{"id":11906,"date":"2020-05-05T23:16:07","date_gmt":"2020-05-05T20:16:07","guid":{"rendered":"https:\/\/www.synevo.ro\/shop\/anticorpi-anti-glutamat-decarboxilaza-gad-in-lcr\/"},"modified":"2025-02-06T12:26:34","modified_gmt":"2025-02-06T10:26:34","slug":"anticorpi-anti-glutamat-decarboxilaza-gad-in-lcr","status":"publish","type":"product","link":"https:\/\/old.synevo.md\/ru\/shop\/anticorpi-anti-glutamat-decarboxilaza-gad-in-lcr\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0433\u043b\u0443\u0442\u0430\u043c\u0430\u0442\u0434\u0435\u043a\u0430\u0440\u0431\u043e\u043a\u0441\u0438\u043b\u0430\u0437\u0435 (GAD-II) \u0432 \u0441\u043f\u0438\u043d\u043d\u043e\u043c\u043e\u0437\u0433\u043e\u0432\u043e\u0439 \u0436\u0438\u0434\u043a\u043e\u0441\u0442\u0438"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong><em>Informa<\/em><\/strong><strong><em>\u021b<\/em><\/strong><strong><em>ii generale <\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Glutamatdecarboxilaza sau decarboxilaza acidului glutamic (GAD) este o enzim\u0103 implicat\u0103 \u00een sinteza acidului gama-aminobutiric (GABA), principalul neurotransmi\u021b\u0103tor inhibitor din sistemul nervos central (SNC)<sup>1;2<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Enzima este exprimat\u0103 selectiv \u00een neuronii GABA-ergici precum \u0219i \u00een celulele \u03b2-pancreatice.<\/p>\n<p style=\"text-align: justify;\">Anticorpii \u00eendrepta\u021bi \u00eempotriva izoformei GAD de 65 kDa (GAD65; GAD-II) sunt detecta\u021bi \u00een ser la aproximativ 80% dintre pacien\u021bii nou diagnostica\u021bi cu diabet zaharat tip 1. Niveluri crescute de anti-GAD II, de obicei de peste 100 ori mai mari dec\u00e2t cele \u00eenregistrate \u00een diabetul zaharat de tip 1, sunt \u00eent\u00e2lnite la pacien\u021bii cu sindromul persoanei rigide (\u201estiff-person syndrome\u201d &#8211; SPS) \u00een p\u00e2n\u0103 la 80% din cazuri, la un subgrup de pacien\u021bi cu ataxie cerebeloas\u0103 izolat\u0103, cu debut tardiv, asociat\u0103 cu diabet zaharat tip 1 sau autoimunitate poliendocrin\u0103, la unii pacien\u021bi cu epilepsie, nistagmus, disfunc\u021bie de trunchi cerebral<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><em>SPS<\/em> este o afec\u021biune rar\u0103 a sistemului nervos central caracterizat\u0103 prin rigiditate muscular\u0103 progresiv\u0103 peste care se suprapun spasme dureroase. Rigiditatea se manifest\u0103 predominant la nivelul por\u021biunii inferioare a trunchiului \u0219i la membrele inferioare dar poate afecta de asemenea membrele superioare \u0219i mu\u0219chii g\u00e2tului. Examenul electrofiziologic indic\u0103 o activitate continu\u0103 a unit\u0103\u021bii motorii. Sindromul se asociaz\u0103 frecvent cu boli autoimune, \u00een special diabetul zaharat tip 1; prezen\u021ba anti-GAD65 reprezint\u0103 un element caracteristic pentru aceast\u0103 comorbiditate de\u0219i sunt identifica\u021bi epitopi diferi\u021bi \u00een cele dou\u0103 boli. SPS poate constitui rar \u0219i o manifestare paraneoplazic\u0103 la persoanele cu cancer de s\u00e2n; \u00een aceste cazuri nu sunt depista\u021bi de obicei anticorpi anti-GAD65 ci anti-amfifizin\u0103 (o protein\u0103 sinaptic\u0103)<sup>2;3<\/sup>.<\/p>\n<p style=\"text-align: justify;\">La pacien\u021bii cu SPS a fost demonstrat\u0103 o sintez\u0103 intratecal\u0103 marcat\u0103 de anti-GAD65, indic\u00e2nd o activare clonal\u0103 a limfocitelor B \u00een SNC<sup>4<\/sup>. Anticorpii perturb\u0103 sinteza GABA av\u00e2nd drept consecin\u021b\u0103 stimularea continu\u0103 a musculaturii scheletice de c\u0103tre neuronii motori<sup>3;4<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Niveluri crescute de anti-GAD II \u00een ser \u0219i LCR au fost raportate de asemenea la unii pacien\u021bi cu <em>ataxie cerebeloas\u0103<\/em>. \u00cen majoritatea cazurilor este vorba de femei cu autoimunitate poliendocrin\u0103 care dezvolt\u0103 un sindrom cerebelos cronic. Profilul CSF este sugestiv pentru o afec\u021biune autoimun\u0103 fiind demonstrat\u0103 o sintez\u0103 intratecal\u0103 de anti-GAD II. Pacien\u021bii pot r\u0103spunde la tratament imunomodulator indic\u00e2nd un posibil rol patogenic pentru anti-GAD<sup>5<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Frecven\u021ba nivelurilor crescute de anti-GAD II la pacien\u021bii cu epilepsie este sc\u0103zut\u0103 (0-4%). Pacien\u021bii cu ace\u0219ti autoanticorpi au o probabilitate de a dezvolta o form\u0103 de epilepsie cu durat\u0103 lung\u0103, refractar\u0103 la tratament. Diabetul zaharat tip I poate fi prezent \u00eenainte de debutul epilepsiei sau poate ap\u0103rea dup\u0103 aceasta. Rolul patogenic al anticorpilor anti-GAD este neclar, \u00eens\u0103 detectarea unei sinteze intratecale crescute de anti-GAD65 sugereaz\u0103 o posibil\u0103 origine autoimun\u0103 a epilepsiei la ace\u0219ti pacien\u021bi<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Anticorpi anti-GAD au fost descri\u0219i \u0219i la c\u00e2\u021biva pacien\u021bi cu epilepsie de lob temporal cauzat\u0103 de <em>encefalit\u0103 limbic\u0103, <\/em>\u00eenmajoritatea cazurilor non-paraneoplazic\u0103. Pacien\u021bii, \u00een special tineri, prezint\u0103 benzi oligoclonale la examenul LCR \u0219i sintez\u0103 intratecal\u0103 de anti-GAD65. Afec\u021biunea are o evolu\u021bie progresiv\u0103 f\u0103r\u0103 perioade de remisiune. Corticoterapia nu determin\u0103 sc\u0103derea nivelului de autoanticorpi<sup>6<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Au fost descrise \u0219i unele cazuri de <em>sindroame neurologice paraneoplazice<\/em> cu anticorpi anti-GAD. Al\u0103turi de asocierea bine cunoscut\u0103 \u00eentre prezen\u021ba anticorpilor anti-amfifizin\u0103 \u0219i forma paraneoplazic\u0103 de SPS au fost raportate \u0219i cazuri rare de SPS paraneoplazic care prezint\u0103 anticorpi anti-GAD, tumorile subiacente fiind reprezentate de timom \u0219i alte cancere solide. De asemenea, au fost comunicate c\u00e2teva cazuri de encefalit\u0103 limbic\u0103 paraneoplazic\u0103 cu anti-GAD asociat\u0103 cu timom, iar la un pacient encefalita limbic\u0103 cu anti-GAD a precedat diagnosticul de cancer pulmonar cu celule mici (SCLC). \u00cen plus, a fost demonstrat\u0103 o sintez\u0103 intratecal\u0103 de anticorpi anti-GAD \u0219i la pacien\u021bi cu encefalomielit\u0103 \u0219i ataxie cerebeloas\u0103 paraneoplazic\u0103 \u00een asociere cu tumori neuroendocrine care exprim\u0103 GAD. Aceste date sugereaz\u0103 faptul c\u0103 reac\u021bia imun\u0103 dezvoltat\u0103 fa\u021b\u0103 de neoexpresia GAD de c\u0103tre tumor\u0103 poate cauza un sindrom neurologic paraneoplazic \u00eentr-un mod similar anticorpilor onconeuronali clasici. Din acest motiv, ar trebui luat\u0103 \u00een considerare posibilitatea unui sindrom neurologic paraneoplazic la pacien\u021bi cu niveluri crescute de anticorpi anti-GAD, mai ales c\u00e2nd ace\u0219tia nu asociaz\u0103 diabet zaharat tip I sau alte afec\u021biuni endocrine autoimune<sup>2<\/sup>.<\/p>\n<p style=\"text-align: justify;\">\u00cen concluzie, exist\u0103 c\u00e2teva aspecte importante legate de evaluarea pacien\u021bilor cu niveluri serice crescute de anti-GAD II \u0219i sindrom neurologic:<\/p>\n<ul style=\"text-align: justify;\">\n<li>nivelurile anti-GAD crescute pot fi asociate cu afec\u021biuni neurologice diverse, pe l\u00e2ng\u0103 SPS;<\/li>\n<li>prezen\u021ba anti-GAD poate s\u0103 reflecte numai prezen\u021ba unui diabet zaharat tip 1 sau a unei alte afec\u021biuni endocrine autoimune concomitente; de aceea, demonstrarea unei sinteze intratecale crescute de anti-GAD este important\u0103 pentru a confirma faptul c\u0103 autoimunitatea GAD este implicat\u0103 \u00een apari\u021bia sindromului neurologic \u0219i c\u0103 pacientul ar putea beneficia de imunoterapie;<\/li>\n<li>la pacien\u021bii f\u0103r\u0103 diabet zaharat tip 1 care dezvolt\u0103 sindroame neurologice ce sugereaz\u0103 o origine paraneoplazic\u0103, depistarea anticorpilor anti-GAD II \u00een LCR nu exclude efectuarea de investiga\u021bii pentru depistarea unei tumori subiacente<sup>2<\/sup>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong><em>Recomand\u0103ri pentru determinarea anticorpilor anti-GAD II \u00een LCR &#8211; <\/em><\/strong>evaluarea pacien\u021bilor cu SPS, ataxie cerebeloas\u0103 \u0219i alte afec\u021biuni SNC dob\u00e2ndite care afecteaz\u0103 neurotransmiterea gabaminergic\u0103<sup>1<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Pentru demonstrarea sintezei intratecale de anticorpi anti-GAD se recomand\u0103 determinarea concomitent\u0103 de<\/p>\n<ul>\n<li style=\"text-align: justify;\">anticorpi anti-GAD II \u00een ser;<\/li>\n<li style=\"text-align: justify;\">index imunoglobulinic ce include dozarea de albumin\u0103 \u0219i imunoglobuline de tip IgA, IgG, IgM \u00een ser \u0219i LCR \u00een vederea evalu\u0103rii integrit\u0103\u021bii barierei hematoencefalice \u0219i a produc\u021biei locale de imunoglobuline<sup>2;7<\/sup>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong><em>Preg\u0103tire pacient <\/em><\/strong><em>&#8211;<\/em>nu este necesar\u0103 o preg\u0103tire special\u0103<sup>7<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Specimen recoltat <\/em><\/strong><em>&#8211; <\/em>LCR(ob\u021binut prin punc\u021bie lombar\u0103)<sup>7<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Recipient de recoltare <\/em><\/strong><em>&#8211;<\/em> eprubet\u0103 steril\u0103<sup>7<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Prelucrare necesar\u0103 dup\u0103 recoltare<\/em><\/strong> \u2013 nu este necesar\u0103<sup>7<\/sup>.<\/p>\n<p style=\"text-align: justify;\"><strong><em>Volum prob\u0103<\/em><\/strong> \u2013 minim 1 mL LCR<sup>7<\/sup><\/p>\n<p style=\"text-align: justify;\"><strong><em>Stabilitate prob\u0103 <\/em><\/strong>- <em>14 zile<\/em> la 2-8<sup>0<\/sup>\u0412<sup>7<\/sup><\/p>\n<p style=\"text-align: justify;\"><strong><em>Metod\u0103 <\/em><\/strong>\u2013 radioimunologic\u0103 (RIA)<sup>7<\/sup><\/p>\n<p style=\"text-align: justify;\"><strong><em>Valori de referin\u021b\u0103 \u0219i interpretarea rezultatelor<\/em><\/strong><\/p>\n<div style=\"text-align: justify;\">Anticorpi anti-GAD II \u00een LCR &lt; 70 mU\/ mL: Negativ<sup>7<\/sup>.<\/div>\n<div style=\"text-align: justify;\">Un rezultat pozitiv trebuie interpretat \u00een contextul clinic al pacientului<sup>1;7<\/sup>.<\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: 10pt;\"><strong>\u0411\u0438\u0431\u043b\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f<\/strong><\/span><\/p>\n<div style=\"text-align: justify;\">1. \u00a0<span style=\"font-size: 10pt;\">Mayo Medical Laboratories. Test Catalog:Glutamic Acid Decarboxylase (GAD65) Antibody Assay, Spinal Fluid. www.mayomedicallaboratories.com. Ref Type: Internet Communication, 2014.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">2. \u00a0Saiz A, Blanco Y, Sabater L, Gonz\u00e1lez F, Bataller L, Casamitjana R, Rami\u00f3-Torrent\u00e0 L, Graus F. Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association. <em>Brain<\/em>. 2008 Oct;131(Pt 10):2553-63.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">3. \u00a0Rodgers-Neame NT. Stiff Person Syndrome. www.emedicine.medscape.com, Ref Type: Internet Communication, February 2012.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">4. Dalakas MC, Li M, Fujii M, Jacobowitz DM. Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodies. <em>Neurology<\/em><em>.<\/em> 2001 Sep 11;57(5):780-4.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">5. \u00a0\u00a0\u00a0Vianello M, Tavolato B, Armani M, Giometto B. Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies. <em>Cerebellum<\/em>. 2003;2(1):77-9.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">6.\u00a0\u00a0 Malter MP, Helmstaedter C, Urbach H, Vincent A, Bien CG. Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. <em>Ann Neurol<\/em><em>. <\/em>2010 Apr;67(4):470-8.<\/span><\/div>\n<div style=\"text-align: justify;\"><span style=\"font-size: 10pt;\">7.\u00a0\u00a0\u00a0\u00a0 Laborator Synevo. Referin\u021bele specifice tehnologiei de lucru utilizate 2014. Ref Type: Catalog.<\/span><\/div>","protected":false},"excerpt":{"rendered":"<p>\u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0442\u044c \u0432 \u0441\u043f\u0438\u043d\u043d\u043e\u043c\u043e\u0437\u0433\u043e\u0432\u043e\u0439 \u0436\u0438\u0434\u043a\u043e\u0441\u0442\u0438 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0433\u043b\u0443\u0442\u0430\u043c\u0430\u0442\u0434\u0435\u043a\u0430\u0440\u0431\u043e\u043a\u0441\u0438\u043b\u0430\u0437\u0435 (GAD) \u2014 \u043e\u0434\u0438\u043d \u0438\u0437 \u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u043d\u0435\u0440\u0432\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b, \u0432 \u0442\u043e\u043c \u0447\u0438\u0441\u043b\u0435 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0433\u043e \u044d\u043d\u0446\u0435\u0444\u0430\u043b\u0438\u0442\u0430, \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0439 \u044d\u043f\u0438\u043b\u0435\u043f\u0441\u0438\u0438, \u043c\u043e\u0437\u0436\u0435\u0447\u043a\u043e\u0432\u043e\u0439 \u0430\u0442\u0430\u043a\u0441\u0438\u0438 (\u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u043a\u043e\u043e\u0440\u0434\u0438\u043d\u0430\u0446\u0438\u0438).<\/p>\n<p>\u0413\u043b\u0443\u0442\u0430\u043c\u0430\u0442\u0434\u0435\u043a\u0430\u0440\u0431\u043e\u043a\u0441\u0438\u043b\u0430\u0437\u0430 (GAD) \u2014 \u0444\u0435\u0440\u043c\u0435\u043d\u0442, \u043a\u043e\u0442\u043e\u0440\u044b\u0439 \u0443\u0447\u0430\u0441\u0442\u0432\u0443\u0435\u0442 \u0432 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0438 \u0433\u0430\u043c\u043c\u0430-\u0430\u043c\u0438\u043d\u043e\u043c\u0430\u0441\u043b\u044f\u043d\u043e\u0439 \u043a\u0438\u0441\u043b\u043e\u0442\u044b.<\/p>\n<p>\u042d\u0442\u0430 \u043a\u0438\u0441\u043b\u043e\u0442\u0430 \u043e\u0447\u0435\u043d\u044c \u0432\u0430\u0436\u043d\u0430 \u0434\u043b\u044f \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430 \u2014 \u043f\u043e\u043c\u043e\u0433\u0430\u0435\u0442 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u0440\u0430\u0431\u043e\u0442\u0443 \u043d\u0435\u0440\u0432\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b, \u043e\u0442\u0432\u0435\u0447\u0430\u0435\u0442 \u0437\u0430 \u043f\u0430\u043c\u044f\u0442\u044c \u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u043c\u044b\u0448\u043b\u0435\u043d\u0438\u044f.<\/p>\n<p>\u041d\u043e \u0435\u0441\u043b\u0438 \u0438\u043c\u043c\u0443\u043d\u043d\u0430\u044f \u0441\u0438\u0441\u0442\u0435\u043c\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0438\u0440\u0443\u0435\u0442 \u0441\u043e \u0441\u0431\u043e\u044f\u043c\u0438, \u0442\u043e \u043e\u043d\u0430 \u043d\u0430\u0447\u0438\u043d\u0430\u0435\u0442 \u0441\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a GAD. \u0418\u0437-\u0437\u0430 \u044d\u0442\u043e\u0433\u043e \u0432\u044b\u0440\u0430\u0431\u043e\u0442\u043a\u0430 \u0433\u0430\u043c\u043c\u0430-\u0430\u043c\u0438\u043d\u043e\u043c\u0430\u0441\u043b\u044f\u043d\u043e\u0439 \u043a\u0438\u0441\u043b\u043e\u0442\u044b \u043d\u0430\u0440\u0443\u0448\u0430\u0435\u0442\u0441\u044f, \u0430 \u0443 \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430 \u0432\u043e\u0437\u043d\u0438\u043a\u0430\u044e\u0442 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u044b \u043d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0440\u0430\u0441\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432 \u2014 \u0441\u0443\u0434\u043e\u0440\u043e\u0433\u0438, \u0441\u043a\u043e\u0432\u0430\u043d\u043d\u043e\u0441\u0442\u044c \u043c\u044b\u0448\u0446, \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u044b \u0441 \u043a\u043e\u043e\u0440\u0434\u0438\u043d\u0430\u0446\u0438\u0435\u0439.<\/p>\n<p>\u0427\u0430\u0449\u0435 \u0432\u0441\u0435\u0433\u043e \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0433\u043b\u0443\u0442\u0430\u043c\u0430\u0442\u0434\u0435\u043a\u0430\u0440\u0431\u043e\u043a\u0441\u0438\u043b\u0430\u0437\u0435 (GAD) \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u0432\u0430\u044e\u0442\u0441\u044f \u0443 \u043b\u044e\u0434\u0435\u0439 \u0441 \u043d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u0440\u0430\u0441\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432\u0430\u043c\u0438.<\/p>\n<p>\u0417\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u043f\u0440\u0438 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0432\u044b\u0440\u0430\u0431\u0430\u0442\u044b\u0432\u0430\u044e\u0442\u0441\u044f \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a GAD:<\/p>\n<ul>\n<li>\u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u044b\u0439 \u044d\u043d\u0446\u0435\u0444\u0430\u043b\u0438\u0442 \u2014 \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u0435 \u0433\u043e\u043b\u043e\u0432\u043d\u043e\u0433\u043e \u043c\u043e\u0437\u0433\u0430;<\/li>\n<li>\u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0440\u0438\u0433\u0438\u0434\u043d\u043e\u0433\u043e \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430 \u2014 \u043d\u0430\u0440\u0430\u0441\u0442\u0430\u044e\u0449\u0430\u044f \u0441\u043a\u043e\u0432\u0430\u043d\u043d\u043e\u0441\u0442\u044c \u0438 \u0441\u043f\u0430\u0437\u043c\u044b \u0432 \u043c\u044b\u0448\u0446\u0430\u0445;<\/li>\n<li>\u043c\u043e\u0437\u0436\u0435\u0447\u043a\u043e\u0432\u0430\u044f \u0430\u0442\u0430\u043a\u0441\u0438\u044f \u2014 \u0432\u043d\u0435\u0437\u0430\u043f\u043d\u043e\u0435 \u043d\u0435\u0441\u043a\u043e\u043e\u0440\u0434\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0435 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\u044f\u0431\u043b\u043e\u043a\u0430\u043c\u0438;<\/li>\n<li>\u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0449\u0438\u0439 \u044d\u043d\u0446\u0435\u0444\u0430\u043b\u043e\u043c\u0438\u0435\u043b\u0438\u0442 \u2014 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u0440\u0430\u0431\u043e\u0442\u044b \u0433\u043e\u043b\u043e\u0432\u043d\u043e\u0433\u043e \u0438 \u0441\u043f\u0438\u043d\u043d\u043e\u0433\u043e \u043c\u043e\u0437\u0433\u0430;<\/li>\n<li>\u0441\u0438\u043d\u0434\u0440\u043e\u043c \u041c\u0438\u043b\u043b\u0435\u0440\u0430-\u0424\u0438\u0448\u0435\u0440\u0430 \u2014 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u0440\u0430\u0431\u043e\u0442\u044b \u0447\u0435\u0440\u0435\u043f\u043d\u043e-\u043c\u043e\u0437\u0433\u043e\u0432\u044b\u0445 \u043d\u0435\u0440\u0432\u043e\u0432, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043e\u0442\u0432\u0435\u0447\u0430\u044e\u0442 \u0437\u0430 \u0434\u0432\u0438\u0436\u0435\u043d\u0438\u044f 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\u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0434\u0438\u0442\u044c \u043f\u0440\u0435\u0434\u043f\u043e\u043b\u043e\u0436\u0435\u043d\u0438\u0435 \u043e\u0431 \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0439 \u043f\u0440\u0438\u0440\u043e\u0434\u0435 \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u044f \u043f\u0440\u0438 \u043d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[934,928],"product_tag":[],"class_list":{"0":"post-11906","1":"product","2":"type-product","3":"status-publish","5":"product_cat-autoanticorpi-in-afectiuni-neurologice","6":"product_cat-markeri-boli-autoimune","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/11906","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=11906"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=11906"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=11906"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=11906"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=11906"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}