{"id":83515,"date":"2026-03-05T09:57:50","date_gmt":"2026-03-05T07:57:50","guid":{"rendered":"https:\/\/synevo.md\/?post_type=product&p=83515"},"modified":"2026-03-05T09:57:51","modified_gmt":"2026-03-05T07:57:51","slug":"bordetella-pertussis-serologie-iga-igg-2","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/bordetella-pertussis-serologie-iga-igg-2\/","title":{"rendered":"Bordetella pertussis – serologie (IgA, IgG)"},"content":{"rendered":"

Informa\u0163ii generale Bordetella pertussis – serologie (IgA, IgG)<\/strong><\/span><\/h2>\n

Bordetella pertussis este un cocobacil Gram negativ, \u00eencapsulat, aerob, patogen strict uman, care determin\u0103 apari\u0163ia tusei convulsive. Se transmite direct, aerogen \u00een perioada cataral\u0103 \u015fi convulsiv\u0103 a bolii.<\/span><\/p>\n

Boala este larg r\u0103sp\u00e2ndit\u0103 pe Glob, av\u00e2nd un caracter epidemic, ciclic (la 2-5 ani), cu inciden\u0163\u0103 crescut\u0103 toamna \u015fi iarna \u00een zonele temperate.<\/span><\/p>\n

Dup\u0103 o perioad\u0103 de incuba\u0163ie ce variaz\u0103 \u00eentre 6 \u015fi 20 zile (medie de 7 zile), evolu\u0163ia bolii se \u00eemparte \u00een 3 etape: cataral\u0103 convulsiv\u0103 (paroxistica) \u015fi convalescen\u0163a, fiecare cu durata de aproximativ 1\u20132 s\u0103pt\u0103m\u00e2ni.<\/span><\/p>\n

Stadiul ini\u0163ial (faza cataral\u0103) este imposibil de distins de infec\u0163iile comune ale c\u0103ilor respiratorii superioare \u015fi se caracterizeaz\u0103 prin congestie nazal\u0103, rinoree, str\u0103nut, lacrimare, sufuziuni conjunctivale \u015fi variabil febr\u0103. Tusea este la \u00eenceput uscat\u0103, apoi devine frecvent\u0103, spasmodic\u0103, cu accentu\u0103ri nocturne. Aceast\u0103 etap\u0103 trece de obicei nediagnosticat\u0103.<\/span><\/p>\n

Stadiul convulsiv este dominat de accesele de tuse specifice bolii, care pot varia \u00eentre 10 \u015fi 30 \u00een decursul unei zile \u015fi au o durat\u0103 de maxim 2-4 minute. Tusea este urmat\u0103 de cele mai multe ori de v\u0103rs\u0103tur\u0103.<\/span><\/p>\n

La copiii mai mici de 6 luni boala este mai grav\u0103, nu prezint\u0103 accesele specifice de tuse, dar pot prezenta episoade de apnee prelungit\u0103, cianoz\u0103 \u015fi convulsii.<\/span><\/p>\n

Stadiul de convalescen\u0163\u0103 se caracterizeaz\u0103 prin r\u0103rirea acceselor de tuse cu sc\u0103derea lor \u00een intensitate, \u00eens\u0103 uneori o tuse moderat\u0103 poate persista \u015fi c\u00e2teva luni.<\/span><\/p>\n

Cele mai frecvente complica\u0163ii ale bolii apar la nivelul aparatului respirator \u015fi includ: pneumonii, bronsiectazii, atelectazii, pleurezii, dar pot ap\u0103rea \u015fi manifest\u0103ri neurologice (convulsii, encefalit\u0103, surditate sau cecitate), complicat\u0163i mecanice (hernie \u00eenghinal\u0103, pneumotorax, prolaps rectal, emfizem mediastinal) sau hemoragice (melena, petesii, hematoame epidurale, hemoragii subconjunctivale).<\/span><\/p>\n

Imunitatea ap\u0103rut\u0103 dup\u0103 boal\u0103 este durabil\u0103, rar put\u00e2nd surveni re\u00eemboln\u0103virea, \u00eens\u0103 imunitatea dup\u0103 vaccinare este temporar\u0103 \u015fi dup\u0103 5-10 ani apare riscul de \u00eemboln\u0103vire. Adul\u0163ii tineri \u015fi adolescen\u0163ii prezint\u0103 forme u\u015foare, atipice de boal\u0103, cu manifest\u0103ri nespecifice de infec\u0163ie de tract respirator.<\/span><\/p>\n

Diagnosticul pozitiv al infec\u0163iei cu Bordetella pertussis se stabile\u015fte pe baza datelor epidemiologice, clinice \u015fi examenelor de laborator1;2<\/sup>.<\/span><\/p>\n

Recomand\u0103ri pentru determinarea anticorpilor anti-Bordetella pertussis<\/strong><\/span><\/h2>\n

Stabilirea diagnosticului precoce de infec\u0163ie cu Bordetella pertussis, agentul cauzator al tusei convulsive<\/a>\u00a04;5<\/sup>.<\/span><\/p>\n

Preg\u0103tire pacient <\/strong><\/span><\/h2>\n

Preferabil \u00e0 jeun (pe nem\u00e2ncate)3<\/sup>.\u00a0\u00a0\u00a0\u00a0<\/span><\/p>\n

Specimen recoltat <\/strong>\u2013 s\u00e2nge venos3<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/strong>\u2013 vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator3<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/strong>\u2013 se separ\u0103 serul prin centrifugare3<\/sup>.<\/span><\/p>\n

Volum prob\u0103 <\/strong>\u2013 minim 2 mL ser3<\/sup>.<\/span><\/p>\n

Cauze de respingere a probei <\/strong>\u2013 specimen intens hemolizat, hemolitic sau contaminat bacterian2<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103 <\/strong>\u2013 2 s\u0103pt\u0103m\u00e2ni la 2-8\u00b0C; timp \u00eendelungat la \u201320\u00b0C; evita\u0163i decongelarea\/recongelarea repetat\u01033<\/sup>.<\/span><\/p>\n

Metod\u0103 <\/b>- CLIA<\/u><\/span><\/p>\n

Valori de referin\u0163\u0103<\/b> Bordetella pertussis – serologie (IgA, IgG)<\/strong><\/span><\/h2>\n

Rezultatele se exprim\u0103 cantitativ:<\/span><\/p>\n