{"id":12118,"date":"2020-05-05T23:16:47","date_gmt":"2020-05-05T20:16:47","guid":{"rendered":"https:\/\/www.synevo.ro\/shop\/anticorpi-anti-nucleozom\/"},"modified":"2025-02-06T11:56:55","modified_gmt":"2025-02-06T09:56:55","slug":"anticorpi-anti-nucleozom","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-nucleozom\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u043d\u0443\u043a\u043b\u0435\u043e\u0441\u043e\u043c\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430"},"content":{"rendered":"<p>Nucleozomii sunt unit\u0103\u021bi fundamentale ale cromatinei \u0219i produse normale ale apoptozei celulare. Ace\u0219tia joac\u0103 un rol cheie \u00een lupusul eritematos sistemic, at\u00e2t \u00een \u200b\u200binducerea anticorpilor patogeni anti-nucleari, c\u00e2t \u0219i ca antigen \u021bint\u0103 al leziunilor tisulare mediate de autoanticorpi<sup>1<\/sup>. Anticorpii anti-nucleozomi apar la pacien\u021bii cu lupus eritematos sistemic \u0219i s-a raportat c\u0103 sunt de ajutor \u00een diagnosticul diferen\u021bial al bolii. Lupusul eritematos sistemic este o boal\u0103 autoimun\u0103 sistemic\u0103 cronic\u0103 care produce un spectru larg de manifest\u0103ri clinice<sup>1,2<\/sup>.<\/p>\n<p>Una dintre caracteristicile imunologice ale LES este pierderea toleran\u021bei la cromatina celular\u0103 proprie, manifest\u00e2ndu-se ca auto-anticorpi circulan\u021bi direc\u021biona\u021bi \u00eempotriva a trei dintre subunit\u0103\u021bile sale majore, \u0219i anume, acizii dezoxiribonucleici dublu catenar (ds-DNA), histonele \u0219i nucleozomii. Exist\u0103 dovezi c\u0103 \u00een lupusul eritematos sistemic, nucleozomii, componenta de baz\u0103 a cromatinei nucleare, reprezint\u0103 at\u00e2t un factor imunogen, c\u00e2t \u0219i o \u021bint\u0103\u00a0<em>in vivo<\/em>\u00a0major\u0103 pentru anticorpi. O apoptoz\u0103 perturbat\u0103 sau o eliminare redus\u0103 a celulelor apoptotice de c\u0103tre fagocite, pot duce la o expunere crescut\u0103 a nucleozomilor apoptotici la sistemul imunitar. Ace\u0219ti nucleozomi, care sunt scinda\u021bi \u0219i modifica\u021bi \u00een timpul procesului de apoptoz\u0103, scap\u0103 de etapa normal\u0103 de clearance \u0219i leag\u0103 epitopi care \u00een mod normal nu exist\u0103 \u00een sistemul imunitar<sup>3<\/sup>. Acest lucru poate duce apoi la producerea de autoanticorpi anti-nucleozomici, anti-histonici \u0219i anti-ADN. Unele subseturi de anticorpi anti-nucleozomi sunt patogeni \u0219i sunt implicate \u00een procesul nefritogen \u00een lupusul eritematos sistemic<sup>4<\/sup>.<\/p>\n<p>\u00cen consecin\u021b\u0103, mai multe studii au raportat cre\u0219terea nucleozomilor plasmatici circulan\u021bi care s-au corelat pozitiv cu o boal\u0103 activ\u0103, agregarea nucleozomilor \u00een depozitele glomerulare tipice, precum \u0219i \u00een membrana bazal\u0103 a pielii nelezionale a pacien\u021bilor cu lupus eritematos sistemic \u0219i o str\u00e2ns\u0103 corela\u021bie \u00eentre nefrit\u0103 \u0219i prezen\u021ba anticorpilor anti-nucleozomici. Studii recente au raportat anticorpi anti-nucleozomici \u0219i \u00een sindromul antifosfolipidic primar \u0219i \u00een special la pacien\u021bii cu boli asem\u0103n\u0103toare lupusului<sup>5,6<\/sup>. Un num\u0103r limitat de studii longitudinale au ar\u0103tat c\u0103 titrurile de anticorpi serici pot fi utile \u00een monitorizarea activit\u0103\u021bii bolii, inclusiv nefrit\u0103 lupic\u0103<sup>7<\/sup>.<\/p>\n<p><strong><em>Recomand\u0103ri pentru determinarea anticorpi anti-nucleozom<\/em><\/strong><\/p>\n<ul>\n<li>Evaluarea pacien\u021bilor diagnostica\u021bi cu lupus eritematos sistemic<sup>1-9<\/sup><\/li>\n<\/ul>\n<p><strong><em>Specimen recoltat \u2013\u00a0<\/em><\/strong>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>8<\/sup><\/p>\n<p><strong><em>Volum prob\u0103 \u2013\u00a0<\/em><\/strong>1 mL<sup>8<\/sup><\/p>\n<p><strong><em>Cauze de respingere a probei<\/em><\/strong><\/p>\n<ul>\n<li>Specimen hemolizat<sup>8<\/sup><\/li>\n<\/ul>\n<p><strong><em>Stabilitate prob\u0103\u00a0<\/em><\/strong>\u2013 la temperatura camerei timp de 14 zile<sup>8<\/sup><\/p>\n<p><strong><em>Metod\u0103 \u2013<\/em><\/strong>\u00a0ELISA<sup>9<\/sup><\/p>\n<p><strong><em>Valori de referin\u021b\u0103\u00a0<\/em><\/strong>&lt;20 U\/mL<sup>8,9<\/sup><\/p>\n<p><strong><em>\u00a0<\/em><\/strong><strong><em>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/em><\/strong><\/p>\n<ol>\n<li>Muller, S., Dieker, J., Tincani, A., &amp; Meroni, P. L. (2008). Pathogenic anti-nucleosome antibodies. Lupus, 17(5), 431\u2013436.\u00a0https:\/\/doi.org\/10.1177\/0961203308090030<\/li>\n<li>Suleiman, S., Kamaliah, D., Nadeem, A., Naing, N. N., &amp; Che Maraina, C. H. (2009). Anti-nucleosome antibodies as a disease activity marker in patients with systemic lupus erythematosus. International journal of rheumatic diseases, 12(2), 100\u2013106.\u00a0https:\/\/doi.org\/10.1111\/j.1756-185X.2009.01391.x<\/li>\n<li>Rodriguez-Jimenez, N.A., Perez-Guerrero, E.E., Gamez-Nava, J.I. et al. Anti-nucleosome antibodies increase the risk of renal relapse in a prospective cohort of patients with clinically inactive systemic lupus erythematosus. Sci Rep 10, 12698 (2020).\u00a0https:\/\/doi.org\/10.1038\/s41598-020-69608-5<\/li>\n<li>Guti\u00e9rrez-Adrianz\u00e9n, O. A., Koutouzov, S., Mota, R. M., das Chagas Medeiros, M. M., Bach, J. F., &amp; de Holanda Campos, H. (2006). Diagnostic value of anti-nucleosome antibodies in the assessment of disease activity of systemic lupus erythematosus: a prospective study comparing anti-nucleosome with anti-dsDNA antibodies. The Journal of rheumatology, 33(8), 1538\u20131544.<\/li>\n<li>Bizzaro, N., Villalta, D., Giavarina, D., &amp; Tozzoli, R. (2012). Are anti-nucleosome antibodies a better diagnostic marker than anti-dsDNA antibodies for systemic lupus erythematosus? A systematic review and a study of metanalysis. Autoimmunity reviews, 12(2), 97\u2013106.\u00a0https:\/\/doi.org\/10.1016\/j.autrev.2012.07.002<\/li>\n<li>Sim\u00f3n, J. A., Cabiedes, J., Ortiz, E., Alcocer-Varela, J., &amp; S\u00e1nchez-Guerrero, J. (2004). Anti-nucleosome antibodies in patients with systemic lupus erythematosus of recent onset. Potential utility as a diagnostic tool and disease activity marker. Rheumatology (Oxford, England), 43(2), 220\u2013224.\u00a0https:\/\/doi.org\/10.1093\/rheumatology\/keh024<\/li>\n<li>Min, D. J., Kim, S. J., Park, S. H., Seo, Y. I., Kang, H. J., Kim, W. U., Cho, C. S., &amp; Kim, H. Y. (2002). Anti-nucleosome antibody: significance in lupus patients lacking anti-double-stranded DNA antibody. Clinical and experimental rheumatology, 20(1), 13\u201318.<\/li>\n<li>Tests. Anti nucleosome antibodies. [on-line]:\u00a0https:\/\/www.labcorp.com\u00a0(Accesat la data de 01.10.2021)<\/li>\n<li>Cairns AP, McMillan SA, Crockard AD, et al (2003). Antinucleosome antibodies in the diagnosis of systemic lupus erythematosus. Annals of the Rheumatic Diseases;62:272-273.<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>\u041d\u0443\u043a\u043b\u0435\u043e\u0441\u043e\u043c\u044b \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0444\u0443\u043d\u0434\u0430\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u044b\u043c\u0438 \u0435\u0434\u0438\u043d\u0438\u0446\u0430\u043c\u0438 \u0445\u0440\u043e\u043c\u0430\u0442\u0438\u043d\u0430 \u0438 \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u044b\u043c\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0430\u043c\u0438 \u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0430\u043f\u043e\u043f\u0442\u043e\u0437\u0430. \u041e\u043d\u0438 \u0438\u0433\u0440\u0430\u044e\u0442 \u043a\u043b\u044e\u0447\u0435\u0432\u0443\u044e \u0440\u043e\u043b\u044c \u0432 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0439 \u043a\u0440\u0430\u0441\u043d\u043e\u0439 \u0432\u043e\u043b\u0447\u0430\u043d\u043a\u0435, \u043a\u0430\u043a \u0432 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