{"id":12120,"date":"2020-05-06T00:16:48","date_gmt":"2020-05-05T21:16:48","guid":{"rendered":"https:\/\/www.synevo.ro\/shop\/cortizol-salivar\/"},"modified":"2025-02-07T12:36:32","modified_gmt":"2025-02-07T10:36:32","slug":"cortizol-salivar","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/cortizol-salivar\/","title":{"rendered":"\u041a\u043e\u0440\u0442\u0438\u0437\u043e\u043b (\u0432 \u0441\u043b\u044e\u043d\u0435)"},"content":{"rendered":"<p><strong><em>Informa\u021bii generale<\/em><\/strong><\/p>\n<p>Cortizolul este cel mai important glucocorticosteroid fiind esen\u021bial pentru men\u021binerea mai multor func\u021bii ale organismului. Ca \u0219i al\u021bi glucocorticosteroizi, cortizolul este sintetizat \u00een zona fasciculat\u0103 a cortico-suprarenalei dintr-un precursor comun cu colesterolul. \u00cen s\u00e2nge 90% din cortizol este legat de proteina de legare a corticosteroizilor (CBG &#8211; corticosteroid binding globulin) \u0219i de albumin\u0103. Doar o mic\u0103 parte din cortizol circul\u0103 nelegat\u0103<strong>,<\/strong> fiind liber\u0103 s\u0103 interac\u021bioneze cu receptorii.<\/p>\n<p>Cele mai importante efecte fiziologice ale cortizolului sunt cre\u0219terea glucozei sanguine (prin stimularea gluconeogenezei), precum \u0219i ac\u021biunea antiinflamatorie \u0219i imunosupresiv\u0103.<\/p>\n<p>Sinteza \u0219i secre\u021bia de cortizol sunt controlate prin feedback negativ de c\u0103tre axul hipotalamo-hipofizo-corticosuprarenalian. Dac\u0103 nivelul cortizolului este sc\u0103zut, hormonul de eliberare al corticotropinei (CRH-corticotropin releasing hormone) este secretat de hipotalamus, iar acesta determin\u0103 eliberarea de ACTH din hipofiz\u0103. ACTH stimuleaz\u0103 sinteza \u0219i secre\u021bia de cortizol \u00een corticosuprarenal\u0103. Cortizolul \u00eensu\u0219i ac\u021bioneaz\u0103 printr-un mecanism de feedback negativ asupra hipofizei \u0219i hipotalamusului. \u00cen plus, stresul determin\u0103 cre\u0219terea secre\u021biei de cortizol<sup>1;<\/sup><sup>2<\/sup>.<\/p>\n<p>CRH este eliberat ciclic de c\u0103tre hipotalamus ceea ce explic\u0103 vaia\u021bia diurn\u0103 a concentra\u021biilor plasmatice de cortizol \u0219i ACTH (crescute diminea\u021ba \u0219i sc\u0103zute seara).<\/p>\n<p>Sindromul Cushing rezult\u0103 ca urmare a produc\u021biei excesive de corticosteroizi datorat\u0103 unei afec\u021biuni suprarenaliene primare (adenom, carcinom sau hiperplazie nodular\u0103) sau unui exces de ACTH (generat de o tumor\u0103 hipofizar\u0103 sau dintr-o surs\u0103 ectopic\u0103). Sindromul Cushing dependent de ACTH cauzat de un adenom hipofizar corticotrof constituie subtipul diagnosticat cel mai frecvent; sunt afectate predominant femeile din grupa de v\u00e2rst\u0103 30-50 ani. La pacien\u021bii cu sindrom Cushing se pierde varia\u021bia diurn\u0103 a cortizolului plasmatic<sup>3<\/sup>.<\/p>\n<p>Spectrul manifest\u0103rilor clinice ale acestei afec\u021biuni este foarte larg astfel c\u0103 diagnosticul poate fi dificil \u00een formele u\u0219oare de boal\u0103. Elementele clinice care diferen\u021biaz\u0103 cel mai bine pacien\u021bii cu sindrom Cushing sunt: echimozele f\u0103r\u0103 o traum\u0103 evident\u0103, vergeturile ro\u0219ii-violacei, faciesul pletoric, sl\u0103biciunea musculaturii proximale, osteoporoza inexplicabil\u0103. \u00cen multe cazuri \u00eens\u0103 pacien\u021bii prezint\u0103 unele simptome \u0219i semne clinice care, de\u0219i sunt cauzate de excesul de cortizol, sunt lipsite de specificitate, fiind frecvent \u00eent\u00e2lnite \u00een popula\u021bia general\u0103: obezitate, depresie, diabet zaharat, HTA, tulbur\u0103ri ale ciclului menstrual. Din acest motiv al\u0103turi de semnele clinice sunt necesare teste de laborator care s\u0103 identifice persoanele care prezint\u0103 \u00een mod real hipercortizolism endogen<sup>4;5<\/sup>.<\/p>\n<p>Pe de alt\u0103 parte, hiperactivitatea axului hipotalamo-hipofizo-corticosuprarenalian (HHCS) poate fi \u00eent\u00e2lnit\u0103 \u0219i \u00een absen\u021ba unui sindrom Cushing veritabil. Acest tip de hipercortizolism func\u021bional, denumit \u0219i pseudo-Cushing, a fost descris \u00een anumite afec\u021biuni psihiatrice (depresie, tulbur\u0103ri anxioase sau obsesiv-compulsive), la pacien\u021bi cu obezitate morbid\u0103, diabet zaharat necontrolat, alcoolism sau chiar \u00een absen\u021ba unor condi\u021bii clinice asociate. Se presupune c\u0103 anumi\u021bi centri corticali stimuleaz\u0103 eliberarea CRH care activeaz\u0103 la r\u00e2ndul s\u0103u \u00eentregul ax HHCS<sup>6<\/sup>. Testele de laborator utilizate \u00een mod obi\u0219nuit pentru diagnosticul sindromului Cushing prezint\u0103 anumite limit\u0103ri determinate \u00een principal de rata mare de rezultate fals-pozitive. De\u0219i m\u0103surarea excre\u021biei de glucocorticoizi este considerat\u0103 a fi testul de elec\u021bie care reflect\u0103 direct hipercortizolismul endogen, determin\u0103rile urinare pot fi influen\u021bate semnificativ de o recoltare inadecvat\u0103 a urinei din 24 ore. De asemenea \u00een pseudo-Cushing se \u00eenregistreaz\u0103 valori crescute ale cortizolului liber urinar de p\u00e2n\u0103 la 4 ori limita superioar\u0103 a normalului.<\/p>\n<p>Testul de supresie \u201covernight\u201d cu 1 mg de dexametazon\u0103 prezint\u0103 avantajul unei proceduri simple \u0219i a unui cost redus, \u00eens\u0103 se \u00eenso\u021be\u0219te de o rat\u0103 mare de rezultate fals-pozitive \u00een special la persoane cu afec\u021biuni cronice, obeze sau cu boli psihiatrice. De asemenea pacientele aflate sub contraceptive orale au o rat\u0103 de rezultate pozitive de ~ 50% datorit\u0103 nivelurilor crescute de CBG.<\/p>\n<p>Testul de supresie cu dexametozon\u0103 2 mg\/zi, 48 ore poate fi utilizat \u00een cazul pacien\u021bilor cu posibil\u0103 hiperactivitate a axului HHCS \u0219i prezint\u0103 o specificitate mai mare dac\u0103 \u00een loc de cortizolul urinar este utilizat cortizolul seric sau plasmatic pentru evaluarea gradului de supresie. Totu\u0219i studiile efectuate indic\u0103 o acurate\u021be diagnostic\u0103 redus\u0103 a acestui test \u00een compara\u021bie cu celelalte teste utilizate \u00een screening-ul sindromului Cushing, din motive insuficient precizate<sup>4;5<\/sup>.<\/p>\n<p>Rezultatele ambelor teste de supresie pot fi influen\u021bate de varia\u021bii individuale \u00een absorb\u021bia \u0219i metabolismul dexametazonei. De asemenea consumul de alcool sau de medicamente cum ar fi, fenitoinul, fenobarbitalul, carbamazepina, rifampicina determin\u0103 un clearance hepatic accelerat prin induc\u021bia citocromului CYP3A4, cu sc\u0103derea consecutiv\u0103 a nivelurilor plasmatice de dexametazon\u0103. Pe de alt\u0103 parte clearance-ul dexametazonei este redus la pacien\u021bii cu insuficien\u021b\u0103 hepatic\u0103 \u0219i \/sau renal\u0103<sup>4<\/sup>.<\/p>\n<p>Spre deosebire de sindromul Cushing, \u00een majoritatea cazurilor de pseudo-Cushing se men\u021bine ritmul circadian fiziologic al secre\u021biei de cortizol astfel c\u0103 m\u0103surarea cortizolului seric la miezul nop\u021bii (ora 24) poate diferen\u021bia cele dou\u0103 condi\u021bii cu o acurate\u021be de 95%. Cu toate acestea utilizarea acestui test nu este practic\u0103 \u00een screening-ul ini\u021bial al sindromului Cushing, fiind rezervat\u0103 pentru confirmarea diagnosticului pozitiv \u00een centre de specialitate<sup>5<\/sup>.<\/p>\n<p>Un alt test recomandat de c\u0103tre grupul de consens interna\u021bional al Societ\u0103\u021bii de Endocrinologie \u00een prima etap\u0103 de testare a pacien\u021bilor cu suspiciune clinic\u0103 de sindrom Cushing este determinarea cortizolului salivar la miezul nop\u021bii.<\/p>\n<p>Cortizolul liber \u00een s\u00e2nge, forma activ\u0103 biologic, se afl\u0103 \u00eentr-un echilibru cu cortizolul din saliv\u0103, iar acesta din urm\u0103 pare s\u0103 nu fie afectat de rata de producere a salivei. Mai mult, o cre\u0219tere a cortizolului \u00een s\u00e2nge este imediat (\u00een decurs de c\u00e2teva minute) reflectat\u0103 \u00eentr-o modificare a concentra\u021biei cortizolului salivar<sup>6<\/sup>. Fiind un marker surogat pentru cortizolul liber plasmatic, cortizolul salivar nu este influen\u021bat de modific\u0103rile concentra\u021biei CBG<sup>1<\/sup>. Investigatori din centre diferite, utiliz\u00e2nd metode de testare \u0219i criterii de diagnostic variate, au raportat pentru nivelurile cortizolului salivar m\u0103surate la miezul nop\u021bii o sensibilitate \u0219i o specificitate pentru diagnosticul sindromului Cushing de 92-100% \u0219i, respectiv, 93-100%. Acest test non-invaziv, u\u0219or de efectuat la domiciliu cu ajutorul unui sistem special de recoltare, a fost utilizat \u0219i \u00een cazul copiilor pentru a diferen\u021bia pacien\u021bii cu sindrom Cushing de cei cu obezitate simpl\u0103 (sensibilitate 100% \u0219i specificitate 92.5%)<sup>4<\/sup>. Dup\u0103 unii autori, determinarea cortizolului salivar la ora 24 este superioar\u0103 celorlate metode \u00een identificarea pacien\u021bilor cu forme u\u0219oare sau ciclice de sindrom Cushing, \u00a0iar cre\u0219terile subtile ale cortizolului salivar nocturn ar reprezenta una din primele anomalii ap\u0103rute \u00een aceast\u0103 afec\u021biune<sup>3;5<\/sup>.<\/p>\n<p>Determinarea cortizolului salivar reprezint\u0103 un instrument util nu numai pentru diagnosticul sindromului Cushing ci \u0219i pentru monitorizarea r\u0103spunsului la tratamentul medical \u0219i\/sau chirurgical. Remiterea hipertensiunii arteriale, hipokaliemiei \u0219i a psihozei sunt asociate cu normalizarea cortizolului salivar. De asemenea cu ajutorul acestui test pot fi evaluate remisiunea sau recuren\u021bele dup\u0103 tratmentul chirurgical al adenomului hipofizar<sup>6<\/sup>.<\/p>\n<p>Unele studii de medicina muncii atest\u0103 rolul m\u0103sur\u0103rii cortizolului salivar \u00een evaluarea stresului mental al personalului<sup>7<\/sup>.<\/p>\n<p><strong><em>Recomand\u0103ri pentru determinarea cortizolului<\/em><\/strong>\u00a0<strong><em>salivar<\/em><\/strong><\/p>\n<p>Cortizolul salivar m\u0103surat la miezul nop\u021bii reprezint\u0103 una din investiga\u021biile de laborator recomandate de c\u0103tre grupul de consens interna\u021bional al Societ\u0103\u021bii de Endocrinologie \u00een prima etap\u0103 de testare a pacien\u021bilor cu suspiciune clinic\u0103 de sindrom Cushing.<\/p>\n<p><em>\u00cen categoria pacien\u021bilor susceptibili se \u00eencadreaz\u0103:<\/em><\/p>\n<ul>\n<li>pacien\u021bi cu obezitate, depresie, diabet zaharat tip II, HTA, tulbur\u0103ri menstruale, osteoporoz\u0103 secundar\u0103;<\/li>\n<li>pacien\u021bi cu afec\u021biuni discordante cu v\u00e2rsta (osteoporoz\u0103, hipertensiune arterial\u0103);<\/li>\n<li>copiii supraponderali cu hipotrofie statural\u0103;<\/li>\n<li>pacien\u021bii cu mas\u0103 suprarenalian\u0103 de tip incidentalom;<\/li>\n<li>pacien\u021bi cu simptome \u0219i semne clinice multiple \u0219i progresive ca evolutivitate care ar putea fi sugestive pentru excesul de glucocorticoizi<sup>4<\/sup>.<\/li>\n<\/ul>\n<p><strong><em>Preg\u0103tire pacient <\/em><\/strong><em>&#8211;<\/em>vor fi evitate:<\/p>\n<p><em>\u2022 <\/em>fumatul \u00een ziua recolt\u0103rii;<\/p>\n<p>\u2022 sp\u0103latul pe din\u021bi \u00eenainte de recoltarea propriu-zis\u0103;<\/p>\n<p>\u2022 consumul de alimente \u0219i lichide cu 30 minute \u00eenaintea recolt\u0103rii;<\/p>\n<p>\u2022 stres-ul \u0219i activitatea intens\u0103 cu 3 ore \u00eenaintea recolt\u0103rii<sup>4;5;8<\/sup>.<\/p>\n<p><strong><em>Recipient de recoltare <\/em><\/strong><em>&#8211; <\/em>Salivette Cortisol<\/p>\n<ol>\n<li>Desface\u0163i capacul tubului Salivette Cortisol pentru a expune tamponul din interior; nu \u00eendep\u0103rta\u0163i suportul pe care se g\u0103se\u015fte tamponul.<\/li>\n<\/ol>\n<p align=\"center\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-11909\" title=\"cortizol-recoltare1\" src=\"\/wp-content\/uploads\/2011\/12\/cortizol-recoltare1.jpg\" alt=\"-\" width=\"142\" height=\"117\"><\/p>\n<ol start=\"2\">\n<li>L\u0103sa\u0163i ca tamponul s\u0103 cad\u0103 direct \u00een cavitatea bucal\u0103 prin bascularea u\u015foar\u0103 a recipientului<\/li>\n<\/ol>\n<p align=\"center\">\u00a0<img decoding=\"async\" class=\"aligncenter size-full wp-image-11910\" title=\"cortizol-recoltare2\" src=\"\/wp-content\/uploads\/2011\/12\/cortizol-recoltare2.jpg\" alt=\"-\" width=\"142\" height=\"117\"><\/p>\n<ol start=\"3\">\n<li>\u0162ine\u0163i tamponul \u00een gur\u0103 mestec\u00e2ndu-l \u015fi rotindu-l u\u015for timp de 2 minute. Dup\u0103 aceea da\u0163i drumul la tampon \u00eenapoi \u00een recipient f\u0103r\u0103 a-l atinge cu degetele.<\/li>\n<\/ol>\n<p align=\"center\">\u00a0<img decoding=\"async\" class=\"aligncenter size-full wp-image-11911\" title=\"cortizol-recoltare3\" src=\"\/wp-content\/uploads\/2011\/12\/cortizol-recoltare3.jpg\" alt=\"-\" width=\"142\" height=\"117\"><\/p>\n<p><strong><em>Prelucrare \u00een laborator <\/em><\/strong><em>&#8211;<\/em>proba va fi centrifugat\u0103 (2 minute la 1000 rota\u021bii); saliva va fi recuperat\u0103 \u00een por\u021biunea conic\u0103 a tubului; se va \u00eendep\u0103rta \u00een final suportul ce con\u021bine tamponul utilizat la recoltare<sup>8<\/sup>.<\/p>\n<p><strong><em>Volum prob\u0103<\/em><\/strong> &#8211; 1 mL saliv\u0103<sup>8<\/sup>.<\/p>\n<p><strong><em>Stabilitate prob\u0103 <\/em><\/strong><em>-3 zile<\/em> la 2-8\u00b0C (se congeleaz\u0103 pentru o perioad\u0103 mai mare de timp)<sup>8<\/sup>.<\/p>\n<p><strong><em>Metod\u0103 <\/em><\/strong>&#8211; <span style=\"text-decoration: underline;\">imunochimic\u0103 cu detec\u021bie prin electrochemiluminiscen\u021b\u0103 (ECLIA)<sup>8<\/sup><\/span>.<\/p>\n<p><strong><em>Valori de referin\u021b\u0103<\/em><\/strong><sup>8<\/sup><\/p>\n<p>orele 6-10 :\u00a0\u00a0\u00a0\u00a0 &lt; 24.1 \u00a0nmol\/L<\/p>\n<p>orele 16 &#8211; 20:\u00a0 &lt; 9.65 nmol\/L<\/p>\n<p>ora 24:\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 &lt; 11.3 nmol\/L<\/p>\n<p><em>Factori de conversie:<\/em> <em>\u03bc<\/em><em>g\/dL x 2.76 = nmol\/L; nmol\/L x 0.3625 = <\/em><em>\u03bc<\/em><em>g\/L<\/em><\/p>\n<p><strong><em>Interpretarea rezultatelor<\/em><\/strong><\/p>\n<p>Sindromul Cushing se caracterizeaz\u0103 prin cre\u0219terea nivelului cortizolului salivar, iar m\u0103surarea acestuia la miezul nop\u021bii reprezint\u0103 un instrument optim pentru testarea ini\u021bial\u0103. Rezultatele pozitive trebuie confirmate pe cel pu\u021bin dou\u0103 recolt\u0103ri diferite<sup>3<\/sup>.<\/p>\n<p><strong><em>Limite \u0219i interferen\u021be<\/em><\/strong><\/p>\n<div>Influen\u021ba v\u00e2rstei, sexului \u0219i a condi\u021biilor medicale asociate asupra valorilor cortizolului salivar nu a fost pe deplin caracterizat\u0103.<\/div>\n<div>Ritmul circadian al cortizolului plasmatic poate fi alterat la unii pacien\u021bi cu afec\u021biuni depresive precum \u0219i la persoanele care lucreaz\u0103 \u00een schimburi de noapte \u0219i poate fi abolit la pacien\u021bii afla\u021bi \u00eentr-o stare critic\u0103. \u00cen aceste situa\u021bii m\u0103surarea cortizolului salivar poate conduce la rezultate eronate.<\/div>\n<div>Contaminarea direct\u0103 a recipientului Salivette cu lo\u021biuni sau geluri orale ce con\u021bin corticosteroizi poate conduce la rezultate fals-pozitive<sup>4<\/sup>.<\/div>\n<div>M\u0103surarea cortizolului salivar matinal nu este util\u0103 pentru diagnosticul insuficien\u021bei suprarenaliene av\u00e2nd o sensibilitate \u0219i o specificitate &lt; 35%. Acest fapt se datoreaz\u0103 spectrului larg de valori ale cortizolului seric \u0219i salivar determinate matinal la persoanele s\u0103n\u0103toase<sup>6<\/sup>.<\/div>\n<p><span style=\"font-size: 10pt;\"><strong>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/span><\/p>\n<ol>\n<li>\u00a0<span style=\"font-size: 10pt;\">Jacques Wallach. Afec\u021biuni endocrine. \u00cen<em> Interpretarea testelor de diagnostic.<\/em> Editura \u0218tiintelor Medicale, Rom\u00e2nia, Ed. 7, 2001, 835-837; 866-868.<\/span><\/li>\n<li><span style=\"font-size: 10pt;\">\u00a0Laboratory Corporation of America. Directory of Services and Interpretive Guide. Salivary Cortisol,\u00a0\u00a0\u00a0 MS. <a href=\"http:\/\/www.labcorp.com\/\" rel=\"nofollow noopener\" target=\"_blank\">www.labcorp.com<\/a> 2016. Ref Type: Internet Communication<\/span><\/li>\n<li><span style=\"font-size: 10pt;\">\u00a0Mayo Clinic\/Mayo Medical Laboratories. Test Catalog. Cortisol,\u00a0\u00a0Saliva.\u00a0\u00a0\u00a0<a href=\"http:\/\/www.mayomedicallaboratories.com\/\" rel=\"nofollow noopener\" target=\"_blank\">\u00a0www.mayomedicallaboratories.com<\/a>. Ref Type: Internet Communication, 2016.<\/span><\/li>\n<li><span style=\"font-size: 10pt;\">Lynnette K. Nieman, Beverly M. K. Biller, James W. Findling, John Newell-Price, Martin O. Savage, Paul M. Stewart, and Victor M. Montor. <strong>\u0423<\/strong>he Diagnosis of Cushing\u2019s Syndrome: An Endocrine Society Clinical Practice Guideline. In <em>The Journal of Clinical Endocrinology <\/em><em>&amp; <\/em><em>Metabolism<\/em>, May 2008, 93(5): 1526-1540.<\/span><\/li>\n<li><span style=\"font-size: 10pt;\">Dimitris A. Papanicolaou\u00a0 at al.\u00a0 Nightime Salivary Cortisol: A Useful Test for the Diagnosis of Cushing\u021bs Syndrome. In <em>The Journal of Clinical Endocrinology <\/em><em>&amp; <\/em><em>Metabolism<\/em>, October 1, 2002, vol.87, no. 10, 4515-4521.<\/span><\/li>\n<li><span style=\"font-size: 10pt;\">Raff H. Utility of Salivary Cortisol Measurements in Cushing&#8217;s Syndrome and Adrenal Insufficiency. In <em>The Journal of Clinical <\/em><em>Endocrinology <\/em><em>&amp; <\/em><em>Metabolism<\/em>, October 2009, 94:3647-3655.<\/span><\/li>\n<li><span style=\"font-size: 10pt;\">Mark Cropley et al. The Relationship Between Long-Term Job Strain and Morning and Evening Cortisol Secretion Amomg White-Collar Workers. In <em>Journal of Occupational Health Psychology<\/em> 2008, Vol.13, No.2, 105-113.<\/span><\/li>\n<li><span style=\"font-size: 10pt;\">Laborator Synevo. Referin\u021bele specifice tehnologiei de lucru utilizate 2016. Ref Type: Catalog.<\/span><\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>\u041a\u043e\u0440\u0442\u0438\u0437\u043e\u043b \u2013 \u043b\u0438\u043f\u043e\u0444\u0438\u043b\u044c\u043d\u044b\u0439 \u0441\u0442\u0435\u0440\u043e\u0438\u0434\u043d\u044b\u0439 \u0433\u043e\u0440\u043c\u043e\u043d \u0441 \u043d\u0435\u0431\u043e\u043b\u044c\u0448\u043e\u0439 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0439 \u043c\u0430\u0441\u0441\u043e\u0439, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0441\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0432 \u043a\u043e\u0440\u0435 \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432. \u041e\u043d \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0433\u043b\u0430\u0432\u043d\u044b\u043c \u0433\u043b\u044e\u043a\u043e\u043a\u043e\u0440\u0442\u0438\u043a\u043e\u0438\u0434\u043d\u044b\u043c \u0433\u043e\u0440\u043c\u043e\u043d\u043e\u043c \u0438 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\u0431\u043e\u043b\u0435\u0437\u043d\u044c \u0410\u0434\u0434\u0438\u0441\u043e\u043d\u0430 (\u0441\u043b\u0430\u0431\u043e\u0441\u0442\u044c, \u0443\u0441\u0442\u0430\u043b\u043e\u0441\u0442\u044c, \u043f\u043e\u043d\u0438\u0436\u0435\u043d\u043d\u043e\u0435 \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0435 \u0434\u0430\u0432\u043b\u0435\u043d\u0438\u0435, \u043f\u0438\u0433\u043c\u0435\u043d\u0442\u0430\u0446\u0438\u044f \u043a\u043e\u0436\u0438);<\/li>\n<li>\u043f\u0440\u0438 \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432;<\/li>\n<li>\u043f\u0440\u0438 \u0432\u044b\u043f\u043e\u043b\u043d\u0435\u043d\u0438\u0438 \u0434\u0435\u043a\u0441\u0430\u043c\u0435\u0442\u0430\u0437\u043e\u043d\u043e\u0432\u043e\u0433\u043e \u0442\u0435\u0441\u0442\u0430;<\/li>\n<li>\u043f\u0440\u0438 \u043e\u0446\u0435\u043d\u043a\u0435 \u0440\u0435\u0430\u043a\u0446\u0438\u0438 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430 \u043d\u0430 \u0441\u0442\u0440\u0435\u0441\u0441.<\/li>\n<\/ol>\n<p>\u041a\u0430\u043a \u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u043e \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u0438\u0442\u044c\u0441\u044f \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e?<\/p>\n<ol>\n<li>\u0418\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u0438\u0437 \u0440\u0430\u0446\u0438\u043e\u043d\u0430 \u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 24 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n<li>\u041d\u0435 \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0442\u044c \u043f\u0438\u0449\u0443 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 2-3 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f, \u043c\u043e\u0436\u043d\u043e \u043f\u0438\u0442\u044c \u0447\u0438\u0441\u0442\u0443\u044e \u043d\u0435\u0433\u0430\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u0443\u044e \u0432\u043e\u0434\u0443.<\/li>\n<li>\u0418\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0438 \u044d\u043c\u043e\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0435 \u043f\u0435\u0440\u0435\u043d\u0430\u043f\u0440\u044f\u0436\u0435\u043d\u0438\u0435 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 3 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n<li>\u041d\u0435 \u0447\u0438\u0441\u0442\u0438\u0442\u044c \u0437\u0443\u0431\u044b, \u043d\u0435 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c \u0437\u0443\u0431\u043e\u0447\u0438\u0441\u0442\u043a\u0438, \u0437\u0443\u0431\u043d\u044b\u0435 \u043d\u0438\u0442\u0438, \u0438\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u043c\u0430\u043d\u0438\u043f\u0443\u043b\u044f\u0446\u0438\u0438, \u0442\u0440\u0430\u0432\u043c\u0438\u0440\u0443\u044e\u0449\u0438\u0435 \u0441\u043b\u0438\u0437\u0438\u0441\u0442\u0443\u044e \u043e\u0431\u043e\u043b\u043e\u0447\u043a\u0443 \u0440\u043e\u0442\u043e\u0432\u043e\u0439 \u043f\u043e\u043b\u043e\u0441\u0442\u0438, \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 3 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0441\u0431\u043e\u0440\u0430 \u0431\u0438\u043e\u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430. \u041f\u0435\u0440\u0435\u0434 \u0441\u0431\u043e\u0440\u043e\u043c \u0431\u0438\u043e\u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430 \u0443\u0431\u0435\u0434\u0438\u0442\u044c\u0441\u044f, \u0447\u0442\u043e \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u044e\u0442 \u043a\u0440\u043e\u0432\u043e\u0442\u043e\u0447\u0438\u0432\u043e\u0441\u0442\u044c \u0434\u0435\u0441\u0435\u043d \u0438 \u0442\u0440\u0430\u0432\u043c\u044b \u0441\u043b\u0438\u0437\u0438\u0441\u0442\u043e\u0439 \u043e\u0431\u043e\u043b\u043e\u0447\u043a\u0438 \u0440\u043e\u0442\u043e\u0432\u043e\u0439 \u043f\u043e\u043b\u043e\u0441\u0442\u0438.<\/li>\n<li>\u041f\u0440\u0438 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0438 \u043e\u0441\u043e\u0431\u044b\u0445 \u0443\u043a\u0430\u0437\u0430\u043d\u0438\u0439 \u0432\u0440\u0430\u0447\u0430 \u0441\u0431\u043e\u0440 \u0431\u0438\u043e\u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u044c \u0432\u0435\u0447\u0435\u0440\u043e\u043c \u043c\u0435\u0436\u0434\u0443 22 \u0438 24 \u0447\u0430\u0441\u0430\u043c\u0438, \u043e\u043f\u0442\u0438\u043c\u0430\u043b\u044c\u043d\u043e \u2013 \u0432 23 \u0447\u0430\u0441\u0430.<\/li>\n<\/ol>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[917],"product_tag":[],"class_list":{"0":"post-12120","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-suprarenalieni","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/12120","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=12120"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=12120"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=12120"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=12120"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=12120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}