{"id":12142,"date":"2020-05-05T23:16:52","date_gmt":"2020-05-05T20:16:52","guid":{"rendered":"https:\/\/www.synevo.ro\/shop\/virus-influenza-a-si-b-serologie\/"},"modified":"2025-02-06T11:46:36","modified_gmt":"2025-02-06T09:46:36","slug":"virus-influenza-a-si-b-serologie","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/virus-influenza-a-si-b-serologie\/","title":{"rendered":"\u0412\u0438\u0440\u0443\u0441 \u0433\u0440\u0438\u043f\u043f\u0430 \u0410 \u0438 \u0412 \u2013 \u0441\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f"},"content":{"rendered":"

Informa\u021bii generale<\/p>\n

Virusurile gripale sunt membri ai familiei Orthomyxoviridae. Aceast\u0103 familie este reprezentat\u0103 de virusuri al c\u0103ror genom const\u0103 \u00een segmente de ARN monocatenare. Exist\u0103 patru genuri din aceast\u0103 familie: tipurile A, B, C \u0219i Thogotovirus, dintre care, numai genurile A \u0219i B sunt relevante clinic pentru oameni1,2.<\/p>\n

Virusurile gripale se transmit \u00een principal prin aerosoli, pic\u0103turi relativ mari (5 \u03bcm) create \u00een special \u00een timpul vorbirii, tusei sau str\u0103nutului, intr\u00e2nd astfel \u00een mucoase prin contact la distan\u021be mici3. Studiile au sugerat, de asemenea, c\u0103 transmisia ar putea avea loc prin intermediul unor pic\u0103turi mai mici de 5 \u03bcm, capabile s\u0103 r\u0103m\u00e2n\u0103 \u00een aer perioade mai lungi (transmisie aerogen\u0103). \u00cen plus, transmiterea poate avea loc prin contactul direct cu suprafe\u021be contaminate cu virusuri (de exemplu, str\u00e2ngerea m\u00e2inilor) \u0219i contactul ulterior gur\u0103-nas. Dup\u0103 debutul infec\u021biei, virusurile se multiplic\u0103 \u00een mucoasele nazal\u0103 \u0219i laringian\u0103. Aceast\u0103 replicare afecteaz\u0103 \u0219i c\u0103ile respiratorii inferioare, pe m\u0103sur\u0103 ce infec\u021bia progreseaz\u01034.<\/p>\n

O caracteristic\u0103 clinic\u0103 a gripei umane este cre\u0219terea brusc\u0103 a temperaturii, ajung\u00e2nd la valori de 38.5\u00b0C, la 1-3 zile dup\u0103 infec\u021bie. Alte simptome includ cefaleea, dureri la nivelul membrelor, oboseal\u0103, tuse uscat\u0103. Starea de infectie poate debuta cu pu\u021bin \u00eenainte de apari\u021bia simptomelor clinice (24 ore) \u0219i persist\u0103 de obicei 3-5 zile. Copiii mici pot excreta virusurile mai devreme \u0219i pe o perioad\u0103 mai lung\u0103 de timp, comparativ cu adul\u021bii5.<\/p>\n

Anticorpii specifici virusului gripal din ser pot fi determina\u021bi sub forma unor niveluri totale de anticorpi sau pot fi identifica\u021bi \u00een subcategorii de anticorpi IgA, IgM, IgG. Metodele utilizate \u00een mod tradi\u021bional includ reac\u021bia de legare a complementului \u0219i metode precum tehnicile imunoenzimatice (EIA) \u0219i testul de imunofluorescen\u021b\u0103 (IFT). Pot fi utilizate si teste rapide de diagnosticare a gripei, care ofer\u0103 rezultate \u00een decurs de aproximativ 10-15 minute, dar acestea pot sa nu fie la fel de specifice, comparativ cu teste gripale serologice, imunoenzimatice.<\/p>\n

Recomand\u0103ri pentru determinarea Virus influenza A \u0219i B \u2013 serologie
\nDiagnosticul infec\u021biilor provocate de virusul influenza A \u0219i B1,2,3<\/p>\n

Specimen recoltat \u2013 s\u00e2nge venos7
\nPrelucrare necesar\u0103 dup\u0103 recoltare \u2013 Proba se centrifugheaz\u0103 \u0219i se alicoteaz\u0103 serul \u00eentr-un tub steril7.<\/p>\n

Volum prob\u0103 \u2013 1 mL7<\/p>\n

Stabilitate prob\u0103 \u2013 prob\u0103 refrigerat\u01037<\/p>\n

Metod\u0103: Enzym-Immunoassay (EIA)<\/p>\n

Valori de referin\u021b\u01037
\nAnticorpi anti- Influenza A IgA <10 U\/ml
\nAnticorpi anti- Influenza A IgG <10 U\/ml
\nAnticorpi anti- Influenza B IgA<10 U\/ml
\nAnticorpi anti- Influenza B IgG<10 U\/ml<\/p>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/p>\n

    \n
  1. Arbeitskreis Blut, Untergruppe \u00abBewertung Blutassoziierter Krankheitserreger\u00bb (2009). Influenza Virus. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 36(1), 32\u201339. https:\/\/doi.org\/10.1159\/000197314<\/li>\n
  2. Hutchinson E. C. (2018). Influenza Virus. Trends in microbiology, 26(9), 809\u2013810. https:\/\/doi.org\/10.1016\/j.tim.2018.05.013<\/li>\n
  3. Te Velthuis, A. J., & Fodor, E. (2016). Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis. Nature reviews. Microbiology, 14(8), 479\u2013493. https:\/\/doi.org\/10.1038\/nrmicro.2016.87<\/li>\n
  4. Pleschka S. (2013). Overview of influenza viruses. Current topics in microbiology and immunology, 370, 1\u201320. https:\/\/doi.org\/10.1007\/82_2012_272
    \nvan der Vries, E., Schutten, M., Fraaij, P., Boucher, C., & Osterhaus, A. (2013). Influenza virus resistance to antiviral therapy. Advances in pharmacology (San Diego, Calif.), 67, 217\u2013246. https:\/\/doi.org\/10.1016\/B978-0-12-405880-4.00006-8<\/li>\n
  5. Bishai, F. R., & Galli, R. (1978). Enzyme-linked immunosorbent assay for detection of antibodies to influenza A and B and parainfluenza type 1 in sera of patients. Journal of clinical microbiology, 8(6), 648\u2013656. https:\/\/doi.org\/10.1128\/jcm.8.6.648-656.1978<\/li>\n
  6. Tests. Influenza A and B antibody. [on-line]: https:\/\/www.labcorp.com (Accesat la data de 20.10.2021)<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"

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    \u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430, \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u044b\u0435 \u043a \u0432\u0438\u0440\u0443\u0441\u0443 \u0433\u0440\u0438\u043f\u043f\u0430 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435, \u043c\u043e\u0436\u043d\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0438\u0442\u044c \u0432 \u0432\u0438\u0434\u0435 \u043e\u0431\u0449\u0435\u0433\u043e \u0443\u0440\u043e\u0432\u043d\u044f \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u0438\u043b\u0438 \u0438\u0434\u0435\u043d\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u0432 \u043f\u043e\u0434\u043a\u0430\u0442\u0435\u0433\u043e\u0440\u0438\u044f\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b IgA, IgM, IgG. \u0422\u0440\u0430\u0434\u0438\u0446\u0438\u043e\u043d\u043d\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u043c\u044b\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u0432\u043a\u043b\u044e\u0447\u0430\u044e\u0442 \u0440\u0435\u0430\u043a\u0446\u0438\u044e \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u043d\u0438\u044f \u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442\u0430 \u0438 \u0442\u0430\u043a\u0438\u0435 \u043c\u0435\u0442\u043e\u0434\u044b, \u043a\u0430\u043a \u0438\u043c\u043c\u0443\u043d\u043e\u0444\u0435\u0440\u043c\u0435\u043d\u0442\u043d\u044b\u0435 \u043c\u0435\u0442\u043e\u0434\u044b (EIA) \u0438 \u0438\u043c\u043c\u0443\u043d\u043e\u0444\u043b\u0443\u043e\u0440\u0435\u0441\u0446\u0435\u043d\u0442\u043d\u044b\u0439 \u0442\u0435\u0441\u0442 (IFT). \u0422\u0430\u043a\u0436\u0435 \u043c\u043e\u0433\u0443\u0442 \u0431\u044b\u0442\u044c \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u044b \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441-\u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0442\u0435\u0441\u0442\u044b \u043d\u0430 \u0433\u0440\u0438\u043f\u043f, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0434\u0430\u044e\u0442 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u043f\u0440\u0438\u043c\u0435\u0440\u043d\u043e 10-15 \u043c\u0438\u043d\u0443\u0442, \u043d\u043e \u043e\u043d\u0438 \u043c\u043e\u0433\u0443\u0442 \u0431\u044b\u0442\u044c \u043d\u0435 \u0442\u0430\u043a\u0438\u043c\u0438 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u044b\u043c\u0438 \u043f\u043e \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044e \u0441 \u0441\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u0438\u043c\u043c\u0443\u043d\u043e\u0444\u0435\u0440\u043c\u0435\u043d\u0442\u043d\u044b\u043c\u0438 \u0442\u0435\u0441\u0442\u0430\u043c\u0438 \u043d\u0430 \u0433\u0440\u0438\u043f\u043f.<\/p>\n

    \u0420\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044e \u0432\u0438\u0440\u0443\u0441\u0430 influenza A \u0438 B \u2013 \u0441\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f
    \n\u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0439, \u0432\u044b\u0437\u0432\u0430\u043d\u043d\u044b\u0445 \u0432\u0438\u0440\u0443\u0441\u043e\u043c influenza A \u0438 B1, 2, 3<\/p>\n

    \u0421\u043e\u0431\u0440\u0430\u043d\u043d\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0435\u0446-\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c 7
    \n\u041d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0430\u044f \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u043a\u0430 \u043f\u043e\u0441\u043b\u0435 \u0441\u0431\u043e\u0440\u0430 \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430-\u043e\u0431\u0440\u0430\u0437\u0435\u0446 \u0446\u0435\u043d\u0442\u0440\u0438\u0444\u0443\u0433\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0438 \u0430\u043b\u0438\u043a\u0432\u0438\u0440\u0443\u0435\u0442 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0443 \u0432 \u0441\u0442\u0435\u0440\u0438\u043b\u044c\u043d\u0443\u044e \u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0443 7.<\/p>\n

    \u041e\u0431\u044a\u0435\u043c \u043e\u0431\u0440\u0430\u0437\u0446\u0430-1 \u043c\u043b7<\/p>\n

    \u0421\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u043e\u0431\u0440\u0430\u0437\u0446\u0430-\u043e\u0445\u043b\u0430\u0436\u0434\u0435\u043d\u043d\u044b\u0439 \u043e\u0431\u0440\u0430\u0437\u0435\u04467<\/p>\n

    \u041c\u0435\u0442\u043e\u0434: Enzym-Immunoassay (EIA)<\/p>\n

    \u0421\u0441\u044b\u043b\u043e\u0447\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f7<\/p>\n

    \u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u0430\u043d\u0442\u0438-\u0433\u0440\u0438\u043f\u043f IgA <10 \u0415\u0434 \/ \u043c\u043b
    \n\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u0430\u043d\u0442\u0438-\u0433\u0440\u0438\u043f\u043f IgG <10 \u0415\u0434 \/ \u043c\u043b
    \n\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u0430\u043d\u0442\u0438-\u0433\u0440\u0438\u043f\u043f B IgA<10 \u0415\u0434 \/ \u043c\u043b
    \n\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u0430\u043d\u0442\u0438-\u0433\u0440\u0438\u043f\u043f B IgG<10 \u0415\u0434 \/ \u043c\u043b<\/p>\n

    \u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/p>\n

      \n
    1. Arbeitskreis Blut, Untergruppe \u00abBewertung Blutassoziierter Krankheitserreger\u00bb (2009). Influenza Virus. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 36(1), 32\u201339. https:\/\/doi.org\/10.1159\/000197314<\/li>\n
    2. Hutchinson E. C. (2018). Influenza Virus. Trends in microbiology, 26(9), 809\u2013810. https:\/\/doi.org\/10.1016\/j.tim.2018.05.013<\/li>\n
    3. Te Velthuis, A. J., & Fodor, E. (2016). Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis. Nature reviews. Microbiology, 14(8), 479\u2013493. https:\/\/doi.org\/10.1038\/nrmicro.2016.87<\/li>\n
    4. Pleschka S. (2013). Overview of influenza viruses. Current topics in microbiology and immunology, 370, 1\u201320. https:\/\/doi.org\/10.1007\/82_2012_272
      \nvan der Vries, E., Schutten, M., Fraaij, P., Boucher, C., & Osterhaus, A. (2013). Influenza virus resistance to antiviral therapy. Advances in pharmacology (San Diego, Calif.), 67, 217\u2013246. https:\/\/doi.org\/10.1016\/B978-0-12-405880-4.00006-8<\/li>\n
    5. Bishai, F. R., & Galli, R. (1978). Enzyme-linked immunosorbent assay for detection of antibodies to influenza A and B and parainfluenza type 1 in sera of patients. Journal of clinical microbiology, 8(6), 648\u2013656. https:\/\/doi.org\/10.1128\/jcm.8.6.648-656.1978<\/li>\n
    6. Tests. Influenza A and B antibody. [on-line]: https:\/\/www.labcorp.com (Accesat la data de 20.10.2021)<\/li>\n<\/ol>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[961],"product_tag":[],"class_list":{"0":"post-12142","1":"product","2":"type-product","3":"status-publish","5":"product_cat-serologie-boli-infectioase","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/12142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=12142"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=12142"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=12142"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=12142"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=12142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}