{"id":67390,"date":"2025-01-31T10:13:37","date_gmt":"2025-01-31T08:13:37","guid":{"rendered":"https:\/\/www.synevo.md\/?post_type=product&p=67390"},"modified":"2025-07-01T07:56:22","modified_gmt":"2025-07-01T04:56:22","slug":"testare-genetica-boala-renala-polichistica","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/testare-genetica-boala-renala-polichistica\/","title":{"rendered":"Testare genetica \u2013 boala renala polichistica"},"content":{"rendered":"

Boala polichistic\u0103 renala este o afec\u021biune ereditar\u0103 caracterizat\u0103 prin dezvoltarea unor\u00a0 formatiuni lichidiene de dimensiuni variabile (chisturi) ce pot duce la m\u0103rirea volumului rinichilor. \u00cen timp, aceasta acumulare de chisturi poate perturba func\u021bionarea normal\u0103 a rinichilor, prin deteriorarea \u021besutul renal, duc\u00e2nd astfel la insuficien\u021b\u0103 renal\u0103.<\/p>\n

Boala polichistic\u0103 renal\u0103 poate fi clasificat\u0103 \u00een dou\u0103 forme, pe baza tiparelor de mo\u0219tenire ereditar\u0103: boala polichistic\u0103 renal\u0103 autosomal dominant\u0103 \u0219i boala polichistic\u0103 renal\u0103 autosomal recesiv\u0103.<\/p>\n

Boala renal\u0103 polichistic\u0103 autosomal dominant\u0103<\/strong> (ADPKD, Autosomal dominant polycystic kidney disease) este cea mai frecvent\u0103 form\u0103 si este o boal\u0103 multisistemic\u0103 \u0219i progresiv\u0103, cu dezvoltare de chisturi renale bilaterale, \u00een zona nefronilor \u0219i a tubilor colectori renali, asociat cu m\u0103rirea de volum a rinichilor \u0219i cu afectarea altor organe, cum ar fi cordul, ficatul, pancreasul, splina sau chiar membrana arahnoida medulo-meningeala.<\/p>\n

Cauzele genetice ale ADPKD sunt \u00een principal determinate de variante patogene \u00een genele PKD1 (78% din cazuri) \u0219i PKD2 (15% din cazuri), si in cazuri mai rare, in genele GANAB (aproximativ 0,3%) \u0219i DNAJB11 (aproximativ 1,2%), asociate unei forme u\u0219oare de ADPKD. Variantele patogene \u00een gena HNF1B pot provoca, de asemenea, un fenotip asem\u0103n\u0103tor ADPKD.<\/p>\n

La purt\u0103torii cu variante patogene \u00een gena PKD1, ADPKD se manifest\u0103 mai devreme, iar insuficien\u021ba renal\u0103 apare, \u00een medie, cu 20 de ani mai devreme, comparativ cu purt\u0103torii de variante patogene \u00een gena PKD2. Variantele genei PKD1 care nu conduc la sinteza unei forme de protein\u0103 trunchiat\u0103, prezint\u0103 o evolu\u021bie clinic\u0103 mult mai usoar\u0103 dec\u00e2t variantele PKD1 care duc la sinteza acestui tip de proteina patologic\u0103.<\/p>\n

\u00cen unele cazuri cu debut foarte precoce al bolii (mai pu\u021bin de 1% din familiile afectate), a fost raportat\u0103 mo\u0219tenirea bialelic\u0103, de exemplu, mo\u0219tenirea unei variante PKD1 familiale \u00een trans cu o a doua variant\u0103 PKD1 cu penetran\u021b\u0103 semnificativ redus\u0103. Pacien\u021bii care poart\u0103 numai alela cu penetran\u021b\u0103 redus\u0103, sunt pu\u021bin susceptibili de a dezvolta insuficien\u021b\u0103 renal\u0103, si vor prezenta un num\u0103r mic de chisturi la v\u00e2rsta adult\u0103.<\/p>\n

Mai putin frecvent, a fost descris\u0103 o mo\u0219tenire digenic\u0103 a mutatiilor PKD1 \u0219i PKD2 sau PKD1 \u0219i HNF1B, care conduce, de asemenea, la o forma de boal\u0103 mai sever\u0103.<\/p>\n

\u00cen prezent, un procent de 7% p\u00e2n\u0103 la 10% dintre cazurile aparute in familiile afectate de ADPKD r\u0103m\u00e2n fara o explicatie, din punct de vedere al etiologiei genetice. P\u00e2n\u0103 la 25% dintre pacien\u021bi nu au antecedente familiale pozitive, iar aproximativ 15-20% din cazuri sunt explicate prin apari\u021bia unor variante de novo.<\/p>\n

Boala polichistic\u0103 renal\u0103 autosomal recesiv\u0103<\/strong> (ARPKD, Autosomal recessive polycystic kidney disease) este o form\u0103 rar\u0103 de boal\u0103 polichistic\u0103 renal\u0103 care, \u00een principal, \u00eesi are originea la nivelul canalelor colectoare renale. Aceasta apare la aproximativ 1:20.000 dintre copii n\u0103scu\u021bi vii.<\/p>\n

Fenotipul clasic al ARPKD se caracterizeaz\u0103 printr-un debut precoce al bolii, cu m\u0103rirea bilateral\u0103 a rinichilor \u0219i afectarea func\u021biei renale, fibroz\u0103 hepatic\u0103<\/a> congenital\u0103 cu dezvoltarea hipertensiunii portale \u0219i dilatarea c\u0103ilor biliare, cu riscul de colangit\u0103 ascendent\u0103. La aproximativ 15-37% dintre pacien\u021bii cu ARPKD descris\u0103, sunt detectate varice gastrointestinale.<\/p>\n

ARPKD se observ\u0103 de obicei in utero<\/em> sau la na\u0219tere \u0219i, \u00een cazurile cele mai severe, include sindrom Potter, niveluri sc\u0103zute ale lichidului amniotic, hipoplazie pulmonar\u0103 \u0219i rinichi ecogeni m\u0103ri\u021bi bilateral. \u00cen timp ce afectarea rinichilor apare de obicei devreme \u00een copil\u0103rie, afectarea hepatic\u0103 tinde s\u0103 apar\u0103 mai t\u00e2rziu.<\/p>\n

ARPKD este \u00een general asociat\u0103 cu o speran\u021b\u0103 de via\u021b\u0103 redus\u0103. O rat\u0103 de mortalitate de 30-40% a fost descris\u0103 \u00een cazurile neonatale cu dificult\u0103\u021bi respiratorii, iar aproximativ 50% dintre pacien\u021bii care supravie\u021buiesc perioadei neonatale vor dezvolta insuficien\u021b\u0103 renal\u0103 terminal\u0103, \u00een primul deceniu de via\u021b\u0103. \u00cen ciuda prezent\u0103rii neonatale clasice a ARPKD, exist\u0103 o variabilitate semnificativ\u0103 \u00een ceea ce prive\u0219te v\u00e2rsta de debut \u0219i simptomele clinice, inclusiv \u00een cadrul aceleia\u0219i familii.<\/p>\n

Cea mai frecvent\u0103 cauz\u0103 molecular\u0103 este reprezentat\u0103 de variantele patogene ale genei PKHD1, cu o frecven\u021b\u0103 a heterozigo\u021bilor de aproximativ 1:70, \u00een popula\u021bia caucazian\u0103.<\/p>\n

\u00cen 13-20% din cazuri, secven\u021bierea nu identific\u0103 nicio variant\u0103 cauzal\u0103 PKHD1, iar\u00a0 dele\u021biile sau duplic\u0103rile genomice sunt rareori detectate. \u00cen cazuri rare, pot fi descoperite modific\u0103ri \u00een gena DZIP1L. Variante \u00een numeroase alte gene, adesea din grupul ciliopatiilor, pot genera un genotip asem\u0103n\u0103tor ARPKD. \u00cen plus, exist\u0103 forme cu manifestare foarte timpurie de PKD autosomal dominant\u0103 sau de nefropatii asociate cu HNF1B care sunt cunoscute sub denumirea de \u201efenocopii\u201d (boli de alte cauze genetice moleculare, cu fenotip similar).<\/p>\n

Recomand\u0103ri de testare Testare genetic\u0103 \u2013 Boala renal\u0103 polichistic\u0103<\/strong><\/h2>\n
    \n
  • istoric familial de boala renala polichistica<\/li>\n
  • chisturi renale de cauza necunoscuta;<\/li>\n
  • la pacientii pediatrici care prezint\u0103 semne de boala renala polichistica;<\/li>\n
  • suport in planificarea \u00eengrijirii unei persoane cu boala renala polichistica;<\/li>\n
  • la pacientii diagnosticati cu boala renala polichistica (sau membrii familiilor acestora)<\/li>\n
  • persoanelor diagnosticate cu boala renala polichistica care isi doresc s\u0103 doneze un rinichi;<\/li>\n<\/ul>\n

    Preg\u0103tire pacient<\/strong><\/h2>\n

    nu este necesar\u0103.<\/p>\n

    Specimen recoltat<\/strong> \u2013 s\u00e2nge venos.<\/p>\n

    Recipient de recoltare<\/strong> \u2013 vacutainer ce con\u021bine EDTA.<\/p>\n

    Cauze de respingere a probei<\/strong> \u2013 folosirea heparinei ca anticoagulant; probe coagulate sau hemolizate; volum insuficient; contaminarea probei<\/p>\n

    Stabilitate prob\u0103<\/strong> \u2013 7 zile la 2-8\u00baC<\/p>\n

    Metoda<\/strong> \u2013 NGS. Este evaluat un panel de gene asociate bolii renale polichistice: DNAJB11, GANAB, HNF1B, PKD1, PKD2, DZIP1L, PKHD1, pentru identificarea variantelor nucleotidice, variantelor indel mai mici de 21 perechi de baze si variatii ale numarului de copii (CNV) cu dimensiunea minima de 1 exon. Sunt, de asemenea, identificate modific\u0103rile unei singure perechi de baze, micile dele\u021bii sau duplica\u021bii \u0219i varia\u021biile num\u0103rului de copii (CNV). Clasificarea variantelor se realizeaz\u0103 \u00een conformitate cu ghidurile ACMG\/ACGS actuale.<\/p>\n

    Interpretarea rezultatelor<\/strong><\/h2>\n

    In urma evalu\u0103rii si clasific\u0103rii, dac\u0103 sunt detectate, vor raportate exclusiv variantele cu semnificatie clinica patogen\u0103, potential patogen\u0103 sau incert\u0103, respectiv clasele 5 (P-Pathogenic), 4 (LP-Likely Pathogenic) sau 3 (VUS-Variant of Uncertain\/ Unknown Significance).<\/p>\n

      \n
    • Rezultat pozitiv<\/strong>: Sunt raportate si descrise variantele identificate din clasele de patogenitate 5 sau 4 care sunt asociate bolii polichistice renale.<\/li>\n
    • Rezultat negativ<\/strong>: Nu a fost identificata nicio varianta raportabila care sa se coreleze cu boala renala polichistica asociata. Este probabil ca pacientul sa nu fie afectat de boala renala polichistica, dar o cauza genetica nu poate fi exclusa cu certitudine prin acest test.<\/li>\n
    • Rezultat neconcludent<\/strong>: A fost identificata o varianta de tip VUS, aceasta insemnand ca dovezile din literatura actuala de specialitate sunt insuficiente sau contradictorii, pentru a incadra mutatia intr-o clasa de patogenitate sau benignitate. Acest tip de variante sunt neactionabile si neinformative, dar sunt raportate in vederea reevaluarii periodice a semnificatiei clinice, fiind probabila o reclasificare la 12 luni \u00een baza unor viitoare noi eviden\u021be, generate de literatura de specialitate.<\/li>\n<\/ul>\n

      Limit\u0103ri \u0219i interferen\u021be<\/strong><\/p>\n

      Testul permite analiza exclusiv\u0103 a genelor incluse in panel.<\/p>\n

      Metoda nu permite identificarea variantelor structurale (translocatii, inversii) la nivelul genelor din panel.<\/p>\n

      Tehnologia utilizata nu permite detectia variantelor indel cu dimensiuni cuprinse intre 21 perechi de baze si 1 exon.<\/p>\n

      \u00a0<\/strong><\/p>\n

      \u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/h2>\n
        \n
      • Cornec-Le Gall et al. 2019, Lancet 393:919 \/ Gimpel et al. 2019, Nat Rev Nephrol doi:10.1038\/s41581-019-0155-2 \/ Douguet et al. 2019, Nat Rev Nephrol 15:412 \/ Cornec-Le Gall et al. 2018, J Am Soc Nephrol 29:13 \/ Haumann et al. 2018, medgen 30:4225 \/ Cornec-Le Gall et al. 2018, Am J Hum Genet 102:832 \/ Willey et al. 2016, Nephrol Dial Transplant 0:1 \/ K\u00fchn et al. 2015, Dtsch Arztebl Int 112:884 \/ Consugar et al. 2008, Kidney Int 74:1468 \/ Phakdeekitcharoen et al. 2001, J Am Soc Nephrol 12: 955<\/li>\n
      • Mahboob M, Rout P, Leslie SW, et al. Autosomal Dominant Polycystic Kidney Disease. [Updated 2024 Mar 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.<\/li>\n
      • Subramanian S, Leslie SW, Ahmad T. Autosomal Recessive Polycystic Kidney Disease. [Updated 2024 Mar 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.<\/li>\n
      • Brugmaier et al. 2019, Sci Rep 9:7919 \/ Szabo\u0301 et al. 2018, Pediatr Nephrol 33:1713 \/ Haumann et al. 2018, medgen 30:422 \/ Melchionda et al. 2016, J Hum Genet 61:811 \/ Zvereff et al. 2010, Genet Test Mol Biomarkers 14:505 \/ Gunay-Aygun et al. 2010, Clin J Am Soc Nephrol 5:972 \/ Michel-Calemard et al. 2009, Clin Genet 75:203 \/ Harris and Torres 2009, Annu Rev Med 60:321<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"

        \u041f\u043e\u043b\u0438\u043a\u0438\u0441\u0442\u043e\u0437 \u043f\u043e\u0447\u0435\u043a \u2014 \u044d\u0442\u043e \u043d\u0430\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435, \u043f\u0440\u0438 \u043a\u043e\u0442\u043e\u0440\u043e\u043c \u0432 \u043f\u043e\u0447\u043a\u0430\u0445 \u043e\u0431\u0440\u0430\u0437\u0443\u044e\u0442\u0441\u044f \u043a\u0438\u0441\u0442\u044b, \u0447\u0442\u043e \u043c\u043e\u0436\u0435\u0442 \u043f\u0440\u0438\u0432\u0435\u0441\u0442\u0438 \u043a \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u044e \u0438\u0445 \u043e\u0431\u044a\u0435\u043c\u0430 \u0438 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044e \u0444\u0443\u043d\u043a\u0446\u0438\u0438. \u0411\u043e\u043b\u0435\u0437\u043d\u044c \u0431\u044b\u0432\u0430\u0435\u0442 \u0434\u0432\u0443\u0445 \u0444\u043e\u0440\u043c: \u0430\u0443\u0442\u043e\u0441\u043e\u043c\u043d\u043e-\u0434\u043e\u043c\u0438\u043d\u0430\u043d\u0442\u043d\u043e\u0439 \u0438 \u0430\u0443\u0442\u043e\u0441\u043e\u043c\u043d\u043e-\u0440\u0435\u0446\u0435\u0441\u0441\u0438\u0432\u043d\u043e\u0439.<\/strong><\/p>\n

        \u0410\u0443\u0442\u043e\u0441\u043e\u043c\u043d\u043e-\u0434\u043e\u043c\u0438\u043d\u0430\u043d\u0442\u043d\u0430\u044f \u043f\u043e\u0447\u0435\u0447\u043d\u0430\u044f \u043f\u043e\u043b\u0438\u043a\u0438\u0441\u0442\u043e\u0437\u043d\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c (\u0410\u0414\u041f\u041a\u0411) \u2014 \u044d\u0442\u043e \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0449\u0435\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435, \u043a\u043e\u0442\u043e\u0440\u043e\u0435 \u0437\u0430\u0442\u0440\u0430\u0433\u0438\u0432\u0430\u0435\u0442 \u043e\u0431\u0430 \u043f\u043e\u0447\u043a\u0438 \u0438 \u043c\u043e\u0436\u0435\u0442 \u0441\u043e\u043f\u0440\u043e\u0432\u043e\u0436\u0434\u0430\u0442\u044c\u0441\u044f \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u0435\u043c \u0434\u0440\u0443\u0433\u0438\u0445 \u043e\u0440\u0433\u0430\u043d\u043e\u0432. \u041e\u0441\u043d\u043e\u0432\u043d\u044b\u0435 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u0438\u0447\u0438\u043d\u044b \u0441\u0432\u044f\u0437\u0430\u043d\u044b \u0441 \u043c\u0443\u0442\u0430\u0446\u0438\u044f\u043c\u0438 \u0432 \u0433\u0435\u043d\u0430\u0445 PKD1 \u0438 PKD2.<\/strong><\/p>\n

        \u0410\u0443\u0442\u043e\u0441\u043e\u043c\u043d\u043e-\u0440\u0435\u0446\u0435\u0441\u0441\u0438\u0432\u043d\u0430\u044f \u043f\u043e\u0447\u0435\u0447\u043d\u0430\u044f \u043f\u043e\u043b\u0438\u043a\u0438\u0441\u0442\u043e\u0437\u043d\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c (\u0410\u0420\u041f\u041a\u0411) \u2014 \u0440\u0435\u0434\u043a\u0430\u044f \u0444\u043e\u0440\u043c\u0430, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u0447\u0430\u0449\u0435 \u0432\u0441\u0435\u0433\u043e \u043f\u0440\u043e\u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0441 \u0440\u043e\u0436\u0434\u0435\u043d\u0438\u044f. \u041e\u043d\u0430 \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a \u0443\u0432\u0435\u043b\u0438\u0447\u0435\u043d\u0438\u044e \u043f\u043e\u0447\u0435\u043a \u0438 \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u044e \u043f\u0435\u0447\u0435\u043d\u0438. \u0410\u0420\u041f\u041a\u0411 \u0447\u0430\u0441\u0442\u043e \u0441\u043e\u043f\u0440\u043e\u0432\u043e\u0436\u0434\u0430\u0435\u0442\u0441\u044f \u0431\u043e\u043b\u0435\u0435 \u0442\u044f\u0436\u0435\u043b\u044b\u043c\u0438 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0430\u043c\u0438 \u0438 \u043d\u0438\u0437\u043a\u043e\u0439 \u043f\u0440\u043e\u0434\u043e\u043b\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u044e \u0436\u0438\u0437\u043d\u0438.<\/strong><\/p>\n

        \u0420\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u0442\u0435\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044e:<\/strong><\/p>\n

          \n
        • \u0418\u0441\u0442\u043e\u0440\u0438\u044f \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u043f\u043e\u043b\u0438\u043a\u0438\u0441\u0442\u043e\u0437\u043e\u043c \u043f\u043e\u0447\u0435\u043a \u0432 \u0441\u0435\u043c\u044c\u0435.<\/li>\n
        • \u041d\u0435\u0438\u0437\u0432\u0435\u0441\u0442\u043d\u043e\u0435 \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u0435 \u043f\u043e\u0447\u0435\u0447\u043d\u044b\u0445 \u043a\u0438\u0441\u0442.<\/li>\n
        • \u0414\u0435\u0442\u044f\u043c \u0441 \u043f\u0440\u0438\u0437\u043d\u0430\u043a\u0430\u043c\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f.<\/li>\n
        • \u041f\u0430\u0446\u0438\u0435\u043d\u0442\u0430\u043c, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0445\u043e\u0442\u044f\u0442 \u0441\u0442\u0430\u0442\u044c \u0434\u043e\u043d\u043e\u0440\u0430\u043c\u0438 \u043f\u043e\u0447\u0435\u043a.<\/li>\n<\/ul>\n

          \u041c\u0435\u0442\u043e\u0434 \u0442\u0435\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f<\/strong>: NGS, \u0430\u043d\u0430\u043b\u0438\u0437 \u0433\u0435\u043d\u043e\u0432 PKD1, PKD2, PKHD1 \u0438 \u0434\u0440\u0443\u0433\u0438\u0445, \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u044b\u0445 \u0441 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0435\u043c.<\/p>\n

          \u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/strong>: \u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u0434\u0435\u043b\u044f\u0442\u0441\u044f \u043d\u0430 \u0442\u0440\u0438 \u0433\u0440\u0443\u043f\u043f\u044b: \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u043d\u044b\u0435, \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u043d\u044b\u0435 \u0438 \u043d\u0435\u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u043d\u044b\u0435.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[15],"product_tag":[],"class_list":{"0":"post-67390","1":"product","2":"type-product","3":"status-publish","5":"product_cat-uncategorized","7":"first","8":"instock","9":"shipping-taxable","10":"purchasable","11":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/67390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=67390"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=67390"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=67390"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=67390"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=67390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}