{"id":12148,"date":"2020-05-05T23:16:53","date_gmt":"2020-05-05T20:16:53","guid":{"rendered":"https:\/\/www.synevo.ro\/shop\/anticorpi-anti-fosfatidilserina-igg-igm-iga\/"},"modified":"2025-02-06T11:54:40","modified_gmt":"2025-02-06T09:54:40","slug":"anticorpi-anti-fosfatidilserina-igg-igm-iga","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-fosfatidilserina-igg-igm-iga\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0444\u043e\u0441\u0444\u0430\u0442\u0438\u0434\u0438\u043b\u0441\u0435\u0440\u0438\u043d\u0443 IgG\/IgM\/IgA"},"content":{"rendered":"

Informa\u021bii generale<\/em><\/strong><\/p>\n

Anticorpii antifosfatidilserin\u0103 sunt markeri de linia a doua \u00een diagnosticul serologic al sindromului antifosfolipidic1<\/sup>.<\/p>\n

Sindromul antifosfolipidic<\/em> (APS) este o boal\u0103 autoimun\u0103 caracterizat\u0103 clinic prin episoade de tromboz\u0103 (venoas\u0103, arterial\u0103 sau ambele) \u0219i\/sau complica\u021bii obstetricale \u0219i prin prezen\u021ba persistent\u0103<\/em> de anticorpi antifosfolipidici circulan\u021bi. APS poate \u00eenso\u021bi o afec\u021biune reumatismal\u0103, cum ar fi lupusul eritematos sistemic (LES), sau poate fi primar, f\u0103r\u0103 o afec\u021biune reumatismal\u0103 asociat\u0103.<\/p>\n

Anticorpii antifosfolipidici sunt imunoglobuline direc\u021bionate fie \u00eempotriva fosfolipidelor, fie \u00eempotriva proteinelor plasmatice legate de fosfolipidele exprimate pe suprafa\u021ba celulelor endoteliale sau a trombocitelor1;2<\/sup>.<\/p>\n

Conform criteriilor de clasificare revizuite \u0219i publicate \u00een 2006 (Sapporo-Sydney), diagnosticul APS necesit\u0103 asocierea cel pu\u021bin a unui criteriu clinic \u0219i a unui criteriu de laborator. Criteriile de laborator se refer\u0103 la detectarea urm\u0103torilor anticorpi antifosfolipidici:<\/p>\n

– lupus anticoagulant (LA), prezent la cel pu\u021bin 2 determin\u0103ri la interval de 12 s\u0103pt\u0103m\u00e2ni;<\/div>\n
– anticorpi cardiolipinici (aCL) IgG \u0219i IgM cu titruri >40 GPL\/MPL, prezen\u021bi la cel pu\u021bin 2 determin\u0103ri la interval de 12 s\u0103pt\u0103m\u00e2ni;<\/div>\n
– anticorpi anti- \u03b22-glicoproteina 1 (\u03b22-GPI) IgG \u0219i IgM, cu titruri crescute (>percentila 99 a limitei superioare de referin\u021b\u0103) prezen\u021bi la cel pu\u021bin 2 determin\u0103ri la interval de 12 s\u0103pt\u0103m\u00e2ni2<\/sup>.<\/div>\n

Detectarea acestor trei tipuri de anticorpi trebuie efectuat\u0103 \u00een paralel: \u00een general, dac\u0103 nu este detectat nici unul dintre ace\u0219ti anticorpi diagnosticul de APS este improbabil, \u00een timp ce detectarea mai multor tipuri de anticorpi se asociaz\u0103 cu forme mai severe de APS3<\/sup>.<\/p>\n

Cu toate acestea, \u00een practic\u0103 pot fi \u00eent\u00e2lni\u021bi pacien\u021bi care prezint\u0103 semne clinice sugestive pentru APS, dar la care se ob\u021bin \u00een mod repetat rezultate negative la cele trei teste men\u021bionate mai sus. Pentru definirea acestor cazuri a fost propus termenul de APS \u201eseronegativ\u201d4<\/sup>.<\/p>\n

\u00cen situa\u021bia unui APS \u201eseronegativ\u201d se poate recurge la efectuarea unor markeri serologici de linia a doua, cum ar fi: aCL IgA, \u03b22-GPI IgA, anticorpi antifosfatidilserin\u0103, anti-fosfoetanolamin\u0103, anti-fosfatidilinozitol, anti-fosfatidilcolin\u0103, anti-fosfatidilglicerol, anti-acid fosfatidic, anti-anexin\u0103, anti-protrombin\u0103. Ace\u0219ti autoanticorpi \u201enon-clasici\u201d au fost asocia\u021bi cu simptome sugestive de APS \u00een studii limitate \u0219i nu au fost inclu\u0219i \u00een criteriile de clasificare pentru a p\u0103stra specificitatea diagnosticului3;4<\/sup>.<\/p>\n

Spre deosebire de cardiolipin\u0103, fosfatidilserina (PS) este un fosfolipid cu relevan\u021b\u0103 fiziologic\u0103 mai mare, datorit\u0103 prezen\u021bei \u00een membrana celulelor endoteliale \u0219i a plachetelor \u0219i a rolului s\u0103u \u00een coagulare. Astfel, activarea PS sub influen\u021ba unor diver\u0219i stimuli (de exemplu, colagenul) duce la translocarea sa pe suprafa\u021ba extern\u0103 a membranei unde se constituie ca suport pentru complexul protrombinazei (ac\u021biune procoagulant\u0103)5;6<\/sup>.<\/p>\n

Niveluri crescute de anticorpi antifosfatidilserin\u0103 (aPS) au fost detectate frecvent la pacien\u021bi cu boli autoimune, \u00een special LES, fiind corelate cu manifest\u0103ri de APS (tromboze venoase \u0219i arteriale). Mai mult, rolul lor patogenic a fost demonstrat in vivo<\/em>, pe un model murin5<\/sup>.<\/p>\n

Titruri \u00eenalte de aPS IgG au fost asociate cu pirderi recurente de sarcin\u0103 \u00een trimestrul I, posibil prin afectarea dezvolt\u0103rii normale a placentei7<\/sup>. De asemenea, aPS IgG \u0219i aCL IgA ar putea constitui un factor de risc pentru accidentele ischemice cerebrale tranzitorii8<\/sup>.<\/p>\n

Un studiu recent a ar\u0103tat o corela\u021bie semnificativ\u0103 \u00eentre aPS \u0219i APS, \u00een special atunci c\u00e2nd ace\u0219ti autoanticorpi sunt utiliza\u021bi pentru a diagnostica cazurile clinice cu markeri de prim\u0103 linie negativi. \u00cen plus, autorii au confirmat o asociere independent\u0103 \u00eentre aPS \u0219i APS primar9<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea anticorpilor antifosfatidilserin\u0103<\/em><\/strong><\/p>\n

    \n
  1. Cazurile cu simptomatologie APS \u0219i markeri serologici de prim\u0103 linie negativi.\u00a0<\/em><\/strong><\/li>\n<\/ol>\n

    Suspiciunile clinice de APS sunt: episoade de tromboz\u0103 venoas\u0103 sau arterial\u0103, survenite \u00een special la pacien\u021bi tineri, \u00een absen\u021ba oric\u0103rui diagnostic alternativ sau a altei etiologii trombotice; complica\u021bii ale sarcinii (una sau mai multe pierderi de sarcin\u0103 dup\u0103 s\u0103pt\u0103m\u00e2na 10 cu f\u0103t morfologic normal, una sau mai multe na\u0219teri premature \u00eenainte de s\u0103pt\u0103m\u00e2na 34 cauzate de preeclampsie sever\u0103 sau insuficien\u021b\u0103 placentar\u0103, sau 3 sau mai multe avorturi spontane \u00eenainte de s\u0103pt\u0103m\u00e2na 10 de sarcin\u0103 la care s-au exclus etiologiile cromozomiale, hormonale sau anatomice); evaluarea riscului trombotic la pacien\u021bii diagnostica\u021bi cu boli de \u021besut conjunctiv (\u00een special LES); evaluarea unei trombocitopenii neexplicabile.<\/p>\n

      \n
    1. Evaluarea pacientelor cu anticorpi anti-cardiolipinici pozitivi care pot dezvolta patologie obstetrical\u01031;2;3;4;10<\/sup><\/li>\n<\/ol>\n

      Preg\u0103tire pacient <\/em><\/strong>– jeun (pe nem\u00e2ncate) sau postprandial (dup\u0103 mese)10<\/sup>.<\/p>\n

      Specimen recoltat <\/em><\/strong>– s\u00e2nge venos10<\/sup>.<\/p>\n

      Recipient de recoltare <\/em><\/strong>– <\/em>vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator10<\/sup>.<\/p>\n

      Prelucrare necesar\u0103 dup\u0103 recoltare <\/em><\/strong>– <\/em>se separ\u0103 serul prin centrifugare10<\/sup>.<\/p>\n

      Volum prob\u0103<\/em><\/strong> – minim 0.5 mL ser10<\/sup>.<\/p>\n

      Cauze de respingere<\/em><\/strong> a probei <\/em><\/strong>– <\/em>ser intens hemolizat, lipemic sau puternic contaminat bacterian10<\/sup>.<\/p>\n

      Stabilitate prob\u0103 <\/em><\/strong>– <\/em>serul separat este stabil 7 zile<\/em> la 4\u00b0C; timp \u00eendelungat<\/em> la -20 \u00b0C10<\/sup>.<\/p>\n

      Metod\u0103<\/em><\/strong> – ELISA<\/u>10<\/sup>.<\/p>\n

      Valori de <\/em><\/strong>referin\u021b\u0103 <\/em><\/strong>– IgG\/IgM\/IgA < 12 E\/mL10<\/sup>.<\/p>\n

      Interpretarea rezultatelor<\/em><\/strong><\/p>\n

      Ob\u021binerea unor titruri crescute de aPS impune repetarea la cel pu\u021bin 12 s\u0103pt\u0103m\u00e2ni a \u00eenc\u0103 unui test pentru a confirma persisten\u021ba acestor anticorpi.<\/div>\n
      Interpretarea rezultatelor se va face numai prin corelarea cu celelalte criterii de APS (clinice \u0219i de laborator).<\/div>\n
      Ob\u021binerea unor rezultate pozitive izolate de aPS are semnifica\u021bie clinic\u0103 discutabil\u0103 pentru diagnosticul de APS sau LES.1;<\/sup>3<\/sup><\/div>\n

      \u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/span><\/strong><\/p>\n

        \n
      1. \n
        ARUP Laboratories. Test Directory: Antiphospholipid Syndrome \u2013 APS. www.aruplab.com 2017. Ref Type: Internet\u00a0<\/span>Communication.<\/span><\/div>\n<\/li>\n
      2. \n
        Miyakis S, Lockshin MD, Atsumi T, et al: International consensus statement on an update of the classification criteria for\u00a0<\/span>definite antiphospholipid syndrome (APS). In J Thromb Haemost 2006;4:295-306.<\/span><\/div>\n<\/li>\n
      3. \n
        Quest Diagnostics. Laboratory Testing in the Identification of Antiphospholipid Syndrome. www.questdiagnostics.com.\u00a0<\/span>Ref type:Internet communication. <\/span><\/div>\n<\/li>\n
      4. \n
        Conti F, Capozzi A, Truglia S, Lococo E, Longo A, Misasi R, Alessandri C, Valesini G, Sorice M. The Mosaic of \u201cSeronegative\u201d\u00a0<\/span>Antiphospholipid Syndrome. J Immunol Res. 2014;2014:389601.<\/span><\/div>\n<\/li>\n
      5. \n
      6. \n
      7. \n
        Sater MS, Finan RR, Abu-Hijleh FM, Abu-Hijleh TM, Almawi WY. Eur J Obstet Gynecol Reprod Biol. 2012 Aug;163(2):170-4.<\/span><\/div>\n<\/li>\n
      8. \n
        Kahles T, Humpich M, Steinmetz H, Sitzer M, Lindhoff-Last E. Phosphatidylserine IgG and beta-2-glycoprotein I IgA antibodies\u00a0may be a risk factor for ischaemic stroke. Rheumatology (Oxford). 2005 Sep;44(9):1161-5.<\/span><\/div>\n<\/li>\n
      9. \n
        Khogeer H, Alfattani A, Al Kaff M, Al Shehri T, Khojah O, Owaidah T. Antiphosphatidylserine antibodies as diagnostic\u00a0indicators of antiphospholipid syndrome. Lupus. 2015 Feb;24(2):186-90.<\/span><\/div>\n<\/li>\n
      10. \n
        Laborator Synevo. Referin\u021bele specifice tehnologiei de lucru utilizate 2017. Ref Type: Catalog<\/span><\/div>\n<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"

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          \n
        • \u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0430\u0445 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0445 \u043a\u0440\u0438\u0442\u0435\u0440\u0438\u0435\u0432 \u0410\u0424\u0421 (\u0432\u043e\u043b\u0447\u0430\u043d\u043e\u0447\u043d\u044b\u0439 \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442, \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u043a\u0430\u0440\u0434\u0438\u043e\u043b\u0438\u043f\u0438\u043d\u0443 \u0438 \u03b2-2-\u0433\u043b\u0438\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u0434\u0443 I);<\/li>\n
        • \u0432\u0435\u043d\u043e\u0437\u043d\u044b\u0445 \/ \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u0442\u0440\u043e\u043c\u0431\u043e\u0437\u0430\u0445 (\u0442\u0440\u043e\u043c\u0431\u043e\u0437\u0435 \u0433\u043b\u0443\u0431\u043e\u043a\u0438\u0445 \u0432\u0435\u043d, \u0438\u043d\u0444\u0430\u0440\u043a\u0442\u0435 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430, \u0438\u043d\u0441\u0443\u043b\u044c\u0442\u0435, \u0422\u042d\u041b\u0410, \u0438\u043d\u0444\u0430\u0440\u043a\u0442\u0430\u0445 \u0432\u043d\u0443\u0442\u0440\u0435\u043d\u043d\u0438\u0445 \u043e\u0440\u0433\u0430\u043d\u043e\u0432, \u0441\u0435\u0442\u0447\u0430\u0442\u043e\u043c \u043b\u0438\u0432\u0435\u0434\u043e, \u044f\u0437\u0432\u0430\u0445 \u0433\u043e\u043b\u0435\u043d\u0438, \u043f\u0440\u0435\u0445\u043e\u0434\u044f\u0449\u0438\u0445 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f\u0445 \u043c\u043e\u0437\u0433\u043e\u0432\u043e\u0433\u043e \u043a\u0440\u043e\u0432\u043e\u043e\u0431\u0440\u0430\u0449\u0435\u043d\u0438\u044f \u0438 \u0434\u0440.);<\/li>\n
        • \u043d\u0435\u0432\u044b\u043d\u0430\u0448\u0438\u0432\u0430\u043d\u0438\u0438 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438, \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0435 \u043f\u043e\u0442\u0435\u0440\u0438 \u043f\u043b\u043e\u0434\u0430 \u043d\u0430 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0445 \u0441\u0440\u043e\u043a\u0430\u0445, \u0431\u0435\u0441\u043f\u043b\u043e\u0434\u0438\u0438, \u043a\u0440\u043e\u0432\u043e\u0442\u0435\u0447\u0435\u043d\u0438\u044f\u0445 \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438, \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0438 \u043f\u0440\u0435- \u0438 \u044d\u043a\u043b\u0430\u043c\u043f\u0441\u0438\u0438, \u043f\u043b\u0430\u0446\u0435\u043d\u0442\u0430\u0440\u043d\u043e\u0439 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u0438 \u0441 \u0417\u0412\u0423\u0420 \u043f\u043b\u043e\u0434\u0430, \u043f\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0439 \u043e\u0442\u0441\u043b\u043e\u0439\u043a\u043e\u0439 \u043f\u043b\u0430\u0446\u0435\u043d\u0442\u044b (\u041f\u041e\u041d\u0420\u041f), \u043c\u0435\u0440\u0442\u0432\u043e\u0440\u043e\u0436\u0434\u0435\u043d\u0438\u044f\u0445;<\/li>\n
        • \u043f\u0435\u0440\u0435\u0434 \u043d\u0430\u0447\u0430\u043b\u043e\u043c \u043f\u0440\u0438\u0435\u043c\u0430 \u043e\u0440\u0430\u043b\u044c\u043d\u044b\u0445 \u043a\u043e\u043d\u0442\u0440\u0430\u0446\u0435\u043f\u0442\u0438\u0432\u043e\u0432, \u0437\u0430\u043c\u0435\u0441\u0442\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0433\u043e\u0440\u043c\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0438 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u0435 \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u043f\u0440\u0438\u0435\u043c\u0430 \u0434\u0430\u043d\u043d\u044b\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432;<\/li>\n
        • \u043f\u0440\u0438 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445;<\/li>\n
        • \u043f\u0440\u0438 \u043b\u044e\u0431\u043e\u0439 \u043e\u043d\u043a\u043e\u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438;<\/li>\n
        • \u0442\u0440\u043e\u043c\u0431\u043e\u0446\u0438\u0442\u043e\u043f\u0435\u043d\u0438\u0438, \u0433\u0435\u043c\u043e\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0430\u043d\u0435\u043c\u0438\u0438.<\/li>\n<\/ul>\n

          \u041f\u043e\u0432\u0442\u043e\u0440\u043d\u043e\u0435 \u0442\u0435\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 — \u043f\u043e\u0441\u043b\u0435 \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0433\u043e \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u043e\u0433\u043e \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0430 \u0447\u0435\u0440\u0435\u0437 12 \u043d\u0435\u0434\u0435\u043b\u044c<\/p>\n

          \u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/p>\n

          \u041f\u0440\u0438 \u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0430\u0445 \u0442\u0435\u0441\u0442\u0430 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e \u0438\u0441\u043a\u043b\u044e\u0447\u0435\u043d\u0438\u0435 \u043d\u0430\u043b\u0438\u0447\u0438\u044f \u0434\u0440\u0443\u0433\u0438\u0445 \u043a\u043b\u0430\u0441\u0441\u043e\u0432 \u0430\u043d\u0442\u0438\u0444\u043e\u0441\u0444\u043e\u043b\u0438\u043f\u0438\u0434\u043d\u044b\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u0434\u043b\u044f \u0438\u0441\u043a\u043b\u044e\u0447\u0435\u043d\u0438\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430 \u0410\u0424\u0421.<\/p>\n

          \u041f\u0440\u0438 \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u043c \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0435 \u0442\u0435\u0441\u0442\u0430 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e \u043f\u043e\u0432\u0442\u043e\u0440\u0438\u0442\u044c \u0442\u0435\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u0447\u0435\u0440\u0435\u0437 12 \u043d\u0435\u0434\u0435\u043b\u044c, \u043f\u0440\u043e\u0432\u0435\u0441\u0442\u0438 \u0442\u0435\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u0434\u0440\u0443\u0433\u0438\u0445 \u043a\u043b\u0430\u0441\u0441\u043e\u0432 \u0430\u043d\u0442\u0438\u0444\u043e\u0441\u0444\u043e\u043b\u0438\u043f\u0438\u0434\u043d\u044b\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b, \u0432\u0445\u043e\u0434\u044f\u0449\u0438\u0445 \u0432 \u043a\u0440\u0438\u0442\u0435\u0440\u0438\u0438 \u043f\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043a\u0438 \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430 \u0410\u0424\u0421 (\u0421\u0430\u043f\u043f\u043e\u0440\u043e, 2006 \u0433.) \u0434\u043b\u044f \u043f\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043a\u0438 \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430 \u0410\u0424\u0421<\/p>\n

          \u041f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442<\/p>\n

          \u041d\u0435\u043b\u044c\u0437\u044f \u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0434\u0438\u0442\u044c \u0410\u0424\u0421, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u0434\u0440\u0443\u0433\u0438\u043c \u0444\u043e\u0441\u0444\u043e\u043b\u0438\u043f\u0438\u0434\u0430\u043c;
          \n\u0410\u0424\u0421;
          \n\u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u0441\/\u0431\u0435\u0437 \u0410\u0424\u0421;
          \n\u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0435 \u043d\u043e\u0432\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f;
          \n\u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f (\u0412\u0418\u0427, \u0412\u042d\u0411, \u043f\u0430\u0440\u0432\u043e\u0432\u0438\u0440\u0443\u0441 \u041219, \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u044b, \u0441\u0438\u0444\u0438\u043b\u0438\u0441, \u0434\u0440\u0443\u0433\u0438\u0435);
          \n\u043f\u0440\u0438\u0435\u043c \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432;
          \n\u0443 2-4% \u0437\u0434\u043e\u0440\u043e\u0432\u044b\u0445 \u043b\u044e\u0434\u0435\u0439, \u0443 10% \u0437\u0434\u043e\u0440\u043e\u0432\u044b\u0445 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0445<\/p>\n

          \u041e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442
          \n\u041d\u0435\u043b\u044c\u0437\u044f \u0438\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u0410\u0424\u0421, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u0434\u0440\u0443\u0433\u0438\u043c \u0444\u043e\u0441\u0444\u043e\u043b\u0438\u043f\u0438\u0434\u0430\u043c<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[930,961],"product_tag":[],"class_list":{"0":"post-12148","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-pentru-sindromul-antifosfolipidic","6":"product_cat-serologie-boli-infectioase","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/12148","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=12148"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=12148"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=12148"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=12148"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=12148"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}