{"id":11978,"date":"2020-05-05T23:16:20","date_gmt":"2020-05-05T20:16:20","guid":{"rendered":"https:\/\/www.synevo.ro\/shop\/predispozitie-genetica-narcolepsie-hla-dr-dq\/"},"modified":"2025-01-30T15:58:08","modified_gmt":"2025-01-30T13:58:08","slug":"predispozitie-genetica-narcolepsie-hla-dr-dq","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/predispozitie-genetica-narcolepsie-hla-dr-dq\/","title":{"rendered":"\u0413\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043f\u0440\u0435\u0434\u0440\u0430\u0441\u043f\u043e\u043b\u043e\u0436\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u043a \u043d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u0438 (HLA-DR\/DQ)"},"content":{"rendered":"

Narcolepsia sau Sindromul Gelineau este o tulburare cronic\u0103 de somn care determin\u0103 somnolen\u0163\u0103 diurn\u0103 excesiv\u0103. Narcolepsia este boal\u0103 rar\u0103, cu prevalen\u021ba 1\/1000 locuitori, caracterizat\u0103 prin imposibilitatea creierului de a men\u021bine cicluri normale de somn-veghe. Termenul deriv\u0103 din cuv\u00e2ntul francez narcolepsie creat de medicul francez Jean-Baptiste-Edouard Gelineau.<\/p>\n

Boal\u0103 neurologic\u0103 rar\u0103, narcolepsia este caracterizat\u0103 prin somnolen\u0163\u0103 diurn\u0103 excesiv\u0103 \u015fi manifest\u0103ri de somn REM \u00een timpul st\u0103rii de veghe (cataplexie, paralizie de somn \u015fi halucina\u0163ii hipnagogice). De obicei, afectarea este cronic\u0103, iar simptomatologia persist\u0103 toat\u0103 via\u0163a. Distribu\u0163ia este u\u015for mai mare la b\u0103rba\u0163i, mai ales pentru formele care asociaz\u0103 cataplexie.<\/p>\n

Cataplexia este un simptom al narcolepsiei reprezent\u00e2nd sc\u0103derea brusc\u0103 a tonusului muscular ca r\u0103spuns la o emo\u0163ie cum ar fi furia, frica, bucuria, r\u00e2sul sau surpriza. Uneori cataplexia poate cauza c\u0103derea pacientului.<\/p>\n

Narcolepsia poate avea un impact major asupra activit\u0103\u021bilor zilnice ale bolnavilor. Pacien\u021bii narcoleptici au dificult\u0103\u021bi \u00een a r\u0103m\u00e2ne treji pentru perioade mai lungi de timp, indiferent de circumstan\u021be. Ace\u0219tia pot adormi la serviciu sau la \u0219coal\u0103, \u00een timp ce se afl\u0103 la volan, \u00een cad\u0103, la joac\u0103, f\u0103r\u0103 a avea control. Chiar \u0219i \u00een momentele \u00een care nu dorm, narcolepticii \u00eent\u00e2mpin\u0103 dificult\u0103\u021bi de concentrare \u0219i resimt o stare constant\u0103 de oboseal\u0103 care \u00eei \u00eempiedic\u0103 s\u0103 duc\u0103 o via\u021b\u0103 normal\u0103.<\/p>\n

Exist\u0103 dou\u0103 tipuri de narcolepsie:<\/p>\n

    \n
  1. Narcolepsia cu cataplexie:<\/strong> presupune experimentarea unei sl\u0103biciuni musculare bru\u0219te, cu posibilitatea ca persoana respectiv\u0103 s\u0103 cad\u0103 la p\u0103m\u00e2nt. Episodul poate fi declan\u0219at de emo\u021bii puternice, precum surpriza, bucuria sau furia, ori de oboseal\u0103 \u0219i dureaz\u0103 mai pu\u021bin de 2 minute. Persoanele care sufer\u0103 de acest tip de narcolepsie au un nivel redus de hipocretin\u0103 (orexin\u0103) la nivelul creierului, aceasta fiind substan\u021ba responsabil\u0103 s\u0103 men\u021bin\u0103 starea de veghe pe timpul zilei.<\/li>\n
  2. Narcolepsia f\u0103r\u0103 cataplexie:<\/strong>\u00a0simptomele sunt mai bl\u00e2nde. Persoanele care sufer\u0103 de acest tip de narcolepsie au un nivel normal de hipocretin\u0103 la nivelul creierului.<\/span><\/li>\n<\/ol>\n

    Semne \u0219i simptome<\/p>\n

    Tr\u0103s\u0103tur\u0103 esen\u021bial\u0103 este somnolen\u021ba instalat\u0103 brusc, f\u0103r\u0103 nici o avertizare prealabil\u0103, \u00een stare de veghe. Dup\u0103 trezirea din somnul narcoleptic pacientul se simte odihnit doar pentru scurt timp, c\u0103 dup\u0103 numai 2-3 ore s\u0103 se simt\u0103 din nou somnoros.<\/p>\n

    Accidentele casnice prin c\u0103dere din cauza somnolen\u021bei \u0219i cataplexiei sunt cele mai frecven\u021be complica\u021bii. Ele pot ap\u0103rea aproape \u00een orice \u00eemprejurare, \u00eens\u0103 cele mai periculoase sunt cele din timpul \u0219ofatului sau din timpul lucrului cu echipamente periculoase.<\/p>\n

    Principalele simptome:<\/p>\n

      \n
    • Somn excesiv \u00een timpul zilei. Pacien\u021bii narcoleptici adorm f\u0103r\u0103 \u201cavertiz\u0103ri\u201d, oric\u00e2nd, \u00een orice condi\u021bii<\/li>\n
    • Cataplexia – pierderea brusc\u0103 a tonusului muscular, care duce la imposibilitatea bolnavului de a-\u0219i p\u0103stra echilibrul. Etapele unui atac de cataplexie cuprind: emo\u021bie puternic\u0103 – sl\u0103biciune a mu\u0219chilor fe\u021bei \u0219i g\u00e2tului – sl\u0103biciune a membrelor \u0219i a trunchiului – sl\u0103biciune total\u0103 \u0219i cataplexie total\u0103 sau stare de le\u0219in<\/li>\n
    • Lipsa aten\u021biei \u0219i concentr\u0103rii<\/li>\n
    • Co\u0219maruri, viziuni \u0219i halucina\u021bii ce nu pot fi deosebite de realitate. Exist\u0103 dou\u0103 tipuri de halucina\u021bii \u00een func\u021bie de perioada de desf\u0103\u0219urare a acestora: cele hipnagogice, ap\u0103rute \u00een timpul somnului \u0219i cele hipnopompice ap\u0103rute \u00een timpul trezirii<\/li>\n
    • Paralizie total\u0103 chiar \u00eenainte de a adormi sau imediat dup\u0103 trezire (somnul paralizant)<\/li>\n
    • Narcolepticii pot suferi \u0219i de apnee obstructiv\u0103 \u00een somn, sindromul piciorului nelini\u0219tit<\/li>\n
    • Insomnii pe timpul noptii. Narcolepticul se poate confrunta cu incapacitatea de a r\u0103m\u00e2ne adormit.<\/li>\n<\/ul>\n

      Unele episoade narcoleptice sunt foarte scurte, dureaz\u0103 c\u00e2teva secunde \u00eens\u0103 pot afecta viata pacien\u021bilor si chiar a celor din jur.<\/p>\n

      Complica\u021bii: anxietate, atacuri de panic\u0103, obezitate, diabet, tulbur\u0103ri alimentare, tulbur\u0103ri de memorie, boli mentale, depresie, schizofrenie, fibromialgie, migrene, disfunc\u021bii cognitive si psihosociale.<\/p>\n

      Cauze<\/p>\n

      Debutul bolii este, \u00een general, \u00een adolescen\u0163\u0103 sau la adultul t\u00e2n\u0103r, de\u015fi poate ap\u0103rea \u015fi sub v\u00e2rsta de 10 ani sau peste 50 de ani. Majoritatea cazurilor sunt sporadice, \u00eens\u0103 40% dintre pacien\u0163i au cel pu\u0163in o rud\u0103 de gradul I cu somnolen\u0163\u0103 diurn\u0103 excesiv\u0103.<\/p>\n

      Principalul mecanism patogen al narcolepsiei este pierderea\/absen\u0163a neuronilor care produc hipocretina\/orexina din hipotalamusul lateral sau afectarea receptorilor pentru hipocretin\u0103. Hipocretina este un neuropeptid care intervine \u00een reglarea ritmului somn-veghe, a temperaturii corporale, a apetitului \u015fi chiar a tensiunii arteriale. Narcolepsia poate fi mo\u0219tenit\u0103, ceea ce \u00eenseamn\u0103 c\u0103 \u0219i deficien\u021ba de hipocretin\u0103 este mo\u0219tenit\u0103. Exist\u0103 studii care sugereaz\u0103 c\u0103 afec\u021biunea poate fi mai frecvent \u00eent\u00e2lnit\u0103 la b\u0103rba\u021bi.<\/p>\n

      \u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439<\/p>\n

      Examinarea fizic\u0103 a pacientului, anamneza, istoricul detaliat al somnului, jurnalul de somn (1-2 s\u0103pt\u0103m\u00e2ni), chestionarele specifice (ex. Epworth) sunt necesare pentru un diagnostic corect. \u00cen timpul cataplexiei, examenul clinic neurologic al pacientului relev\u0103 atonie muscular\u0103, sc\u0103derea sau absen\u0163a reflexelor osteotendioase, pierderea reflexului fotomotor \u015fi uneori semnul Babinski. Polisomnografia, testul multiplu de laten\u021b\u0103 \u00een somn (MSLT), RMN cerebral ajut\u0103 la identificarea bolii. Este foarte important a se face diagnosticul diferen\u0163ial cu: sincopa, crizele epileptice, hipotensiunea ortostatic\u0103, accidentul vascular tranzitoriu, paraliziile tranzitorii \u015fi tulbur\u0103rile psihice.<\/p>\n

      Evaluarea gradului de handicap \u00een narcolepsie<\/p>\n

      Handicap u\u0219or – Persoane cu somnolen\u021b\u0103 diurn\u0103 cu episoade scurte de somn pe parcursul zilei (episoade de c\u00e2teva minute), asociate cu tulbur\u0103ri u\u0219oare ale func\u021biilor mnezice \u0219i prosexice.<\/p>\n

      Handicap mediu – Somnolen\u021b\u0103 diurn\u0103 excesiv\u0103 \u0219i episoade de somn pe parcursul zilei. Episoade de cataplexie cu frecven\u021ba de 1-2\/an asociate cu prezen\u021ba unor tulbur\u0103ri psihice (anxietate, depresie u\u0219oar\u0103).<\/p>\n

      Handicap accentuat – Somnolen\u021b\u0103 diurn\u0103 excesiv\u0103 \u0219i episoade de somn pe parcursul zilei. Tulbur\u0103ri de somn nocturn. Episoade de cataplexie cu frecven\u021ba de cel pu\u021bin 1-2\/lun\u0103 asociate cu prezen\u021ba unor tulbur\u0103ri psihice (anxietate, depresie moderat\u0103).<\/p>\n

      Handicap grav – Episoade de somn pe parcursul zilei frecvente \u0219i care sub terapie medicamentoas\u0103 nu se reduc ca frecven\u021b\u0103 \u0219i durat\u0103. Episoade de cataplexie cu frecven\u021ba de cel pu\u021bin 5\/lun\u0103 (status cataplecticus), asociate cu prezen\u021ba unor tulbur\u0103ri psihice severe (anxietate, depresie sever\u0103). Prezen\u021ba paraliziei de somn. Prezen\u021ba automatismului ambulator nocturn. Halucina\u021bii hipnagogice \u0219i hipnapompice. Prezen\u021ba unor tulbur\u0103ri psihice severe: depresie sever\u0103.<\/p>","protected":false},"excerpt":{"rendered":"

      \u041d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u044f \u2014 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0440\u0430\u0441\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432\u043e, \u043a\u043e\u0442\u043e\u0440\u043e\u0435 \u043d\u0430\u0440\u0443\u0448\u0430\u0435\u0442 \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u043e\u0441\u0442\u044c \u043c\u043e\u0437\u0433\u0430 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u0446\u0438\u043a\u043b\u044b \u0441\u043d\u0430 \u0438 \u0431\u043e\u0434\u0440\u0441\u0442\u0432\u043e\u0432\u0430\u043d\u0438\u044f. \u042d\u0442\u043e \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0435 \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u0433\u043b\u0443\u0431\u043e\u043a\u043e \u0440\u0430\u0437\u0440\u0443\u0448\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u043c, \u0432\u043b\u0438\u044f\u044f \u043d\u0435 \u0442\u043e\u043b\u044c\u043a\u043e \u043d\u0430 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u043e \u0441\u043d\u0430, \u043d\u043e \u0438 \u043d\u0430 \u043e\u0431\u0449\u0435\u0435 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u043e \u0436\u0438\u0437\u043d\u0438.<\/p>\n

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      \u0421\u0443\u0449\u0435\u0441\u0442\u0432\u0443\u0435\u0442 \u0434\u0432\u0430 \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u0445 \u0442\u0438\u043f\u0430 \u043d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u0438:<\/p>\n

        \n
      1. \u041d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u044f \u0442\u0438\u043f\u0430 1 (\u041d\u04221): \u042d\u0442\u043e\u0442 \u0442\u0438\u043f \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u0443\u0435\u0442\u0441\u044f \u043a\u0430\u0442\u0430\u043f\u043b\u0435\u043a\u0441\u0438\u0435\u0439 \u0438 \u0447\u0430\u0441\u0442\u043e \u0441\u0432\u044f\u0437\u0430\u043d \u0441 \u043d\u0438\u0437\u043a\u0438\u043c \u0443\u0440\u043e\u0432\u043d\u0435\u043c \u043d\u0435\u0439\u0440\u043e\u043c\u0435\u0434\u0438\u0430\u0442\u043e\u0440\u0430 \u0433\u0438\u043f\u043e\u043a\u0440\u0435\u0442\u0438\u043d\u0430 (\u0442\u0430\u043a\u0436\u0435 \u0438\u0437\u0432\u0435\u0441\u0442\u043d\u043e\u0433\u043e \u043a\u0430\u043a \u043e\u0440\u0435\u043a\u0441\u0438\u043d), \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0443\u0435\u0442 \u0431\u043e\u0434\u0440\u0441\u0442\u0432\u043e\u0432\u0430\u043d\u0438\u0435.<\/li>\n
      2. \u041d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u044f \u0442\u0438\u043f\u0430 2 (\u041d\u04222): \u042d\u0442\u043e\u0442 \u0442\u0438\u043f \u043d\u0435 \u0432\u043a\u043b\u044e\u0447\u0430\u0435\u0442 \u043a\u0430\u0442\u0430\u043f\u043b\u0435\u043a\u0441\u0438\u044e \u0438 \u043e\u0431\u044b\u0447\u043d\u043e \u043f\u0440\u043e\u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u044b\u043c \u0443\u0440\u043e\u0432\u043d\u0435\u043c \u0433\u0438\u043f\u043e\u043a\u0440\u0435\u0442\u0438\u043d\u0430.<\/li>\n<\/ol>\n

        \u041d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u044f \u0438\u043c\u0435\u0435\u0442 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043a\u043e\u043c\u043f\u043e\u043d\u0435\u043d\u0442, \u0445\u043e\u0442\u044f \u0438 \u043d\u0435 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0447\u0438\u0441\u0442\u043e \u043d\u0430\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439. \u041e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u043d\u044b\u0435 \u0433\u0435\u043d\u044b, \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e \u0442\u0435, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0441\u0432\u044f\u0437\u0430\u043d\u044b \u0441 \u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u043e\u0439, \u0441\u0432\u044f\u0437\u0430\u043d\u044b \u0441 \u043d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u0435\u0439. \u0413\u0435\u043d HLA-DQB1*06:02 \u043e\u0431\u044b\u0447\u043d\u043e \u0430\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0441 NT1.<\/p>\n

        \u041f\u043e\u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0432\u0441\u0435 \u0431\u043e\u043b\u044c\u0448\u0435 \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u0441\u0442\u0432 \u0442\u043e\u0433\u043e, \u0447\u0442\u043e \u043d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u044f \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0435 \u0440\u0430\u0441\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432\u043e. \u0421\u0447\u0438\u0442\u0430\u0435\u0442\u0441\u044f, \u0447\u0442\u043e \u0438\u043c\u043c\u0443\u043d\u043d\u0430\u044f \u0441\u0438\u0441\u0442\u0435\u043c\u0430 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430 \u043e\u0448\u0438\u0431\u043e\u0447\u043d\u043e \u0430\u0442\u0430\u043a\u0443\u0435\u0442 \u043d\u0435\u0439\u0440\u043e\u043d\u044b \u043c\u043e\u0437\u0433\u0430, \u0432\u044b\u0440\u0430\u0431\u0430\u0442\u044b\u0432\u0430\u044e\u0449\u0438\u0435 \u0433\u0438\u043f\u043e\u043a\u0440\u0435\u0442\u0438\u043d, \u0447\u0442\u043e \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a NT1.<\/p>\n

        \u0418\u043d\u0444\u0435\u043a\u0446\u0438\u0438, \u0441\u0442\u0440\u0435\u0441\u0441 \u0438 \u0434\u0440\u0443\u0433\u0438\u0435 \u0444\u0430\u043a\u0442\u043e\u0440\u044b \u043e\u043a\u0440\u0443\u0436\u0430\u044e\u0449\u0435\u0439 \u0441\u0440\u0435\u0434\u044b \u043c\u043e\u0433\u0443\u0442 \u0441\u043f\u0440\u043e\u0432\u043e\u0446\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u043d\u0430\u0447\u0430\u043b\u043e \u043d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u0438 \u0443 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438 \u043f\u0440\u0435\u0434\u0440\u0430\u0441\u043f\u043e\u043b\u043e\u0436\u0435\u043d\u043d\u044b\u0445 \u043b\u044e\u0434\u0435\u0439. \u041d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043f\u0440\u0435\u0434\u043f\u043e\u043b\u0430\u0433\u0430\u044e\u0442 \u0441\u0432\u044f\u0437\u044c \u043c\u0435\u0436\u0434\u0443 \u043d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u0435\u0439 \u0438 \u0432\u0438\u0440\u0443\u0441\u043e\u043c \u0433\u0440\u0438\u043f\u043f\u0430 H1N1 \u0438\u043b\u0438 \u0432\u0430\u043a\u0446\u0438\u043d\u0430\u043c\u0438.<\/p>\n

        \u0421\u0438\u043c\u043f\u0442\u043e\u043c\u044b \u043d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u0438<\/p>\n

          \n
        1. \u0427\u0440\u0435\u0437\u043c\u0435\u0440\u043d\u0430\u044f \u0434\u043d\u0435\u0432\u043d\u0430\u044f \u0441\u043e\u043d\u043b\u0438\u0432\u043e\u0441\u0442\u044c (EDS) \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043e\u0442\u043b\u0438\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u043c \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u043c \u043d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u0438. \u041b\u044e\u0434\u0438 \u0441 \u043d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u0435\u0439 \u0447\u0430\u0441\u0442\u043e \u0438\u0441\u043f\u044b\u0442\u044b\u0432\u0430\u044e\u0442 \u043d\u0435\u043f\u0440\u0435\u043e\u0434\u043e\u043b\u0438\u043c\u043e\u0435 \u0436\u0435\u043b\u0430\u043d\u0438\u0435 \u0441\u043f\u0430\u0442\u044c \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u0434\u043d\u044f, \u043d\u0435\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e \u043e\u0442 \u0442\u043e\u0433\u043e, \u0441\u043a\u043e\u043b\u044c\u043a\u043e \u043e\u043d\u0438 \u0441\u043f\u044f\u0442 \u043d\u043e\u0447\u044c\u044e.<\/li>\n
        2. \u041a\u0430\u0442\u0430\u043f\u043b\u0435\u043a\u0441\u0438\u044f \u0432\u043a\u043b\u044e\u0447\u0430\u0435\u0442 \u0432\u043d\u0435\u0437\u0430\u043f\u043d\u044b\u0435, \u043a\u0440\u0430\u0442\u043a\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u044d\u043f\u0438\u0437\u043e\u0434\u044b \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u0441\u043b\u0430\u0431\u043e\u0441\u0442\u0438 \u0438\u043b\u0438 \u043f\u0430\u0440\u0430\u043b\u0438\u0447\u0430, \u0432\u044b\u0437\u0432\u0430\u043d\u043d\u044b\u0435 \u0441\u0438\u043b\u044c\u043d\u044b\u043c\u0438 \u044d\u043c\u043e\u0446\u0438\u044f\u043c\u0438, \u0442\u0430\u043a\u0438\u043c\u0438 \u043a\u0430\u043a \u0441\u043c\u0435\u0445, \u0433\u043d\u0435\u0432 \u0438\u043b\u0438 \u0443\u0434\u0438\u0432\u043b\u0435\u043d\u0438\u0435. \u042d\u0442\u043e\u0442 \u0441\u0438\u043c\u043f\u0442\u043e\u043c \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0435\u043d \u0434\u043b\u044f NT1.<\/li>\n
        3. \u041b\u044e\u0434\u0438 \u0441 \u043d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u0435\u0439 \u043c\u043e\u0433\u0443\u0442 \u0438\u0441\u043f\u044b\u0442\u044b\u0432\u0430\u0442\u044c \u0441\u043e\u043d\u043d\u044b\u0439 \u043f\u0430\u0440\u0430\u043b\u0438\u0447, \u0432\u0440\u0435\u043c\u0435\u043d\u043d\u0443\u044e \u043d\u0435\u0441\u043f\u043e\u0441\u043e\u0431\u043d\u043e\u0441\u0442\u044c \u0434\u0432\u0438\u0433\u0430\u0442\u044c\u0441\u044f \u0438\u043b\u0438 \u0433\u043e\u0432\u043e\u0440\u0438\u0442\u044c \u0432\u043e \u0432\u0440\u0435\u043c\u044f \u0437\u0430\u0441\u044b\u043f\u0430\u043d\u0438\u044f \u0438\u043b\u0438 \u043f\u0440\u043e\u0431\u0443\u0436\u0434\u0435\u043d\u0438\u044f. \u042d\u0442\u043e \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u043f\u0443\u0433\u0430\u044e\u0449\u0438\u043c \u043e\u043f\u044b\u0442\u043e\u043c, \u043d\u043e, \u043a\u0430\u043a \u043f\u0440\u0430\u0432\u0438\u043b\u043e, \u044d\u0442\u043e \u0431\u0435\u0437\u0432\u0440\u0435\u0434\u043d\u043e.<\/li>\n
        4. \u0413\u0438\u043f\u043d\u0430\u0433\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0433\u0430\u043b\u043b\u044e\u0446\u0438\u043d\u0430\u0446\u0438\u0438. \u042d\u0442\u043e \u044f\u0440\u043a\u0438\u0435, \u0447\u0430\u0441\u0442\u043e \u043f\u0443\u0433\u0430\u044e\u0449\u0438\u0435, \u043f\u043e\u0445\u043e\u0436\u0438\u0435 \u043d\u0430 \u0441\u043d\u044b \u043f\u0435\u0440\u0435\u0436\u0438\u0432\u0430\u043d\u0438\u044f, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0434\u044f\u0442 \u043f\u0440\u0438 \u0437\u0430\u0441\u044b\u043f\u0430\u043d\u0438\u0438 \u0438\u043b\u0438 \u043f\u0440\u043e\u0431\u0443\u0436\u0434\u0435\u043d\u0438\u0438. \u041e\u043d\u0438 \u043c\u043e\u0433\u0443\u0442 \u0432\u043a\u043b\u044e\u0447\u0430\u0442\u044c \u0437\u0440\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0435, \u0441\u043b\u0443\u0445\u043e\u0432\u044b\u0435 \u0438\u043b\u0438 \u0442\u0430\u043a\u0442\u0438\u043b\u044c\u043d\u044b\u0435 \u043e\u0449\u0443\u0449\u0435\u043d\u0438\u044f.<\/span><\/li>\n
        5. \u041d\u0430\u0440\u0443\u0448\u0435\u043d\u043d\u044b\u0439 \u043d\u043e\u0447\u043d\u043e\u0439 \u0441\u043e\u043d. \u0412\u043e\u043f\u0440\u0435\u043a\u0438 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u043d\u043e\u043c\u0443 \u043c\u043d\u0435\u043d\u0438\u044e, \u043b\u044e\u0434\u0438 \u0441 \u043d\u0430\u0440\u043a\u043e\u043b\u0435\u043f\u0441\u0438\u0435\u0439 \u043d\u0435 \u0441\u043f\u044f\u0442 \u0431\u043e\u043b\u044c\u0448\u0435, \u0447\u0435\u043c \u0441\u0440\u0435\u0434\u043d\u0435\u0441\u0442\u0430\u0442\u0438\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0447\u0435\u043b\u043e\u0432\u0435\u043a; \u0438\u0445 \u0441\u043e\u043d \u043f\u0440\u043e\u0441\u0442\u043e \u0431\u043e\u043b\u0435\u0435 \u0444\u0440\u0430\u0433\u043c\u0435\u043d\u0442\u0430\u0440\u043d\u044b\u0439. \u041e\u043d\u0438 \u0447\u0430\u0441\u0442\u043e \u043f\u0440\u043e\u0441\u044b\u043f\u0430\u044e\u0442\u0441\u044f \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u043e \u0440\u0430\u0437 \u0437\u0430 \u043d\u043e\u0447\u044c.<\/li>\n<\/ol>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[969],"product_tag":[],"class_list":{"0":"post-11978","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-de-genetica-umana","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/11978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=11978"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=11978"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=11978"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=11978"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=11978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}