{"id":12073,"date":"2020-05-05T23:16:38","date_gmt":"2020-05-05T20:16:38","guid":{"rendered":"https:\/\/www.synevo.ro\/shop\/inhibina-a\/"},"modified":"2025-02-07T12:40:04","modified_gmt":"2025-02-07T10:40:04","slug":"inhibina-a","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/inhibina-a\/","title":{"rendered":"\u0418\u043d\u0433\u0438\u0431\u0438\u043d \u0410"},"content":{"rendered":"<p>Determinarea\u00a0Inhibinei A din ser\u00a0este recomandat\u0103 \u00een screeningul prenatal al unor boli cromozomiale fetale \u0219i al preeclampsiei; ca biomarker tumoral \u00een diagnosticarea anumitor forme histologice de cancer ovarian (stromal), postmenopauz\u0103, \u00een combina\u021bie cu inhibina B.<\/p>\n<p><strong><em>Informa\u021bii generale<\/em><\/strong><\/p>\n<p>Inhibina este un hormon proteic heterodimeric secretat de celulele granuloase ale ovarului \u0219i celulele Sertoli din testicul. Ele suprim\u0103 selectiv secre\u021bia hormonului hipofizar de stimulare a foliculilor (FSH) \u0219i au ac\u021biuni paracrine locale, \u00een gonade<sup>1,2<\/sup>. Inhibinele au structur\u0103 dimer\u0103 de subunit\u0103\u021bi omologe, o subunitate alfa \u0219i fie o subunitate beta-A, fie o subunitate beta-B, pentru a forma inhibin\u0103 A \u0219i, respectiv, inhibin\u0103 B<sup>3<\/sup>.<\/p>\n<p>La femei, inhibina A este produs\u0103 \u00een principal de foliculul dominant \u0219i corpul luteal, \u00een timp ce inhibina B este produs\u0103 predominant de foliculi mici, \u00een curs de dezvoltare. Nivelurile de inhibin\u0103 seric\u0103 A \u0219i B fluctueaz\u0103 \u00een timpul ciclului menstrual. La menopauz\u0103, odat\u0103 cu epuizarea foliculilor ovarieni, inhibina seric\u0103 A \u0219i B ajung la niveluri foarte sc\u0103zute sau nedetectabile<sup>3,4<\/sup>.<\/p>\n<p>Cre\u0219teri ale valorilor inhibinei serice A \u0219i B sunt detectate la unii pacien\u021bi cu tumori cu celule granuloase. Cre\u0219teri ale inhibinei A au fost raportate la aproximativ 70% din tumorile cu celule granuloase<sup>4,5<\/sup>. La ace\u0219ti pacien\u021bi, nivelurile de inhibin\u0103 A tind s\u0103 prezinte o cre\u0219tere de 6 p\u00e2n\u0103 la 7 ori fa\u021b\u0103 de valoarea intervalului de referin\u021b\u0103. Valoarea nivelurilor considerate crescute variaz\u0103 de la un studiu la altul, probabil datorit\u0103 particularit\u0103\u021bilor diferite ale anticorpilor utiliza\u021bi \u00een testele imunologice folosite<sup>6<\/sup>.<\/p>\n<p>Sunt studii care arat\u0103 c\u0103 inhibina A poate fi un biomarker potrivit pentru tumorile epiteliale de tip mucinos, cu aproximativ 20% din cazurile cu niveluri crescute de inhibin\u0103 A. \u00cen schimb, inhibina nu este un biomarker foarte util \u00een cazul tumorilor epiteliale nonmucinoase. \u00cens\u0103 exist\u0103 studii care demonstreaz\u0103 faptul c\u0103 inhibina total\u0103 poate fi crescut\u0103 \u00een 15% p\u00e2n\u0103 la 35% din cazurile de cancer ovarian epitelial nonmucinous. Inhibina pare a fi un biomarker complementar antigenului cancerului 125 (CA 125) ca \u0219i biomarker pentru cancerul ovarian<sup>7-9<\/sup>.<\/p>\n<p>Majoritatea studiilor pentru inhibina A ca biomarker al cancerului ovarian au fost limitate la femeile aflate \u00een postmenopauz\u0103, unde valorile ambelor proteine sunt \u00een mod normal foarte sc\u0103zute. Inhibina A are o utilitate limitat\u0103 ca biomarker de cancer ovarian, la femeile aflate \u00een premenopauz\u0103, unde nivelurile circulante sunt mai mari \u0219i fluctueaz\u0103 pe tot parcursul ciclului menstrual \u0219i acestea pot fi dificil de interpretat<sup>4,7,10<\/sup>.<\/p>\n<p><strong><em>Recomand\u0103ri pentru determinarea inhibinei A<\/em><\/strong><sup>11<\/sup><\/p>\n<ul>\n<li>Diagnosticul pacien\u021bilor cu tumori celulare granuloase ale ovarului<\/li>\n<li>Monitorizarea pacien\u021bilor cu tumori celulare granuloase \u0219i tumori epiteliale mucinoase ale ovarului, cunoscute ca secret\u0103 inhibina A<\/li>\n<\/ul>\n<p><strong><em>Specimen recoltat \u2013<\/em><\/strong>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>11<\/sup><\/p>\n<p><strong><em>Volum prob\u0103\u00a0<\/em><\/strong>\u2013 0.6 mL<sup>11<\/sup><\/p>\n<p><strong><em>Cauze de respingere a probei\u00a0<\/em><\/strong>\u2013 specimen hemolizat<sup>11<\/sup><\/p>\n<p><strong><em>Stabilitate prob\u0103\u00a0<\/em><\/strong>\u2013 timp de 7 zile refrigerat<sup>11<\/sup><\/p>\n<p><strong><em>Metod\u0103 \u2013\u00a0<\/em><\/strong>Test imunoenzimatic<sup>11<\/sup><\/p>\n<p><strong><em>Valori de referin\u021b\u0103<\/em><\/strong><sup>11<\/sup><\/p>\n<table width=\"414\">\n<tbody>\n<tr>\n<td width=\"102\"><strong>Genul<\/strong><\/td>\n<td width=\"132\"><strong>V\u00e2rsta (ani)<\/strong><\/td>\n<td width=\"180\"><strong>Valori de referin\u021b\u0103 (ng\/L)<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"102\">B\u0103rba\u021bi<\/td>\n<td width=\"132\">Indiferent de varsta<\/td>\n<td width=\"180\">&lt;7.0<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"4\" width=\"102\">Femei<\/td>\n<td width=\"132\">0-12<\/td>\n<td width=\"180\">&lt;4.7<\/td>\n<\/tr>\n<tr>\n<td width=\"132\">12-55<\/td>\n<td width=\"180\">Faza folicular\u0103: &lt; 20 ng\/l<\/p>\n<p>Faza luteal\u0103: &lt; 70 ng\/l<\/td>\n<\/tr>\n<tr>\n<td width=\"132\">&gt;55<\/td>\n<td width=\"180\">&lt;7<\/td>\n<\/tr>\n<tr>\n<td width=\"132\">Postmenopauz\u0103<\/td>\n<td width=\"180\">&lt;2.1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong><em>\u00a0<\/em><\/strong><\/p>\n<p><strong><em>Limite \u0219i interferen\u021be<\/em><\/strong><sup>11<\/sup><\/p>\n<p>Valorile inhibinei fluctueaz\u0103 \u00een timpul ciclului menstrual. Nivelurile de inhibin\u0103 la femeile aflate \u00een premenopauz\u0103 trebuie interpretate \u00eempreun\u0103 cu alte investiga\u021bii.<\/p>\n<p><strong><em>\u00a0<\/em><\/strong><strong><em>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/em><\/strong><\/p>\n<ol>\n<li>Overlie, I., M\u00f8rkrid, L., Andersson, A. M., Skakkebaek, N. E., Moen, M. H., &amp; Holte, A. (2005). Inhibin A and B as markers of menopause: a five-year prospective longitudinal study of hormonal changes during the menopausal transition. Acta obstetricia et gynecologica Scandinavica, 84(3), 281\u2013285.\u00a0<a href=\"https:\/\/doi.org\/10.1111\/j.0001-6349.2005.00490.x\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1111\/j.0001-6349.2005.00490.x<\/a><\/li>\n<li>Mom CH, Engelen MJ, Willemse PH, et al: Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort. Gynecol Oncol 2007 May;105(2):365-372<\/li>\n<li>Robertson DM, Pruysers E, Jobling T: Inhibin as a diagnostic marker for ovarian cancer. Cancer Lett 2007;249:14-17<\/li>\n<li>Kusumoto, S., Kurashige, M., Ohshima, K., Tahara, S., Matsui, T., Nojima, S., Hattori, S., &amp; Morii, E. (2021). An immature inhibin-\u03b1-expressing subpopulation of ovarian clear cell carcinoma cells is related to an unfavorable prognosis. Cancer medicine, 10(5), 1485\u20131500.\u00a0<a href=\"https:\/\/doi.org\/10.1002\/cam4.3801\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1002\/cam4.3801<\/a><\/li>\n<li>Singh, P., Jenkins, L. M., Horst, B., Alers, V., Pradhan, S., Kaur, P., Srivastava, T., Hempel, N., Gy\u0151rffy, B., Broude, E. V., Lee, N. Y., &amp; Mythreye, K. (2018). Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis. Cancer research, 78(11), 2978\u20132989.\u00a0<a href=\"https:\/\/doi.org\/10.1158\/0008-5472\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1158\/0008-5472<\/a>.CAN-17-2316<\/li>\n<li>Jamieson S, Fuller PJ: Management of granulosa cell tumour of the ovary. Curr Opin Oncol 2008;20(5):560-564<\/li>\n<li>Sturgeon C: Ch 31 Tumor Markers, In Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Sixth edition. Edited by N Rafai, AR Horvath, CT Wittwer. Elsevier, 2018, pp 436-478<\/li>\n<li>Yarbrough ML, Stout M, Gronowski AM: Ch 69 Pregnancy and Its Disorders. In Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Sixth edition. Edited by N Rafai, AR Horvath, CT Wittwer. Elsevier, 2018, pp 1655-1696<\/li>\n<li>Makanji Y, Zhu J, Mishra R, et al: Inhibin at 90: from discovery to clinical application, a historical review. Endocr Rev 2014;35(5):747\u2013794. doi:10.1210\/er.2014-1003<\/li>\n<li>Walentowicz P, Krintus M, Sadlecki P, et al: Serum inhibin A and inhibin B levels in epithelial ovarian cancer patients. PLoS One. 2014;9(3):e90575. doi:10.1371\/journal.pone.0090575<\/li>\n<li>Mayo Clinic. Mayo Medical Laboratories. Test Catalog. [on-line]:\u00a0<a href=\"https:\/\/www.mayocliniclabs.com\/\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/www.mayocliniclabs.com<\/a>\u00a0[Accesat la data de 11.07.2021]<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>\u0418\u043d\u0433\u0438\u0431\u0438\u043d \u0410 \u2013 \u0433\u043e\u0440\u043c\u043e\u043d \u0431\u0435\u043b\u043a\u043e\u0432\u043e\u0439 \u043f\u0440\u0438\u0440\u043e\u0434\u044b, \u0441\u043e\u0441\u0442\u043e\u044f\u0449\u0438\u0439 \u0438\u0437 \u0434\u0432\u0443\u0445 \u0441\u0443\u0431\u044a\u0435\u0434\u0438\u043d\u0438\u0446. \u041a\u0430\u043a \u0438 \u0438\u043d\u0433\u0438\u0431\u0438\u043d \u0412, \u043e\u043d \u043e\u0442\u043d\u043e\u0441\u0438\u0442\u0441\u044f \u043a \u043f\u043e\u043b\u043e\u0432\u044b\u043c \u0433\u043e\u0440\u043c\u043e\u043d\u0430\u043c. \u041e\u0442\u043b\u0438\u0447\u0430\u044e\u0442\u0441\u044f \u044d\u0442\u0438 \u0434\u0432\u0430 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\u043c\u0435\u0436\u0434\u0443 \u0434\u0432\u0443\u043c\u044f \u043f\u043e\u0434\u0442\u0438\u043f\u0430\u043c\u0438 \u0438\u043d\u0433\u0438\u0431\u0438\u043d\u0430 \u0441\u043e\u0441\u0442\u043e\u0438\u0442 \u0432 \u0442\u043e\u043c, \u0447\u0442\u043e \u0438\u043d\u0433\u0438\u0431\u0438\u043d \u0412 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0434\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0439 \u0444\u0435\u0440\u0442\u0438\u043b\u044c\u043d\u043e\u0439 \u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u043c\u0443\u0436\u0447\u0438\u043d \u0438 \u0436\u0435\u043d\u0449\u0438\u043d, \u0432 \u0442\u043e \u0432\u0440\u0435\u043c\u044f \u043a\u0430\u043a \u0438\u043d\u0433\u0438\u0431\u0438\u043d \u0410 \u043f\u0440\u0438\u043c\u0435\u043d\u044f\u0435\u0442\u0441\u044f \u0434\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0432\u0440\u043e\u0436\u0434\u0435\u043d\u043d\u043e\u0439 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u0432 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u043c\u0430\u0440\u043a\u0435\u0440\u0430 \u0443\u0433\u0440\u043e\u0436\u0430\u044e\u0449\u0435\u0433\u043e \u0430\u0431\u043e\u0440\u0442\u0430. \u042d\u0442\u043e \u043e\u0431\u0443\u0441\u043b\u043e\u0432\u043b\u0435\u043d\u043e \u043a\u0430\u043a \u0440\u0430\u0437\u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u044f\u043c\u0438 \u0441\u0438\u043d\u0442\u0435\u0437\u0430 \u044d\u0442\u043e\u0433\u043e \u0433\u043e\u0440\u043c\u043e\u043d\u0430.<\/p>\n<p>\u0412\u043e \u0432\u0440\u0435\u043c\u044f \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f \u0438\u043d\u0433\u0438\u0431\u0438\u043d\u0430 A \u0432 \u043a\u0440\u043e\u0432\u0438 \u043f\u043e\u0441\u0442\u0435\u043f\u0435\u043d\u043d\u043e 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