Distrofie musculara a centurilor LGMD2A (PCMD, distrofia muscular\u0103 a membrelor, LGMD; ICD-10: G71.0) este un grup eterogen de boli ereditare caracterizate prin sl\u0103biciune muscular\u0103 progresiv\u0103 \u0219i atrofie muscular\u0103 cu leziuni predominante ale extremit\u0103\u021bilor proximale.<\/p>\n
LGMD2A include mai mult de 25 de forme, variind \u00een severitate, fenotip, v\u00e2rsta de debut \u0219i modific\u0103ri patologice \u00een \u021besutul muscular.<\/p>\n
Tratamentul bolilor este simptomatic, precum \u0219i de sus\u021binere.<\/p>\n
Boala se bazeaz\u0103 pe muta\u021bii \u00een cel pu\u021bin 24 de gene. Diferite forme de LGMD2A sunt mo\u0219tenite at\u00e2t de tip autosomal dominant, c\u00e2t \u0219i de tip autosomal recesiv. \u00cen acela\u0219i timp, mo\u0219tenirea autosomal\u0103 recesiv\u0103 este caracteristic\u0103 a 24 de tipuri de boal\u0103, iar mo\u0219tenirea autosomal\u0103 dominant\u0103 este caracteristic\u0103 a cinci tipuri. Tipul de mo\u0219tenire depinde de natura muta\u021biei genetice<\/p>","protected":false},"excerpt":{"rendered":"
\u041f\u043e\u044f\u0441\u043d\u043e-\u043a\u043e\u043d\u0435\u0447\u043d\u043e\u0441\u0442\u043d\u0430\u044f \u043c\u044b\u0448\u0435\u0447\u043d\u0430\u044f \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u044f (\u041f\u041a\u041c\u0414, limb-girdle muscular dystrophy, LGMD; \u041c\u041a\u0411-10: G71.0) \u2014 \u0433\u0435\u0442\u0435\u0440\u043e\u0433\u0435\u043d\u043d\u0430\u044f \u0433\u0440\u0443\u043f\u043f\u0430 \u043d\u0430\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u0443\u044e\u0442\u0441\u044f \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0449\u0435\u0439 \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u0441\u043b\u0430\u0431\u043e\u0441\u0442\u044c\u044e \u0438 \u0430\u0442\u0440\u043e\u0444\u0438\u0435\u0439 \u043c\u044b\u0448\u0446 \u0441 \u043f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u0435\u043c \u043f\u0440\u043e\u043a\u0441\u0438\u043c\u0430\u043b\u044c\u043d\u044b\u0445 \u043e\u0442\u0434\u0435\u043b\u043e\u0432 \u043a\u043e\u043d\u0435\u0447\u043d\u043e\u0441\u0442\u0435\u0439.<\/p>\n
\u041f\u041a\u041c\u0414 \u0432\u043a\u043b\u044e\u0447\u0430\u044e\u0442 \u0431\u043e\u043b\u0435\u0435 25 \u0444\u043e\u0440\u043c, \u0440\u0430\u0437\u043b\u0438\u0447\u0430\u044e\u0449\u0438\u0445\u0441\u044f \u043f\u043e \u0442\u044f\u0436\u0435\u0441\u0442\u0438 \u0442\u0435\u0447\u0435\u043d\u0438\u044f, \u0444\u0435\u043d\u043e\u0442\u0438\u043f\u0443, \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0443 \u043d\u0430\u0447\u0430\u043b\u0430 \u0438 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f\u043c \u0432 \u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438.<\/p>\n
\u041b\u0435\u0447\u0435\u043d\u0438\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0435, \u0430 \u0442\u0430\u043a\u0436\u0435 \u043f\u043e\u0434\u0434\u0435\u0440\u0436\u0438\u0432\u0430\u044e\u0449\u0435\u0435.<\/p>\n
\u0412 \u043e\u0441\u043d\u043e\u0432\u0435 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043b\u0435\u0436\u0430\u0442 \u043c\u0443\u0442\u0430\u0446\u0438\u0438 \u043a\u0430\u043a \u043c\u0438\u043d\u0438\u043c\u0443\u043c \u0432 24 \u0433\u0435\u043d\u0430\u0445. \u0420\u0430\u0437\u043d\u044b\u0435 \u0444\u043e\u0440\u043c\u044b \u041f\u041a\u041c\u0414 \u043d\u0430\u0441\u043b\u0435\u0434\u0443\u044e\u0442\u0441\u044f \u043a\u0430\u043a \u043f\u043e \u0430\u0443\u0442\u043e\u0441\u043e\u043c\u043d\u043e-\u0434\u043e\u043c\u0438\u043d\u0430\u043d\u0442\u043d\u043e\u043c\u0443, \u0442\u0430\u043a \u0438 \u043f\u043e \u0430\u0443\u0442\u043e\u0441\u043e\u043c\u043d\u043e-\u0440\u0435\u0446\u0435\u0441\u0441\u0438\u0432\u043d\u043e\u043c\u0443 \u0442\u0438\u043f\u0443. \u041f\u0440\u0438 \u044d\u0442\u043e\u043c \u0430\u0443\u0442\u043e\u0441\u043e\u043c\u043d\u043e-\u0440\u0435\u0446\u0435\u0441\u0441\u0438\u0432\u043d\u043e\u0435 \u043d\u0430\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u043e \u0434\u043b\u044f 24 \u0442\u0438\u043f\u043e\u0432 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u0430 \u0430\u0443\u0442\u043e\u0441\u043e\u043c\u043d\u043e-\u0434\u043e\u043c\u0438\u043d\u0430\u043d\u0442\u043d\u043e\u0435 \u2014 \u0434\u043b\u044f \u043f\u044f\u0442\u0438 \u0442\u0438\u043f\u043e\u0432. \u0422\u0438\u043f \u043d\u0430\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0437\u0430\u0432\u0438\u0441\u0438\u0442 \u043e\u0442 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0430 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043c\u0443\u0442\u0430\u0446\u0438\u0438.<\/p>","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[969],"product_tag":[],"class_list":{"0":"post-10349","1":"product","2":"type-product","3":"status-publish","5":"product_cat-teste-de-genetica-umana","7":"first","8":"instock","9":"sold-individually","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product\/10349","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/comments?post=10349"}],"wp:attachment":[{"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/media?parent=10349"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_brand?post=10349"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_cat?post=10349"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/old.synevo.md\/ru\/wp-json\/wp\/v2\/product_tag?post=10349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}