{"id":12357,"date":"2020-05-07T17:00:42","date_gmt":"2020-05-07T14:00:42","guid":{"rendered":"https:\/\/www.synevo.ro\/shop\/anticorpi-anti-transportor-8-zinc\/"},"modified":"2025-02-06T12:28:41","modified_gmt":"2025-02-06T10:28:41","slug":"anticorpi-anti-transportor-8-zinc","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-transportor-8-zinc\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0435\u0440\u0443 \u0446\u0438\u043d\u043a\u0430 8"},"content":{"rendered":"<div class=\"info-content content-informatii-generale\">\n<p><strong><em>Informa\u021bii generale<\/em><\/strong><\/p>\n<p>Diabetul zaharat de tip 1 este o boal\u0103 metabolic\u0103 rezultat\u0103 din r\u0103spunsul autoimun \u00eendreptat \u00eempotriva celulelor \u03b2 pancreatice. O consecin\u021b\u0103 a atacului autoimun, \u00een diabetul de tip 1, este distrugerea selectiv\u0103 a celulelor \u03b2, av\u00e2nd ca rezultat apari\u021bia unui deficit de insulin\u0103<sup>1-3<\/sup>. \u00cen anul 1988, au fost identificate mai multe autoantigene \u00eempotriva c\u0103rora sunt direc\u021biona\u021bi anticorpii anti-insulin\u0103.<\/p>\n<p>Acestea includ <em>proteina 2 asociat\u0103 insulinomului<\/em> (IA-2), <em>acidul glutamic decarboxilaza 65<\/em> (GAD65), <em>insulina<\/em> \u0219i, cel mai recent, <em>transportorul de zinc ZnT8<\/em><sup>4<\/sup>. Doar 4% p\u00e2n\u0103 la 7% dintre pacien\u021bii cu diabet zaharat de tip 1 au autoanticorpi negativi, mai pu\u021bin de 10% au doar 1 biomarker \u0219i aproximativ 70% au 3 sau 4 biomarkeri. Aceste descoperiri au fost confirmate \u00een mai multe laboratoare de specialitate, la nivel interna\u021bional<sup>5<\/sup>.<\/p>\n<p>Unul sau mai mul\u021bi dintre ace\u0219ti autoanticorpi sunt detecta\u021bi la 93% p\u00e2n\u0103 la 96% dintre pacien\u021bii cu diabet zaharat de tip 1, at\u00e2t la adul\u021bi, c\u00e2t \u0219i la copii. Ace\u0219ti anticorpi sunt, de asemenea, detectabili la rudele pacien\u021bilor diabetici de tip 1, cu risc de a dezvolta diabet, \u00eenainte de debutul clinic<sup>6<\/sup>. Datorit\u0103 apari\u021biei simptomelor la v\u00e2rsta adult\u0103, a obezit\u0103\u021bii sociale \u0219i a non-dependen\u021bei ini\u021biale de insulin\u0103, unii pacien\u021bi cu diabet de tip 1 sunt diagnostica\u021bi ini\u021bial ca av\u00e2nd diabet de tip 2.<\/p>\n<p>Ace\u0219ti pacien\u021bi cu \u201ediabet autoimun latent la v\u00e2rsta adult\u0103\u201d sau diabet zaharat de tip 1, pot fi diferen\u021bia\u021bi de pacien\u021bii cu diabet zaharat de tip 2, prin detectarea unuia sau mai multor autoanticorpi \u00eendrepta\u021bi impotriva insulinei, inclusiv anticorpul ZnT8<sup>7<\/sup>. La pacien\u021bii cu diabet gesta\u021bional pot s\u0103 fie utilizati pentru stratificarea riscul viitor de aparti\u021bie a diabetului, prin detectarea a unu sau mai mul\u021bi autoanticorpi anti-insulari (inclusiv anticorp ZnT8)<\/p>\n<p>Anticorpii ZnT8 sunt prezen\u021bi at\u00e2t \u00een diabetul cu debutul juvenil, c\u00e2t \u0219i \u00een diabetul autoimun cu debut la adult, av\u00e2nd \u00eens\u0103 o prevalen\u021b\u0103 mai mare la copii. Cu toate acestea, prezen\u021ba acestora variaz\u0103 \u00eentre diferite popula\u021bii, fiind foarte sc\u0103zut\u0103 (&lt;3%) la popula\u021bia asiatic\u0103 \u0219i mult mai mare la popula\u021bia caucazian\u0103 (p\u00e2n\u0103 la 60-80%)<sup>8<\/sup>.<\/p>\n<p><strong><em>\u00a0<\/em><\/strong><strong><em>Recomand\u0103ri pentru determinarea anticorpilor tip anti-transportor 8 zinc<sup>9<\/sup><\/em><\/strong><\/p>\n<ul>\n<li>Diferen\u021bierea clinic\u0103 \u00eentre diabet zaharat tip 1 \u0219i diabetul zaharat de tip 2<\/li>\n<li>Identificarea persoanelor cu risc de diabet de tip 1 (inclusiv rudele cu risc crescut ale pacien\u021bilor cu diabet zaharat \u0219i ale celor cu diabet gesta\u021bional)<\/li>\n<li>Predic\u021bia necesit\u0103\u021bii tratamentului cu insulin\u0103, la pacien\u021bii diabetici cu debut la v\u00e2rst\u0103 adult\u0103<\/li>\n<\/ul>\n<p><strong><em>\u00a0<\/em><\/strong><strong><em>Specimen recoltat \u2013 <\/em><\/strong>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>9<\/sup><\/p>\n<p><strong><em>Volum prob\u0103 \u2013 <\/em><\/strong>300 microlitri<\/p>\n<p><strong><em>Stabilitate prob\u0103 \u2013 <\/em><\/strong>serul refrigerat timp de 28 de zile<sup>9<\/sup><\/p>\n<p><strong><em>Metod\u0103 \u2013 <\/em><\/strong>ELISA<sup>9<\/sup><\/p>\n<p><strong><em>Valori de referin\u021b\u0103<\/em><\/strong><strong><em>: <\/em><\/strong>&lt;15.0 IE\/mL<sup>9<\/sup><\/p>\n<p>Seropozitivitatea pentru autoanticorpi tip ZnT8 (\u226515 IE\/ml) sus\u021bine<sup>9<\/sup>:<\/p>\n<ul>\n<li>Un diagnostic de diabet de tip 1<\/li>\n<li>Un risc ridicat de dezvoltarea diabetului<\/li>\n<li>Nevoia introducerii insulinei \u00een tratamentul pacien\u021bilor cu diabet zaharat<\/li>\n<\/ul>\n<p><strong><em>\u00a0<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><strong><em>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/em><\/strong><\/p>\n<ol>\n<li>Rogowicz-Frontczak, A., Pilacinski, S., Wyka, K., Wierusz-Wysocka, B., &amp; Zozulinska-Ziolkiewicz, D. (2018). Zinc transporter 8 autoantibodies (ZnT8-ab) are associated with higher prevalence of multiple diabetes-related autoantibodies in adults with type 1 diabetes. Diabetes research and clinical practice, 146, 313\u2013320. https:\/\/doi.org\/10.1016\/j.diabres.2018.11.007<\/li>\n<li>Bluestone JA, Herold K, Eisenbarth G. (2010). Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature;464:1293\u2013300.<\/li>\n<li>Barker JM. (2006). Clinical review: type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screening. J Clin Endocrinol Metab;91:1210\u20137.<\/li>\n<li>Atkinson MA, Eisenbarth GS. (2001). Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet;358:221\u20139.<\/li>\n<li>Eisenbarth GS. (1986). Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med;314:1360\u20138.<\/li>\n<li>Insel RA, Dunne JL, Atkinson MA, Chiang JL, Dabelea D, Gottlieb PA, et al. (2015) Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care;38:1964\u201374.<\/li>\n<li>Zhang L, Eisenbarth GS. (2011). Prediction and prevention of Type 1 diabetes mellitus. J Diabetes;3:48\u201357.<\/li>\n<li>Xiang Y, Zhou Z, Deng C, Leslie RD. (2013). Latent autoimmune diabetes in adults in Asians: similarities and differences between East and West. J Diabetes;5:118\u201326.<\/li>\n<li>Mayo Clinic. Mayo Medical Laboratories. Test Catalog. [on-line]: https:\/\/www.mayocliniclabs.com [Accesat la data de 11.09.2021]<\/li>\n<\/ol>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0435\u0440\u0443 \u0446\u0438\u043d\u043a\u0430 \u2013 \u0434\u043e\u0432\u043e\u043b\u044c\u043d\u043e \u043d\u043e\u0432\u044b\u0439, \u043d\u043e \u0443\u0436\u0435 \u0445\u043e\u0440\u043e\u0448\u043e \u0438\u0437\u0443\u0447\u0435\u043d\u043d\u044b\u0439 \u043c\u0430\u0440\u043a\u0435\u0440 \u0441\u0430\u0445\u0430\u0440\u043d\u043e\u0433\u043e \u0434\u0438\u0430\u0431\u0435\u0442\u0430 1-\u0433\u043e \u0442\u0438\u043f\u0430. \u041e\u043d\u0438 \u0432 \u0431\u043e\u043b\u044c\u0448\u043e\u043c \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435 \u043f\u043e\u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0443\u0436\u0435 \u043d\u0430 \u043f\u0435\u0440\u0432\u044b\u0445 \u044d\u0442\u0430\u043f\u0430\u0445 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f.<\/p>\n<p>\u0414\u0430\u043d\u043d\u044b\u0439 \u0430\u043d\u0430\u043b\u0438\u0437 \u0448\u0438\u0440\u043e\u043a\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0434\u043b\u044f \u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0441\u0430\u0445\u0430\u0440\u043d\u043e\u0433\u043e \u0434\u0438\u0430\u0431\u0435\u0442\u0430 \u043f\u0435\u0440\u0432\u043e\u0433\u043e \u0442\u0438\u043f\u0430, \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u0432\u044b\u0440\u0430\u0436\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u0432\u043e\u0439 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u0438, \u0438, \u043a\u0430\u043a \u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0438\u0435, \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0439 \u043a\u043e\u0440\u0440\u0435\u043a\u0446\u0438\u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u0438.<\/p>\n<p>\u041f\u0440\u0435\u0434\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d \u0434\u043b\u044f \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0435\u0440\u0443 \u0446\u0438\u043d\u043a\u0430 8 \u0432 \u043e\u0431\u0440\u0430\u0437\u0446\u0430\u0445 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0438 \u0438\u043b\u0438 \u043f\u043b\u0430\u0437\u043c\u044b. \u041f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0449\u0435\u0435 \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043c\u0430\u0441\u0441\u044b \u03b2-\u043a\u043b\u0435\u0442\u043e\u043a \u043f\u0440\u0438 \u0434\u0438\u0430\u0431\u0435\u0442\u0435 1-\u0433\u043e \u0442\u0438\u043f\u0430 (\u0421\u04141) \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u043c \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0439 \u0430\u0442\u0430\u043a\u0438, \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u043d\u043e\u0439 \u043f\u0440\u043e\u0442\u0438\u0432 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0445 \u043c\u043e\u043b\u0435\u043a\u0443\u043b, \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u03b2-\u043a\u043b\u0435\u0442\u043a\u0430\u043c\u0438 \u043f\u043e\u0434\u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b. \u041d\u0435\u0434\u0430\u0432\u043d\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u043e \u043d\u043e\u0432\u044b\u0439 \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0433\u0435\u043d \u2013 \u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0435\u0440 \u0446\u0438\u043d\u043a\u0430 8 (ZnT8).<\/p>\n<p>\u0410\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0435\u0440\u0443 \u0446\u0438\u043d\u043a\u0430 (ZnT8Ab) \u0432\u044b\u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0442\u043e\u043b\u044c\u043a\u043e \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0441\u0430\u0445\u0430\u0440\u043d\u044b\u043c \u0434\u0438\u0430\u0431\u0435\u0442\u043e\u043c 1-\u0433\u043e \u0442\u0438\u043f\u0430 (\u0421\u04141), \u0430 \u043d\u0435 \u0442\u0438\u043f\u0430 2 (\u0421\u04142), \u0438\u043b\u0438 \u0433\u0435\u0441\u0442\u0430\u0446\u0438\u043e\u043d\u043d\u044b\u043c \u0434\u0438\u0430\u0431\u0435\u0442\u043e\u043c. \u041d\u0430\u043b\u0438\u0447\u0438\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a ZnT8 \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u0442\u0430\u043a\u0436\u0435 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0438\u0442\u044c \u0432\u044b\u0440\u0430\u0436\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u0432\u043e\u0439 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u0438 \u0438 \u0442\u043e\u0447\u043d\u0435\u0435 \u0441\u043f\u0440\u043e\u0433\u043d\u043e\u0437\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[932,928],"product_tag":[],"class_list":{"0":"post-12357","1":"product","2":"type-product","3":"status-publish","5":"product_cat-autoanticorpi-in-diabetul-zaharat","6":"product_cat-markeri-boli-autoimune","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/12357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=12357"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=12357"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=12357"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=12357"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=12357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}