{"id":11967,"date":"2020-05-05T23:16:18","date_gmt":"2020-05-05T20:16:18","guid":{"rendered":"https:\/\/www.synevo.ro\/shop\/gentamicina-nivel-seric\/"},"modified":"2025-02-10T15:49:34","modified_gmt":"2025-02-10T13:49:34","slug":"gentamicina-nivel-seric","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/gentamicina-nivel-seric\/","title":{"rendered":"\u0423\u0440\u043e\u0432\u0435\u043d\u044c \u0433\u0435\u043d\u0442\u0430\u043c\u0438\u0446\u0438\u043d\u0430 \u0432 \u043a\u0440\u043e\u0432\u0438"},"content":{"rendered":"<p><strong><em>Informa\u021bii generale<\/em><\/strong><\/p>\n<p>Gentamicina este un antibiotic utilizat pentru tratarea infec\u021biilor sanguine, cauzate de bacili Gram negativi, \u00een special\u00a0<em>Citrobacter freundii<\/em>, specii Acinetobacter, Enterobacter,\u00a0<em>Escherichia coli<\/em>,\u00a0<em>Klebsiella pneumoniae<\/em>,\u00a0<em>Proteus mirabilis<\/em>,\u00a0<em>Providencia stuartii, Pseudomonas aeruginosa \u0219i Serratia<\/em>. Este adesea utilizat \u00een asociere cu terapia beta-lactamic\u0103<sup>1,2<\/sup>.<\/p>\n<p>O concentra\u021bie inhibitoare minim\u0103 de gentamicin\u0103 (CMI) mai mic\u0103 sau egal\u0103 cu 4 mcg\/mL este considerat\u0103 susceptibil\u0103 pentru bacilii Gram-negativi. O concentra\u021bie inhibitoare minim\u0103 mai mic\u0103 sau egal\u0103 cu 500 mcg\/mL este considerat\u0103 sinergic\u0103 atunci c\u00e2nd este combinat\u0103 cu antibioticele adecvate, pentru tratamentul infec\u021biilor enterococice grave<sup>3<\/sup>.<\/p>\n<p>Gentamicina este administrat\u0103 de obicei de 2 p\u00e2n\u0103 la 3 ori pe zi prin injec\u021bii intravenoase sau intramusculare \u00een doze specifice \u00een func\u021bie de tipul de infec\u021bie. Gentamicina poate fi, de asemenea, administrat\u0103 la doze mai mari (de obicei 5-7 mg\/kg) o dat\u0103 pe zi, pacien\u021bilor cu func\u021bie renal\u0103 bun\u0103 (cunoscut\u0103 sub numele de dozare pulsat\u0103). Cantitatea sau intervalul de dozare trebuie sc\u0103zut, in cazul unei func\u021bii\u00a0 renale reduse<sup>4<\/sup>.<\/p>\n<p>Ototoxicitatea \u0219i nefrotoxicitatea sunt principalele complica\u021bii asociate cu supradozarea de gentamicin\u0103. Acest risc este amplificat \u00een prezen\u021ba altor medicamente ototoxice sau nefrotoxice. Monitorizarea nivelurilor serice \u0219i a simptomelor, \u00een concordan\u021b\u0103 cu ototoxicitatea, este important\u0103. Pentru durate mai mari de utilizare, testarea audiologic\u0103\/vestibular\u0103 trebuie luat\u0103 \u00een considerare la momentul ini\u021bial, \u0219i periodic, \u00een timpul terapiei<sup>2-5<\/sup>.<\/p>\n<p><strong><em>\u00a0<\/em><\/strong><strong><em>Recomand\u0103ri pentru determinarea gentamicinei la nivel seric<\/em><\/strong><\/p>\n<ul>\n<li>Monitorizarea concentra\u021biei serice optime, \u00een timpul terapiei cu gentamicin\u0103<sup>5,6<\/sup><\/li>\n<\/ul>\n<p><strong><em>Specimen recoltat \u2013\u00a0<\/em><\/strong>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>6<\/sup><\/p>\n<p><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong><\/p>\n<ul>\n<li>Proba se centrifugheaz\u0103 \u00een decursul a dou\u0103 ore de la recoltarea s\u00e2ngelui \u0219i se alicoteaz\u0103 serul<sup>6<\/sup><\/li>\n<\/ul>\n<p><strong><em>Volum prob\u0103 \u2013\u00a0<\/em><\/strong>2 mL<\/p>\n<p><strong><em>Cauze de respingere a probei<\/em><\/strong><\/p>\n<ul>\n<li>Specimen hemolizat<sup>6<\/sup><\/li>\n<\/ul>\n<p><strong><em>Stabilitate prob\u0103 \u2013\u00a0<\/em><\/strong>serul refrigerat timp de 7 zile<sup>6<\/sup><\/p>\n<p><strong><em>Metod\u0103 \u2013<\/em><\/strong>\u00a0FPIA<sup>8<\/sup><\/p>\n<p><strong><em>Valori de referin\u021b\u0103<sup>6<\/sup><\/em><\/strong><\/p>\n<ul>\n<li>Terapeutic<sup>8<\/sup>: &lt;2 \u00b5g \/mL predoz\u0103<\/li>\n<\/ul>\n<p>5-10\u00b5g\/ml postdoz\u0103<\/p>\n<ul>\n<li>Toxic: &gt;2 mcg\/mL predoz\u0103<\/li>\n<\/ul>\n<p>Concentra\u021biile maxime depind de tipul de infec\u021bie tratat\u0103.<\/p>\n<p><strong><em>Limite \u0219i interferen\u021be<sup>6,7<\/sup><\/em><\/strong><\/p>\n<p>Probele de s\u00e2nge provenite de la pacien\u021bii care sunt sub tratament cu medicamentul sisomicin\u0103 vor produce valori fals crescute pentru gentamicin\u0103. Cu toate acestea, acest medicament nu este de obicei administrat concomitent cu gentamicin\u0103.<\/p>\n<p>S-a demonstrat c\u0103 concentra\u021bii mari de peniciline sau cefalosporine inactiveaz\u0103 gentamicina\u00a0<em>in vitro<\/em>. Gradul de inactivare depinde de aminoglicozida particular m\u0103surat\u0103, de tipul \u0219i concentra\u021bia penicilinei sau cefalosporinei care este prezent\u0103 \u0219i de condi\u021biile de depozitare a probei. Anticorpii heterofili interferen\u021bi apar cu o frecven\u021b\u0103 sc\u0103zut\u0103 \u00een popula\u021bia general\u0103.<\/p>\n<p><strong><em>\u00a0<\/em><\/strong><strong><em>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/em><\/strong><\/p>\n<ol>\n<li>Tang, W., Cho, Y., Hawley, C. M., Badve, S. V., &amp; Johnson, D. W. (2014). The role of monitoring gentamicin levels in patients with gram-negative peritoneal dialysis-associated peritonitis. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 34(2), 219\u2013226.\u00a0<a href=\"https:\/\/doi.org\/10.3747\/pdi.2012.00318\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.3747\/pdi.2012.00318<\/a><\/li>\n<li>Ali, B. H., Al Za\u2019abi, M., Blunden, G., &amp; Nemmar, A. (2011). Experimental gentamicin nephrotoxicity and agents that modify it: a mini-review of recent research. Basic &amp; clinical pharmacology &amp; toxicology, 109(4), 225\u2013232.\u00a0<a href=\"https:\/\/doi.org\/10.1111\/j.1742-7843.2011.00728.x\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1111\/j.1742-7843.2011.00728.x<\/a><\/li>\n<li>Hurkacz, M., Nowakowska, J. M., Paluszy\u0144ska, D., &amp; Kr\u00f3lak-Olejnik, B. (2019). Individualization of treatment with gentamicin in neonates based on drug concentration in the blood serum. Developmental period medicine, 23(1), 21\u201327.<\/li>\n<li>Randjelovic, P., Veljkovic, S., Stojiljkovic, N., Sokolovic, D., &amp; Ilic, I. (2017). Gentamicin nephrotoxicity in animals: Current knowledge and future perspectives. EXCLI journal, 16, 388\u2013399.\u00a0<a href=\"https:\/\/doi.org\/10.17179\/excli2017-165\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.17179\/excli2017-165<\/a><\/li>\n<li>Saleh, P., Abbasalizadeh, S., Rezaeian, S., Naghavi-Behzad, M., Piri, R., &amp; Pourfeizi, H. H. (2016). Gentamicin-mediated ototoxicity and nephrotoxicity: A clinical trial study. Nigerian medical journal : journal of the Nigeria Medical Association, 57(6), 347\u2013352.\u00a0<a href=\"https:\/\/doi.org\/10.4103\/0300-1652.193861\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.4103\/0300-1652.193861<\/a><\/li>\n<li>Mayo Clinic. Mayo Medical Laboratories. Test Catalog. [on-line]:\u00a0<a href=\"https:\/\/www.mayocliniclabs.com\/\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/www.mayocliniclabs.com<\/a>\u00a0[Accesat la data de 06.09.2021]<\/li>\n<li>Singu, B. S., Mubita, M., Thikukutu, M. M., Mufenda, J. K., McKenzie, S. B., &amp; Verbeeck, R. K. (2018). Monitoring of gentamicin serum concentrations in obstetrics and gynaecology patients in Namibia. International journal of clinical pharmacy, 40(3), 520\u2013525.\u00a0<a href=\"https:\/\/doi.org\/10.1007\/s11096-018-0626-8\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1007\/s11096-018-0626-8<\/a><\/li>\n<li>Sunevo internal refference values<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>\u0410\u043c\u0438\u043d\u043e\u0433\u043b\u0438\u043a\u043e\u0437\u0438\u0434\u044b \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u044b\u043c\u0438 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u043c\u0438\u043a\u0440\u043e\u0431\u043d\u044b\u043c\u0438 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0430\u043c\u0438, \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e \u0430\u043a\u0442\u0438\u0432\u043d\u044b\u043c\u0438 \u043f\u0440\u043e\u0442\u0438\u0432 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0439, \u0432\u044b\u0437\u0432\u0430\u043d\u043d\u044b\u0445 \u0430\u044d\u0440\u043e\u0431\u043d\u044b\u043c\u0438 \u0433\u0440\u0430\u043c\u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u043c\u0438 \u043c\u0438\u043a\u0440\u043e\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430\u043c\u0438. \u0413\u0435\u043d\u0442\u0430\u043c\u0438\u0446\u0438\u043d \u2013 \u044d\u0442\u043e \u0430\u043c\u0438\u043d\u043e\u0433\u043b\u0438\u043a\u043e\u0437\u0438\u0434 \u0441 \u0448\u0438\u0440\u043e\u043a\u0438\u043c \u0441\u043f\u0435\u043a\u0442\u0440\u043e\u043c \u0430\u043d\u0442\u0438\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 (Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Serratia spp., Proteus spp., Pseudomonas aeruginosa, Acinetobacter spp. \u0438 \u0434\u0440.). \u041c\u0435\u0445\u0430\u043d\u0438\u0437\u043c \u0435\u0433\u043e \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f \u0441\u0432\u044f\u0437\u0430\u043d \u0441 \u043f\u0440\u043e\u043d\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u0438\u0435\u043c \u0447\u0435\u0440\u0435\u0437 \u043a\u043b\u0435\u0442\u043e\u0447\u043d\u0443\u044e \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u0443 \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0439 \u0438 \u043d\u0435\u043e\u0431\u0440\u0430\u0442\u0438\u043c\u044b\u043c \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u043d\u0438\u0435\u043c \u0441 30S-\u0441\u0443\u0431\u044a\u0435\u0434\u0438\u043d\u0438\u0446\u0435\u0439 \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u0440\u0438\u0431\u043e\u0441\u043e\u043c. \u0422\u0430\u043a\u0438\u043c \u043e\u0431\u0440\u0430\u0437\u043e\u043c, \u0433\u0435\u043d\u0442\u0430\u043c\u0438\u0446\u0438\u043d \u0443\u0433\u043d\u0435\u0442\u0430\u0435\u0442 \u0441\u0438\u043d\u0442\u0435\u0437 \u0431\u0435\u043b\u043a\u0430 \u0432\u043e\u0437\u0431\u0443\u0434\u0438\u0442\u0435\u043b\u044f.<\/p>\n<p>\u0413\u0435\u043d\u0442\u0430\u043c\u0438\u0446\u0438\u043d, \u043a\u0430\u043a \u0438 \u0434\u0440\u0443\u0433\u0438\u0435 \u0430\u043c\u0438\u043d\u043e\u0433\u043b\u0438\u043a\u043e\u0437\u0438\u0434\u044b, \u0438\u043c\u0435\u0435\u0442 \u0443\u0437\u043a\u0438\u0439 \u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0434\u0438\u0430\u043f\u0430\u0437\u043e\u043d, \u0442\u043e \u0435\u0441\u0442\u044c \u0434\u043b\u044f \u043d\u0435\u0433\u043e \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0435\u043d \u043d\u0435\u0431\u043e\u043b\u044c\u0448\u043e\u0439 \u0440\u0430\u0437\u0440\u044b\u0432 \u043c\u0435\u0436\u0434\u0443 \u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0438 \u0442\u043e\u043a\u0441\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043c. \u041f\u043e\u044d\u0442\u043e\u043c\u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u043c \u0441 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435\u043c \u0432\u044b\u0434\u0435\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u043f\u043e\u0447\u0435\u043a \u0438 \u043f\u043e\u0436\u0438\u043b\u044b\u043c \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430\u043c, \u0430 \u0442\u0430\u043a\u0436\u0435 \u043f\u0440\u0438 \u0442\u044f\u0436\u0435\u043b\u043e\u0439 \u043e\u0436\u043e\u0433\u043e\u0432\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0434\u043b\u044f \u0430\u0434\u0435\u043a\u0432\u0430\u0442\u043d\u043e\u0433\u043e \u0432\u044b\u0431\u043e\u0440\u0430 \u0440\u0435\u0436\u0438\u043c\u0430 \u0434\u043e\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0442\u0440\u0435\u0431\u0443\u0435\u0442\u0441\u044f \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u0433\u0435\u043d\u0442\u0430\u043c\u0438\u0446\u0438\u043d\u0430 \u0432 \u043f\u043b\u0430\u0437\u043c\u0435.<\/p>\n<p>\u0414\u043b\u044f \u0447\u0435\u0433\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/p>\n<ol>\n<li>\u0414\u043b\u044f \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u0432 \u043a\u0440\u043e\u0432\u0438.<\/li>\n<li>\u0414\u043b\u044f \u043f\u043e\u0434\u0431\u043e\u0440\u0430 \u0438\u043d\u0434\u0438\u0432\u0438\u0434\u0443\u0430\u043b\u044c\u043d\u043e\u0439 \u0434\u043e\u0437\u0438\u0440\u043e\u0432\u043a\u0438 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430.<\/li>\n<li>\u0414\u043b\u044f \u043e\u043f\u0442\u0438\u043c\u0438\u0437\u0430\u0446\u0438\u0438 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044f \u0437\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435\u043c \u0441 \u043f\u043e\u043c\u043e\u0449\u044c\u044e \u043a\u043e\u0440\u0440\u0435\u043a\u0446\u0438\u0438 \u0434\u043e\u0437\u044b.<\/li>\n<li>\u0414\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f.<\/li>\n<li>\u0414\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u043f\u0435\u0440\u0435\u0434\u043e\u0437\u0438\u0440\u043e\u0432\u043a\u0438.<\/li>\n<li>\u0414\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0439 \u043f\u043e \u0440\u0435\u0436\u0438\u043c\u0443 \u043f\u0440\u0438\u0435\u043c\u0430 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430.<\/li>\n<li>\u0414\u043b\u044f \u043f\u0440\u0435\u0434\u043e\u0442\u0432\u0440\u0430\u0449\u0435\u043d\u0438\u044f \u0442\u043e\u043a\u0441\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430.<\/li>\n<\/ol>\n<p>\u041a\u043e\u0433\u0434\u0430 \u043d\u0430\u0437\u043d\u0430\u0447\u0430\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/p>\n<ol>\n<li>\u041f\u0440\u0438 \u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0438 \u0432\u0430\u043d\u043a\u043e\u043c\u0438\u0446\u0438\u043d\u0430 \u0432 \u0446\u0435\u043b\u044f\u0445 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0439, \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043a \u0434\u0430\u043d\u043d\u043e\u043c\u0443 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\u043a\u043e\u0440\u0440\u0435\u043a\u0446\u0438\u0438 \u0434\u043e\u0437\u044b.<\/li>\n<li>\u041f\u0440\u0438 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0438 \u0434\u043e\u0437\u0438\u0440\u043e\u0432\u043a\u0438 \u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u0444\u043e\u0440\u043c\u044b \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430.<\/li>\n<li>\u041f\u0440\u0438 \u043f\u043e\u0434\u043e\u0437\u0440\u0435\u043d\u0438\u0438 \u043d\u0430 \u043f\u0435\u0440\u0435\u0434\u043e\u0437\u0438\u0440\u043e\u0432\u043a\u0443 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u043c.<\/li>\n<\/ol>\n<p>\u0427\u0442\u043e \u043e\u0437\u043d\u0430\u0447\u0430\u044e\u0442 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b?<\/p>\n<p>\u0420\u0435\u0444\u0435\u0440\u0435\u043d\u0441\u043d\u044b\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f: 0 &#8211; 2 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\u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0442\u044c \u043f\u0438\u0449\u0443 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 2-3 \u0447\u0430\u0441\u043e\u0432 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f, \u043c\u043e\u0436\u043d\u043e \u043f\u0438\u0442\u044c \u0447\u0438\u0441\u0442\u0443\u044e \u043d\u0435\u0433\u0430\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u0443\u044e \u0432\u043e\u0434\u0443.<\/li>\n<li>\u041d\u0435 \u043a\u0443\u0440\u0438\u0442\u044c \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 30 \u043c\u0438\u043d\u0443\u0442 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n<\/ul>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[984],"product_tag":[],"class_list":{"0":"post-11967","1":"product","2":"type-product","3":"status-publish","5":"product_cat-monitorizare-terapeutica-medicamente-tdm","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/11967","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=11967"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=11967"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=11967"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=11967"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=11967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}