{"id":11941,"date":"2020-05-06T00:16:13","date_gmt":"2020-05-05T21:16:13","guid":{"rendered":"https:\/\/www.synevo.ro\/shop\/profil-anticorpi-antineuronali-blot-amfifizina-cv2-pnma2-ma2-ta-ri-yo-hu-recoverin-sox1\/"},"modified":"2025-02-06T12:23:09","modified_gmt":"2025-02-06T10:23:09","slug":"profil-anticorpi-anti-neuronali-blot","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/profil-anticorpi-anti-neuronali-blot\/","title":{"rendered":"\u041f\u0440\u043e\u0444\u0438\u043b\u044c \u0430\u043d\u0442\u0438\u043d\u0435\u0439\u0440\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u2013 \u0431\u043b\u043e\u0442"},"content":{"rendered":"

Informa\u021b<\/i><\/b>ii generale \u0219i recomand\u0103ri pentru determinarea anticorpilor anti-neuronali<\/i><\/b><\/span><\/p>\n

Anticorpii anti-neuronali reprezint\u0103 o categorie special\u0103 de autoanticorpi ce asociaz\u0103 cu sindroamele neurologice paraneoplazice.<\/span><\/p>\n

Sindroamele neurologice paraneoplazice (paraneoplastic neurological syndromes, PNSs)<\/i> sunt definite ca sindroame clinice neurologice care acompaniaz\u0103 tumorile maligne, dar care nu sunt determinate de acestea sau de metastazele lor, nu au origine vascular\u0103 sau infec\u021bioas\u0103 \u0219i nu constituie efecte adverse ale medica\u021biei. Aceste sindroame au la baz\u0103 mecanisme imunologice al c\u0103ror efect se manifest\u0103 la distan\u021ba de tumor\u0103 primar\u0103 \u0219i\/sau site-ul metastatic1<\/sup>.<\/span><\/p>\n

\u00cen literatur\u0103 sunt utilizate dou\u0103 tipuri de nomenclaturi pentru anticorpii antineuronali: una dintre acestea este bazat\u0103 pe primele 2 litere ale pacientului la care a fost descris\u00a0prima dat\u0103 anticorpul respectiv (Hu de la Hull, Yo de la Young, Ma de la Margret), iar cealalt\u0103 pe ini\u021bialele colora\u021biei imunohistochimice (ANNA = anticorpi antinucleari antineuronali)2<\/sup>.<\/span><\/p>\n

\u00cen func\u021bie de tipul tumorii celulele tumorale exprim\u0103 antigene care induc formarea de autoanticorpi specifici. Ace\u0219ti autoanticorpi reac\u021bioneaz\u0103 \u00eencruci\u0219at cu antigene identice localizate la nivelul \u021besutului nervos \u0219i sunt probabil implica\u021bi \u00een dezvoltarea\u00a0sindroamelor paraneoplazice1<\/sup>.<\/span><\/p>\n

Din momentul \u00een care au fost descri\u0219i pentru prima dat\u0103 anticorpii anti-Hu (1985) este bine cunoscut faptul c\u0103 mai mult de 2\/3 din\u00a0 pacien\u021bii cu sindroame paraneoplazice\u00a0prezint\u0103 \u00een ser autoanticorpi\u00a0 specifici. Reac\u021biile\u00a0antigen-anticorp nu numai c\u0103 demonstreaz\u0103 etiologia paraneoplazic\u0103 \u00een aproape 100% din cazuri, dar sunt de asemenea str\u00e2ns asociate cu tumori specifice, care p\u00e2n\u0103 atunci nu au fost detectate la ace\u0219ti pacien\u021bi3<\/sup>. Astfel, depistarea anticorpilor anti-neuronali poate fi foarte util\u0103 \u00een diagnosticul precoce al tumorilor2<\/sup>.<\/span><\/p>\n

PNS\u00a0apar \u00een aproximativ 15% din afec\u021biunile neoplazice, \u00een particular\u00a0\u00een tumorile pulmonare \u0219i gastrice. Sindroamele\u00a0paraneoplazice oto-neuro-oftalmologice rezult\u0103 de obicei din encefalita de trunchi cerebral\u00a0 \u0219i\/sau degenerescen\u021ba cerebeloas\u0103. Acestea se pot dezvolta ca urmare a r\u0103spunsului imun fa\u021b\u0103 de proteine onconeurale (ca de exemplu, anti-Hu, anti-Yo, anti-Ri) sau alte antigene necunoscute.<\/span><\/p>\n

PNS apar cel mai adesea asociate cu carcinomul\u00a0 pulmonar cu celule mici (SCLC), carcinomul mamar sau ovarian. Sindromul\u00a0 miastenic Lambert-Eaton (LEMS)<\/b>, unul din cele mai frecvente PNS, prezint\u0103 cea mai mare valoare predictiv\u0103 \u00een ceea ce prive\u0219te existen\u021ba unei tumori de baz\u0103 (\u00een acest caz SCLC). In majoritatea PNS, \u00een special encefalita limbic\u0103 paraneoplazic\u0103<\/b> (PLE),<\/b> degenerescen\u021ba cerebeloas\u0103 paraneoplazic\u0103<\/b> (PCD<\/b>), sindromul opsoclonus-mioclonus-ataxie <\/b>(POMA<\/b>), sindromul \u201estiff man\u201d <\/b>(SPS<\/b>) \u0219i retinopatia paraneoplazic\u0103 (amauroza subacuta)<\/b>, detec\u021bia anticorpilor specifici are valoare predictiv\u0103 pozitiv\u0103 crescut\u0103, corel\u00e2ndu-se mai bine cu prezen\u021ba tumorii de baz\u0103 dec\u00e2t simptomele clinice propriu-zise4;5<\/sup>.<\/b><\/span><\/p>\n

Spre exemplu, PCD\u00a0 este determinat\u0103\u00a0 de mecanismele autoimune care apar \u00een unele neoplazii, mai ales \u00een stadiile precoce ale carcinoamelor mamare, ovariene, pulmonare precum \u0219i \u00een limfomul Hodgkin. Reac\u021bia imun\u0103 \u00eendreptat\u0103 \u00eempotriva antigenelor tumorale, identice cu antigenele\u00a0 cerebeloase, duce la formarea de anticorpi anti-Hu, anti-Yo, anti-Ri ce pot fi detecta\u021bi at\u00e2t \u00een s\u00e2nge c\u00e2t \u0219i\u00a0\u00een lichidul cefalorahidian. Asocierea existent\u0103 \u00eentre afec\u021biunea neoplazic\u0103 \u0219i modific\u0103rile cerebeloase este demonstrat\u0103 prin reac\u021bia de imunofluorescen\u021b\u0103 indirect\u0103 \u00een care anticorpii\u00a0anti-Yo reac\u021bioneaz\u0103 at\u00e2t cu celulele Purkinje cerebeloase c\u00e2t \u0219i cu celulele carcinomatoase2<\/sup>.<\/span><\/p>\n

PNS nu numai c\u0103 acompaniaza tumorile maligne, dar pot\u00a0 fi \u00eent\u00e2lnite \u0219i \u00een afec\u021biuni\u00a0autoimune ca diabetul zaharat tip 1, c\u00e2nd se poate demonstra apari\u021bia \u00een paralel\u00a0a anticorpilor specifici\u00a0 anti-substan\u021b\u0103 cenu\u0219ie\u00a0\u0219i a\u00a0celor \u00eendrepta\u021bi \u00eempotriva celulelor insulare pancreatice. Astfel, detectarea autoanticorpilor fa\u021b\u0103 de enzima glutamat-decarboxilaz\u0103 (GAD) este important\u0103 at\u00e2t pentru depistarea precoce a diabetului zaharat tip 1 c\u00e2t \u0219i pentru diagnosticul unor afec\u021biuni neurologice, cum ar fi sindromul \u201estiff man\u201d asociat cu limfomul Hodgkin6<\/sup>.<\/span><\/p>\n

Conform\u00a0recomand\u0103rilor Societ\u0103\u021bii\u00a0Germane de Neurologie, determinarea anticorpilor din sindroamele paraneoplazice (anticorpi antineuronali) ar trebui efectuat\u0103 utiliz\u00e2nd\u00a0cel pu\u021bin dou\u0103 metode: screening prin\u00a0 imunofluorescen\u021b\u0103 indirect\u0103 \u0219i confirmare\u00a0prin tehnica imunoblot. Rezultatele ob\u021binute au relevan\u021b\u0103 diagnostic\u0103 numai dac\u0103 sunt concordante prin cele dou\u0103 metode \u0219i se integreaz\u0103 \u00een tabloul clinic al pacien\u021bilor8;9<\/sup>.<\/span><\/span><\/p>\n

I\u00ce tabelul de mai jos sunt prezenta\u021bi principalii anticorpi \u00eendrepta\u021bi \u00eempotriva antigenelor neuronale intracelulare \u00eempreun\u0103 cu afec\u021biunile neurologice asociate \u0219i cu posibilele tumori asociate4;10<\/sup>:<\/span><\/p>\n

\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Autoanticorp<\/b><\/span><\/p>\n

(Sinonime)<\/span><\/p>\n<\/td>\n

\n

Antigen<\/b><\/span><\/p>\n

(masa molecular\u0103)<\/span><\/p>\n

localizare (L<\/b>)<\/span><\/p>\n<\/td>\n

\n

Boli neurologice asociate<\/b><\/span><\/p>\n

Cele mai frecvente sindroame (SF)<\/b><\/span><\/p>\n

Alte sindroame (AS)<\/b><\/span><\/p>\n<\/td>\n

\n

Tumori asociate<\/b><\/span><\/p>\n

Cele mai frecvente tumori (TF)<\/b><\/span><\/p>\n

Alte tumori (AT)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Anti-Hu<\/b><\/span><\/p>\n

(ANNA-1, anticorpi antinucleari anti-neuronali tip1)<\/span><\/p>\n<\/td>\n

\n

Proteina Hu<\/b>, proteina neuronal\u0103 specific\u0103 de legare a ARN-ului, <\/span><\/p>\n

(38 kDa)<\/span><\/p>\n

\u041c<\/b>: nucleii neuronilor din sistemul nervos central \u0219i periferic<\/span><\/p>\n<\/td>\n

\n

SF<\/b>: encefalite ce afecteaz\u0103 in special trunchiul cerebral, cerebelul \u0219i sistemul limbic; mielite; polineuropatii (autonome, senzitive \u0219i senzitivo-motorii)<\/span><\/p>\n

AS<\/b>: PCD, sindroame motorii\u00a0 extrapiramidale, LEMS, epilepsie focal\u0103, POMA, pseudo-obstruc\u021bie\u00a0 gastrointestinal\u0103 cronica\u0103 retinopatie<\/span><\/p>\n<\/td>\n

\n

TF<\/b>: SCLC, neuroblastom<\/span><\/p>\n

AT<\/b>: carcinom prostatic, carcinom de vezic\u0103 urinar\u0103, ovarian, mamar, pancreatic, tumori\u00a0 gastrointestinale maligne<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Anti-Ri<\/b><\/span><\/p>\n

(ANNA-2, anticorpi antinucleari anti-neuronali tip 2)<\/span><\/p>\n<\/td>\n

\n

NOVA,<\/b><\/span><\/p>\n

Ri\/NOVA1,\u00a0 proteine de legare a ARN-ului <\/span><\/p>\n

(55 kDa si 80 kDa)<\/span><\/p>\n

\u041c<\/b>: nucleii neuronilor din sistemul nervos central<\/span><\/p>\n<\/td>\n

\n

SF<\/b>: <\/b>POMA<\/span><\/p>\n

AS<\/b>: PCD, rombencefalita<\/span><\/p>\n<\/td>\n

\n

TF: <\/b>SCLC,<\/span><\/p>\n

carcinom mamar<\/span><\/p>\n

AT<\/b>: limfom Hodgkin si non-Hodgkin, tumora de trunchi cerebral cu proliferare rapida, carcinom ovarian<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Anti-Yo<\/b> (PCA-1, anticorpi tip 1 fa\u021b\u0103 de celula Purkinje)<\/span><\/p>\n<\/td>\n

\n

CDR2, CDR62,<\/b><\/span><\/p>\n

antigenul Yo, proteinele de transduc\u021bie a semnal (34 kDa si 62 kDa)<\/span><\/p>\n

\u041c<\/b>: <\/b>Citoplasma (reticul endoplasmatic rugos, aparat Golgi, membran\u0103 citoplasmatic\u0103) celulelor Purkinje din cerebel<\/span><\/p>\n<\/td>\n

\n

SF<\/b>: PCD<\/span><\/p>\n

AS<\/b>: POMA<\/span><\/p>\n<\/td>\n

\n

TF<\/b>: carcinom uterin, ovarian, mamar<\/span><\/p>\n

AT<\/b>: adenocarcinom esofagian, carcinom al vezicii biliare, <\/span>carcinom prostatic, limfom Hodgkin \u0219i non-Hodgkin, timom<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Anti- CV-2<\/b><\/span><\/p>\n

(Anti-CRMP5)<\/span><\/p>\n

\u00a0<\/span><\/p>\n<\/td>\n

\n

CV2\/CRMP5<\/b><\/span><\/p>\n

(proteina de 66 kDa)<\/span><\/p>\n

L:<\/strong> <\/b>citoplasma oligodendrocitelor<\/span><\/p>\n<\/td>\n

\n

SF<\/b>: encefalita limbic\u0103<\/span><\/p>\n

AS<\/b>: PCD, polineuropatii (autonome, senzitive \u0219i senzitivo-motorii), retinopatie, uveita, sindrom miastenic, pseudo-obstruc\u021bie gastrointestinala cronic\u0103, coree, POMA, rombencefalita, epilepsie focal\u0103<\/span><\/p>\n<\/td>\n

\n

TF<\/b>: SCLC , timom<\/span><\/p>\n

AT<\/b>: sarcom uterin<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Anti-PNMA2<\/b><\/span><\/p>\n

(Ma2\/Ta)<\/span><\/p>\n<\/td>\n

\n

Proteina Ma <\/b>(40 kDa)<\/span><\/p>\n

L:<\/strong> nucleolii neuronali<\/span><\/p>\n<\/td>\n

\n

SF<\/b>: rombencefalit\u0103, PLE, encefalopatie de trunchi cerebral<\/span><\/p>\n

AS<\/b>: <\/b>POMA, PCD, epilepsie focala, sindroame motorii extrapiramidale, retinopatie<\/span><\/p>\n<\/td>\n

\n

TF<\/b>: seminom testicular <\/span><\/p>\n

AT<\/b>: carcinom pulmonar altul dec\u00e2t cel cu celule mici, parotidian, mamar, ovarian, de colon, renal, limfom<\/span><\/p>\n

\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Anti-amfifizina<\/b><\/span><\/p>\n<\/td>\n

\n

Amfifizina<\/b><\/span><\/p>\n

(proteina de 128 kDa)<\/span><\/p>\n

L:<\/strong> membrana veziculelor sinaptice<\/span><\/p>\n

Rol \u00een endocitoza veziculelor<\/span><\/p>\n<\/td>\n

\n

SF<\/b>: <\/b>SPS<\/span><\/p>\n

AS<\/b>: <\/b>sindrom miastenic, polineuropatii (autonome, senzitive si senzitivo-motorii), encefalomielita cu rigiditate, ataxie cerebeloas\u0103, POMA<\/b><\/span><\/p>\n<\/td>\n

\n

TF<\/b>: carcinom mamar, SCLC<\/span><\/p>\n

AT<\/b>: timom, limfom Hodgkin, carcinom de colon<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Anti-PNMA-1<\/b><\/span><\/p>\n

(Ma1)<\/span><\/p>\n<\/td>\n

\n

Proteina Ma<\/b><\/span><\/p>\n

(37 kDa)<\/span><\/p>\n<\/td>\n

\n

SF<\/b>: rombencefalita, (trunchi cerebral) encefalita limbic\u0103<\/span><\/p>\n<\/td>\n

\n

TF<\/b>: carcinom mamar<\/span><\/p>\n

AT<\/b>: tumori diverse<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Anti-GAD<\/b><\/span><\/p>\n<\/td>\n

\n

Decarboxilaza acidului glutamic<\/b><\/span><\/p>\n

(65kDa si 67kDa)<\/span><\/p>\n<\/td>\n

\n

SF<\/b>: <\/b>SPS<\/span><\/p>\n<\/td>\n

\n

TF<\/b>: SCLC, carcinom mamar, carcinom de colon<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

PCA-2<\/b><\/span><\/p>\n<\/td>\n

\n

Proteina\u00a0 din celulele Purkinje<\/b> (280 kDa)<\/span><\/p>\n<\/td>\n

\n

SF<\/b>: encefalite, neuropatii<\/span><\/p>\n<\/td>\n

\n

TF<\/b>: SCLC<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Anticorpi antinucleari anti-gliali<\/b><\/span><\/p>\n

(AGNA)<\/span><\/p>\n<\/td>\n

\n

Proteina SOX1<\/b> ce leaga ADN-ul cu rol \u00een activarea transcrip\u021biei<\/span><\/p>\n

L:<\/strong> nuclei celulelor gliale Bergmann din stratul celulelor Purkinje al cerebelului<\/span><\/p>\n<\/td>\n

\n

SF<\/b>: LEMS, PCD<\/span><\/p>\n<\/td>\n

\n

TF<\/b>: <\/b>SCLC<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Anti-recoverin<\/b><\/span><\/p>\n<\/td>\n

\n

Recoverin<\/b> (23kDa \u0219\u00eeni 65KDa) – proteina care leag\u0103 Ca2+ la nivelul retinei cu func\u021bie de reglare a fototransduc\u021biei)<\/span><\/p>\n

\u041c<\/b>: fotoreceptorii retinei<\/span><\/p>\n<\/td>\n

\n

SF<\/b>: <\/b>retinopatie<\/b><\/span><\/p>\n<\/td>\n

\n

TF<\/b>: <\/b>SCLC<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Anti-titin<\/b><\/span><\/p>\n<\/td>\n

\n

Titin<\/b> <\/span><\/p>\n

(proteina filamentoas\u0103 a mu\u0219chiului striat)<\/span><\/p>\n<\/td>\n

\n

SF<\/b>: <\/b>miastenia gravis<\/b><\/span><\/p>\n<\/td>\n

\n

TF<\/b>: <\/b>timom<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Anti-Tr<\/b><\/span><\/p>\n

(PCA-Tr)<\/span><\/p>\n<\/td>\n

\n

necunoscut<\/span><\/p>\n<\/td>\n

\n

FS<\/b>: <\/b>PCD<\/span><\/p>\n<\/td>\n

\n

TF<\/b>: limfom Hodgkin<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/span><\/p>\n

Preg\u0103tire pacient <\/i><\/b>– \u00e0 jeun (pe nem\u00e2ncate) sau postprandial (dup\u0103 mese)9<\/sup>.<\/span><\/p>\n

Specimen recoltat <\/i><\/b>– s\u00e2nge venos9<\/sup>.<\/span><\/p>\n

Recipient de recoltare <\/i><\/b>– <\/i>vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator9<\/sup>.<\/span><\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/i><\/b>– <\/i>se separ\u0103 serul prin centrifugare9<\/sup>.<\/span><\/p>\n

Volum prob\u0103<\/i><\/b> – minim 0.5 mL ser9<\/sup>.<\/span><\/p>\n

Cauze de respingere<\/i><\/b> a probei <\/i><\/b>– <\/i>ser intens hemolizat, lipemic sau puternic contaminat bacterian9<\/sup>.<\/span><\/p>\n

Stabilitate prob\u0103 <\/i><\/b>– <\/b><\/i>serul separat este stabil 14 zile<\/i> la 4\u00b0C; timp mai \u00eendelungat<\/i> la -20 \u00b0C9<\/sup>.<\/span><\/p>\n

Metod\u0103<\/i><\/strong> – imunoblot<\/span>. <\/span>Testul utilizeaz\u0103 9 antigene care sunt fixate \u00een cip-uri paralele pe membrana unui strip. Antigenele sunt reprezentate, \u00een ordinea fix\u0103rii pe strip, de:<\/span><\/p>\n

– Amfifizina<\/span><\/div>\n
– CV2 <\/span><\/div>\n
– PNMA2 (Ma2\/Ta)<\/span><\/span><\/div>\n
– Ri<\/span><\/div>\n
– Yo<\/span><\/div>\n
– Hu<\/span><\/div>\n
– Recoverin<\/span><\/div>\n
– SOX1<\/span><\/div>\n
– Titin<\/span><\/div>\n

\u00centr-o prim\u0103 etap\u0103 strip-ul \u00eenc\u0103rcat cu antigenele purificate este incubat \u00eempreun\u0103 cu serul diluat al pacientului. Dac\u0103 \u00een ser sunt prezen\u021bi anticorpi specifici, ace\u0219tia se vor lega de antigenele corespunz\u0103toare de pe strip. Dup\u0103 o etap\u0103 de sp\u0103lare, strip-ul este incubat cu un conjugat anti-IgG uman marcat cu fosfataz\u0103 alcalin\u0103. Conjugatul se va ata\u0219a la por\u021biunea IgG a complexului antigen-anticorp. Dup\u0103 \u00eendep\u0103rtarea prin sp\u0103lare a conjugatului nelegat se adaug\u0103 solu\u021bia de colorare (substratul enzimei) \u2013 un sistem de detec\u021bie enzimatic\u0103 colorimetric\u0103. Dac\u0103 este prezent conjugatul legat reac\u021bia enzimatic\u0103 va genera un produs colorat albastru-\u00eenchis la nivelul benzilor ocupate de anticorpi specifici. Astfel, benzile vizualizate la nivelul stripului sunt rezultatul leg\u0103rii\u00a0 anticorpilor specifici de antigenele individuale de la nivelul strip-ului.<\/span><\/p>\n

Pe fiecare strip\u00a0 exist\u0103 o band\u0103 de control intern. Apari\u021bia unei reac\u021bii de culoare intense la acest nivel certific\u0103 faptul c\u0103 toate etapele testului imunoblot au fost executate corect9<\/sup>.<\/span><\/p>\n

Valori de referin\u021b\u0103 <\/i><\/b>\u0438<\/strong><\/em> interpretarea rezultatelor<\/i><\/b><\/span><\/p>\n

Interpretarea definitiv\u0103 a rezultatelor testului se face cu ajutorul unui software (dup\u0103 scanarea strip-urilor) care \u00een func\u021bie de intensitatea semnalului, acord\u0103 un punctaj pentru fiecare band\u0103 a strip-ului, astfel:<\/span><\/p>\n\n\n\n\n\n\n\n
\n

EVALUARE SEMNAL<\/b><\/span><\/p>\n<\/td>\n

\n

INTENSITATE\u00a0 SEMNAL<\/b><\/span><\/p>\n<\/td>\n

\n

REZULTAT<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

F\u0103r\u0103 band\u0103 <\/span><\/td>\n\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 0-5<\/span><\/td>\n\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/td>\n\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 NEGATIV<\/span><\/td>\n<\/tr>\n
Band\u0103 slab\u0103<\/span><\/td>\n\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 6-10\u00a0\u00a0\u00a0 <\/span><\/td>\n\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (+)<\/span><\/td>\n\u00a0\u00a0\u00a0\u00a0\u00a0 ECHIVOC<\/span><\/td>\n<\/tr>\n
Band\u0103 medie-intens\u0103<\/span><\/td>\n\u00a0\u00a0 11-25 sau 26-50<\/span><\/td>\n\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 +,++<\/span><\/td>\n\u00a0\u00a0\u00a0\u00a0\u00a0 POZITIV<\/span><\/td>\n<\/tr>\n
Band\u0103 foarte intens\u0103<\/span><\/td>\n\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 >50<\/span><\/td>\n\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 +++<\/span><\/td>\n\u00a0\u00a0\u00a0\u00a0 INTENS POZITIV<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
<\/div>\n
\u00cen final este calculat\u0103 suma\u00a0punctelor acordate \u0219i se va genera rezultatul testului.<\/span><\/div>\n
Un rezultat pozitiv confirm\u0103 prezen\u021ba anticorpilor specifici.<\/span><\/div>\n
Un rezultat echivoc indic\u0103 faptul c\u0103 prezen\u021ba auto- anticorpilor\u00a0este incert\u0103; \u00een func\u021bie de contextul clinic al pacientului testul va fi repetat la un interval de 1-2 luni. <\/span><\/div>\n
Un rezultat negativ indic\u0103 absen\u021ba auto-anticorpilor specifici9<\/sup>.<\/span><\/div>\n

Valori de referin\u021b\u01039<\/sup><\/span><\/i><\/b><\/span><\/p>\n

– Amfifizina<\/b>: negativ<\/span><\/div>\n
– CV2<\/b>: negativ<\/span><\/div>\n
– PNMA2 (<\/b>Ma2\/Ta)<\/span><\/b>: negativ <\/b><\/span><\/div>\n
– Ri<\/b>: negativ<\/span><\/div>\n
–\u00a0 Yo<\/b>: negativ<\/span><\/div>\n
– Hu<\/b>: negativ<\/span><\/div>\n
– Recoverin<\/b>: negativ<\/span><\/div>\n
– SOX1<\/b>: negativ<\/span><\/div>\n
– Titin<\/strong>: negativ<\/span><\/div>\n

\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/span><\/p>\n

1. Graus F, Saiz A, Dalmau J. Antibodies and neuronal autoimmune disorders of the CNS. In J Neurol 257 (2010) 509-517.<\/span><\/span><\/div>\n
2. Dalmau J, Rosenfeld MR. Paraneoplastic syndromes of the CNS. In Lancet Neurol 7 (2008) 327-340.<\/span><\/div>\n
3. Darnell RB, Posner JB. Paraneoplastic syndromes affecting the nervous system. In Semin Oncol 33 (2006) 270-298.<\/span><\/div>\n
4. Roceanu A, Bajenaru O. Sindroamele paraneoplazice \u00een practica neurologic\u0103. Articol preluat din Revista Rom\u00e2n\u0103 de Neurologie pentru sec\u021biunea EMC Neurologie, iulie 2008. Ref Type: Internet Communication.<\/span><\/div>\n
5. Dalmau J, Porta-Etessam J. Paraneoplastic cerebral syndromes with oto-neuroophthalomologic manifestations. In Rev Neurol 31 (2000) 1213-1219.<\/span><\/div>\n
6. Graus F, Saiz A, Dalmau J. Antibodies and neuronal autoimmune disorders of the CNS. In J Neurol 257 (2010) 509-517.<\/span><\/div>\n
7. Graus F, Delattre JY, Antoine JC, Dalmau J, Giometto B, Grisold W, Honnorat J, Smitt PS, Vedeler C, Verschuuren J, Vincent A, Voltz R for the Paraneoplastic Neurological Syndrome Euronetwork (2004). Recommended diagnostic criteria for paraneoplastic neurological syndromes. JNNP 75 (2004) 1135-1140.<\/span><\/div>\n
8. Diener HC (Hrsg.) Leitlinien f\u00fcr Diagnostik und Therapie in der Neurologie. 3. \u00fcberarbeitete Auflage 2005, Georg Thieme Verlag Stuttgart.<\/span><\/div>\n
9. Laborator Synevo. Referin\u021bele specifice tehnologiei de lucru utilizate 2013. Ref Type: Catalog.<\/span><\/div>\n
10. Lorusso L, Hart IK, Giometto B, Pezzani R, Broome JC, Gritti D, Gasparetto C, Ricevuti G. Immunological features of neurological paraneoplastic syndromes. Int J Immunopathol Pharmacol 17 (2004) 135-144.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

\u0410\u043d\u0442\u0438\u043d\u0435\u0439\u0440\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0443\u044e\u0442 \u0432 \u043a\u0440\u043e\u0432\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u043c\u0438 \u044d\u043d\u0446\u0435\u0444\u0430\u043b\u0438\u0442\u0430\u043c\u0438 \u2013 \u0433\u0440\u0443\u043f\u043f\u043e\u0439 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439, \u0434\u043b\u044f \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u043e \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043a \u043d\u0435\u0440\u0432\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438. \u0412\u044b\u0434\u0435\u043b\u044f\u044e\u0442 \u0442\u0440\u0438 \u0433\u0440\u0443\u043f\u043f\u044b \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0445 \u044d\u043d\u0446\u0435\u0444\u0430\u043b\u0438\u0442\u043e\u0432:<\/p>\n

    \n
  • \u043f\u0430\u0440\u0430\u043d\u0435\u043e\u043f\u043b\u0430\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u2013 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u043a\u043b\u0435\u0442\u043a\u0430\u043c \u0441\u043e\u0431\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u043d\u0435\u0440\u0432\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438 \u043d\u0430\u0447\u0438\u043d\u0430\u044e\u0442 \u0432\u044b\u0440\u0430\u0431\u0430\u0442\u044b\u0432\u0430\u0442\u044c\u0441\u044f \u043d\u0430 \u0444\u043e\u043d\u0435 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0430 \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0435;<\/li>\n
  • \u043f\u043e\u0441\u0442\u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0439 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0439 \u044d\u043d\u0446\u0435\u0444\u0430\u043b\u0438\u0442 \u2013 \u0432\u043e\u0437\u043d\u0438\u043a\u0430\u0435\u0442 \u043f\u043e\u0441\u043b\u0435 \u043f\u0435\u0440\u0435\u043d\u0435\u0441\u0435\u043d\u043d\u043e\u0433\u043e \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u043e\u0433\u043e \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u044f \u043d\u0435\u0440\u0432\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b;<\/li>\n
  • \u0438\u0434\u0438\u043e\u043f\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0439 \u044d\u043d\u0446\u0435\u0444\u0430\u043b\u0438\u0442 \u2013 \u0440\u0430\u0437\u0432\u0438\u0432\u0430\u0435\u0442\u0441\u044f \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u043e \u0438 \u043d\u0435 \u0441\u0432\u044f\u0437\u0430\u043d \u0441 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u043e\u043c.<\/li>\n<\/ul>\n

    \u0421\u0438\u043c\u043f\u0442\u043e\u043c\u044b \u0432\u043a\u043b\u044e\u0447\u0430\u044e\u0442 \u0432 \u0441\u0435\u0431\u044f \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0435 \u043d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0438 \u043f\u0441\u0438\u0445\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f. \u0417\u0430\u0447\u0430\u0441\u0442\u0443\u044e \u0430\u043d\u0442\u0438\u043d\u0435\u0439\u0440\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u044e\u0442\u0441\u044f \u0432 \u043a\u0440\u043e\u0432\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430 \u0435\u0449\u0435 \u0434\u043e \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0438\u044f \u043d\u0435\u043f\u043e\u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u043e\u043f\u0443\u0445\u043e\u043b\u0438\u00a0\u0438 \u043f\u043e\u044d\u0442\u043e\u043c\u0443 \u043c\u043e\u0433\u0443\u0442 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c\u0441\u044f \u0434\u043b\u044f \u0440\u0430\u043d\u043d\u0435\u0439 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u043e\u043d\u043a\u043e\u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439. \u041f\u0430\u0440\u0430\u043d\u0435\u043e\u043f\u043b\u0430\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0439 \u043f\u0440\u043e\u0446\u0435\u0441\u0441 \u043c\u043e\u0436\u0435\u0442 \u0440\u0430\u0437\u0432\u0438\u0442\u044c\u0441\u044f \u043f\u0440\u0438 \u043c\u0435\u043b\u043a\u043e\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u043c \u0440\u0430\u043a\u0435 \u043b\u0435\u0433\u043a\u043e\u0433\u043e, \u043d\u0435\u0439\u0440\u043e\u0431\u043b\u0430\u0441\u0442\u043e\u043c\u0435, \u0440\u0430\u043a\u0435 \u043c\u043e\u043b\u043e\u0447\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b, \u044f\u0438\u0447\u043d\u0438\u043a\u043e\u0432 \u0438 \u0440\u0430\u043a\u0435 \u044f\u0438\u0447\u043a\u0430. \u0421\u0443\u0449\u0435\u0441\u0442\u0432\u0443\u0435\u0442 \u0431\u043e\u043b\u0435\u0435 30 \u0432\u0438\u0434\u043e\u0432 \u0430\u043d\u0442\u0438\u043d\u0435\u0439\u0440\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b. \u041d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0438\u0437 \u043d\u0438\u0445 \u0445\u043e\u0440\u043e\u0448\u043e \u0438\u0437\u0443\u0447\u0435\u043d\u044b, \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0430 \u0438\u0445 \u0441\u0442\u0440\u043e\u0433\u0430\u044f \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e\u0441\u0442\u044c \u0432 \u0441\u0432\u044f\u0437\u0438 \u0441 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u043d\u044b\u043c\u0438 \u0432\u0438\u0434\u0430\u043c\u0438 \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0439.<\/p>\n

    \u041d\u0435\u0439\u0440\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043c\u043e\u0436\u043d\u043e \u0440\u0430\u0437\u0434\u0435\u043b\u0438\u0442\u044c \u043d\u0430 \u0442\u0440\u0438 \u0433\u0440\u0443\u043f\u043f\u044b:<\/p>\n

      \n
    • \u043f\u0430\u0440\u0430\u043d\u0435\u043e\u043f\u043b\u0430\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0432\u043d\u0443\u0442\u0440\u0438\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u043c \u0431\u0435\u043b\u043a\u0430\u043c \u043d\u0435\u0440\u0432\u043d\u044b\u0445 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u00a0– \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u0435 \u0434\u0430\u043d\u043d\u043e\u0433\u043e \u0442\u0438\u043f\u0430 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u0432 95 % \u0441\u043b\u0443\u0447\u0430\u0435\u0432 \u0441\u0432\u0438\u0434\u0435\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0443\u0435\u0442 \u043e \u043d\u0430\u043b\u0438\u0447\u0438\u0438 \u043f\u0430\u0440\u0430\u043d\u0435\u043e\u043f\u043b\u0430\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0430, \u0434\u0430\u0436\u0435 \u0435\u0441\u043b\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u044c \u0435\u0449\u0435 \u043d\u0435 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0435\u043d\u0430;<\/li>\n
    • \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u044e\u0442\u0441\u044f \u043a\u0430\u043a \u043f\u0440\u0438 \u043f\u0430\u0440\u0430\u043d\u0435\u043e\u043f\u043b\u0430\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0435, \u0442\u0430\u043a \u0438 \u043f\u0440\u0438 \u0438\u0434\u0438\u043e\u043f\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u043c;<\/li>\n
    • \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0447\u0430\u0449\u0435 \u0432\u0441\u0435\u0433\u043e \u0432\u044b\u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0442\u043e\u043b\u044c\u043a\u043e \u043f\u0440\u0438 \u0438\u0434\u0438\u043e\u043f\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u043c \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u0438 \u043d\u0435\u0440\u0432\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438.<\/li>\n<\/ul>\n

      \u041f\u0440\u0438 \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u0438 \u043b\u044e\u0431\u044b\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u043e \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c \u0442\u0449\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u0438 \u0434\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u043e\u043d\u043a\u043e\u043f\u043e\u0438\u0441\u043a, \u043f\u043e\u0441\u043a\u043e\u043b\u044c\u043a\u0443 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0439 \u043f\u0440\u043e\u0446\u0435\u0441\u0441 \u043c\u043e\u0436\u0435\u0442 \u0440\u0430\u0437\u0432\u0438\u0432\u0430\u0442\u044c\u0441\u044f \u043d\u0430 \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u043e \u043c\u0435\u0441\u044f\u0446\u0435\u0432, \u0430 \u0432 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u0438 \u043b\u0435\u0442, \u0440\u0430\u043d\u044c\u0448\u0435, \u0447\u0435\u043c \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u0435\u0442\u0441\u044f \u043e\u043f\u0443\u0445\u043e\u043b\u044c.<\/p>\n

      \u0414\u043b\u044f \u0447\u0435\u0433\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n

        \n
      • \u0414\u043b\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0433\u043e \u044d\u043d\u0446\u0435\u0444\u0430\u043b\u0438\u0442\u0430.<\/li>\n
      • \u0414\u043b\u044f \u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u043e\u0432 \u0433\u043e\u043b\u043e\u0432\u043d\u043e\u0433\u043e \u043c\u043e\u0437\u0433\u0430.<\/li>\n
      • \u041f\u0440\u0438 \u043f\u043e\u0434\u043e\u0437\u0440\u0435\u043d\u0438\u0438 \u043d\u0430 \u043f\u0430\u0440\u0430\u043d\u0435\u043e\u043f\u043b\u0430\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0441 \u043d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0430\u0442\u0438\u043a\u043e\u0439 \u043d\u0430 \u0444\u043e\u043d\u0435 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0430.<\/li>\n<\/ul>\n

        \u041a\u043e\u0433\u0434\u0430 \u043d\u0430\u0437\u043d\u0430\u0447\u0430\u0435\u0442\u0441\u044f \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435?<\/strong><\/p>\n

          \n
        • \u041f\u0440\u0438 \u043f\u043e\u0434\u043e\u0437\u0440\u0435\u043d\u0438\u0438 \u043d\u0430 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0435 \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u0435 \u043d\u0435\u0440\u0432\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u043c\u0438.<\/li>\n
        • \u0414\u043b\u044f \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0430\u0442\u0438\u043a\u043e\u0439 \u0438\/\u0438\u043b\u0438 \u043f\u0441\u0438\u0445\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f\u043c\u0438.<\/li>\n
        • \u041f\u0440\u0438 \u043f\u043e\u0434\u043e\u0437\u0440\u0435\u043d\u0438\u0438 \u043d\u0430 \u0438\u0434\u0438\u043e\u043f\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0438\u043b\u0438 \u043f\u043e\u0441\u0442\u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u044b\u0439 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0439 \u044d\u043d\u0446\u0435\u0444\u0430\u043b\u0438\u0442.<\/li>\n<\/ul>\n

          \u041a\u0430\u043a \u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u043e \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u0438\u0442\u044c\u0441\u044f \u043a \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044e?<\/strong><\/p>\n

            \n
          • \u041d\u0435 \u043a\u0443\u0440\u0438\u0442\u044c \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 30 \u043c\u0438\u043d\u0443\u0442 \u0434\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/li>\n<\/ul>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[934],"product_tag":[],"class_list":{"0":"post-11941","1":"product","2":"type-product","3":"status-publish","5":"product_cat-autoanticorpi-in-afectiuni-neurologice","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/11941","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=11941"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=11941"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=11941"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=11941"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=11941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}