{"id":11956,"date":"2020-05-05T23:16:16","date_gmt":"2020-05-05T20:16:16","guid":{"rendered":"https:\/\/www.synevo.ro\/shop\/estrona-e1\/"},"modified":"2025-02-07T12:38:45","modified_gmt":"2025-02-07T10:38:45","slug":"estrona-e1","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/estrona-e1\/","title":{"rendered":"\u042d\u0441\u0442\u0440\u043e\u043d (\u04151)"},"content":{"rendered":"<p>Determinarea\u00a0estronei plasmatice\u00a0este recomandat\u0103 \u00een: diagnosticarea \u0219i monitorizarea evolu\u021biei \u00eent\u00e2rzierilor de pubertate (\u00een special la fete \u0219i \u00een m\u0103sur\u0103 mai mic\u0103 la baie\u021bi), diagnosticul suspiciunilor de tulbur\u0103ri \u00een metabolismul steroizilor sexuali, \u00een special \u00een suspiciunea de deficit de aromataza \u0219i 17-hidroxilaza, evaluarea riscului de fracturi \u00een special la femeile postmenopauza (\u00een m\u0103sura mai mic\u0103 la b\u0103rba\u021bii v\u00e2rstnici), evaluarea s\u00e2ngerarilor vaginale \u00een postmenopauza, monitorizarea terapiei de substitu\u021bie hormonal\u0103 (\u00een doze mici) \u00een postmenopauza, monitorizarea terapiei antiestrogenice (inhibitori de aromataz\u0103).<\/p>\n<p>Estrona (E1) face parte din grupul hormonilor estrogeni, implica\u021bi \u0103n dezvoltarea \u0219i men\u021binerea fenotipului feminin, m\u0103turarea celulelor germinale \u0219i sarcina. De asemenea, sunt implica\u021bi \u0219i \u00een procesul de cre\u0219tere, dezvoltare a sistemului nervos, metabolismul osos, func\u021bionalitatea normal\u0103 a endoteliului vascular. Principalii estrogeni activi la popula\u021bia adult\u0103, \u00een afara sarcinii sunt: estrona (E1) \u0219i estradiolul (E2). Un al treilea estrogen, estriolul (E3) este principalul estrogen din sarcin\u0103, concentra\u0163iile sale r\u0103m\u00e2n constante la b\u0103rba\u0163ii adul\u0163i, dar acestea vor cre\u015fte \u015fi vor fluctua la femei \u00een timpul ciclului menstrual. Dup\u0103 menopauz\u0103, E1 devine estrogenul major, iar valorile E2 \u015fi E3 scad foarte mult.<\/p>\n<p><b><i>Informa\u021bii generale<\/i><\/b><\/p>\n<p>Estrogenii sunt implica\u021bi \u00een dezvoltarea \u0219i men\u021binerea fenotipului feminin, maturarea celulelor germinale \u0219i sarcin\u0103. De asemenea, acestea sunt importante pentru multe alte procese specifice inclusiv cre\u0219terea, maturarea sistemului nervos, metabolismul\/remodelarea oaselor \u0219i mentinerea functionarii endoteliale fiziologice . Cei doi estrogeni biologic activi majori sunt\u00a0estrona\u00a0(E1) \u0219i\u00a0estradiolul. Un al treilea estrogen bioactiv,\u00a0estriolul, este principalul estrogen al sarcinii<sup>1<\/sup>.<\/p>\n<p>Estradiolul este produs \u00een principal \u00een ovare \u0219i testicule, printr-o reac\u021bie de aromatizare a testosteronului. Cantit\u0103\u021bi mici sunt produse \u00een glandele suprarenale \u0219i \u00een unele \u021besuturi periferice \u0219i \u00een \u021besuturile adipoase.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>\u00cen schimb, cea mai mare parte a estronei circulante este produs\u0103 printr-o reac\u021bie de aromatizare periferic\u0103 a\u00a0androstendionului\u00a0(\u00een principal suprarenalele)<sup>2<\/sup>. Estradiolul \u0219i estrona pot fi transformate unul \u00een cel\u0103lalt \u0219i ambele pot fi inactivate prin hidroxilare \u0219i conjugare. Estradiolul prezint\u0103 concentra\u021bii circulante de 1,5-4 ori mai mari dec\u00e2t concentra\u021bia de estron\u0103 la femei, in premenopauz\u0103, care nu sunt gravide<sup>3<\/sup>. Nivelurile de estradiol la b\u0103rba\u021bi \u0219i la femeile aflate \u00een postmenopauz\u0103 sunt mult mai mici dec\u00e2t cele corespunz\u0103toare femeilor care nu sunt gravide, \u00een timp ce nivelurile de estron\u0103 difer\u0103 mai pu\u021bin, rezult\u00e2nd o inversare a raportului estradiol:estron\u0103 (din premenopauz\u0103).<\/p>\n<p>Nivelurile de estradiol la femeile aflate \u00een premenopauz\u0103 fluctueaz\u0103 \u00een timpul ciclului menstrual. Acestea sunt cele mai sc\u0103zute \u00een faza folicular\u0103 timpurie. Nivelurile de estradiol cresc apoi treptat, la 2 -3 zile \u00eenainte de ovula\u021bie, etap\u0103 \u00een care \u00eencep s\u0103 creasc\u0103 mai rapid \u0219i ating un maxim chiar \u00eenainte de cre\u0219terea hormonului luteinizant<span class=\"Apple-converted-space\">\u00a0\u00a0<\/span>care creste<span class=\"Apple-converted-space\">\u00a0\u00a0<\/span>de 5 p\u00e2n\u0103 la 10 ori comparativ cu nivelurile foliculare timpurii<sup>4<\/sup>. Aceasta este urmat\u0103 de o sc\u0103dere lent\u0103 \u00een timpul fazei ovulatorii. Nivelurile de estradiol cresc apoi din nou treptat p\u00e2n\u0103 la mijlocul fazei luteale \u0219i, ulterior, scad la niveluri foliculare minime, timpurii.<\/p>\n<p>Determinarea estradiolului face parte integrant\u0103 din evaluarea func\u021biei de reproducere la femei, inclusiv evaluarea infertilit\u0103\u021bii, oligo-amenoreei \u0219i a st\u0103rii de menopauz\u0103. \u00cen plus, este utilizat pe scar\u0103 larg\u0103 pentru monitorizarea induc\u021biei de ovula\u021bie, precum \u0219i \u00een timpul preg\u0103tirii pentru fertilizarea\u00a0<i>in vitro<\/i><i><sup>3<\/sup><\/i>.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><b><i>Recomand\u0103ri pentru determinarea estronei<\/i><\/b><sup>5,6,7,8<\/sup><\/p>\n<ul>\n<li>Diagnosticarea pubert\u0103\u021bii precoce \u0219i \u00eent\u00e2rziat\u0103 la femei \u0219i, \u00eentr-o m\u0103sur\u0103 mai mic\u0103, la b\u0103rba\u021bi<\/li>\n<li>Diagnosticarea bolilor metabolismului steroizilor sexuali (de exemplu, deficit de aromataz\u0103 \u0219i deficit de 17 alfa-hidroxilaz\u0103)<\/li>\n<li>M\u0103surarea densit\u0103\u021bii minerale osoase \u00een evaluarea riscului de fractur\u0103 la femeile aflate \u00een postmenopauz\u0103 \u0219i, \u00eentr-un grad mai mic, la b\u0103rba\u021bii \u00een v\u00e2rst\u0103<\/li>\n<li>Monitorizarea terapiei de substitu\u021bie hormonal\u0103<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<li>Monitorizarea terapiei anti-estrogen (de exemplu, terapia cu inhibitori de aromataz\u0103)<\/li>\n<\/ul>\n<p><b><i>Specimen recoltat\u00a0\u2013<\/i><\/b>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>3<\/sup><\/p>\n<p><b><i>Prelucrare necesar\u0103 dup\u0103 recoltare\u00a0<\/i><\/b>\u2013centrifugare \u00een maxim 2 ore de la recolt\u0103 \u0219i alicotarea serului<b><i>\u00a0<\/i><\/b><sup>3<\/sup><\/p>\n<p><b><i>Volum prob\u0103\u00a0\u2013\u00a0<\/i><\/b>1.2 mL<sup>3<\/sup><\/p>\n<p><b><i>Stabilitate prob\u0103\u00a0\u2013\u00a0<\/i><\/b>28 de zile refrigerat<sup>3<\/sup><\/p>\n<p><b><i>Metod\u0103<\/i><\/b><i>\u00a0<\/i><i>-\u00a0<\/i><i>Cromatografie \u2013de lichide cuplat\u0103 cu spectrometrie de mas\u0103\u00een tandem (LC-MS \/ MS)<\/i><sup>7<\/sup><\/p>\n<p><b><i>Valori de referin\u021b\u0103<\/i><\/b><b><i>\u00a0<\/i><\/b><sup>3<\/sup><\/p>\n<p>\u0414\u0435\u0442\u0438<\/p>\n<table cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\"><b>Stadiu<\/b><\/td>\n<td rowspan=\"6\" valign=\"middle\"><b>\u0415<\/b><\/td>\n<td valign=\"middle\"><b>V\u00e2rst\u0103 (ani)<\/b><\/td>\n<td valign=\"middle\"><b>Valori<\/b><\/td>\n<td rowspan=\"6\" valign=\"middle\"><b>\u041d<\/b><\/td>\n<td valign=\"middle\"><b>V\u00e2rst\u0103 (ani)<\/b><\/td>\n<td valign=\"middle\"><b>Valori<\/b><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\">II<\/td>\n<td valign=\"middle\">7.1<\/td>\n<td valign=\"top\">Nedetectabil<\/p>\n<p>29 pg\/mL<\/td>\n<td valign=\"middle\">7.1<\/td>\n<td valign=\"top\">Nedetectabil<\/p>\n<p>16 pg\/mL<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\">III<\/td>\n<td valign=\"middle\">10.5<\/td>\n<td valign=\"top\">10-33 pg\/mL<\/td>\n<td valign=\"middle\">11.5<\/td>\n<td valign=\"top\">Nedetectabil-22 pg\/mL<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\">IV<\/td>\n<td valign=\"middle\">11.6<\/td>\n<td valign=\"top\">15-43 pg\/mL<\/td>\n<td valign=\"middle\">13.6<\/td>\n<td valign=\"top\">10-25 pg\/mL<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\" valign=\"top\">\u0425<\/td>\n<td valign=\"middle\">12.3<\/td>\n<td valign=\"top\">16-77 pg\/mL<\/td>\n<td valign=\"middle\">15.1<\/td>\n<td valign=\"top\">10-46 pg\/mL<\/td>\n<\/tr>\n<tr>\n<td valign=\"middle\">14.5<\/td>\n<td valign=\"top\">17-200 pg\/mL<\/td>\n<td valign=\"middle\">18<\/td>\n<td valign=\"top\">10-60 pg\/mL<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u0412\u0437\u0440\u043e\u0441\u043b\u044b\u0435<\/p>\n<p><b>B\u0103rba\u021bi\u00a0<\/b>15-65 pg\/mL<\/p>\n<p><b>Gravida<\/b>:<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<ul>\n<li>Trim I de sarcin\u0103: 155 \u2013 30.77pg\/ml\u00a0<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<li>Trim II de sarcin\u0103: 408 \u2013 62.15pg\/ml<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<\/ul>\n<p><b>Femei:<\/b><\/p>\n<p>Femei sub contraceptive orale: 48,0 \u2013 342,4 pg\/ml<\/p>\n<p>Faza folicular\u0103: 36,1 \u2013 156,5 pg\/ml<\/p>\n<p>Faza luteal\u0103: 47,3 \u2013 198,1pg\/ml<\/p>\n<p>Faza periovulatorie: 57,9 \u2013 255,9 pg\/ml<\/p>\n<p>Postmenopauza sub ERT*: 50,9 \u2013 487,5<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>Postmenopauza f\u0103r\u0103 ERT: 30,9 \u2013 99,8<\/p>\n<p>*ERT= Estrogen replacement therapy<\/p>\n<p><b><i>Limite si interferente<\/i><\/b><sup>3<\/sup><\/p>\n<p>Perioadele menstruale neregulate sau absente, cu niveluri normale sau ridicate de estradiol (\u0219i adesea niveluri ridicate de estron\u0103) semnalizeaz\u0103 un posibil sindrom ovarian polichistic, tumori produc\u0103toare de androgen sau tumori care produc estrogen.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>Recomand\u0103rile actuale pentru aport exogen de hormon feminin postmenopauz\u0103 sunt de a administra terapia \u00een cele mai mici doze benefice, c\u00e2t mai scurt posibil. \u00cen mod ideal, nivelurile de estradiol \u0219i de estron\u0103 ar trebui men\u021binute sub sau aproape de limita inferioar\u0103 a intervalului de referin\u021b\u0103 feminin premenopauzal.<\/p>\n<p>Ginecomastia sau alte semne de feminizare la b\u0103rba\u021bi se pot datora unui surplus absolut sau relativ (\u00een raport cu androgenii) de estrogeni. Cauzele cre\u0219terii nivelurilor de estron\u0103 sau estradiol includ:<\/p>\n<p>-niveluri ridicate de androgeni cauzate de tumori sau terapie cu androgeni (\u00eembun\u0103t\u0103\u021birea performan\u021bei medicale sau sportive), cu cre\u0219terea nivelului de estron\u0103 \u0219i estradiol<\/p>\n<p>-obezitate cu produc\u021bie crescut\u0103 de estron\u0103<\/p>\n<p>-diminuarea clearance-ului estronei \u0219i estradiolului \u00een afec\u021biunile hepatice<\/p>\n<p>-tumori produc\u0103toare de estrogen<\/p>\n<p>-ingestia de estrogeni de sintez\u0103<\/p>\n<p><b><i>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/i><\/b><\/p>\n<ol>\n<li>Samavat, H., &amp; Kurzer, M. S. (2015). Estrogen metabolism and breast cancer. Cancer letters, 356(2 Pt A), 231\u2013243.\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.canlet.2014.04.018\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1016\/j.canlet.2014.04.018<\/a><\/li>\n<li>Davis, S. R., Bell, R. J., Robinson, P. J., Handelsman, D. J., Gilbert, T., Phung, J., Desai, R., Lockery, J. E., Woods, R. L., Wolfe, R. S., Reid, C. M., Nelson, M. R., Murray, A. M., McNeil, J. J., &amp; ASPREE Investigator Group (2019). Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study. The Journal of clinical endocrinology and metabolism, 104(12), 6291\u20136300.\u00a0<a href=\"https:\/\/doi.org\/10.1210\/jc.2019-00743\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1210\/jc.2019-00743<\/a><\/li>\n<li>Mayo Clinic. Mayo Medical Laboratories. Test Catalog. [on-line]:\u00a0<a href=\"https:\/\/www.mayocliniclabs.com\/\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/www.mayocliniclabs.com<\/a>\u00a0[Accesat la data de 8.05.2021]<\/li>\n<li>Blair I. A. (2010). Analysis of estrogens in serum and plasma from postmenopausal women: past present, and future. Steroids, 75(4-5), 297\u2013306.\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.steroids.2010.01.012\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1016\/j.steroids.2010.01.012<\/a><\/li>\n<li>Cirrincione, L. R., Winston McPherson, G., Rongitsch, J., Sadilkova, K., Drees, J. C., Krasowski, M. D., Dickerson, J. A., &amp; Greene, D. N. (2021). Sublingual Estradiol Is Associated with Higher Estrone Concentrations than Transdermal or Injectable Preparations in Transgender Women and Gender Nonbinary Adults. LGBT health, 8(2), 125\u2013132.\u00a0<a href=\"https:\/\/doi.org\/10.1089\/lgbt.2020.0249\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1089\/lgbt.2020.0249<\/a><\/li>\n<li>Ismail, A. A., &amp; Barth, J. H. (2001). Endocrinology of gynaecomastia. Annals of clinical biochemistry, 38(Pt 6), 596\u2013607.\u00a0<a href=\"https:\/\/doi.org\/10.1258\/0004563011900993\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1258\/0004563011900993<\/a><\/li>\n<li>Vihma, V., Wang, F., Savolainen-Peltonen, H., Turpeinen, U., H\u00e4m\u00e4l\u00e4inen, E., Leidenius, M., Mikkola, T. S., &amp; Tikkanen, M. J. (2016). Quantitative determination of estrone by liquid chromatography-tandem mass spectrometry in subcutaneous adipose tissue from the breast in postmenopausal women. The Journal of steroid biochemistry and molecular biology, 155(Pt A), 120\u2013125.\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.jsbmb.2015.10.004\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1016\/j.jsbmb.2015.10.004<\/a><\/li>\n<li>Hsu, B., Cumming, R. G., Seibel, M. J., Naganathan, V., Blyth, F. M., Bleicher, K., Dave, A., Le Couteur, D. G., Waite, L. M., &amp; Handelsman, D. J. (2015). Reproductive Hormones and Longitudinal Change in Bone Mineral Density and Incident Fracture Risk in Older Men: The Concord Health and Aging in Men Project. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(9), 1701\u20131708.<a href=\"https:\/\/doi.org\/10.1002\/jbmr.2493\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">\u00a0https:\/\/doi.org\/10.1002\/jbmr.2493<\/a><\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>\u042d\u0441\u0442\u0440\u043e\u043d \u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043e\u0434\u043d\u043e\u0439 \u0438\u0437 \u0434\u0432\u0443\u0445 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438 \u0430\u043a\u0442\u0438\u0432\u043d\u044b\u0445 \u0444\u043e\u0440\u043c \u044d\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u043e\u0432 \u0443 \u043d\u0435\u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0445 \u0436\u0435\u043d\u0449\u0438\u043d \u0438 \u043c\u0443\u0436\u0447\u0438\u043d. \u041e\u0431\u0440\u0430\u0437\u0443\u0435\u0442\u0441\u044f, \u0432 \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u043c, \u043f\u0440\u0438 \u0430\u0440\u043e\u043c\u0430\u0442\u0438\u0437\u0430\u0446\u0438\u0438 \u0430\u043d\u0434\u0440\u043e\u0441\u0442\u0435\u043d\u0434\u0438\u043e\u043d\u0430 \u043d\u0430 \u043f\u0435\u0440\u0438\u0444\u0435\u0440\u0438\u0438. \u042d\u0441\u0442\u0440\u043e\u043d \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u043f\u0440\u0435\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d \u0432 \u044d\u0441\u0442\u0440\u0430\u0434\u0438\u043e\u043b \u0438 \u043e\u0431\u0440\u0430\u0442\u043d\u043e, \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043c\u0435\u043d\u0435\u0435 \u0430\u043a\u0442\u0438\u0432\u043d\u044b\u043c \u044d\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u043e\u043c \u043f\u043e \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044e \u0441 \u044d\u0441\u0442\u0440\u0430\u0434\u0438\u043e\u043b\u043e\u043c (\u0432 1,25-5 \u0440\u0430\u0437), \u0435\u0433\u043e \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f \u0432 4 \u0440\u0430\u0437\u0430 \u043c\u0435\u043d\u044c\u0448\u0435 \u0443 \u0436\u0435\u043d\u0449\u0438\u043d \u0432 \u043f\u0440\u0435\u043c\u0435\u043d\u043e\u043f\u0430\u0443\u0437\u0430\u043b\u044c\u043d\u043e\u043c \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435. \u0421 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u043e\u043c \u044d\u0442\u043e \u0441\u043e\u043e\u0442\u043d\u043e\u0448\u0435\u043d\u0438\u0435 \u043c\u0435\u043d\u044f\u0435\u0442\u0441\u044f: \u0443\u0440\u043e\u0432\u043d\u0438 \u044d\u0441\u0442\u0440\u0430\u0434\u0438\u043e\u043b\u0430 \u0441\u043d\u0438\u0436\u0430\u044e\u0442\u0441\u044f, \u0430 \u044d\u0441\u0442\u0440\u043e\u043d\u0430 &#8211; \u043f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0438 \u043e\u0441\u0442\u0430\u044e\u0442\u0441\u044f \u0441\u043e\u043e\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0443\u044e\u0449\u0438\u043c\u0438 \u043f\u0440\u0435\u043c\u0435\u043d\u043e\u043f\u0430\u0443\u0437\u0430\u043b\u044c\u043d\u043e\u043c\u0443 \u0443\u0440\u043e\u0432\u043d\u044e \u0438 \u0441\u043e\u043e\u0442\u043d\u043e\u0448\u0435\u043d\u0438\u0435 \u04152\/\u04151 \u0438\u0437\u043c\u0435\u043d\u044f\u0435\u0442\u0441\u044f \u0438 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u043a\u0430\u043a \u043e\u0434\u0438\u043d \u0438\u0437 \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432 \u043a\u043b\u0438\u043c\u0430\u043a\u0442\u0435\u0440\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0435\u0440\u0438\u043e\u0434\u0430.<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"262\"><b>\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c<\/b><\/td>\n<td colspan=\"2\" width=\"361\"><b>\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b<\/b><\/td>\n<td colspan=\"2\" width=\"361\">\u0412\u0435\u043d\u043e\u0437\u043d\u0430\u044f\u00a0\u043a\u0440\u043e\u0432\u044c<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0438\u00a0\u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430<\/b><\/td>\n<td colspan=\"2\" width=\"361\">\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u0422\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u043d\u0430\u044f\u00a0\u0441\u0440\u0435\u0434\u0430,\u00a0\u043f\u0440\u043e\u0431\u0438\u0440\u043a\u0430<\/b><\/td>\n<td colspan=\"2\" width=\"361\">\u0412\u0430\u043a\u0443\u0442\u0430\u0439\u043d\u0435\u0440\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u00a0\u0441\/\u0431\u0435\u0437\u00a0\u0433\u0435\u043b\u0435\u0432\u043e\u0439\u00a0\u0444\u0430\u0437\u044b<\/td>\n<\/tr>\n<tr>\n<td width=\"262\"><b>\u041f\u0440\u0430\u0432\u0438\u043b\u0430\u00a0\u0438\u00a0\u0443\u0441\u043b\u043e\u0432\u0438\u044f\u00a0\u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0438\u0440\u043e\u0432\u043a\u0438,\u00a0<\/b><\/p>\n<p><b>\u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u00a0\u043f\u0440\u043e\u0431\u044b<\/b><\/td>\n<td colspan=\"2\" width=\"361\">\u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u044b\u0435<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" width=\"623\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" width=\"623\"><b>\u0418\u043d\u0442\u0435\u0440\u0444\u0435\u0440\u0438\u0440\u0443\u044e\u0449\u0438\u0435\u00a0\u0444\u0430\u043a\u0442\u043e\u0440\u044b.\u00a0\u041c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u044b<\/b><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" width=\"347\"><b>\u041f\u043e\u0432\u044b\u0448\u0430\u044e\u0442<\/b><\/td>\n<td width=\"276\"><b>\u0421\u043d\u0438\u0436\u0430\u044e\u0442<\/b><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" width=\"347\">\u0410\u043d\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0441\u0442\u0435\u0440\u043e\u0438\u0434\u044b, \u043a\u0430\u0440\u0431\u0430\u043c\u0430\u0437\u0435\u043f\u0438\u043d, \u0446\u0438\u043c\u0435\u0442\u0438\u0434\u0438\u043d (\u0443 \u043c\u0443\u0436\u0447\u0438\u043d \u0438 \u0443 \u0436\u0435\u043d\u0449\u0438\u043d \u0432 \u043f\u043e\u0441\u0442\u043c\u0435\u043d\u043e\u043f\u0430\u0443\u0437\u0435\u00a0 \u043f\u0440\u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u0434\u043e\u0437\u0430\u043c\u0438 2,4 \u0433\/\u0441\u0443\u0442 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 1 \u043c\u0435\u0441.), \u043a\u043b\u043e\u043c\u0438\u0444\u0435\u043d (\u0432 \u043f\u043e\u0441\u0442\u043c\u0435\u043d\u043e\u043f\u0430\u0443\u0437\u0435 \u0443 \u0436\u0435\u043d\u0449\u0438\u043d), \u043a\u0435\u0442\u043e\u043a\u043e\u043d\u0430\u0437\u043e\u043b(\u0443 \u0433\u0438\u043f\u0435\u0440\u0430\u043d\u0434\u0440\u043e\u0433\u0435\u043d\u043d\u044b\u0445 \u0436\u0435\u043d\u0449\u0438\u043d), \u043c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d (\u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043c\u0435\u043d\u0438\u043d\u0433\u0438\u043e\u043c\u0430\u043c\u0438),\u00a0\u043d\u0430\u0444\u0430\u0440\u0435\u043b\u0438\u043d (\u043f\u0440\u0438\u00a0\u043f\u043e\u0434\u043a\u043e\u0436\u043d\u043e\u043c\u00a0\u0432\u0432\u0435\u0434\u0435\u043d\u0438\u0438\u00a0\u043f\u0440\u0438\u00a0\u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0435\u00a0\u043f\u043e\u043b\u0438\u043a\u0438\u0441\u0442\u043e\u0437\u0430\u00a0\u044f\u0438\u0447\u043d\u0438\u043a\u043e\u0432),\u00a0\u0444\u0435\u043d\u0438\u0442\u043e\u0438\u043d,\u00a0\u0442\u0430\u043c\u043e\u043a\u0441\u0438\u0444\u0435\u043d,<\/p>\n<p>\u0442\u0440\u043e\u043b\u0435\u0430\u043d\u0434\u043e\u043c\u0438\u0446\u0438\u043d,\u00a0\u0432\u0430\u043b\u044c\u043f\u0440\u043e\u0435\u0432\u0430\u044f\u00a0\u043a\u0438\u0441\u043b\u043e\u0442\u0430;<\/p>\n<p>\u044d\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u044b\u00a0(\u043e\u0440\u0430\u043b\u044c\u043d\u044b\u0435\u00a0\u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0437\u0430\u0447\u0430\u0442\u043e\u0447\u043d\u044b\u0435\u00a0\u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0430)<\/td>\n<td width=\"276\">\u0410\u043c\u0438\u043d\u043e\u0433\u043b\u044e\u0442\u0435\u0442\u0438\u043c\u0438\u0434,\u00a0\u0445\u0438\u043c\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435\u00a0\u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u044b,<\/p>\n<p>\u0446\u0438\u043c\u0435\u0442\u0438\u0434\u0438\u043d,\u00a0\u0446\u0438\u043f\u0440\u043e\u0442\u0435\u0440\u043e\u043d,\u00a0\u0434\u0430\u043d\u0430\u0437\u043e\u043b,\u00a0\u0434\u0435\u043a\u0441\u0430\u043c\u0435\u0442\u0430\u0437\u043e\u043d,<\/p>\n<p>\u044d\u043f\u043e\u0441\u0442\u0430\u043d,\u00a0\u043c\u0435\u0433\u0435\u0441\u0442\u0440\u043e\u043b,\u00a0\u043c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d,\u00a0\u043c\u043e\u043a\u043b\u043e\u0431\u0435\u043c\u0438\u0434,<\/p>\n<p>\u043d\u0430\u0444\u0430\u0440\u0435\u043b\u0438\u043d, \u043d\u0430\u043d\u0434\u0440\u043e\u043b\u043e\u043d, \u043e\u043a\u0442\u0440\u0435\u043e\u0442\u0438\u0434, \u043f\u0435\u0440\u043e\u0440\u0430\u043b\u044c\u043d\u044b\u0435 \u043a\u043e\u043d\u0442\u0440\u0430\u0446\u0435\u043f\u0442\u0438\u0432\u044b, \u043f\u0440\u0430\u0432\u0430\u0441\u0442\u0430\u0442\u0438\u043d<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\" width=\"623\"><b>\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u00a0\u043a\u00a0\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044e<\/b><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" width=\"623\"><b>\u041d\u0430\u0437\u043d\u0430\u0447\u0430\u0435\u0442\u0441\u044f\u00a0\u0432\u00a0\u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u0435\u00a0\u0441\u00a0\u044d\u0441\u0442\u0440\u0430\u0434\u0438\u043e\u043b\u043e\u043c\u00a0\u0434\u043b\u044f\u00a0\u043e\u0446\u0435\u043d\u043a\u0438\u00a0\u044d\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u043d\u043e\u0439\u00a0\u043f\u0440\u043e\u0434\u0443\u043a\u0446\u0438\u0438\u00a0\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430<\/b><\/p>\n<p><b>\u0412\u00a0\u043f\u0435\u0434\u0438\u0430\u0442\u0440\u0438\u0438:\u00a0<\/b>\u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f\u00a0\u043f\u043e\u043b\u043e\u0432\u043e\u0433\u043e\u00a0\u0441\u043e\u0437\u0440\u0435\u0432\u0430\u043d\u0438\u044f.<\/p>\n<p><b>\u0423\u00a0\u043c\u0443\u0436\u0447\u0438\u043d<\/b>:\u00a0\u0431\u0435\u0441\u043f\u043b\u043e\u0434\u0438\u0435,\u00a0\u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f\u00a0\u0433\u0438\u043f\u043e\u0442\u0430\u043b\u0430\u043c\u043e-\u0433\u0438\u043f\u043e\u0444\u0438\u0437\u0430\u0440\u043d\u043e-\u0433\u043e\u043d\u0430\u0434\u043d\u043e\u0439\u00a0\u0441\u0438\u0441\u0442\u0435\u043c\u044b,\u00a0\u0433\u0438\u043d\u0435\u043a\u043e\u043c\u0430\u0441\u0442\u0438\u044f,\u00a0\u0442\u0435\u0441\u0442\u0438\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0435\u00a0\u043e\u043f\u0443\u0445\u043e\u043b\u0438<\/p>\n<p>\u0438\u00a0\u0433\u0438\u043f\u0435\u0440\u043f\u043b\u0430\u0437\u0438\u044f\u00a0\u043a\u043e\u0440\u044b\u00a0\u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432,\u00a0\u043e\u0441\u0442\u0435\u043e\u043f\u043e\u0440\u043e\u0437.<\/p>\n<p><b>\u0423\u00a0\u0436\u0435\u043d\u0449\u0438\u043d<\/b>:\u00a0\u0431\u0435\u0441\u043f\u043b\u043e\u0434\u0438\u0435,\u00a0\u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f\u00a0\u0433\u0438\u043f\u043e\u0442\u0430\u043b\u0430\u043c\u043e-\u0433\u0438\u043f\u043e\u0444\u0438\u0437\u0430\u0440\u043d\u043e-\u0433\u043e\u043d\u0430\u0434\u043d\u043e\u0439\u00a0\u0441\u0438\u0441\u0442\u0435\u043c\u044b,\u00a0\u0433\u0438\u043d\u0435\u043a\u043e\u043c\u0430\u0441\u0442\u0438\u044f\u00a0\u0438\u00a0\u043e\u043f\u0443\u0445\u043e\u043b\u0438\u00a0\u044f\u0438\u0447\u043d\u0438\u043a\u043e\u0432,\u00a0\u0433\u0438\u043f\u0435\u0440\u043f\u043b\u0430\u0437\u0438\u044f\u00a0\u043a\u043e\u0440\u044b\u00a0\u043d\u0430\u0434\u043f\u043e\u0447\u0435\u0447\u043d\u0438\u043a\u043e\u0432.<\/p>\n<p>\u041c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433 \u043e\u0432\u0443\u043b\u044f\u0446\u0438\u0438 \u0432 \u0446\u0438\u043a\u043b\u0430\u0445\u00a0\u0441\u0442\u0438\u043c\u0443\u043b\u044f\u0446\u0438\u0438.\u00a0\u041e\u0441\u0442\u0435\u043e\u043f\u043e\u0440\u043e\u0437.<\/p>\n<p>\u0421\u043e\u043e\u0442\u043d\u043e\u0448\u0435\u043d\u0438\u0435\u00a0\u04152\/\u04151\u00a0\u043a\u0430\u043a\u00a0\u043c\u0430\u0440\u043a\u0435\u0440\u00a0\u043a\u043b\u0438\u043c\u0430\u043a\u0442\u0435\u0440\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e\u00a0\u043f\u0435\u0440\u0438\u043e\u0434\u0430<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" width=\"623\"><b>\u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f\u00a0\u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"311\"><b>\u041f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/b><\/td>\n<td width=\"311\"><b>\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435\u00a0\u0443\u0440\u043e\u0432\u043d\u044f<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"311\">\u00b7\u00a0\u0410\u043d\u0434\u0440\u043e\u0433\u0435\u043d\u043f\u0440\u043e\u0434\u0443\u0446\u0438\u0440\u0443\u044e\u0449\u0438\u0435\u00a0\u043e\u043f\u0443\u0445\u043e\u043b\u0438,\u00a0\u043f\u0440\u0438\u0435\u043c\u00a0\u0430\u043d\u0434\u0440\u043e\u0433\u0435\u043d\u043e\u0432;<\/p>\n<p>\u00b7\u00a0\u044d\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u043f\u0440\u043e\u0434\u0443\u0446\u0438\u0440\u0443\u044e\u0449\u0438\u0435\u00a0\u043e\u043f\u0443\u0445\u043e\u043b\u0438,\u00a0\u043f\u0440\u0438\u0435\u043c\u00a0\u044d\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u043e\u0432;<\/p>\n<p>\u00b7\u00a0\u043f\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0435\u00a0\u043f\u043e\u043b\u043e\u0432\u043e\u0435\u00a0\u0441\u043e\u0437\u0440\u0435\u0432\u0430\u043d\u0438\u0435\u00a0(\u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435\u00a0\u0441\u043e\u0432\u043c\u0435\u0441\u0442\u043d\u043e\u00a0\u0441\u00a0\u041b\u0413\/\u0424\u0421\u0413);<\/p>\n<p>\u00b7\u00a0\u043b\u043e\u0436\u043d\u043e\u0435\u00a0\u043f\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0435\u00a0\u043f\u043e\u043b\u043e\u0432\u043e\u0435\u00a0\u0441\u043e\u0437\u0440\u0435\u0432\u0430\u043d\u0438\u0435\u00a0(\u043d\u0430\u00a0\u0444\u043e\u043d\u0435\u00a0\u043d\u0438\u0437\u043a\u0438\u0445\u00a0\u041b\u0413\/\u0424\u0421\u0413);<\/p>\n<p>\u00b7\u00a0\u043e\u0436\u0438\u0440\u0435\u043d\u0438\u0435<\/td>\n<td 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