Determinare\u00a0Des-carboxi-protrombina (DCP)\u00a0din ser este recomandat\u0103 \u00een evaluarea riscului de dezvoltare a carcinomului hepatocelular (CHC), \u00een cazul unor boli cronice hepatice \u0219i \u00een monitorizarea r\u0103spunsului la tratament, dac\u0103 nivelurile sale au fost ini\u021bial crescute (inainte de terapie).<\/p>\n
Des-\u03b3-carboxi protrombina (DCP), denumit\u0103 \u0219i protein\u0103 indus\u0103 de absen\u021ba vitaminei K (PIVKA-II), este un precursor nefunc\u021bional al protrombinei. Valori crescute ale DCP se observa si in icterul obstructiv, ingestia de medicamente(warfarina sau antibiotice cu spectru larg). Intre 25% si 50% dintre pacientii cu CHC pot avea o valoare DCP normala si de aceea o valoare normala a sa nu exclude diagnosticul de CHC.<\/p>\n
Intr-un studiu prospectiv al pacientilor diagnosticati cu CHC, sensibilitatea clinica individuala pentru AFP, AFP-L3, DCP a fost de 68%, 62% respectiv 73%. La dozarea cei 3 markeri, sensibilitatea a crescut la 86%. Prin combinarea biomarkerilor celor trei biomarkeri cu varsta si sexul pacientului, se poate calcula scorul GALAD, mai sensibil pentru detectarea precoce a CHC, in comparatie cu evaluarea serica individuala a aestor biomarkeri sau exclusiv a testarii combinate a acestora.<\/p>","protected":false},"excerpt":{"rendered":"
\u041e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 Des-\u043a\u0430\u0440\u0431\u043e\u043a\u0441\u0438-\u043f\u0440\u043e\u0442\u0440\u043e\u043c\u0431\u0438\u043d (DCP) \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0443\u0435\u0442\u0441\u044f \u043f\u0440\u0438 \u043e\u0446\u0435\u043d\u043a\u0435 \u0440\u0438\u0441\u043a\u0430 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0433\u0435\u043f\u0430\u0442\u043e\u0446\u0435\u043b\u043b\u044e\u043b\u044f\u0440\u043d\u043e\u0439 \u043a\u0430\u0440\u0446\u0438\u043d\u043e\u043c\u044b (CHC), \u043f\u0440\u0438 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445 \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u043f\u0440\u0438 \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433\u0435 \u043e\u0442\u0432\u0435\u0442\u0430 \u043d\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435, \u0435\u0441\u043b\u0438 \u0435\u0433\u043e \u0443\u0440\u043e\u0432\u043d\u0438 \u0431\u044b\u043b\u0438 \u043f\u0435\u0440\u0432\u043e\u043d\u0430\u0447\u0430\u043b\u044c\u043d\u043e \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u044b (\u0434\u043e \u0442\u0435\u0440\u0430\u043f\u0438\u044f).<\/p>\n
Des-\u03b3-\u043a\u0430\u0440\u0431\u043e\u043a\u0441\u0438 \u043f\u0440\u043e\u0442\u0440\u043e\u043c\u0431\u0438\u043d (DCP), \u0442\u0430\u043a\u0436\u0435 \u043d\u0430\u0437\u044b\u0432\u0430\u0435\u043c\u044b\u0439 \u0431\u0435\u043b\u043a\u043e\u043c, \u0432\u044b\u0437\u0432\u0430\u043d\u043d\u044b\u043c \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435\u043c \u0432\u0438\u0442\u0430\u043c\u0438\u043d\u0430 \u041a (PIVKA-II), \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043d\u0435\u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u043c \u043f\u0440\u0435\u0434\u0448\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u0438\u043a\u043e\u043c \u043f\u0440\u043e\u0442\u0440\u043e\u043c\u0431\u0438\u043d\u0430. \u041f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f DCP \u0442\u0430\u043a\u0436\u0435 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u044e\u0442\u0441\u044f \u043f\u0440\u0438 \u043e\u0431\u0441\u0442\u0440\u0443\u043a\u0442\u0438\u0432\u043d\u043e\u0439 \u0436\u0435\u043b\u0442\u0443\u0445\u0435, \u043f\u0440\u0438\u0435\u043c\u0435 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432 (\u0432\u0430\u0440\u0444\u0430\u0440\u0438\u043d \u0438\u043b\u0438 \u0430\u043d\u0442\u0438\u0431\u0438\u043e\u0442\u0438\u043a\u0438 \u0448\u0438\u0440\u043e\u043a\u043e\u0433\u043e \u0441\u043f\u0435\u043a\u0442\u0440\u0430 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f). \u041e\u0442 25% \u0434\u043e 50% \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0425\u0421\u041d \u043c\u043e\u0433\u0443\u0442 \u0438\u043c\u0435\u0442\u044c \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 DCP, \u0438 \u043f\u043e\u044d\u0442\u043e\u043c\u0443 \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u043d\u0435 \u0438\u0441\u043a\u043b\u044e\u0447\u0430\u0435\u0442 \u0434\u0438\u0430\u0433\u043d\u043e\u0437 \u0425\u0421\u041d.<\/p>\n
\u0412 \u043f\u0440\u043e\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u043c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u043e\u043c CHC \u0438\u043d\u0434\u0438\u0432\u0438\u0434\u0443\u0430\u043b\u044c\u043d\u0430\u044f \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u043a AFP, AFP-L3, DCP \u0441\u043e\u0441\u0442\u0430\u0432\u0438\u043b\u0430 68%, 62% \u0441\u043e\u043e\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0435\u043d\u043d\u043e 73%. \u041f\u0440\u0438 \u0434\u043e\u0437\u0438\u0440\u043e\u0432\u043a\u0435 3 \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432 \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u0443\u0432\u0435\u043b\u0438\u0447\u0438\u043b\u0430\u0441\u044c \u0434\u043e 86%. \u041a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u0443\u044f \u0431\u0438\u043e\u043c\u0430\u0440\u043a\u0435\u0440\u044b \u0442\u0440\u0435\u0445 \u0431\u0438\u043e\u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432 \u0441 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u043e\u043c \u0438 \u043f\u043e\u043b\u043e\u043c \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430, \u043c\u043e\u0436\u043d\u043e \u0440\u0430\u0441\u0441\u0447\u0438\u0442\u0430\u0442\u044c \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c \u0413\u0430\u043b\u0430\u0434\u0430, \u0431\u043e\u043b\u0435\u0435 \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u0434\u043b\u044f \u0440\u0430\u043d\u043d\u0435\u0433\u043e \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0425\u0421\u041d, \u043f\u043e \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044e \u0441 \u0438\u043d\u0434\u0438\u0432\u0438\u0434\u0443\u0430\u043b\u044c\u043d\u043e\u0439 \u043e\u0446\u0435\u043d\u043a\u043e\u0439 \u0431\u0438\u043e\u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432 aestor \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u0438\u043b\u0438 \u0438\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u0438\u0445 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u043c \u0442\u0435\u0441\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435\u043c.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[923],"product_tag":[],"class_list":{"0":"post-11973","1":"product","2":"type-product","3":"status-publish","5":"product_cat-markeri-tumorali","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/11973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=11973"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=11973"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=11973"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=11973"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=11973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}