{"id":11907,"date":"2020-05-05T23:16:07","date_gmt":"2020-05-05T20:16:07","guid":{"rendered":"https:\/\/www.synevo.ro\/shop\/anticorpi-anti-c1q\/"},"modified":"2025-02-06T12:27:21","modified_gmt":"2025-02-06T10:27:21","slug":"anticorpi-anti-c1q","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-c1q\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u04211q \u0444\u0430\u043a\u0442\u043e\u0440\u0443 \u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442\u0430"},"content":{"rendered":"<p>Sistemul complementului este unul dintre principalele mecanisme efectoare ale sistemului imunitar \u00eenn\u0103scut \u0219i joac\u0103 un rol important \u00een imunitate<sup>2<\/sup>. C1q este prima component\u0103 a c\u0103ii clasice de activare a complementului \u0219i func\u021bia sa principal\u0103 este de a elimina complexele imune din \u021besuturi \u0219i autoantigenele generate \u00een timpul apoptozei<sup>3,4<\/sup>. O expunere prelungit\u0103 a epitopilor C1q la sistemul imunitar ar putea duce \u00een cele din urm\u0103 la un r\u0103spuns autoimun \u00eempotriva sa.<sup>4<\/sup>\u00a0Anticorpii anti-C1q \u00a0se dezvolt\u0103 \u00een tulbur\u0103ri caracterizate prin leziuni ale colegenului,\u00a0 mediate de complexul imun, mai frecvent la nivelul pielii \u0219i al microvasculariza\u021biei glomerulare. Anti-C1q Ab sunt de tip IgG si se observ\u0103 \u00een sindromul de vasculit\u0103 urticarian\u0103 hipocomplementemic\u0103 (100%), tulburarea mixt\u0103 a \u021besutului conjunctiv (94%), sindromul Felty (76%), lupus eritermatos sistemic (LES) (30-60%) \u0219i \u00een vasculita reumatoida (32%). Anticorpii Anti-C1q apar \u0219i \u00een tulbur\u0103rile vasculitice, cum ar fi poliarterita nodoz\u0103 (PAN), arterita cu celule gigante, boala vascular\u0103 Behcet \u0219i vasculita asociat\u0103 crioglobulinei. Anticorpii Anti-C1q\u00a0 sunt, de asemenea, observa\u021bi la pacien\u021bii cu vasculit\u0103 de etiologie infec\u021bioas\u0103 (toxocariaz\u0103 \u0219i infec\u021bia cu virusul hepatic C).<\/p>\n<p>Prezen\u021ba acestora \u00een ser este semnificativ asociat\u0103 cu LES. Specificitatea prezen\u021bei anticorpilor anti-C1q pentru diagnosticul LES a fost de p\u00e2n\u0103 la 90%. Una dintre ipotezele legate de patogeneza lupusului eritematos sistemic (LES) presupune c\u0103 boala este produs\u0103 de un clearance defectuos al celulelor moarte (prin apoptoz\u0103). \u00cen contextul unei elimin\u0103ri modificate, celulele apoptotice ar putea deveni antigenice, putand declansa un r\u0103spuns de tip autoimun. S-a demonstrat c\u0103 sistemul complement joac\u0103 un rol important \u00een eliminarea celulelor apoptotice, iar deficien\u021ba uneia dintre componentele timpurii ale c\u0103ii clasice a complementului ( C1q sau C4) este puternic asociat\u0103 cu dezvoltarea LES. Lupusul eritematos sistemic (LES) este o boal\u0103 autoimun\u0103 caracterizat\u0103 printr-un spectru clinic larg, de la leziuni cutanate p\u00e2n\u0103 la manifestari sistemice severe. LES se caracterizeaz\u0103 prin leziuni inflamatorii acute \u0219i cronice localizate la nivelul pielii sau la nivelul unor alte \u021besuturi \u0219i organe, precum rinichiul \u0219i sistemul nervos central<sup>1<\/sup>. Autoanticorpi \u00eempotriva C1q au fost identifica\u021bi \u0219i la 3-5% dintre indivizii normali. Ini\u021bial, anticorpii anti-C1q au fost observa\u021bi la 100% dintre pacien\u021bii cu vasculit\u0103 urticariant\u0103 hipocomplementemic\u0103 \u0219i la 30-48% dintre pacien\u021bii cu LES<sup>5,6<\/sup>.<\/p>\n<p>Peste o treime dintre pacien\u021bii cu LES prezint\u0103 complexe autoanticorp-antigen, care con\u021bin unele proteine \u200b\u200bale complemenentului seric, \u00een special C1q, protein\u0103 declan\u0219atoare a caii clasice de activare a acestuia.<\/p>\n<p>Deficien\u021ba ereditar\u0103 a acestei componente (C1q) prin muta\u021biii \u00een genele complementului, este un factor de risc cunoscut pentru dezvoltarea LES<sup>3<\/sup>. \u00centr-un astfel de caz, unele componente ale sistemului complementului ar putea fi inactivate. Anticorpii anti-C1q sunt puternic asocia\u021bi cu dezvoltarea nefritei lupice proliferative, inflama\u021bia renal\u0103 activ\u0103 la pacien\u021bii cu LES fiind foarte pu\u021bin probabil\u0103, dac\u0103 ace\u0219ti anticorpi nu sunt prezen\u021bi<sup>8<\/sup>. De\u0219i anticorpii anti-C1q au suscitat mult interes \u00een ultimii ani, func\u021biile lor biologice r\u0103m\u00e2n neclare. Cu toate acestea, valoarea lor predictiv\u0103 negativ\u0103 ridicat\u0103 pentru nefrita lupus activ\u0103, sugereaz\u0103 un rol patogen la pacien\u021bii cu LES. \u00cen plus, eliminarea anticorpilor anti C1q prin plasmaferez\u0103 repetat\u0103 sau imunoabsorb\u021bie C1q a \u00eembun\u0103t\u0103\u021bit starea clinic\u0103 a pacien\u021bilor cu LES<sup>9, 10<\/sup>.<\/p>\n<p><strong><em>\u00a0<\/em><\/strong><strong><em>Recomand\u0103ri pentru determinarea anticorpilor anti-C1q<\/em><\/strong><\/p>\n<ul>\n<li>Determinarea profilului autoimun de activitate renal\u0103, \u00een cazul lupusului eritematos sistemic<sup>10<\/sup>.<\/li>\n<\/ul>\n<p><strong><em>Specimen recoltat \u2013\u00a0<\/em><\/strong>\u0432\u0435\u043d\u043e\u0437\u043d\u0430\u044f \u043a\u0440\u043e\u0432\u044c<sup>11<\/sup><\/p>\n<p><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong><\/p>\n<ul>\n<li>Proba se centrifugheaz\u0103 \u0219i se colecteaz\u0103 serul \u00eentr-un tub steril<sup>11<\/sup>.<\/li>\n<\/ul>\n<p><strong><em>Volum prob\u0103\u00a0<\/em><\/strong>\u2013 1 mL<sup>11<\/sup><\/p>\n<p><strong><em>Cauze de respingere a probei\u00a0<\/em><\/strong><sup>11<\/sup><\/p>\n<ul>\n<li>Specimen hemolizat<\/li>\n<li>Specimen contaminat bacterian<\/li>\n<li>Specimen lipemic<\/li>\n<li>Specimen icteric<\/li>\n<\/ul>\n<p><strong><em>Stabilitate prob\u0103 \u2013\u00a0<\/em><\/strong>refrigerat timp de 14 zile<sup>11<\/sup><\/p>\n<p><strong><em>Metod\u0103\u00a0<\/em><\/strong>\u2013 ELISA<sup>2,11<\/sup><\/p>\n<p><strong><em>Valori de referin\u021b\u0103:\u00a0<\/em><\/strong>&lt;10U\/mL\u00a0<sup>2<\/sup><\/p>\n<p><strong><em>\u00a0<\/em><\/strong><strong><em>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/em><\/strong><\/p>\n<ol>\n<li>Mahler, M., van Schaarenburg, R. A., &amp; Trouw, L. A. (2013). Anti-C1q autoantibodies, novel tests, and clinical consequences. Frontiers in immunology, 4, 117.\u00a0https:\/\/doi.org\/10.3389\/fimmu.2013.00117<\/li>\n<li>Jayakanthan, K., Gupta, A. N., Mathew, J., Ravindran, R., Mahasampth, G., &amp; Danda, D. (2017). Clinical utility of anti-C1q antibody in primary and secondary vasculitic conditions. International journal of health sciences, 11(5), 3\u20136.<\/li>\n<li>Seelen, M. A., Trouw, L. A., &amp; Daha, M. R. (2003). Diagnostic and prognostic significance of anti-C1q antibodies in systemic lupus erythematosus. Current opinion in nephrology and hypertension, 12(6), 619\u2013624.\u00a0https:\/\/doi.org\/10.1097\/00041552-200311000-00008<\/li>\n<li>Katsumata, Y., Miyake, K., Kawaguchi, Y., Okamoto, Y., Kawamoto, M., Gono, T., Baba, S., Hara, M., &amp; Yamanaka, H. (2011). Anti-C1q antibodies are associated with systemic lupus erythematosus global activity but not specifically with nephritis: a controlled study of 126 consecutive patients. Arthritis and rheumatism, 63(8), 2436\u20132444.\u00a0https:\/\/doi.org\/10.1002\/art.30401<\/li>\n<li>Tsirogianni, E. Pipi, K. Soufleros (2009). Relevance of anti-C1q autoantibodies to lupus nephritis. Ann N Y Acad Sci, 1173, pp. 243-251<\/li>\n<li>Wisnieski JJ, Baer AN, Christensen J, et al. Hypocomplementemic urticarial vasculitis syndrome. Clinical and serologic findings in 18 patients. Medicine. 1995 Jan;74(1):24-41. DOI: 10.1097\/00005792-199501000-00003. PMID: 7837968.<\/li>\n<li>Karamehic, J., Subasic, D., Kasumovic, M., Hodzic, H., Prljaca-Zecevic, L., Tufekcic, M., &amp; Aganovic-Musinovic, I. (2010). Clinical management of patients with systemic lupus erythematosus (sle ) with different C1q-cic and C3 concentrations. Medical Archives, 64(2), 75. Retrieved from\u00a0https:\/\/www.proquest.com\/scholarly-journals\/clinical-management-patients-with-systemic-lupus\/docview\/1170606634\/se-2?accountid=7257<\/li>\n<li>Pickering, M., Botto, M. (2010). Are anti-C1q antibodies different from other SLE autoantibodies?. Nat Rev Rheumatol 6, 490\u2013493 https:\/\/doi.org\/10.1038\/nrrheum.2010.56<\/li>\n<li>Orbai, A. M., Truedsson, L., Sturfelt, G., Nived, O., Fang, H., Alarc\u00f3n, G. S., Gordon, C., Merrill, J., Fortin, P. R., Bruce, I. N., Isenberg, D. A., Wallace, D. J., Ramsey-Goldman, R., Bae, S. C., Hanly, J. G., Sanchez-Guerrero, J., Clarke, A. E., Aranow, C. B., Manzi, S., Urowitz, M. B., \u2026 Petri, M. (2015). Anti-C1q antibodies in systemic lupus erythematosus. Lupus, 24(1), 42\u201349.\u00a0https:\/\/doi.org\/10.1177\/0961203314547791<\/li>\n<li>Chen, Z., Wang, G. S., Wang, G. H., &amp; Li, X. P. (2012). Anti-C1q antibody is a valuable biological marker for prediction of renal pathological characteristics in lupus nephritis. Clinical rheumatology, 31(9), 1323\u20131329.\u00a0https:\/\/doi.org\/10.1007\/s10067-012-2017-1<\/li>\n<li>Test. Anti-C1q antibodies. [on-line]:\u00a0https:\/\/www.labcorp.com\/\u00a0Accesat la data de 10.10.2021<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>\u04211q \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043f\u0435\u0440\u0432\u044b\u043c \u0433\u043b\u0438\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043e\u043c \u0432 \u043a\u0430\u0441\u043a\u0430\u0434\u0435 \u0440\u0435\u0430\u043a\u0446\u0438\u0439 \u043f\u0440\u0438 \u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u0438 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442\u0430 \u043f\u043e \u043a\u043b\u0430\u0441\u0441\u0438\u0447\u0435\u0441\u043a\u043e\u043c\u0443 \u043f\u0443\u0442\u0438. \u041f\u043e\u0441\u043b\u0435 \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u043d\u0438\u044f C1q \u0441 \u0438\u043c\u043c\u0443\u043d\u043d\u044b\u043c\u0438 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u0430\u043c\u0438 \u0438\u043b\u0438 \u0441 \u0434\u0440\u0443\u0433\u0438\u043c\u0438 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0443\u044e\u0449\u0438\u043c\u0438 \u0441\u0443\u0431\u0441\u0442\u0430\u043d\u0446\u0438\u044f\u043c\u0438 \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0434\u0438\u0442 \u043a\u043e\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u043e\u043d\u043d\u0430\u044f \u043f\u0435\u0440\u0435\u0441\u0442\u0440\u043e\u0439\u043a\u0430 C1r \u0438 C1s \u0434\u043e \u043f\u0440\u043e\u0442\u0435\u043e\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0444\u0435\u0440\u043c\u0435\u043d\u0442\u043e\u0432, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043e\u0442\u0432\u0435\u0447\u0430\u044e\u0442 \u0437\u0430 \u043f\u0440\u043e\u0434\u043e\u043b\u0436\u0435\u043d\u0438\u0435 \u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u0438 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442\u0430 \u043f\u043e \u043a\u043b\u0430\u0441\u0441\u0438\u0447\u0435\u0441\u043a\u043e\u043c\u0443 \u043f\u0443\u0442\u0438. \u0421\u0438\u0441\u0442\u0435\u043c\u0430 \u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442\u0430 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0432\u0430\u0436\u043d\u044b\u043c \u0437\u0432\u0435\u043d\u043e\u043c \u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0445 \u0437\u0430\u0449\u0438\u0442\u043d\u044b\u0445 \u0440\u0435\u0430\u043a\u0446\u0438\u0439 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430, \u043e\u0431\u0435\u0441\u043f\u0435\u0447\u0438\u0432\u0430\u0435\u0442 \u0432\u044b\u0432\u0435\u0434\u0435\u043d\u0438\u0435 \u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0445 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043e\u0432 \u0438 \u0430\u043f\u043e\u043f\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0442\u0435\u043b\u0435\u0446 \u0438\u0437 \u043a\u0440\u043e\u0432\u043e\u0442\u043e\u043a\u0430, \u043f\u0440\u0435\u043f\u044f\u0442\u0441\u0442\u0432\u0443\u0435\u0442 \u0438\u0445 \u043d\u0430\u043a\u043e\u043f\u043b\u0435\u043d\u0438\u044e \u0432 \u0442\u043a\u0430\u043d\u044f\u0445.<\/p>\n<p>\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a C1q-\u0444\u0430\u043a\u0442\u043e\u0440\u0443 \u043f\u0440\u0438\u0432\u043e\u0434\u044f\u0442 \u043a \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u044e \u0443\u0440\u043e\u0432\u043d\u044f C1q \u0432 \u043a\u0440\u043e\u0432\u0438, \u0441\u043f\u043e\u0441\u043e\u0431\u0441\u0442\u0432\u0443\u044e\u0442 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044e \u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0445 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043e\u0432, \u043a\u043e\u0442\u043e\u0440\u044b\u0435, \u0432 \u0441\u0432\u043e\u044e \u043e\u0447\u0435\u0440\u0435\u0434\u044c, \u043e\u0442\u043a\u043b\u0430\u0434\u044b\u0432\u0430\u044e\u0442\u0441\u044f \u0432 \u0442\u043a\u0430\u043d\u044f\u0445 \u0438 \u043d\u0430\u0440\u0443\u0448\u0430\u044e\u0442 \u0438\u0445 \u0444\u0443\u043d\u043a\u0446\u0438\u044e. \u0412\u043f\u0435\u0440\u0432\u044b\u0435 \u0430\u0443\u0442\u043e\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a C1q \u0431\u044b\u043b\u0438 \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u044b \u0432 1984 \u0433\u043e\u0434\u0443 \u0432 \u0441\u044b\u0432\u043e\u0440\u043e\u0442\u043a\u0435 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0439 \u043a\u0440\u0430\u0441\u043d\u043e\u0439 \u0432\u043e\u043b\u0447\u0430\u043d\u043a\u043e\u0439 (\u0421\u041a\u0412). \u041c\u043d\u043e\u0433\u043e\u0447\u0438\u0441\u043b\u0435\u043d\u043d\u044b\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u0438, \u0447\u0442\u043e \u0430\u043d\u0442\u0438-C1q-\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 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