013 menopauz\u0103<\/td>\n0.17-0.83<\/td>\n<\/tr>\n
B\u0103rba\u0163i:<\/strong><\/td>\n0.24 \u2013 2.24<\/td>\n<\/tr>\n
B\u0103ie\u021bi 13-18 ani:
\n<\/strong><\/td>\n		0.42 – 2.24<\/td>\n<\/tr>\n
Copii:<\/strong><\/td>\n<\/td>\n<\/tr>\n
\u00a0< 30 zile:<\/td>\n1-16.97<\/td>\n<\/tr>\n
31 – 60 zile:<\/td>\n1.63 – 9.76<\/td>\n<\/tr>\n
61 – 90 zile:<\/td>\n0.5 – 4.09<\/td>\n<\/tr>\n
91 – 120 zile:<\/td>\n0.2 – 4.32<\/td>\n<\/tr>\n
1 – 12 ani:<\/td>\n0.08 – 1.93<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Dup\u0103 stimulare cu ACTH: < 3.2 ng\/mL<\/p>\n

Factor de conversie:\u00a0 ng\/mL x 3.026 = nmol\/L.<\/em><\/p>\n

Limita de detec\u0163ie<\/em><\/strong> \u2013 0.034 ng\/mL3<\/sup>.<\/p>\n

Limite \u015fi interferen\u0163e<\/em><\/strong><\/p>\n

Rezultate fals pozitive pot fi ob\u0163inute \u00een cazul unor probe recoltate \u00een primele 2 zile de via\u0163\u0103 (concentra\u0163ii crescute fiziologic) sau la prematuri\/dismaturi (cre\u015fteri induse de stres)2<\/sup>.<\/p>\n

\u00a0<\/span><\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

1. Laboratory Corporation of America. Directory of Services and Interpretive Guide. 17-OH Progesterone LC\/MS. www.labcorp.com<\/a> 2017.\u00a0 Ref Type: Internet Communication.<\/span><\/div>\n
2. <\/span>Lothar Thomas. Hypothalamic-pituitary-adrenal system. In Clinical Laboratory Diagnostics<\/em>, TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998, 1066-1070<\/span><\/div>\n
3. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2017. Ref Type: Catalog<\/span><\/div>","protected":false},"excerpt":{"rendered":"

Informa\u0163ii generale ACTH (corticotropina) stimuleaz\u0103 sinteza \u015fi secre\u0163ia suprarenalian\u0103 de hormoni glucocorticoizi, mineralocorticoizi \u015fi androgeni. Sinteza\u00a0 celor 3 tipuri de hormoni\u00a0 porne\u015fte de la un precursor comun (pregnenolon). 17-hidroxiprogesteron reprezint\u0103 substratul pentru procesele de hidroxilare \u00een pozi\u0163iile 21 \u015fi 11 \u00een etapa de sintez\u0103 a cortizolului, un rol critic av\u00e2ndu-l enzimele 21-hidroxilaza \u015fi 11-beta-hidroxilaza. Dac\u0103 … Continued<\/a><\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[911,917],"product_tag":[],"class_list":{"0":"post-9111","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-endocrini","6":"product_cat-markeri-suprarenalieni","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/9111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=9111"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=9111"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=9111"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=9111"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=9111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}